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| 1 | Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016显示文摘Portal vein tumor thrombosis(PVTT) is a common phenomenon in hepatocellular carcinoma(HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer tolerance to treatment. Conventionally, HCC with PVTT is grouped together with metastatic HCC during the planning of its management, and most patients are offered palliative treatment with sorafenib or other systemic agents. As a result, most data on the management of HCC with PVTT comes from subgroup analyses or retrospective series. In the past few years, there have been several updates on management of HCC with PVTT. First, it is evident that HCC with PVTT consists of heterogeneous subgroups with different prognoses. Different classifications have been proposed to stage the degree of portal vein invasion/thrombosis, suggesting that different treatment modalities may be individualized to patients with different risks. Second, more studies indicate that more aggressive treatment, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. In this review, we aim to discussthe recent conceptual changes and summarize the data on the management of HCC with PVTT. | Stephen L Chan Charing CN Chong Anthony WH Chan Darren MC Poon Kenneth SH Chok | 2016 | World Journal of Gastroenterology2016，22，32： | 44 |
| 2 | Upregulation of plasma C9 protein in gastric cancer patients显示文摘 | Chong PK Lee H Loh MC | | 0，，18： | 1 |
| 3 | Controlling the pro- liferation and differentiation stages to initiate periodontal re- generation显示文摘 | Chong LY Chien LY Chung MC | 2013 | Connect Tissue Res2013，54，2： | 1 |
| 4 | Preserved foods and nasopharyngeal carcinoma: a case-control study in Guangxi, China 显示文摘 | Yu MC Mo CC Chong WX | 1988 | Cancer Res1988，48，7： | 1 |
| 5 | Idiopathic pulmonary fibrosis is associated with circulating antiepithelial antibodies 显示文摘 | Fahim A Chong MC Crooks MG | 2012 | Lung2012，190，4： | 1 |
| 6 | Controlling the proliferation and differentiation stages to initiate periodontal regeneration 显示文摘 | Chong LY Chien LY Chung MC | 2013 | Connect Tissue Res2013，54，2： | 1 |
| 7 | Intracerebral coinfectionwith Burkholdefia pseudomallei and Cryptococcus neoformans in a patient with systemic lupus erythematosus 显示文摘 | Samad I Wang MC Chong VH | 2014 | Southeast Asian J Trop Med Public Health2014，45，2： | 1 |
| 8 | Preimplantation single-cell analysis of multiple genetic loci by wholegenome amplification 显示文摘 | Snabes MC Chong SS Subramanian SB | 1994 | Proc Natl Acad Sci USA1994，91，： | 1 |
| 9 | Central insulin signaling mod- ulates hypothamus-pituitary-adrenal axis responsiveness显示文摘 | Chong ACN Vogt MC Hill AS | 2015 | Molec- ular metabolism2015，4，24： | 1 |
| 10 | Upregulation of plasma C9 protein in gastric cancer patients 显示文摘 | Chong PK Lee H Loh MC | 2010 | Proteomics2010，10，18： | 1 |
| 11 | Polymorphism of nine X chromosomal STR loci in Koreans 显示文摘 | Jin YS Yoon SL Chong MC | 2002 | Int J Leg Med2002，116，： | 1 |
| 12 | Ischaemic stroke among young people aged 15 to 50 years in Adelaide, South Australia显示文摘 | Phillips MC Leyden JM Chong WK | 2011 | MedJ Aust2011，195，10： | 1 |
| 13 | Preserved foods and nasopharyngeal carcinoma: a case-control study in Guangxi, China 显示文摘 | Yu MC Mo CC Chong WX | 1988 | Cancer Res1988，48，7： | 1 |
| 14 | Characterization of the hinding domains on platelet glycoproteins Ⅰb-Ⅸ and Ⅱb/Ⅲa complexes for the quinine/quinidine-dependent antibodies显示文摘 | Chong BH Du XP Bemdt MC | 1991 | Blood1991，77，： | 1 |
| 15 | Controlling the prolifera- tion and differentiation stages to initiate periodontal regeneratiun 显示文摘 | Chong LY Chien LY Chung MC | 2013 | Connect Tissue Res2013，54，2： | 1 |
| 16 | Transthoracic echocardiography assists appropriate pulmonary artery catheter placement: An observational study显示文摘AIM: To investigate the utility of transthoracic echocardiography in confirming appropriate pulmonary artery catheter(PAC) placement. METHODS: Three commonly used transthoracic echocardiography(TTE) views were used to confirm PAC position in 103 patients undergoing elective cardiac surgery- the parasternal short axis right ventricular inflow-outflow view; the subcostal short axis right ventricular inflow-outflow view; and the parasternal short axis ascending aortic view. All PACs were inserted by the managing anesthesiologist under pressure waveform guidance alone, who was blinded to all sonographic information. A sonographer blinded to all pressure waveform information confirmed visualisation of an 'empty' PA before PAC insertion, and visualisation of the PAC balloon in the main PA(MPA) or right PA(RPA) after attempts at placement were complete. Agreement, sensitivity and specificity of TTE in confirming appropriate PAC placement was compared against pressure waveformguidance as the 'gold standard'. The successful view used was compared against patients' anthropomorphic indices, presence of lung hyperinflation, and insertion of PAC during positive pressure ventilation. Agreement between TTE and pressure waveform guidance was analysed using Cohen's Kappa statistic. The relative proportion of total RPA seen by subcostal vs parasternal TTE views was also compared with a further 20 patients' computed tomography(CT) pulmonary angiograms(CTPA), to determine efficacy in detection of distal RPA PAC placement. RESULTS: Appropriate positioning of the PAC balloon, and its to-and-fro movement consistent with a nonwedged state, within the MPA or RPA was confirmed by TTE in 98 of the 103 patients [sensitivity 95%(95%CI: 89%-98%)], and absence of the PAC balloon before insertion correctly established in 100 patients [specificity 97%(92%-99%)]. This was in very good agreement with pressure waveform guidance [Cohen's Kappa 0.92,(0.87-0.98)]. The subcostal view was the best view to visualise the PAC tip when it was placed in the right pulmonary artery(OR 70, P < 0.0001), was more successful in patients with COAD(OR 9.5, P = 0.001), and visualized 61%(vs 44% by parasternal views, P < 0.001) of mean RPA lengths compared with CTPA; however the parasternal views were more successful in patients with higher body mass indexs(OR 0.78 for success with subcostal views, P < 0.001). There was a trend towards insertion during intermittent positive pressure ventilation favoring visualisation by subcostal views(OR 3.9, P = 0.08). The subcostal view visualized a greater length of the RPA than parasternal views(3.9 cm vs 2.9 cm, P < 0.0001). PACs were more often placed in the MPA than RPA(80 vs 18 patients). Three patient's pulmonary arteries were not visible by any TTE view; in a further 2 patients, despite preinsertion visualisation of their pulmonary arteries, the PAC balloon was not visible by any view with TTE where correct placement by pressure waveform was unequivocal. | Chong Oon Tan Laurence Weinberg David Andrew Story Larry Mc Nicol | 2015 | World Journal of Anesthesiology2015，4，2： | 0 |
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