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| 1 | Hybrid multi-chip assembly of optical communication engines by in situ 3D nanolithography显示文摘Three-dimensional(3D)nano-printing of freeform optical waveguides,also referred to as photonic wire bonding,allows for efficient coupling between photonic chips and can greatly simplify optical system assembly.As a key advantage,the shape and the trajectory of photonic wire bonds can be adapted to the mode-field profiles and the positions of the chips,thereby offering an attractive alternative to conventional optical assembly techniques that rely on technically complex and costly high-precision alignment.However,while the fundamental advantages of the photonic wire bonding concept have been shown in proof-of-concept experiments,it has so far been unclear whether the technique can also be leveraged for practically relevant use cases with stringent reproducibility and reliability requirements.In this paper,we demonstrate optical communication engines that rely on photonic wire bonding for connecting arrays of silicon photonic modulators to InP lasers and single-mode fibres.In a first experiment,we show an eight-channel transmitter offering an aggregate line rate of 448 Gbit/s by low-complexity intensity modulation.A second experiment is dedicated to a four-channel coherent transmitter,operating at a net data rate of 732.7 Gbit/s-a record for coherent silicon photonic transmitters with co-packaged lasers.Using dedicated test chips,we further demonstrate automated mass production of photonic wire bonds with insertion losses of(0.7±0.15)dB,and we show their resilience in environmental-stability tests and at high optical power.These results might form the basis for simplified assembly of advanced photonic multi-chip systems that combine the distinct advantages of different integration platforms. | Matthias Blaicher Muhammad Rodlin Billah Juned Kemal Tobias Hoose Pablo Marin-Palomo Andreas Hofmann Yasar Kutuvantavida Clemens Kieninger Philipp-Immanuel Dietrich Matthias Lauermann Stefan Wolf Ute Troppenz Martin Moehrle Florian Merget Sebastian Skacel Jeremy Witzens Sebastian Randel Wolfgang Freude Christian Koos | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 2 | Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) lasers for point-of-care diagnostics显示文摘Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health protection.Within this context,waveguide-(WG)-based optical biosensors on the siliconnitride(Si_(3)N_(4))platform represent a particularly promising option,offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength range.However,while passive Si_(3)N_(4)-based photonic circuits lend themselves to highly scalable mass production,the integration of low-cost light sources remains a challenge.In this paper,we demonstrate optical biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic lasers.These Si_(3)N_(4)-organic hybrid(SiNOH)lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light source.Fabrication of the devices is simple:The underlying Si_(3)N_(4)WGs are structured in a single lithography step,and the organic gain medium is subsequently applied by dispensing,spin-coating,or ink-jet printing processes.A highly parallel read-out of the optical sensor signals is accomplished with a simple camera.In our proof-of-concept experiment,we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length(L-)-related sensitivity of S/L=0.16 rad nM^(-1)mm^(-1).To our knowledge,this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light source.We expect that the versatility of the device concept,the simple operation principle,and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics. | Daria Kohler Gregor Schindler Lothar Hahn Johannes Milvich Andreas Hofmann Kerstin Lange Wolfgang Freude Christian Koos | 2021 | Light(Science & Applications)2021，10，4： | 2 |
| 3 | Localization of the glucosyhransferase activity of clostridium difficile toxin B to the N-terminal part of the holotoxin显示文摘 | HOFMANN Fred CHRISTIAN Busch ULRIKE Prepens | 1997 | J Biol Chem1997，272，11： | 1 |
| 4 | Supplier's pricing policy in Just-in-Time environment显示文摘 | Christian Hofmann | 2000 | Computer & Operations Research2000，27，： | 1 |
| 5 | Treatment of malignant effusion by oncolytic virotherapy in an experimental subcutaneous xenograft model of lung cancer显示文摘 | Stephanie Weibel Elisabeth Hofmann Thomas Christian | 2013 | Journal of Translational Medicine2013，11，6： | 1 |
| 6 | Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers显示文摘 | Antonis C. Antoniou Amanda B. Spurdle Olga M. Sinilnikova Sue Healey Karen A. Pooley Rita K. Schmutzler Beatrix Versmold Christoph Engel Alfons Meindl Norbert Arnold Wera Hofmann Christian Sutter Dieter Niederacher Helmut Deissler Trinidad Caldes Kati K?m | 2008 | The American Journal of Human Genetics2008，，4： | 1 |
| 7 | Localization of the glucosyltransferase activity or Clostridium difficile toxin B to the N-terminal part of the holotoxin显示文摘 | FRED HOFMANN CHRISTIAN BUSCHM ULRIKE PREPENS | 1997 | J Biol Chem1997，272，11： | 1 |
| 8 | N‐methyl‐ D ‐aspartate receptor antibodies in herpes simplex encephalitis显示文摘 | Harald Prüss Carsten Finke Markus H?ltje Joerg Hofmann Christine Klingbeil Christian Probst Kathrin Borowski Gudrun Ahnert‐Hilger Lutz Harms Jan M. Schwab Christoph J. Ploner Lars Komorowski Winfried Stoecker Josep Dalmau Klaus‐Peter Wandinger | 2012 | Ann Neurol2012，，6： | 1 |
