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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Magnetic structure and Fe moment distribution in rare-earth iron intermetallic compounds by first-principles calculations 显示文摘 | Ching W Y Xu Y N | 2000 | J Magn Magn Mate2000，209，： | 1 |
| 3 | An accurate power control strategy for power electronics interfaced distributed generation units operating in a low voltage multibus microgrid 显示文摘 | Li Y W Ching N K | 2009 | IEEE Transactions on Power Electronics2009，24，12： | 1 |
| 4 | Grain boundary strengthening in alumina by rare earth impurities显示文摘 | BUBAN J P MATSUNAGA K CHEN J SHIBATA N CHING W Y IKUHARA Y | 2006 | Science2006，311，5758： | 1 |
| 5 | A lasermicromachined multi - modal resonating power transducer for wireless sensing systems 显示文摘 | Ching Neil N H Wong H Y Li Wen J | 2002 | Sensors and Actuators A2002，9798，： | 1 |
| 6 | 显示文摘 | Ching W Y Yong N X Rulis P | 2002 | Appl Phys Lett2002，80，： | 1 |
| 7 | A laser-micromachined multi-modal resonating power transducer for wireless sensing systems显示文摘 | Ching N N H Wong H Y Li Wen J | 2002 | Sensors and Actuators A2002，9798，： | 1 |
| 8 | Electronic,optical,and structuralproperties of some wurtzite crystals显示文摘 | XU Y N CHING W Y | 1993 | Physical Review B1993，48，7： | 1 |
| 9 | The use of growth factor and other humoral agents to accelerate and enhance burn wound healing显示文摘 | Ching H Y Sutton T L Pierpont Y N | 2011 | Eplasty2011，11，： | 1 |
| 10 | Strategies for improving the efficiency of semiconductor metal oxide photocatalysis 显示文摘 | Djurisic A B Leung Y H Ching N A M | 2014 | Materials Horizons2014，，4： | 1 |
| 11 | Iterative algorithms based on decoupling of deblurring and denoising for image restoration显示文摘 | Wen Y W Michael K N and Ching W K | 2008 | SIAM Journal on Scientific Computing2008，30，5： | 1 |
| 12 | A laser-mieroma-chined multi-modal resonating power transducer for wireless sensing systems 显示文摘 | Ching N N H Wong H Y Li W J | 2002 | Sensors and Actuators A2002，9798，： | 1 |
| 13 | Uhrafihration in food process- ing industry: review on application, membrane fouling, and fouling control显示文摘 | Abdul W M Ching Y N Ying P L | 2012 | Food bioprocess technology2012，5，4： | 1 |
| 14 | Antioxidant Activity of Extracts of Peh - Hue - Juwa - Chi - Can in a Cell Free System 显示文摘 | Chun - Ching L Lean - Teik N Jenq - Jer Y | 2004 | The American Journal of Chinese Medicine2004，32，3： | 1 |
| 15 | Ground-state and Optical Properties of Cu20 and CuO Crystals显示文摘 | Ching W Y Xu Y N Wong K W | 1998 | Physical Review B1998，40，11： | 1 |
| 16 | A laser-micromachined multi-modal resonating power transducer for wireless sensing systems 显示文摘 | Ching N N H Wong H Y Li W J | 2002 | Sensors and Actuators A : Physical2002，9798，： | 1 |
| 17 | A laser-micromachined multi-modal resonating power transducer for wireless sensing systems 显示文摘 | Ching Neil N H Wong H Y Li Wen J | 2002 | Sensors and Actuators A2002，9798，： | 1 |
| 18 | 显示文摘 | Xu Y N Ching W Y | 2000 | Philos Mag B2000，80，6： | 1 |
| 19 | A laser-micromachi-ned multi-modal resonating power transducer for wireless sen-singsystems显示文摘 | Ching N N H Wong H Y Li Wen J | 2002 | Sensors and Actuators A2002，9798，： | 1 |
| 20 | Strategies for improving the efficiency of semiconductor metal oxide photocatalysis显示文摘 | Djurisic A B Leung Y H Ching N AM | 2014 | Ma- terials Horizons2014，1，4： | 1 |
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