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| 1 | Circulating adhesion molecules in patients with virus-related chronic diseases of the liver显示文摘AIM: In the inflammatory state, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) play a key role in promoting migration of immunological cells from the circulation to target site.Aim of our study was to investigate soluble forms of these molecules in patients with virus-related chronic liver diseases, to assess their behavior in different pathologies and correlation with severity of liver damage.METHODS: Circulating ICAM-1 and VCAM-1 were assayed by EIA commercial kits (R&D System Co.,Abington, UK) in 23 patients with chronic active hepatitis (CH), 50 subjects affected by liver cirrhosis (LC) and 15 healthy controls comparable for sex and age. In patients, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also detected by autoanalyzer.RESULTS: LC patients had significantly higher ICAM-1 values than CH patients (38.56±7.4 ng/mL vs 20.89±6.42 ng/mL; P<0.001) and these ones had significantly higher values than controls (12.92±1.08 ng/mL; P<0.001). In CH group, ICAM-1 levels were significantly related to inflammatory activity (P= 0.041) and ALT values (r= 0.77;P<0.05). VCAM-1 values were significantly increased only in LC patients (P<0.001) and related to severity of liver impairment.CONCLUSION: These findings suggest that the determination of serum ICAM-1 can be considered as an additional useful marker of hepatocellular necrosis and inflammatory activity in chronic hepatitis, while serum VCAM-1 is an indicator of liver fibrogenesis and severity of disease in cirrhosis. | Cosimo Marcello Bruno Claudio Sciacca Danila Cilio Gaetano Bertino Anna Elisa Marchese Gaetana Politi Lucia Chinnici | 2005 | World Journal of Gastroenterology2005，11，29： | 19 |
| 2 | Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis 显示文摘 | Yao Y Chinnici C Tang H | 2004 | J Neuroinflam2004，1，1： | 1 |
| 3 | Optimization of the determination of organic acids and sugars in fruit juices by ion exclusion liquid chromatography 显示文摘 | Chinnici F Spinabelli U Riponi C | 2005 | J Food Composition and Analysis2005，18，： | 1 |
| 4 | Optimization of the determination of organic acids and sugars in fruit juices by ion- exclusion liquid chromatography显示文摘 | CHINNICI F SPINABELLJ U RIPONI C | 2005 | Journal of Food Composition and Analysis2005，18，2： | 1 |
| 5 | Mesenchymal stromal cell secretome in liver failure:Perspectives on COVID-19 infection treatment显示文摘Due to their immunomodulatory potential and release of trophic factors that promote healing,mesenchymal stromal cells(MSCs)are considered important players in tissue homeostasis and regeneration.MSCs have been widely used in clinical trials to treat multiple conditions associated with inflammation and tissue damage.Recent evidence suggests that most of the MSC therapeutic effects are derived from their secretome,including the extracellular vesicles,representing a promising approach in regenerative medicine application to treat organ failure as a result of inflammation/fibrosis.The recent outbreak of respiratory syndrome coronavirus,caused by the newly identified agent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has forced scientists worldwide to use all available instruments to fight the infection,including the inflammatory cascade caused by this pandemic disease.The use of MSCs is a valid approach to combat organ inflammation in different compartments.In addition to the lungs,which are considered the main inflammatory target for this virus,other organs are compromised by the infection.In particular,the liver is involved in the inflammatory response to SARS-CoV-2 infection,which causes organ failure,leading to death in coronavirus disease 2019(COVID-19)patients.We herein summarize the current implications derived from the use of MSCs and their soluble derivatives in COVID-19 treatment,and emphasize the potential of MSCbased therapy in this clinical setting. | Cinzia Maria Chinnici Giovanna Russelli Matteo Bulati Vitale Miceli Alessia Gallo Rosalia Busà Rosaria Tinnirello Pier Giulio Conaldi Gioacchin Iannolo | 2021 | World Journal of Gastroenterology2021，27，17： | 1 |
| 6 | The 5-1ipoxygenase enzymatic pathway in the mouse brain: young versus old显示文摘 | Chinnici CM Yao Y Pratic 1) | 2007 | Neurobiol Aging2007，28，： | 1 |
| 7 | Optimization of the determination of organic acids and sugarsof fruit juices by ion-exclusion liquid chromatography显示文摘 | Fabio Chinnici Umberto Spinabelli Claudio Riponi | 2005 | Journal of Food Composition and Analysis2005，18，： | 1 |
| 8 | Optimization of the determination of organic acids and sugars in fruit juices by ion-exclusion liquid chromatography显示文摘 | Chinnici F Spinabelli U Riponi C | 2005 | J Food Composition and Analysis2005，18，： | 1 |
| 9 | Optimization of the determination of organic acids and sugars in fruit juices by ion-exclusion liquid chromatography显示文摘 | CHINNICI F SPINABELLI U RIPONI C | 2005 | Journal of food composition and analysis2005，18，2： | 1 |
| 10 | Optimization of the determination of organic acids and sugars in fruit juices by ion-exclusion liquid chromatography显示文摘 | Chinnici F Spinabelli U Riponi C | 2005 | Journal of Food Composition and Analysis2005，18，： | 1 |
| 11 | CiC3-1a-mediated chemotaxis in the deuterostome invertebrate Ciona intestinalis (Urochordata) 显示文摘 | Pinto M R Chinnici C M Kimura Y | 2003 | J Immunol2003，171，10： | 1 |
| 12 | Optimization of the determination of organic acids and sugars in fruit juices by ion-exclusion liquid chromatography显示文摘 | Fabio Chinnici Umberto Spinabelli Claudio Riponi | 2005 | Journal of Food Composition and Analysis2005，18，： | 1 |
| 13 | Colour features and pigment composition of Italian carbonic macerated red wines显示文摘 | Chinnici F Sonni F Natali N | 2009 | Food Chemis try2009，113，： | 1 |
| 14 | A Multivariate Statistical Analysis on the Consumers of Organic Products显示文摘 | Chinnici G Amico M D Pecorino B | 2002 | British Food Journal2002，104，345： | 1 |
| 15 | The 5-lipoxygenase enzymatic pathway in the mouse brain:young versus old显示文摘 | Chinnici CM Yao Y Praticò D | 2007 | Neurobiol Aging2007，28，9： | 1 |
| 16 | Solid-phase extraction method for determination of volatile compounds in traditional balsamic vinegar显示文摘 | GUERRERO E D CHINNICI F NATALI N | 2008 | Journal of Separation Science2008，31，： | 1 |
| 17 | Optimization of the determination of organic acids and sugars in fruit juices by ion-exclusion liquid chromatography显示文摘 | Chinnici F Spinabelli U Riponi C | 2005 | Journal of food composition and analysis2005，18，23： | 1 |
| 18 | Colour features and pigment composition of Italian carbonic macerated redwines显示文摘 | Chinnici F Sonni F Natali N | 2009 | Food Chemistry2009，113，： | 1 |
| 19 | Revision cochlear implant surgery in children:the Johns Hopkins experience 显示文摘 | Marlowe A Chinnici J Rivas A | 2010 | Otol Neurotol2010，31，1： | 1 |
| 20 | Phenoloxidnses in ascidian hemocytes:characterization of the prophenoloxidase activating system显示文摘 | Parrinello N Arizza V Chinnici C | | 0，，4： | 1 |
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