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| 1 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 2 | Relationship between splanchnic vasodilation and postprandial hypotension in patients with primary autonomic failure显示文摘 | Jaspal S. Kooner Sarah Raimbach Laura Watson Roger Bannister Stanley Peart Christopher J. Mathias | 1989 | Journal of Hypertension1989，，： | 2 |
| 3 | Open Reduction and Internal Fixation of Proximal Humerus Fractures Using a Proximal Humeral Locked Plate: A Prospective Multicenter Analysis显示文摘 | Felix Brunner Christoph Sommer Christian Bahrs Rainer Heuwinkel Christian Hafner Paavo Rillmann Georges Kohut Anders Ekelund Mathias Muller Laurent Audigé Reto Babst | 2009 | Journal of Orthopaedic Trauma2009，，3： | 2 |
| 4 | Assessment of reduced models for the detection of modal interaction through rotor stator contacts显示文摘 | Alain Batailly Mathias Legrand Patrice Cartraud Christophe Pierre | 2010 | Journal of Sound and Vibration2010，329，： | 1 |
| 5 | Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes显示文摘 | Aaron Ochel Marcin Cebula Mathias Riehn Upneet Hillebrand Christoph Lipps Reinhold Schirmbeck Hansjorg Hauser Dagmar Wirth | 2016 | Cellular & Molecular Immunology2016，13，6： | 1 |
| 6 | Droxidopa for neurogenic orthostatic hypotension: A randomized, placebo-controlled, phase 3 trial显示文摘 | Horacio Kaufmann Roy Freeman Italo Biaggioni Phillip Low Simon Pedder L. Arthur Hewitt Joe Mauney Michael Feirtag Christopher J. Mathias | 2014 | Neurology2014，，4： | 1 |
| 7 | Firstclinical results of the locking compression plate(LCP)显示文摘 | Christoph Sommer Emanuel Gautier Mathias Mller | 2003 | Injury2003，34，： | 1 |
| 8 | Treatment of branch retinal vein?occlusion induced maeular edema with bevacizumabf显示文摘 | Mathias A Christoph T Ute W | 2009 | Graefe S ArchClin Exp Ophthalm2009，247，1： | 1 |
| 9 | Self-assembled gold nanoparticle thin films with nonmetallic optical and electronic properties显示文摘 | Mathias Brust Donald Bethell Christopher J Kiely | 1998 | Langmuir1998，14，19： | 1 |
| 10 | 68 Ga-DOTATOC PET/CT provides accurate tumour extent in patients with extraadrenal paraganglioma compared to 123 I-MIBG SPECT/CT显示文摘 | Alexander Kroiss Barry Lynn Shulkin Christian Uprimny Andreas Frech Rudolf Wolfgang Gasser Christoph Url Kurt Gautsch Ruth Madleitner Bernhard Nilica Georg Mathias Sprinzl Guenther Gastl Gustav Fraedrich Irene Johanna Virgolini | 2015 | European Journal of Nuclear Medicine and Molecular Imaging2015，，： | 1 |
| 11 | Effect of phosphate buffer upon CuO/Al2O3 and Cu (II) catalyzed ozonation of oxalic acid solution显示文摘 | Yunzheng Pi Mathias Ernst Jean Christophe Schrotter | 2003 | Ozone-Science & Engi- neering2003，25，5： | 1 |
| 12 | Cardiovascular autonomic dysfunction in MSA and Parkinson’s disease: Similarities and differences显示文摘 | Valeria Iodice David A. Low Ekawat Vichayanrat Christopher J. Mathias | 2011 | Journal of the Neurological Sciences2011，，： | 1 |
| 13 | Effects of the peptide release inhibitor, octreotide, on daytime hypotension and on nocturnal hypertension in primary autonomic failure显示文摘 | Darrell V. Pavitt Christopher J. Mathias Maria Alam Gareth Smith Katharine Bleasdale-Barr | 1995 | Journal of Hypertension1995，，12： | 1 |
| 14 | Molecular self-assembly and nanochemistry:a chemical strategy for the synthesis of nanostructures显示文摘 | GEORGE M Whitesides JOHN P Mathias CHRISTOPHER T Seto | 1991 | Science1991，254，5036： | 1 |
| 15 | Two dimensional modeling of an aircraft engine structural bladed disk-casing modal interaction显示文摘 | Mathias L Christophe P Patrice C | 2009 | Journal of Sound and Vibration2009，319，1： | 1 |
| 16 | Observations on recurrent syncope and presyncope in 641 patients显示文摘 | Christopher J Mathias Kazushi Deguchi Irwin Schatz | 2001 | The Lancet . 2001 (9253)2001，，： | 1 |
| 17 | Treatment of branch retinal vein occlusion induced macular edema with bevacizumab显示文摘 | Mathias A Christoph T Ute W | 2009 | Graefe'' s Arch Clin Exp Ophthalmol2009，247，： | 1 |
| 18 | Large-sized hepotocellular carcinoma (HCC): a neoadjuvant treatment protocol with repetitive transarterial chemoembolization (TACE) before percutaneous MR-guided laser-induced thermotherapy (LITT)显示文摘 | Stephan Zangos Katrin Eichler J?rn O. Balzer Ralf Straub Renate Hammerstingl Christopher Herzog Thomas Lehnert Mathias Heller Axel Thalhammer Martin G. Mack Thomas J. Vogl | 2007 | European Radiology2007，，2： | 1 |
| 19 | Shape from polarization: a method for solving zenithal angle ambiguity显示文摘 | Christophe Stolz Mathias Ferraton Fabriee Meriaudeau | 2012 | Optics Letters2012，37，20： | 1 |
| 20 | Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke显示文摘 | Yi-Lin Cheng Jong-Sung Park Silvia Manzanero Yuri Choi Sang-Ha Baik Eitan Okun Mathias Gelderblom David Yang-Wei Fann Tim Magnus Bradley S. Launikonis Mark P. Mattson Christopher G. Sobey Dong-Gyu Jo Thiruma V. Arumugam | 2014 | Neurobiology of Disease2014，，： | 1 |
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