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| 1 | Cross-kingdom inhibition of breast cancer growth by plant miR159显示文摘MicroRNAs (miRNAs ) 是基因表示的批评管理者,并且在优核质的开发,生理学,和疾病施加广泛的影响。并行的高度在植物和动物在 miRNA 生物的续生说和行动的分子的基础被发现。最近的研究有趣地建议导出植物的 miRNAs 的一个潜在的跨王国的行动,通过饮食的吸入,在调整哺乳动物的基因表示。尽管在哺乳动物的标本检测的植物 miRNAs 的来源和范围仍然保持争论,这些起始的研究鼓舞了我们决定植物 miRNAs 是否能在西方的人的 sera 被检测并且这些植物 miRNAs 是否能影响与象癌症那样的人的疾病有关的基因表示和细胞的过程。这里,我们发现西方的施主 sera 包含了植物 miRNA miR159,其在浆液的丰富相反地在病人与乳癌发生和前进被相关。在人的 sera, miR159 主要在细胞外的泡被检测,并且对在 3 ′ 上建议发源植物的 2'-O-methylation 的钠 periodate 氧化抵抗;终端核糖。在乳癌房间然而并非非癌的乳房的上皮的房间,一合成 miR159 模仿能够由指向编码表明抄写因素的 Wnt 的 TCF7 禁止增长,在 MYC 蛋白质层次导致减少。miR159 的口头的管理显著地模仿在老鼠压制了异种皮移植胸肿瘤的生长。这些结果第一次证明植物 miRNA 能在哺乳动物禁止癌症生长。 | Andrew R Chin Miranda Y Fong George Somlo Jun Wu Piotr Swiderski Xiwei Wu Shizhen Emily Wang | 2016 | Cell Research2016，26，2： | 35 |
| 2 | Management of patients with stercoral perforation of the sigmoid colon:Report of five cases显示文摘到我们的知识,冒号的粪的穿孔很少比 90 个案例在文学报导到日期为止与少数被看见。我们探索了管理的原则与这个条件在五个病人阻止逼近的死亡。五个病人,二男性和三女性,其中部的年龄是 64 年,支撑了 S 字形的冒号的粪的穿孔。长期的便秘是在这些病人之中的普通症状。三个病人经历了一个 Hartmannos 过程和另外一个二与吻合和转移结肠开口术与部分结肠切除术被对待。有一外科的死亡,另外的病人让一所平静医院留下来。与广泛的腹洗室年龄一起阻止或对待任何联系败血的及时干预和在主要粪的溃疡地点的结肠的织物结合了移开 diseased 的外科的干预为腹膜炎的好攻击的治疗是在抢救与冒号的粪的穿孔介绍的病人的关键治疗形式。 | Wen-Shih Huang Chia-Siu Wang Ching-Chuan Hsieh Paul Y Lin Chih-Chien Chin Jeng-Yi Wang | 2006 | World Journal of Gastroenterology2006，12，3： | 18 |
| 3 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 4 | Tunable and switchable polarization rotation with non-reciprocal plasmonic thin films at designated wavelengths显示文摘We experimentally demonstrate an ultra-thin plasmonic optical rotator in the visible regime that induces a polarization rotation that is continuously tunable and switchable by an external magnetic field.The rotator is a magneto-plasmonic hybrid structure consisting of a magneto-optical EuSe slab and a one-dimensional plasmonic gold grating.At low temperatures,EuSe possesses a large Verdet constant and exhibits Faraday rotation,which does not saturate over a regime of several Tesla.By combining these properties with plasmonic Faraday rotation enhancement,a large tuning range of the polarization rotation of up to 8.4° for a film thickness of 220 nm is achieved.Furthermore,through experiments and simulations,we demonstrate that the unique dispersion properties of the structure enable us to tailor the wavelengths of the tunable polarization rotation to arbitrary spectral positions within the transparency window of the magneto-optical slab.The demonstrated concept might lead to important,highly integrated,non-reciprocal,photonic devices for light modulation,optical isolation,and magnetic field optical sensing.The simple fabrication of EuSe nanostructures by physical vapor deposition opens the way for many potentially interesting magneto-plasmonic systems and three-dimensional magneto-optical metamaterials. | Dominik Floess Jessie Y Chin Akihito Kawatani Daniel Dregely Hanns-Ulrich Habermeier Thomas Weiss Harald Giessen | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 5 | Adult metaplastic hutch diverticulum with robotic-assisted diverticulectomy and reconstruction:A case report显示文摘BACKGROUND Hutch diverticulum arises from the compromised muscular development at the ureteral orifice.It is a congenital disease and extremely rare in adult,only accounting for about 3%occurrence worldwide.It can be either symptomatic or asymptomatic,and relies on image tools for diagnosis and preoperative planning.Indications for surgery are dependent on the complications from the diverticulum.Metaplasia is about 10%among those with hutch diverticulum,and it still has chances turning into malignancy,especially urothelial cell carcinoma.CASE SUMMARY A 27-year-old man