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| 1 | Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension显示文摘AIM: To study the mechanism involved in the potentially beneficial effect of ultra low dose aspirin (ULDA) in prehepatic portal hypertension, rats were pretreated with selective COX 1 or 2 inhibitors (SC-560 or NS-398 respectively), and subsequently injected with ULDA or placebo. METHODS: Portal hypertension was induced by portal vein ligation. Platelet activity was investigated with an in-vivo model of laser induced thrombus production in mesenteric circulation and induced hemorrhagic time (IHT). Platelet aggregation induced by ADP and dosing of prostanoid products 6-keto-PGF1α, TXB2, PGE2 and LTB4 were also performed. RESULTS: The portal hypertensive group receiving a placebo showed a decreased in vivo platelet activity with prolonged IHT, an effect that was normalized by ULDA. SC-560 induced a mild antithrombotic effect in the normal rats, and an unmodified effect of ULDA. NS-398 had a mild prothrombotic action in portal hypertensive rats, similar to ULDA, but inhibited a further effect when ULDA was added. An increased 6-keto-PGF1α was observed in portal hypertensive group that was normalised after ULDA administration. TXA2 level after ULDA, remained unchanged. CONCLUSION: These results suggest that the effect of ULDA on platelet activity in portal hypertensive rats, could act through a COX 2 pathway more than the COX 1, predominant for aspirin at higher doses. | Francisco X Eizayaga Omar Aguejouf Vanessa Desplat Philippe Belon Christian Doutremepuich | 2007 | World Journal of Gastroenterology2007，13，38： | 4 |
| 2 | Role for 3-Osulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts显示文摘 | Vaibhav T Christian C Ding X | 2006 | J Virol2006，80，18： | 1 |
| 3 | Botox, dilation, or myotomy? Clinical outcome of interventional and surgical therapies for achalasia显示文摘 | Christian Alexander Gutschow Ulrich T?x Jessica Leers Hartmut Sch?fer Klaus Ludwig Prenzel Arnulf H. H?lscher | 2010 | Langenbeck’s Archives of Surgery2010，，8： | 1 |
| 4 | CT and endoscopic ultrasound in comparison to endoluminal MRI—Preliminary results in staging gastric carcinoma显示文摘 | Tobias Heye Christian Kuntz Markus Düx Jens Encke Moritz Palmowski Frank Autschbach Frank Volke Guenter Werner Kauffmann Lars Grenacher | 2008 | European Journal of Radiology2008，，2： | 1 |
| 5 | Hepatocyte Growth Factor Induces ERK-dependent Paxillin Phosphorylation and Regulates Paxillin-Focal Adhesion Kinase Association显示文摘 | Liu Z X Cheng F Y Christian N | 2002 | J Bio Chem2002，277，10： | 1 |
| 6 | Expression and redistribution of cellular Bad, Bax, and Bcl-XL protein is associated with VCD-induced ovotoxicity in rats 显示文摘 | Hu X M Christian P Sipes I G | 2001 | Biol Reprod2001，65，5： | 1 |
| 7 | Regulatory variation at glypican-3 underlies a major growth QTL in mice 显示文摘 | Oliver F Christians JK Liu X | 2005 | PLoS Bi- ol2005，3，5： | 1 |
| 8 | Evaluation and classification of RING-finger domains encoded by the Arabidopsis genome显示文摘 | Peter K Klaus F X M Christian S H | 2002 | Genome Biology2002，3，4： | 1 |
| 9 | Monomeric indole alkaloids from Ervatamia hainanensis显示文摘 | Feng X Z Christiane K Pierre P | 1982 | Planta Med1982，44，2： | 1 |
| 10 | Model- centered approach to early planning and design of an eco- industrial park around an oilrefinery显示文摘 | ZHANG X P ANDERS H S CHRISTIAN S | 2008 | Environ Sci Technol2008，42，13： | 1 |
| 11 | Apoptosis induced in rats by 4-vinylcyclohexene diepoxide is associated with activation of the caspase cascades 显示文摘 | Hu X Christian PJ Thompson KE | 2001 | Biol Reprod2001，65，： | 1 |
| 12 | Expression and redistribution of cellular bad, bax and bcl-x1 protein is associated with VCD-induced ovotoxicity in rats 显示文摘 | Hu X Christian PJ Sipes IG | 2001 | Biol Reprod2001，65，： | 1 |
| 13 | Expression and redistri-bution of cellular Bad, Bax, and Bcl - x( L) protein is associatedwith VCD - induced ovotoxicity in rats 显示文摘 | HU X CHRISTIAN P SIPES I G | 2001 | Biol Reprod2001，65，5： | 1 |
| 14 | Insulin antagonizes interleukin-6 signaling and is anti -inflammatory in 3T3 -L1 adipocytes 显示文摘 | Christian X Andersson VS Emelie W | 2007 | J Biol Chem2007，282，13： | 1 |
| 15 | Apoptosis in-duced in rats by 4 - vinylcyclohexene diepoxide is associated withactivation of the caspase cascades 显示文摘 | HU X CHRISTIAN P J THOMPSON K E | 2001 | Biol Reprod2001，65，1： | 1 |
| 16 | Real-time DNA sequencing from single polymerase molecules显示文摘 | Eid J Fehr A Gray J Luong K Lyle J Otto G Peluso P Rank D Baybayan P Bettman B Bibillo A Bjornson K Chaudhuri B Christians F Cicero R Clark S Dalal R Dewinter A Dixon J Foquet M Gaertner A Hardenbol P Heiner C Hester K Holden D Kearns G Kong X Kuse R Lacr | | 0，，5910： | 1 |
| 17 | Botox, dilation, or myotomy? Clinical outcome of interventional and surgical therapies for achalasia显示文摘 | Christian Alexander Gutschow Ulrich T?x Jessica Leers Hartmut Sch?fer Klaus Ludwig Prenzel Arnulf H. H?lscher | 2010 | Langenbeck’s Archives of Surgery2010，，8： | 1 |
| 18 | 查看详情显示文摘 | W X Cao J F Christian P M Champion | | 0，，19： | 1 |
| 19 | Perturbations in mitochondrial dynamics induced by human mutant P1NKI can be rescued by the mitochondrial division inhibitor mdivi-1 显示文摘 | Cui M Tang X Christian WV | 2010 | J Biol Chem2010，285，11： | 1 |
| 20 | Synthesis and aqueous solution properties of polyelectrolyte-grafted silaca particles prepared by surface-initiated atom transfer radical polymerization 显示文摘 | CHEN X Y DAVID P R CHRISTIAN P | 2003 | Colloid Interface Science2003，157，257： | 1 |
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