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| 1 | Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on proton pump inhibitors(PPIs) therapy and the risk of Clostridium difficile infection(CDI). METHODS We conducted a systematic search of MEDLINE/Pub Med and seven other databases through January 1990 to March 2017 for published studies that evaluated the association between PPIs and CDI. Adult case-control and cohort studies providing information on the association between PPI therapy and the development of CDI were included. Pooled odds ratios(ORs) estimates with 95% confidence intervals(CIs) were calculated using the random effect. Heterogeneity was assessed by I^2 test and Cochran's Q statistic.Potential publication bias was evaluated via funnel plot, and quality of studies by the Newcastle-Otawa Quality Assessment Scale(NOS). RESULTS Fifty-six studies(40 case-control and 16 cohort) involving 356683 patients met the inclusion criteria and were analyzed. Both the overall pooled estimates and subgroup analyses showed increased risk for CDI despite substantial statistical heterogeneity among studies. Meta-analysis of all studies combined showed a significant association between PPI users and the risk of CDI(pooled OR = 1.99, CI: 1.73-2.30, P < 0.001) as compared with non-users. The association remained significant in subgroup analyses: by design-case-control(OR = 2.00, CI: 1.68-2.38, P < 0.0001), and cohort(OR = 1.98, CI: 1.51-2.59, P < 0.0001); adjusted(OR = 1.95, CI: 1.67-2.27, P < 0.0001) and unadjusted(OR = 2.02, CI: 1.41-2.91, P < 0.0001); unicenter(OR = 2.18, CI: 1.72-2.75, P < 0.0001) and multicenter(OR = 1.82, CI: 1.51-2.19, P < 0.0001); age ≥ 65 years(OR = 1.93, CI: 1.40-2.68, P < 0.0001) and < 65 years(OR = 2.06, CI: 1.11-3.81, P < 0.01). No significant differences were found in subgroup analyses(test for heterogeneity): P = 0.93 for case-control vs cohort, P = 0.85 for adjusted vs unadjusted, P = 0.24 for unicenter vs multicenter, P = 0.86 for age ≥ 65 years and < 65 years. There was significant heterogeneity across studies(I^2 = 85.4%, P < 0.001) as well as evidence of publication bias(funnel plot asymmetry test, P = 0.002). CONCLUSION This meta-analysis provides further evidence that PPI use is associated with an increased risk for development of CDI. Further high-quality, prospective studies are needed to assess whether this association is causal. | Anca Trifan Carol Stanciu Irina Girleanu Oana Cristina Stoica Ana Maria Singeap Roxana Maxim Stefan Andrei Chiriac Alin Ciobica Lucian Boiculese | 2017 | World Journal of Gastroenterology2017，23，35： | 15 |
| 2 | Update on adrenal insufficiency in patients with liver cirrhosis显示文摘Liver cirrhosis is a major cause of mortality worldwide,often with severe sepsis as the terminal event.Over the last two decades,several studies have reported that in septic patients the adrenal glands respond inappropriately to stimulation,and that the treatment with corticosteroids decreases mortality in such patients.Both cirrhosis and septic shock share many hemodynamic abnormalities such as hyperdynamic circulatory failure,decreased peripheral vascular resistance,increased cardiac output,hypo-responsiveness to vasopressors,increased levels of proinflammatory cytokines [interleukine(IL)-1,IL-6,tumor necrosis factor-alpha] and it has,consequently,been reported that adrenal insufficiency(AI) is common in critically ill cirrhotic patients.AI may also be present in patients with stable cirrhosis without sepsis and in those undergoing liver transplantation.The term hepato-adrenal syndrome defines AI in patients with advanced liver disease with sepsis and/or other complications,and it suggests that it could be a feature of liver disease per se,with a dif-ferent pathogenesis from that of septic shock.Relative AI is the term given to inadequate cortisol response to stress.More