|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cross-kingdom inhibition of breast cancer growth by plant miR159显示文摘MicroRNAs (miRNAs ) 是基因表示的批评管理者,并且在优核质的开发,生理学,和疾病施加广泛的影响。并行的高度在植物和动物在 miRNA 生物的续生说和行动的分子的基础被发现。最近的研究有趣地建议导出植物的 miRNAs 的一个潜在的跨王国的行动,通过饮食的吸入,在调整哺乳动物的基因表示。尽管在哺乳动物的标本检测的植物 miRNAs 的来源和范围仍然保持争论,这些起始的研究鼓舞了我们决定植物 miRNAs 是否能在西方的人的 sera 被检测并且这些植物 miRNAs 是否能影响与象癌症那样的人的疾病有关的基因表示和细胞的过程。这里,我们发现西方的施主 sera 包含了植物 miRNA miR159,其在浆液的丰富相反地在病人与乳癌发生和前进被相关。在人的 sera, miR159 主要在细胞外的泡被检测,并且对在 3 ′ 上建议发源植物的 2'-O-methylation 的钠 periodate 氧化抵抗;终端核糖。在乳癌房间然而并非非癌的乳房的上皮的房间,一合成 miR159 模仿能够由指向编码表明抄写因素的 Wnt 的 TCF7 禁止增长,在 MYC 蛋白质层次导致减少。miR159 的口头的管理显著地模仿在老鼠压制了异种皮移植胸肿瘤的生长。这些结果第一次证明植物 miRNA 能在哺乳动物禁止癌症生长。 | Andrew R Chin Miranda Y Fong George Somlo Jun Wu Piotr Swiderski Xiwei Wu Shizhen Emily Wang | 2016 | Cell Research2016，26，2： | 35 |
| 2 | LITHOSPHERE-ASTHENOSPHERE INTERACTION: A COMPARATIVE STUDY ON CENOZOIC AND MESOZOIC BASALTS AROUND BOHAI AREA | Yigang Xu Weiming Fan and Ge Lin( Guangzhou Institute of Geochemistry , Chinese Academy of Sciences , Guangzhou , P. R, China)(Department of Gedegy, Royal Holoway Univoersity of London, Egham, Surrey, TW20OEX , UK)(Changsha Institute of Geotectonics,Chin | 1995 | Geotectonica et Metallogenia1995，19，4： | 16 |
| 3 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 4 | Analysis of thinning algorithms using mathematical morphology 显示文摘 | JANG B K CHIN R T | 1990 | Pattern Analysis and Machine Intelligence1990，12，6： | 2 |
| 5 | On image analysis by the method of moments 显示文摘 | The C H Chin R T | 1988 | IEEE Trans PAMI1988，10，4： | 2 |
| 6 | On image analysis by the methods of moments显示文摘 | The C H Chin R T | 1988 | IEEE Transaction on Pattern Analysis and Machine Intelligence1988，10，： | 1 |
| 7 | Antioxidant activities of Sophora subprosrate polysaccharide in immunosuppressed mice 显示文摘 | Chin J Hu T Zheng R | 2007 | Int Immunopharmacol2007，7，4： | 1 |
| 8 | A new species of Memnoniella显示文摘 | De-wei Li Chins Yang Haugland R | 2003 | Mycotaxon2003，，： | 1 |
| 9 | Automated Visual Inspection:A Survey显示文摘 | Chin R T | | 0，，06： | 1 |
| 10 | TargetingROS1 with anaplastic lymphoma kinaseinhibitors: a promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer 显示文摘 | Chin LP1 Soo RA Soong R | 2012 | J Thorac Oncol2012，7，11： | 1 |
| 11 | Thetwo-component sensor kinase KdpD is required forSalmonella typhimurium colonization ofCaenorhabditis elegans and survival in macrophages显示文摘 | Alegado R A Chin C Y Monack D M | 2011 | Cellular Microbiology2011，13，10： | 1 |
| 12 | Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation显示文摘 | Gomez F Saiki R Chin R Srinivasan C Clarke CF | 2012 | Gene2012，506，： | 1 |
| 13 | Magnetic resonance neurogra- phy for the evaluation of peripheral nerve, braehial plexus, and nerve root disorders显示文摘 | Du R Auguste KI Chin CT | 2010 | I Neurosurg2010，112，2： | 1 |
| 14 | Microsurgical renal transplant models in rats: a comparison of four anastomotic techniques 显示文摘 | Chin J Zhong R Duff J | 1989 | Transplant Proe1989，21，2： | 1 |
| 15 | Function of AKT/PKB signaling to cell motility,invation,and the tumor stroma in cancer显示文摘 | CHIN Y R TOXER A | 2009 | Cell Signal2009，21，： | 1 |
| 16 | Deformable contours:modeling and extraction显示文摘 | LAI K F CHIN R T | 1995 | IEEE Trans on Pattern Analysis and Machine Intelligence1995，17，11： | 1 |
| 17 | Scale_based detection of corners of planar curves显示文摘 | ANOTHAI R CHIN RT | 1992 | IEEE Transaction on Pattern Analysis and Machine Intelligence1992，14，4： | 1 |
| 18 | Journals of Materials Processing Technology显示文摘 | Zee R H Xiao Z Chin B A | 2001 | 113:752001，113，： | 1 |
| 19 | On image analysis by the methods of moments显示文摘 | Teh C H Chin R T | 1988 | IEEE Trans Pattern Anal Mach Intell1988，10，4： | 1 |
| 20 | Molecular evolution ofH6influenza viruses from poultry in Southeastern China:preva-lence of H6N1influenza viruses possessingseven A/Hong Kong/156/97(H5N1)-like genes in poultry显示文摘 | Chin PS Hoffmann E Webby R | 2002 | JVirol2002，76，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员