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您的检索式：作者名="Christian Freund"
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| 1 | Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4^(+) T cell activation显示文摘Classical human leukocyte antigen(HLA)molecules of the major histocompatibility classⅡ(MHCⅡ)complex present peptides for the development,surveillance and activation of CD4^(+) T cells.The nonclassical MHCⅡ-like protein HLA-DM(DM)catalyzes the exchange and loading of peptides onto MHCⅡmolecules,thereby shaping MHCⅡimmunopeptidomes.Natural variations of DM in both chains of the protein(DMA and DMB)have been hypothesized to impact peptide presentation,but no evidence for altered function has been reported.Here we define the presence of DM allotypes in human populations covered by the 1000 Genomes Project and probe their activity.The functional properties of several allotypes are investigated and show strong enhancement of peptide-induced T cell activation for a particular combination of DMA and DMB.Biochemical evidence suggests a broader pH activity profile for the new variant relative to that of the most commonly expressed DM allotype.Immunopeptidome analysis indicates that the compartmental activity of the new DM heterodimer extends beyond the late endosome and suggests that the natural variation of DM has profound effects on adaptive immunity when antigens bypass the canonical processing pathway. | Miguel Álvaro-Benito Eliot Morrison Friederike Ebner Esam T.Abualrous Marie Urbicht Marek Wieczorek Christian Freund | 2020 | Cellular & Molecular Immunology2020，17，2： | 1 |
| 2 | Neurological complications after intrathecal liposomal cytarabine application in patients after allogeneic haematopoietic stem cell transplantation显示文摘 | Inken Hilgendorf Daniel Wolff Christian Junghanss Christoph Kahl Malte Leithaeuser Beate Steiner Jochen Casper Mathias Freund | 2008 | Annals of Hematology2008，，： | 1 |
| 3 | Requirement of Nuclear Factor-κB in Angiotensin II– and Isoproterenol-Induced Cardiac Hypertrophy In Vivo显示文摘 | Christian Freund Ruth Schmidt-Ullrich Anthony Baurand Sandra Dunger Wolfgang Schneider Peter Loser Amina El-Jamali Rainer Dietz Claus Scheidereit Martin W. Bergmann | 2005 | Circulation2005，，18： | 1 |
| 4 | Autologous bone-marrow stem-cell transplantation for myocardial regeneration显示文摘 | Christof Stamm Bernd Westphal Hans-Dieter Kleine Michael Petzsch Christian Kittner Heiko Klinge Carl Schümichen Christoph A Nienaber Mathias Freund Gustav Steinhoff | 2003 | The Lancet2003，，9351： | 1 |
| 5 | The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function显示文摘Scaffolding proteins play pivotal roles in the assembly of macromolecular machines such as the spliceosome.The adaptor protein CD2BP2,originally identified as a binding partner of the adhesion molecule CD2,is a pre-spliceosomal assembly factor that utilizes its glycine-tyrosine-phenylalanine(GYF)domain to co-localize with spliceosomal proteins.So far,its function in vertebrates is unknown.Using conditional gene targeting in mice,we show that CD2BP2 is crucial for embryogenesis,leading to growth retardation,defects in vascularization,and premature death at embryonic day 10.5 when absent.Ablation of the protein in bone marrow-derived macrophages indicates that CD2BP2 is involved in the alternative splicing of mRNA transcripts from diverse origins.At the molecular level,we identified the phosphatase PP1 to be recruited to the spliceosome via the N-terminus of CD2BP2.Given the strong expression of CD2BP2 in podocytes of the kidney,we use selective depletion of CD2BP2,in combination with next-generation sequencing,to monitor changes in exon usage of genes critical for podocyte functions,including VEGF and actin regulators.CD2BP2-depleted podocytes display foot process effacement,and cause proteinuria and ultimately lethal kidney failure in mice.Collectively,our study defines CD2BP2 as a non-redundant splicing factor essential for embryonic development and podocyte integrity. | Gesa I.Albert Christoph Schell Karin M.Kirschner Sebastian Schafer Ronald Naumann Alexandra Muller Oliver Kretz Benno Kuropka Mathias Girbig Norbert Hubner Eberhard Krause Holger Scholz Tobias B.Huber Klaus-Peter Knobeloch Christian Freund | 2015 | Journal of Molecular Cell Biology2015，7，5： | 0 |
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