was presented with frequently recurrent urinary tract infection for one year,and had suffered from intermittent right flank pain for 3 mo.No past medical histories were recorded before.No obvious abnormalities on laboratory data and urine examination were found.Under ultrasound,right hydronephrosis was seen and an anatomical abnormality was observed on intravenous pyelography.Further computed tomography urogram showed one diverticulum seated at superolateral side of right ureteral orifice.Cystoscopy was done and biopsy results showed focal metaplasia.After discussing with him,roboticassisted diverticulectomy with reconstruction was performed.Right hydronephrosis was greatly improved after surgery.He has completed his 1.5-year follow-ups,and no malignancies were seen from urine cytology and image of intravenous pyelography.CONCLUSION Robotic-assisted diverticulectomy and reconstruction to hutch diverticulum is a safe and efficient operation,providing several advantages over open and laparoscopic ones. | Che H Yang Yi S Lin Yen C Ou Wei C Weng Li H Huang Chin H Lu Chao Y Hsu Min C Tung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 6 | A hybrid rough-cut process planning for quality 显示文摘 | Chin K S Zheng L Y Wei L | 2003 | International Journal of Advanced Manufacturing Teehnology2003，22，910： | 2 |
| 7 | Preeclampsia is associated with abnormal expression of adhesion molecule by invasive cytotrophoblasts显示文摘 | Zhou Y Damsky K Chin JM | 1993 | J Clin Invest1993，91，： | 1 |
| 8 | Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra)显示文摘 | Chin Y W Jung H A Liu Y | 2007 | J Agric Food Chem2007，55，12： | 1 |
| 9 | Thetwo-component sensor kinase KdpD is required forSalmonella typhimurium colonization ofCaenorhabditis elegans and survival in macrophages显示文摘 | Alegado R A Chin C Y Monack D M | 2011 | Cellular Microbiology2011，13，10： | 1 |
| 10 | Induction of vascular endthelial growth factor by nitric oxide in human glioblastoma and hepatoeellular carcinoma cell显示文摘 | Chin K Kurashima Y 0gura T et aI | 1997 | Oncogeoe1997，15，： | 1 |
| 11 | The effect of innova- tive activity on firm performance: the experience ofTaiwan 显示文摘 | ANANDARAJAN A CHIN C - L CHI H - Y | 2007 | Ad- vances in Accounting2007，23，1： | 1 |
| 12 | New ternary Ni-Ta-Sn bulk metallic glasses显示文摘 | TIEN H Y LIN C Y CHIN T S | 2006 | Intermetallies2006，14，： | 1 |
| 13 | Function of AKT/PKB signaling to cell motility,invation,and the tumor stroma in cancer显示文摘 | CHIN Y R TOXER A | 2009 | Cell Signal2009，21，： | 1 |
| 14 | Inclusion degree:a perspective on measures for rough set data analysis显示文摘 | Xu Z B Liang J Y Dang C Y Chin K S | 2002 | Information Sciences2002，141，： | 1 |
| 15 | 显示文摘 | Zhang S Y Chin | 1991 | Chem Phys1991，，4： | 1 |
| 16 | Bulk elastic wave propagation in partially saturated porous solids 显示文摘 | Berryman J G Thigpen L Chin R C Y | 1988 | Jourual of the Acoustical Society of America1988，84，1： | 1 |
| 17 | Evaluation of pre- heating and extraction solvents in antioxidant and antimicrobial activities of garlic, and their application in fresh pork patties 显示文摘 | PARK S Y CHIN K B | 2010 | International Journal of Food Science and Technology2010，45，2： | 1 |
| 18 | Very high density RF MIM capacitors (17 fF/μm) using high-k Al2O3 doped Ta2O5 dielectrics显示文摘 | YANG M Y HUANG C H CHIN A | | 0，，10： | 1 |
| 19 | Optofluidie waveguide as a transformation optics device for lightwave bending and manipulation显示文摘 | Yang Y Liu A Q Chin L K | 2012 | Nature Communications2012，3，： | 1 |
| 20 | Mutual infor- mation-based selection of optimal spatial-temporal patterns for single-trial EEG-based BCIs显示文摘 | Ang K K Chin Z Y Zhang H | 2012 | Pattern Recognition2012，45，6： | 1 |
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