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| 1 | Arterial vs venous blood gas differences during hemorrhagic shock显示文摘AIM: To characterize differences of arterial(ABG) and venous(VBG) blood gas analysis in a rabbit model of hemorrhagic shock. METHODS: Following baseline arterial and venous blood gas analysis, fifty anesthetized, ventilated New Zealand white rabbits were hemorrhaged to and maintained at a mean arterial pressure of 40 mm Hg until a state of shock was obtained, as defined by arterial p H ≤ 7.2 and base deficit ≤-15 mmol/L. Simultaneous ABG and VBG were obtained at 3 minute intervals. Comparisons of p H, base deficit, p CO2, and arteriovenous(a-v) differences were then made between ABG and VBG at baseline and shock states. Statistical analysis was applied where appropriate with a significance of P < 0.05. RESULTS: All 50 animals were hemorrhaged to shockstatus and euthanized; no unexpected loss occurred. Significant differences were noted between baseline and shock states in blood gases for the following parameters: p H was significantly decreased in both arterial(7.39 ± 0.12 to 7.14 ± 0.18) and venous blood gases(7.35 ± 0.15 to 6.98 ± 0.26, P < 0.05), base deficit was significantly increased for arterial(-0.9 ± 3.9 m Eq/L vs-17.8 ± 2.2 m Eq/L) and venous blood gasses(-0.8 ± 3.8 m Eq/L vs-15.3 ± 4.1 m Eq/L, P < 0.05). p CO2 trends(baseline to shock) demonstrated a decrease in arterial blood(40.0 ± 9.1 mm Hg vs 28.9 ± 7.1 mm Hg) but an increase in venous blood(46.0 ± 10.1 mm Hg vs 62.8 ± 15.3 mm Hg), although these trends were non-significant. For calculated arteriovenous differences between baseline and shock states, only the p CO2 difference was shown to be significant during shock.CONCLUSION: In this rabbit model, significant differences exist in blood gas measurements for arterial and venous blood after hemorrhagic shock. A widened p CO2 a-v difference during hemorrhage, reflective of poor tissue oxygenation, may be a better indicator of impending shock. | Kristopher Burton Williams Ashley Britton Christmas Brant Todd Heniford Ronald Fong Sing Joseph Messick | 2014 | World Journal of Critical Care Medicine2014，3，2： | 6 |
| 2 | Cytokine and acute pancreatitis显示文摘 | Brady M Christmas S | 1999 | Baillieres Best Pract Res Clin Gastroenterol1999，13，2： | 2 |
| 3 | The anti-inflammatory effects of dexamethasone and therapeutic ultrasound in oral surgery显示文摘 | ElHag M Coghlan K Christmas P | 1985 | Br J Oral Maxillofac Surg1985，23，1： | 1 |
| 4 | Endoscopic view of a hemostatic technique for endoscopic sinus surgery显示文摘 | Yanagisawa E Mirante JP Christmas DA | 2003 | Ear Nose Throat J2003，82，10： | 1 |
| 5 | Selective managemen t of blunt hepatic injuries including nonoperative management is a safe and effective trategy显示文摘 | Christmas AB Wilson AK Manrfing B | 2005 | Surgery2005，138，4： | 1 |
| 6 | Antrochoanal polyp displacing the uvula and the soft palate显示文摘 | Christmas DA Yanagisawa K Yanagisawa E | | 0，，05： | 1 |
| 7 | Neurosurgery for mental disorder,vagus nerve stimulation and deep brain stimulation显示文摘 | Christmas DMB Curran S Matthews K Eljamel MS | | 0，，： | 1 |
| 8 | BCR-ABL fusion peptides and cytotoxic T cells in chronic myeloid leukemia显示文摘 | Clark RE Christmas SE | 2001 | Leuk Lymphoma2001，42，5： | 1 |
| 9 | Growth hormone and sex steroid effects on bone metabolism and bone mineral density in healthy aged women and men显示文摘 | CHRISTMAS C O'CONNOR KG HARMAN SM | 2002 | J Gerontol A Biol Sci Med Sci2002，57，1： | 1 |
| 10 | COPD prevalence is increased in lung cancer,independent of age,sex and smoking history显示文摘 | Young RP Hopkins RJ Christmas T | 2009 | Eur Respir J2009，34，2： | 1 |
| 11 | Prophylactic antibiotics in surgery and surgical wound infections 显示文摘 | Polk HC Jr Christmas AB | 2000 | Am Surg2000，66，2： | 1 |
| 12 | COPD prevalence is in- creased in lung cancer, independent of age, sex ang smoking history显示文摘 | Young RP Hopkins RJ Christmas T | 2009 | EUR Respir J2009，34，2： | 1 |
| 13 | Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes:identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4显示文摘 | Christmas P Tolentino K Primo V | 2006 | J Biol Chem2006，281，11： | 1 |
| 14 | Selective management of blunt hepatic injuries including nonoperative management is a safe and effective strategy显示文摘 | Christmas AB Wilson AK Manning B | 2005 | Surgery2005，138，4： | 1 |
| 15 | Drug abuse and dependency during pregnancy:anaesthetic issues显示文摘 | Ludlow J Christmas T Paech MJ | 2007 | Anaesth intensive care2007，35，6： | 1 |
| 16 | Expression of the chemokines MCP-1/JE and cytokine-induced neutrophil chemoattractant in early acute pancreatitis显示文摘 | BRADY M BHATIA M CHRISTMAS S | 2002 | Pancreas2002，25，3： | 1 |
| 17 | Structural matching in computer vision using probabilistic relaxation显示文摘 | Christmas W J Kittler J | 1995 | IEEE Transactions on Pattern Analysis and Machine Intelligence1995，17，8： | 1 |
| 18 | COPD prevalence is in- creased in lung cancer, independent of age, sex ang smoking history 显示文摘 | Young RP Hopkins RJ Christmas T | 2009 | EUR Respir J2009，34，2： | 1 |
| 19 | Expression of the CYP4F3 gene显示文摘 | Christmas P Ursino SR Fox JW | 1999 | J Biol Chem1999，274，21： | 1 |
| 20 | Myeloid expression of cytochrome P450 4F8 is determined by a lineage- specific alter native promoter显示文摘 | Christmas P Carlesso N Shang H | 2003 | J Biol Chem2003，278，25： | 1 |
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