recently,another term is used,namely 'critical illness related corticosteroid insufficiency' to define 'an inadequate cellular corticosteroid activity for the severity of the patient's illness'.The mechanisms of AI in liver cirrhosis are not completely understood,although decreased levels of high-density lipoprotein cholesterol and high levels of proinflammatory cytokines and circulatory endotoxin have been suggested.The prevalence of AI in cirrhotic patients varies widely according to the stage of the liver disease(compensated or decompensated,with or without sepsis),the diagnostic criteria defining AI and the methodology used.The effects of corticosteroid therapy on cirrhotic patients with septic shock and AI are controversial.This review aims to summarize the existing published information regarding AI in patients with liver cirrhosis. | Anca Trifan Stefan Chiriac Carol Stanciu | 2013 | World Journal of Gastroenterology2013，19，4： | 10 |
| 3 | Immunohistochemical evaluation of vitamin D receptor(VDR) expression in cutaneous melanoma tissues and four VDR gene polymorphisms显示文摘Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:'F'and'f'for Fok I,'B'and'b'for Bsm I,'A'and'a'for ApaI,and 'T'and't'for TaqI endonuclease.Seventy-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ melanomas.VDR expression was categorized as follows:100% positive vs.<100%;over the median 20%(high VDR expression)vs.≤20%(low VDR expression);absence vs.presence of VDR-expressing cells.Results:Stage I melanomas,Breslow thickness of<1.00 mm,level II Clark invasion,Aa heterozygous genotype,and AaTT combined genotype were more frequent in melanomas with high vs.low VDR expression.Combined genotypes BbAA,bbAa,AATt,BbAATt,and bbAaTT were more frequent in 100%vs.<100%VDR-expressing cells.Combined genotype AATT was more frequent in melanomas lacking VDR expression(odds ratio=14.5;P=0.025).VDR expression was not associated with metastasis,ulceration,mitosis>1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma familiarity.Conclusions:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma cells.Low VDR expression in AATT carriers is a new finding that merits further study.VDR expression possibly poses implications for vitamin D supplementation against melanoma.VDR expression and VDR genotype may become precise medicinal tools for melanoma in the future. | Francesco La Marra Giuseppe Stinco Cinzia Buligan Giovanni Chiriacò Diego Serraino Carla Di Loreto Sabina Cauci | 2017 | Cancer Biology & Medicine2017，14，2： | 5 |
| 4 | Split-dose or hybrid nonsteroidal anti-inflammatory drugs and Nacetylcysteine therapy for prevention of post-retrograde cholangiopancreatography pancreatitis显示文摘BACKGROUND Despite significant technical and training improvements, the incidence of postendoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP) has not significantly dropped. Although many studies have evaluated the efficacy of various agents, e.g. nonsteroidal anti-inflammatory drugs, octreotide,antioxidants, administered via various dosages, routes(oral, intrarectal or parenteral), and schedules(before or after the procedure), the results have been conflicting.AIM To evaluate efficacy of three pharmacologic prophylactic methods for prevention of PEP.METHODS In this prospective, single-center randomized trial, patients who underwent firsttime ERCP for choledocholithiasis were randomly assigned to three groups. The first group received 600 mg N-acetylcysteine 15 min prior to ERCP, and perrectum administration of 50 mg indomethacin both prior to and after completion of the ERCP. The second group was administered only the 50 mg indomethacin per-rectum both prior to and after the ERCP. The third group was administeredper-rectum 100 mg indomethacin only after the ERCP, representing the control group given the guideline-recommended regimen. The primary end-point was PEP