3篇
您的检索式：作者名="Christian Frezza"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | OPAl controls apoptotic cristae remodeling independently from mitochondrial fusion 显示文摘 | Frezza Christian Cipolat Sara Martins De Brito Olga | 2006 | Ce112006，126，1： | 1 |
| 2 | Mitochondria in cancer: Not just innocent bystanders显示文摘 | Christian Frezza Eyal Gottlieb | 2008 | Seminars in Cancer Biology2008，，1： | 1 |
| 3 | Inborn and acquired metabolic defects in cancer显示文摘The observation that altered metabolism is the fundamental cause of cancer was made by Otto Warburg nearly a century ago. However, the subsequent identification of oncogenes and tumor suppressor genes has displaced Warburg's theory pointing towards genetic aberrations as the underlining cause of cancer. Nevertheless, in the last decade, cancer-associated mutations have been identified in genes coding for tricarboxylic acid cycle(TCA cycle, also known as Krebs cycle) and closely related enzymes that have essential roles in cellular metabolism. These observations have revived interest in Warburg's hypothesis and prompted a flurry of functional studies in the hope of gaining mechanistic insight into the links between mitochondrial dysfunction, metabolic alterations, and cancer. In this review, we discuss the potential pro-oncogenic signaling role of some TCA cycle metabolites and their derivatives(oncometabolites). In particular, we focus on their effects on dioxygenases, a family of oxygen and-ketoglutaratedependent enzymes that control, among other things, the levels and activity of the hypoxia-inducible transcription factors and the activity of DNA and histone demethylases. | Christian Frezza Patrick J Pollard Eyal Gottlieb | 2015 | 世界最新医学信息文摘2015，15，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员