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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 3 | The quality of reconstructed 3D images in mutidetector-row helical CT: experimental study involving scan parameters显示文摘 | Shin J H Lee H K Choi C G | 2002 | Korean J Radiol2002，3，1： | 2 |
| 4 | Compliant control of a two-link flexible manipulator featuring piezoelectric actuators显示文摘 | Kim H K Choi S B Thompson B S | 2001 | Mechanism and Machine Theory2001，，36： | 2 |
| 5 | Preoperative hyperfractionated radiotherapy with concurrent chemotherapy in resectable esophageal cancer显示文摘 | Kim J H Choi E K Kim S B | 2001 | Int J Radiat Oncol Biol Phys2001，50，1： | 2 |
| 6 | Formation of ultrafine ferrite by strain- induced dynamic transformation in plain low carbon steel 显示文摘 | Choi J K Seo D H Lee J S | 2003 | ISIJ International2003，43，5： | 1 |
| 7 | Study of the enhanced thermal conductivity of Fe nanofluids显示文摘 | Hong T K Yang H S Choi C J | 2005 | Journal of Applied Physics2005，97，6： | 1 |
| 8 | An interactive procedure for multiple attribute group decision-making with incomplete information: Range-based approach显示文摘 | CHOI S H KIM J K | 1999 | Euro J Oper Res1999，118，： | 1 |
| 9 | Polymerase chain reaction(PCR)for human herpes virus 8 and heteroduplex PCR for clonality assessment in angiolymphoid hyperplasia with eosinophilia and Kimura's disease显示文摘 | Jang K A Ahn S J Choi J H | 2001 | J Cutan Pathol2001，28，： | 1 |
| 10 | Antifungal activity of the methanol extract of Myristica malabarica fruit rinds and the active ingredients malabaricones against phytopathogenic fungi 显示文摘 | Choi H N Choi J G Jang S K | 2008 | Plant Pathol2008，24，3： | 1 |
| 11 | Purine-Rich Foods,Dairy and Protein Intake,and the Risk of Gout in Men显示文摘 | CHOI H ATKINSON K KARISON E | 2004 | N Engl J Med2004，350，11： | 1 |
| 12 | Improvement of 4I11/2→4I13/2 transition rate and thermal stabilities in Er3+-doped TeO2-B2O3-(GeO2)ZnO-K2O Glasses 显示文摘 | Cho D H Choi Y G Kim K H | 2001 | ETRI Joural(S1225-6463)2001，2，4： | 1 |
| 13 | Low pressure sintering of Sialon using different sintering additives 显示文摘 | Jung H J Aim K Y Choi C | 2008 | Journal of the Ceramic Society of Japan2008，116，1： | 1 |
| 14 | Prevalence of the metabolic syndrome in indi-viduals with hyperuricemia 显示文摘 | Choi H K Ford E S | 2007 | Am J Med2007，120，5： | 1 |
| 15 | Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E cadherin/beta catenin complex 显示文摘 | Choi H N Kim K R Lee J H | 2009 | Oncol Rep2009，21，1： | 1 |
| 16 | Purification and characteriza-tion of iron superoxide dismutase and copper-zine superoxide dismutase from Acanthamoeba castellanii显示文摘 | Choi D H N a B K Seo M S | 2000 | J Parasitol2000，86，5： | 1 |
| 17 | Spinal involvement of hematopoietic malignancies and metastasis: differentiation using MR imaging显示文摘 | Kim H J Ryu K N Choi W S | 1999 | Clin Imaging1999，23，2： | 1 |
| 18 | Recombinant chicken interferon-gamma-mediated inhibition of Eimeria tenella development in vitro and reduction of oocyst production and body weight loss following Eimeria acervulina challenge infection 显示文摘 | Lillehoj H S Choi K D | 1998 | Avian Diseases1998，42，2： | 1 |
| 19 | Thermally driven thin film bulk acoustic resonator voltage controlled oscillators integrated with microheater elements 显示文摘 | Lee H M Kim H T Choi H K | 2004 | Jpn J Appl Phys Part2-Lett2004，43，1： | 1 |
| 20 | Transformed-key asymmetric watermarking system显示文摘 | CHOI H LEE K KIM T | 2004 | IEEE Signal Processing Letters2004，11，2： | 1 |
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