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| 1 | Cell transplantation for the treatment of spinal cord injury–bone marrow stromal cells and choroid plexus epithelial cells显示文摘Transplantation of bone marrow stromal cells(BMSCs) enhanced the outgrowth of regenerating axons and promoted locomotor improvements of rats with spinal cord injury(SCI).BMSCs did not survive long-term,disappearing from the spinal cord within 2–3 weeks after transplantation.Astrocyte-devoid areas,in which no astrocytes or oligodendrocytes were found,formed at the epicenter of the lesion.It was remarkable that numerous regenerating axons extended through such astrocyte-devoid areas.Regenerating axons were associated with Schwann cells embedded in extracellular matrices.Transplantation of choroid plexus epithelial cells(CPECs) also enhanced axonal regeneration and locomotor improvements in rats with SCI.Although CPECs disappeared from the spinal cord shortly after transplantation,an extensive outgrowth of regenerating axons occurred through astrocyte-devoid areas,as in the case of BMSC transplantation.These findings suggest that BMSCs and CPECs secret neurotrophic factors that promote tissue repair of the spinal cord,including axonal regeneration and reduced cavity formation.This means that transplantation of BMSCs and CPECs promotes 'intrinsic' ability of the spinal cord to regenerate.The treatment to stimulate the intrinsic regeneration ability of the spinal cord is the safest method of clinical application for SCI.It should be emphasized that the generally anticipated long-term survival,proliferation and differentiation of transplanted cells are not necessarily desirable from the clinical point of view of safety. | Chizuka Ide Norihiko Nakano Kenji Kanekiyo | 2016 | Neural Regeneration Research2016，11，9： | 8 |
| 2 | Points regarding cell transplantation for the treatment of spinal cord injury显示文摘Transplantation of somatic cells,including bone marrow stromal cells(BMSCs),bone marrow mononuclear cells(BMNCs),and choroid plexus epithelial cells(CPECs),enhances the outgrowth of regenerating axons and promotes locomotor improvements.They are not integrated into the host spinal cord,but disappear within 2-3 weeks after transplantation.Regenerating axons extend at the spinal cord lesion through the astrocyte-devoid area that is filled with connective tissue matrices.Regenerating axons have characteristics of peripheral nerves:they are associated with Schwann cells,and embedded in connective tissue matrices.It has been suggested that neurotrophic factors secreted from BMSCs and CPECs promote 'intrinsic' ability of the spinal cord to regenerate.Transplanted Schwann cells survive long-term,and are integrated into the host spinal cord,serving as an effective scaffold for the outgrowth of regenerating axons in the spinal cord.The disadvantage that axons are blocked to extend through the glial scar at the border of the lesion is overcome.Schwann cells have been approved for clinical applications.Neural stem/progenitor cells(NSPCs) survive long-term,proliferate,and differentiate into glial cells and/or neurons after transplantation.No method is available at present to manipulate and control the behaviors of NPSCs to allow them to appropriately integrate into the host spinal cord.NPSP transplantation is not necessarily effective for locomotor improvement. | Chizuka Ide Kenji Kanekiyo | 2016 | Neural Regeneration Research2016，11，7： | 5 |
| 3 | Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation显示文摘 | Masayoshi Ohta Yoshihisa Suzuki Toru Noda Yoko Ejiri Mari Dezawa Kazuya Kataoka Hirotomi Chou Namiko Ishikawa Naoya Matsumoto Yasushi Iwashita Eiji Mizuta Sadako Kuno Chizuka Ide | 2004 | Experimental Neurology2004，，2： | 2 |
| 4 | Prophylactic action of oral fluconazole against fungal infection in neutropenicpa- tients显示文摘 | Kanda Y Yamamoto R Chizuka A | 2000 | Cancer2000，89，7： | 1 |
| 5 | Prophylactic action of oral fluconazole against fungal infection in neutropenic patients:a meta-analysis of 16 randomized,controlled trials显示文摘 | Kanda Y Yamamoio R Chizuka A | | 0，，07： | 1 |
| 6 | Treatment of deep veinthrombosis using temporary vena caval filters after allogeneic bone marrow transplantation显示文摘 | Kanda Y Yamamoto R Chizuka A | 2000 | Leuk Lymphoma2000，38，34： | 1 |
| 7 | The diagnostic value of kappa/lambda ratios determined by flow cytometric analysis of biopsy specimens in B-cell lymphoma显示文摘 | CHIZUKA A KANDA Y NANNYA Y | 2002 | Clin Lab Haematol2002，24，1： | 1 |
| 8 | Do fetal heart rate deceleration patterns during labor differ between various umbilical cord abnormalities显示文摘 | Hasegawa J Matsuoka I Chizuka K | 2009 | J Perinat Med2009，37，3： | 1 |
| 9 | The diagnostic value of kappa/lambda ratios determined by flow cytometric analysis of biopsy specimens in B-cell lymphoma 显示文摘 | Chizuka A Kanda Y Nannya Y | 2002 | Clin Lab Haematol2002，24，1： | 1 |
| 10 | Administration of cultured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patients: A pilot study显示文摘 | Fukuki Saito Toshio Nakatani Masaaki Iwase Yuji Maeda Yoshinori Murao Yoshihisa Suzuki Masanori Fukushima Chizuka Ide | 2012 | Restorative Neurology and Neuroscience2012，，2： | 1 |
| 11 | A high serum-soluble interleukin-2 receptor level is associated with a poor outcome of aggressive non-Hodgkin's lymphoma显示文摘 | Niitsu N Iijima K Chizuka A | 2001 | Eur J Haematol2001，66，： | 1 |
| 12 | Peripheral Nerve Regeneration显示文摘 | Chizuka Ide | 1996 | Neurosci Research1996，25，： | 1 |
| 13 | A novel putative a novel putative mechanism of anti-Myeloma activity targeted against heat shock protein 27 by derivative of artemisinin,artesunate显示文摘 | Chizuka A Uchida H Xian MJ | 2007 | Blood2007，110，1： | 1 |
| 14 | Regeneration in the rat opticnerve after cold injury显示文摘 | Mineko Murakarru Chizuka lde | 1989 | Neurosurg1989，71，： | 1 |
| 15 | The diagnostic value of kappa /lambda ratios determined by flow cytometric analysis of biopsy specimens in B-cell lymphoma显示文摘 | Chizuka A Kanda Y Nannya Y | 2002 | ClinLab Haematol2002，24，1： | 1 |
| 16 | A novel morphological technique to investigate a single climbing fibre synapt- ogenesis with a Purkinje cell in the developing mouse cerebellum:DiI injection into the inferior cerebellar peduncle 显示文摘 | Yoshimoto Kiyohara Katsuaki Endo Chizuka Ide | 2003 | Journal of electron microscopy2003，52，3： | 1 |
| 17 | Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat显示文摘 | Chizuka Ide Yoshiyasu Nakai Norihiko Nakano Tae-Beom Seo Yoshihiro Yamada Katsuaki Endo Toru Noda Fukuki Saito Yoshihisa Suzuki Masanori Fukushima Toshio Nakatani | 2010 | Brain Research2010，，： | 1 |
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