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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Expression of vascular endothelial growth factor and inducible nitric oxide synthase in pterygia显示文摘 | Lee DH Cho H J Kim JT Choi JS Joo CK | 2001 | Cornea2001，20，7： | 1 |
| 3 | Diffusion-weighted magnetic resonance imaging for the evaluation of prostate cancer: optimal b value at 3 T显示文摘 | Koo JH Kim CK Choi D | 2013 | Korean J Radiol2013，14，： | 1 |
| 4 | Activation of MAPK and CREB by GMI induces survival of RGCS in the retina with axotomized nerve显示文摘 | Choi JS kim JA Joo CK | 2003 | Invest Ophthalmol Vis SCI2003，44，4： | 1 |
| 5 | Clinical evaluation of 3 types of plate osteosynthesis for fixation of condylar neck fractures 显示文摘 | Choi BH Yi CK Yoo JH | 2001 | J Oral Maxillofac Surg2001，59，7： | 1 |
| 6 | Cross correlated fluctuation analy-sis reveals phosphorylation-regulated paxillin-FAK Complexes in nascent adhesions 显示文摘 | Choi CK Zareno J Digman MA | 2011 | Bio phys J2011，100，3： | 1 |
| 7 | Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas显示文摘 | Jung JH Jung CK Choi HJ | 2009 | Pathol Res Pract2009，205，6： | 1 |
| 8 | Nonviral vector for effi- cient gene transfer to human ovarian adenocarcinoma ceils 显示文摘 | Kim CK Haider KH Choi SH | 2002 | Gynecol Oncol2002，84，1： | 1 |
| 9 | Hydrogen peroxide is a novel inducerof connective tissue growth factor显示文摘 | Park SK Kim J Seomun Y Choi J Kim DH Han IO LeeEH Chung SK Joo CK | 2001 | Biochem Biophys ResCommun2001，284，： | 1 |
| 10 | Increases in airway eosino- philia and a Thl cytokine during the chronic asymptomatic phase of asthma显示文摘 | Kim CK Choi J Callaway Z | 2010 | Respir Med2010，104，10： | 1 |
| 11 | Pulmonary infection caused by Mycobacterium neoaurum:the first case in Korea显示文摘 | Kim CK Choi SI Jeon BR | 2014 | Ann Lab Med2014，34，3： | 1 |
| 12 | Quality of life outcomes in chi- nese patients with implantable cardioverter defibrillators 显示文摘 | Chair SY Lee CK Choi KC | 2011 | Pacing Clin Electrophysio12011，34，7： | 1 |
| 13 | PhosPho -STAT3expression and correlation with VEGF, p53, and Bel-2 ingastric carcinoma using tissue microarray显示文摘 | Choi JH Ahn MJ Park CK | 2006 | APMIS2006，114，9： | 1 |
| 14 | Activation of MAPK and CREB by GM1 induces survival of RGCs in retina with axotomized nerve 显示文摘 | Choi JS Kim JA Joo CK | 2003 | Invest Ophthalmol Vis Sci2003，44，4： | 1 |
| 15 | Expression of vascular endothelial growth factor and inducible nireic oxide synthase in pterygia显示文摘 | Lee DH Cho HJ Kim JT Choi JS Joo CK | 2001 | Cornea2001，20，7： | 1 |
| 16 | ESE - 1/Egr - 1 pathway plays a role in tolfenamic acid induced apoptosis in colorectal cancer cells 显示文摘 | Lee SH Bahn JH Choi CK | 2008 | Mol Cancer THER2008，7，12： | 1 |
| 17 | A randomized intervention of morttel- ukast for post-bronehiolitis: effect on eosinophil degranulation 显示文摘 | Kim CK Choi J Kim HB | 2010 | J Pediatr2010，156，5： | 1 |
| 18 | ESE-1/EGR-I pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells显示文摘 | Lee SH Bahn JH Choi CK | 2008 | Mol Cancer Ther2008，7，12： | 1 |
| 19 | Electroacupunture up-regulates natural killer ceil activity identification of genes altering their expressions in electroacupunture induced up-regu- lates of natural killer cell activity显示文摘 | Kim CK Choi GS Oh SD | 2005 | Neuroimmunol2005，168，12： | 1 |
| 20 | In situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability 显示文摘 | Choi HG Oh YK Kim CK | 1998 | Int J Pharm1998，165，1： | 1 |
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