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| 1 | Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor cells.Among human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and NK2.Using the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone marrow.Pseudotime analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological conditions.Transcriptomic profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell heterogeneity.Bone marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 5 |
| 2 | Antimicrobial resistance of abnormal vaginal discharges microorganisms in Ouagadougou,Burkina Faso显示文摘Objective:To assess the prevalence of bacterial strains and fungal strains infecting the vaginal tract and test their sensitivity to antibiotics in women attending Saint Camille Medical Centre in Ouagadougou.Methods:From January 2008 to December 2009,a total of 2000 vaginal swabs were cultivated for bacterial and fungal identification and isolation.Furthermore,bacterial strains were tested for their susceptibility to several antibiotics used in routine in the centre. Results:The results revealed that microbial isolation and identification was attempted for 1536/2000 sample,a positivity rate of 76.80%.Candida albicans(48.76%),followed by Escherichia coli(16.67%),Streptococcus agalactiae(8-14%) and Staphylococcus aureus(7.55%) were the major agents of genital tract infections in patients.Mycoplasma hominis and Ureaplasma urealyticum combined accounted for less than 7%.Trichomonas vaginalis was identified in 1.04%coses.The antimicrobial tests revealed that the microorganisms developed resistance to several antibiotics including beta lactams.However,antibiotics such as cefamenzol,ciprofloxacin and norfloxacin were still active on these bacteria.Conclusions:The results reveal that many sexually active women are infected by one or more microbial pathogens,probably because of the lock of hygiene or the adoption of some risky behaviors,such as not using condoms or having multiple sexual partners.Efforts should be made to address these points in the country. | Simplice D Karou Florencia Djigma Tani Sagna Christelle Nadembega Moctar Zeba Aboudoulaye Kabre Kokou Anani Djeneba Ouermi Charlemagne Gnoula Virginio Pietra Salvatore Pignatelli Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 2 |
| 3 | Spatial distribution of arsenic andheavy metals in willow roots from a contaminated floodplain soil mea-sured by X-ray fluorescence spectroscopy显示文摘 | Christel B Kruse J Zimmer D | 2011 | Science of the Total En-vironment2011，409，： | 1 |
| 4 | Novel n-demethylation of ketolide:application to the solution phase paralld synthesis of N-desosaminyl-substituted ketolides using ion exchange resins显示文摘 | ALEXIS D CHRISTELLE R | 2002 | Tetrahedron Letters2002，43，： | 1 |
| 5 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 6 | Double walled carbon nanotuJbe/polymer composites via in situ nitroxide mediated polymerisation of amphiphilic block copolymers 显示文摘 | Vitaliy D Christelle G P Sylvie D etal | 2005 | Carbon2005，43，4： | 1 |
| 7 | Correction:Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Correction to:Cellular&Molecular Immunology https://doi.org/10.1038/S41423-020-00574-8,published online 25 November 2020 In the version of this article initially published,two unintended errors were made during manuscript preparation.(1)The figure legend for Panel 3B was missing;the correct legend is as follows. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 8 | Pharmacoki- netics of cyanide in poisoning of dogs, and the effect of 4-dimethylaminophenol or thiosulfate显示文摘 | Christel D Eyer P Hegemann M | 1977 | Archives of Toxicology1977，38，3： | 1 |
| 9 | Role of PI3K in mediating short- and long-term effects of IGF-1 on calcium handling in adult cardiac myocytes显示文摘 | Elke A D Virginie B Christel H | 2007 | J Mol Cell Cardiol2007，42，6： | 1 |
| 10 | Clinical Outcome After Radical Excision of Moderate—Severe Endometriosis With or Without Bowel Resection and Reanastomosis: A Prospective Cohort Study显示文摘 | Christel Meuleman Carl Tomassetti Albert Wolthuis Ben Van Cleynenbreugel Annouschka Laenen Freddy Penninckx Ignace Vergote André D?Hoore Thomas D?Hooghe | 2014 | Annals of Surgery2014，，3： | 1 |
| 11 | New intumescent formulations of fire-retardant polypropylene-discussion of the free radical mechanism of the formation of carbonaceous protective materiaJ during the therme-oxidative treatment of the additives显示文摘 | Le Bras M Bourbigot S Christelle D | 1996 | Fire Mater1996，20，4： | 1 |
| 12 | Peyerimhoff study of the dependence of spin-orbit matrix elements on AO basis set composition for inner and valence shells: Besults for the multiplet splitting of X3 - and C311 of SO and X' II in SO' 显示文摘 | RAINER K CHRISTEL M M SIGRID D | 1983 | Chem Phys1983，76，3： | 1 |
| 13 | Risk factors of anxiety and depression in inflammatory bowel disease显示文摘 | Stéphane Nahon Pierre Lahmek Christelle Durance Alain Olympie Bruno Lesgourgues Jean‐Frédéric Colombel Jean‐Pierre Gendre | 2012 | Inflamm Bowel Dis2012，，11： | 1 |
| 14 | Outcome after multidisciplinary CO 2 laser laparoscopic excision of deep infiltrating colorectal endometriosis显示文摘 | Christel Meuleman André D’Hoore Ben Van Cleynenbreugel Nele Beks Thomas D’Hooghe | 2009 | Reproductive BioMedicine Online2009，，2： | 1 |
| 15 | Problem -based and project - based learning in engineering and medicine: Determinants of students' engagement and persistance 显示文摘 | Denis B Christelle L Dmliel D | 2012 | Interdisciplinary Journal of Problem - based Learning2012，，2： | 1 |
| 16 | Lessons Leamed from Building a Terabyte Digital Video Library 显示文摘 | Wactlar H D Christel M G Gong Y Hauptmann A G | 1999 | IEEE Computer1999，42，2： | 1 |
| 17 | Primary nucleation of paracetamol in acetone-water mixtures显示文摘 | Roger A G Christelle D Sandra G Rasmuson A C | | 0，，07： | 1 |
| 18 | Combined docking and molecular dynamics simulations to enlighten the capacity of < i > Pseudomonas cepacia and < i > Candida antarctica lipases to catalyze quercetin acetylation显示文摘 | Christelle B Eduardo B D O Latifa C | 2011 | Journal of biotechnology2011，156，3： | 1 |
| 19 | Hauptmann, Lessons learned from building a terabyte digital video library 显示文摘 | H D Wactlar M G Christel Y Gong A G | 1999 | IEEE Computer1999，32，： | 1 |
| 20 | An environmentally benign access to carbamates and ureas显示文摘 | Isabelle Vauthey Frédéric Valot Christel Gozzi Fabienne Fache Marc Lemaire | 2000 | Tetrahedron Letters2000，，33： | 1 |
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