prevention.RESULTS Among the total 211 patients evaluated during the study, 186 fulfilled the inclusion criteria and completed the protocol. The percentages of patients who developed PEP in each of the three groups were not significantly different(χ2 =2.793, P = 0.247). Among the acute PEP cases, for all groups, 14 patients developed mild pancreatitis(77.77%) and 4 moderate. No severe cases of PEP occurred, and in all PEP cases the resolution was favorable. No adverse events related to the medications(digestive hemorrhage, rectal irritation, or allergies)occurred.CONCLUSION The efficacies of split-dose indomethacin and combined administration(Nacetylcysteine with indomethacin) for preventing PEP were similar to that of the standard regimen. | Laura Pavel Gheorghe Gh Balan Alexandra Nicorescu Georgiana Emmanuela Gilca-Blanariu Catalin Sfarti Stefan Chiriac Smaranda Diaconescu Vasile Liviu Drug Gheorghe Balan Gabriela Stefanescu | 2019 | World Journal of Clinical Cases2019，7，3： | 3 |
| 5 | Amorphous glass-covered magnetic wires: preparation, properties, application显示文摘 | H chiriac T A Ovari | 1997 | Progress in Materials Science1997，40，： | 2 |
| 6 | Fe-based amorphous thin film as a magnetoelastic sensor material显示文摘 | Chiriac H Pletea M Hristoforou E | 2000 | Sensors and Actuators A: Physical2000，81，13： | 1 |
| 7 | Synergistic behavior of poly(aspartic acid) and Pluronic F127 in aqueous solution as studied by viscometry and dynamic light scattering显示文摘 | Loredana E. Nita Aurica Chiriac Maria Bercea Bernhard A. Wolf | 2013 | Colloids and Surfaces B: Biointerfaces2013，，： | 1 |
| 8 | Autogenous bone chips: influence of a new piezoelectric device (Piezosurgery) on chip morphology,cell viability and differentiation显示文摘 | Chiriac G Herten M Schwarz F | 2005 | J Clin Periodon- tol2005，32，9： | 1 |
| 9 | The effect of HRG gas addition on diesel engine combustion characteristics and exhaust emissions显示文摘 | Adrian Birtas Iulian Voicu Cristian Petcu Radu Chiriac Nicolae Apostolescu | 2011 | International Journal of Hydrogen Energy2011，，18： | 1 |
| 10 | The improvement of adhesive character of an acrylovinylic macromolecular compound显示文摘 | CHIRIAC A P | 2001 | Polymer Testing2001，20，： | 1 |
| 11 | Internal stress distribution in glass-covered amorphous magnetic wires 显示文摘 | Chiriac H 0vSxi T A Pop G | 1995 | Phys RevB1995，52，10： | 1 |
| 12 | Amorphous glass-covered magnetic wires:preparation,properties,applications显示文摘 | CHIRIAC H OVARI T A | 1996 | Prog Mater Sci1996，40，： | 1 |
| 13 | Design and preparation of new soft magnetic bulk amorphous alloys for applications显示文摘 | Chiriac H Lupu N | 2004 | Mater Sci Eng2004，，： | 1 |
| 14 | Heat capacity measurements of various biomass types and pyrolysis residues显示文摘 | Capucine Dupont Rodica Chiriac Guillaume Gauthier | 2014 | Fuel2014，1，1： | 1 |
| 15 | Hard and Soft Amorphous Magnetic Materials Based Micro Rotary - Encoder 显示文摘 | Chiriac H Marinescu CS Marinescu M | 2001 | Materials Science Forum2001，，373： | 1 |
| 16 | Acrylovinylic macromolecular compounds with adhesive properties 显示文摘 | IORDANA NEAMTU CHIRIAC A P | 1999 | Polymer Testing1999，，18： | 1 |
| 17 | Magnetic behavior of amorphous wires covered by glass显示文摘 | Chiriac H Pop G Barariu F | 1994 | J Appl Phys1994，75，： | 1 |
| 18 | Magnetic properties of amorphous wires with different diameters显示文摘 | CHIRIAC H TIBU M DOBREA V | 2005 | J Magn Magn Mater2005，，： | 1 |
| 19 | Current and future miniature re- frigeration cooling technologies for high power microelectronics 显示文摘 | Phelan P E Chiriac V A Lee T Y T | 2002 | IEEE Transactions on Components and Packaging Technologies2002，25，3： | 1 |
| 20 | Forecasting Multivariate Volatility Using the Varfima Model on Realized Co- variance Cholesky Factors显示文摘 | Chiriac R Voev V | 2011 | Journal of Economics and Statistics2011，231，： | 1 |
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