| 9 | Advanced manufacturing technology adoption—the German experience显示文摘 | Christian Hofmann Stuart Orr | 2004 | Technovation2004，，7： | 1 |
| 10 | Introducing the Open Energy Ontology: Enhancing data interpretation and interfacing in energy systems analysis显示文摘Heterogeneous data,different definitions and incompatible models are a huge problem in many domains,with no exception for the field of energy systems analysis.Hence,it is hard to re-use results,compare model results or couple models at all.Ontologies provide a precisely defined vocabulary to build a common and shared conceptu-alisation of the energy domain.Here,we present the Open Energy Ontology(OEO)developed for the domain of energy systems analysis.Using the OEO provides several benefits for the community.First,it enables consistent annotation of large amounts of data from various research projects.One example is the Open Energy Platform(OEP).Adding such annotations makes data semantically searchable,exchangeable,re-usable and interoperable.Second,computational model coupling becomes much easier.The advantages of using an ontology such as the OEO are demonstrated with three use cases:data representation,data annotation and interface homogenisation.We also describe how the ontology can be used for linked open data(LOD). | Meisam Booshehri Lukas Emele Simon Flügel Hannah Förster Johannes Frey Ulrich Frey Martin Glauer Janna Hastings Christian Hofmann Carsten Hoyer-Klick Ludwig Hülk Anna Kleinau Kevin Knosala Leander Kotzur Patrick Kuckertz Till Mossakowski Christoph Muschner Fabian Neuhaus Michaja Pehl Martin Robinius Vera Sehn Mirjam Stappel | 2021 | Energy and AI2021，5，3： | 1 |
| 11 | Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation显示文摘 | Claudia Ortlepp Christine Steudel Caroline Heiderich Sina Koch Angela Jacobi Martin Ryser Sebastian Brenner Martin Bornh?user Benedikt Brors Wolf-Karsten Hofmann Gerhard Ehninger Christian Thiede | 2013 | Experimental Hematology2013，，5： | 1 |
| 12 | A convergence rates result for Tikhonov regularization in Banach spaces with non - smooth operators 显示文摘 | Bernd Hofmann Barbara Kahenbacher Christiane Poeschl | 2010 | Inverse Problems2010，，23： | 1 |
| 13 | Nanoparticles: structure, properties, preparation and behaviour in environmental media显示文摘 | P. Christian F. Kammer M. Baalousha Th. Hofmann | 2008 | Ecotoxicology2008，，5： | 1 |
| 14 | Effects of external temperature and dead volume on laboratory measurements of pore pressure and injected volume in a rock fracture显示文摘The accurate evaluation of pore pressure and injected volume is crucial for the laboratory characterization of hydromechanical responses of rock fractures. This study reports a series of laboratory experiments to systematically demonstrate the effects of external temperature and dead volume on laboratory measurements of pore pressure and injected volume in a rock fracture. We characterize the hydraulic aperture of the fracture as a function of effective normal stress using the exponential aperture model.This model is then employed to predict the pore pressure change and injected volume in the fracture without the influences of external temperature and dead volume. The external temperature changes in the cyclic loading test due to the Joule-Thompson effect for fluids. The effect of external temperature on pore pressure change in the fracture can be well explained by thermal pressurization of fluids. Our results also show that the external dead volume can significantly lower the pore pressure change in the fracture during the cyclic loading test under undrained conditions. The injected volume can also be substantially enlarged due to the external dead volume in a typical pore pressure system. Internal measurement of the pore pressure in the fracture using a fiber optic sensor cannot exclude the influences of external temperature and dead volume, primarily because of the good hydraulic communication between the fracture and pore pressure system. This study suggests that the effects of external temperature and dead volume on pore pressure response and injected volume should be evaluated for accurate laboratory characterization and inter-laboratory comparison. | Yinlin Ji Christian Kluge Hannes Hofmann Guido Blöcher | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，5： | 0 |
| 15 | Cell:新分子或可有效清除肝脏和血液中的脂肪显示文摘肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果,但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。 | Brian Finan Christoffer Clemmensen Zhimeng Zhu Kerstin Stemmer Karine Gauthier Luisa M uuml ller Meri De Angelis Kristin Moreth Frauke Neff Diego Perez-Tilve Katrin Fischer Dominik Lutter Miguel A. S aacute nchez-Garrido Peng Liu Jan Tuckermann Mohsen Malehmir Marc E. Healy Achim Weber Mathias Heikenwalder Martin Jastroch Maximilian Kleinert Sigrid Jall Sara Brandt Fr eacute d eacute ric Flamant Karl-Werner Schramm Heike Biebermann Yvonne D ouml ring Christian Weber Kirk M. Habegger Michaela Keuper Vasily Gelfanov Fa Liu Josef K ouml hrle Jan Rozman Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Susanna M. Hofmann Bin Yang Matthias H. Tsch ouml p Richard DiMarchi Timo D. M uuml ller | 2017 | 现代生物医学进展2017，17，4： | 0 |
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