5篇
您的检索式：作者名="Christina Weber"
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| 1 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 2 | Dichlorodiphenyltrichloroethane and risk of hepatocellular carcinoma显示文摘 | E. Christina Persson Barry I. Graubard Alison A. Evans W. Thomas London Jean‐Philippe Weber Alain LeBlanc Gang Chen Wenyao Lin Katherine A. McGlynn | 2012 | Int. J. Cancer2012，，9： | 1 |
| 3 | Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia显示文摘 | Seija Lehnardt Sabrina Lehmann David Kaul Katharina Tschimmel Olaf Hoffmann Sabine Cho Christina Krueger Robert Nitsch Andreas Meisel Joerg R. Weber | 2007 | Journal of Neuroimmunology2007，，1： | 1 |
| 4 | Triphasic contrast injection improves evaluation of dual energy lung perfusion in pulmonary CT angiography显示文摘 | J. Matthias Kerl Ralf W. Bauer Matthias Renker Eva Weber Philipp Weisser Huedayi Korkusuz Boris Schell Maya Christina Larson Wolfgang Kromen Volkmar Jacobi Thomas J. Vogl | 2010 | European Journal of Radiology2010，，3： | 1 |
| 5 | IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses显示文摘Dear Editor,A rapid immune response to signals released from pathogens and injuries is critical for maintaining tissue integrity and restoring homeostasis.This response is largely mediated by the concerted action of pattern recognition receptors(PRRs).Such cooperativity has been described for Toll-like receptors(TLRs)and NACHT,LRR,and pyrin domain-containing protein 3(NLRP3),but the underlying molecular mechanisms remain incompletely understood.Inflammasomes are multi-protein complexes defined by a cytosolic innate immune sensor,usually a PRR,which recruits the adaptor molecule apoptosis-associated speck-like protein containing a caspase-recruitment domain(ASC)to activate the effector caspase-1 leading to the release of matured IL-1βand IL-18.Active caspase-1 further cleaves gasdermin D(GSDMD)allowing the N-terminal domain of GSDMD(GSDMD-N)to form pores in the plasma membrane,thus facilitating the release of matured IL-1βand IL-18.Pore-forming GSDMD-N further induces pyroptosis,an inflammatory form of cell death. | Yaw Asare Margarita Shnipova LukaŽivković Christina Schlegl Federica Tosato Arailym Aronova Markus Brandhofer Laura Strohm Nathalie Beaufort Rainer Malik Christian Weber Jürgen Bernhagen Martin Dichgans | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
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