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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | 糖基化终产物对脉络膜微血管内皮细胞增生和管腔形成的影响(英文)显示文摘目的:研究糖基化终产物(advanced glycationendproducts, AGEs)在年龄相关性黄斑变性发生中的作用。方法:使用lycopersiconesculentum agglutinin包被磁珠的改良方法分离牛脉络膜微血管内皮细胞(bovine choroidalendothelialcells, CEC),采用抗VIII因子免疫细胞化学法和摄取低密度脂蛋白(dil-acetylated low-density lipoprotein,dil-ac-LDL)法进行细胞鉴定。将50g/L牛血清白蛋白和150g/L葡萄糖在37℃孵育6wk 以制备AGEs,通过抗-AGEs 抗体点杂交法定性分析。用MTT 法(3,(4,5-dimethylthiazol-2-yl)-2,5- diphenyl te-trazolium bromide assay)测定CEC 增生,用Vit-rogen凝胶系统观察管腔形成情况。结果:培养细胞中90%以上呈因子阳性,并具有摄取dil-ac-LDL的能力,表明具有内皮细胞的特征。制备的AGEs 与抗-AGEs 抗体具有亲和力。浓度在62.5~500mg/L范围内的AGEs 处理CEC 3d 后,细胞增生呈剂量依赖性增加。碱性成纤维细胞生长因子(basic fibroblastgrowth factor, bFGF)可明显增强CEC 中管腔样结构的形成(P <0.05),但500mg/L和50mg/L的AGEs 对CEC 管腔形成无明显影响(P >0.05)。结论:AGEs 可以促进CEC 的增生,但对其管腔形成无影响。提示AGEs 通过增强CEC 增生,可能是渗出型AMD 发病中潜在的启动因子之一? | 王雨生 Ulrike Friedrichs Wolfram Eichler Stephan Hoffmann Peter Wiedemann | 2005 | 国际眼科杂志2005，5，2： | 3 |
| 3 | The costs of limited health literacy: a systematic review显示文摘 | Klaus Eichler Simon Wieser Urs Brügger | 2009 | International Journal of Public Health2009，，5： | 3 |
| 4 | Test-retest reliability of the Mini Nutritional Assessment–Short Form(MNA-SF)in older patients undergoing cardiac rehabilitation显示文摘Malnutrition is described as a state of insufficient intake of energy,protein and other nutrients leading to changes in body composition(weight loss,reduced fat-free mass)as well as adverse functional and clinical outcomes.[1]Depending on the assessments and definition used,the prevalence in older patients ranges between 12%in communitydwelling adults to 60%of patients in geriatric care facilities.[2–5]Older populations are at high risk of nutritional deficiencies because of risk factors such as multimorbidity,polypharmacy,cognitive and physical decline,poor appetite,depressive syndromes and socioeconomic changes.[4,6]. | Fritz Kather Miralem Hadzic Teresa Hehle Sarah Eichler Julia Klein Heinz Völler Annett Salzwedel | 2020 | Journal of Geriatric Cardiology2020，17，9： | 2 |
| 5 | BAS (BaO-Al2O3-SiO2) glasses for high temperature applications 显示文摘 | EICHLER K SOLOW G OTSCHIK P | 1999 | J Eur Ceram Soc1999，19，： | 2 |
| 6 | Formation and photocatalytic decomposition of a pellicle on anatase surfaces显示文摘 | Rupp F Haupt M Eichler M | 2012 | J Dent Res2012，91，1： | 1 |
| 7 | Boron nitride (BN) and composites for high-temperature applications显示文摘 | Jens Eichler Christoph Lesniak | 2008 | J Eur Ceram Soc2008，28，： | 1 |
| 8 | Flavins are sourceof visible-light-induced free radical formation in cells 显示文摘 | EICHLER M LAVI R SHAINBERG A | 2005 | LasSurg Med2005，37，4： | 1 |
| 9 | Drug policy for an aging population - the European Medicine Agency' s geriatric medicines strategy 显示文摘 | Cerreta F Eichler HG Rasi G | 2012 | N EnglJMed2012，367，21： | 1 |
| 10 | Comparative analysis of mesen- ehymal stem cells from bone marrow, umbilical cord blood, or adipose tissue显示文摘 | Kern S Eichler H Stoeve J | 2006 | Stem Ceils2006，24，5： | 1 |
| 11 | Establishment of a real-time PCR-based approach for accurate quantification of bacterial RNA targets in water,using Salmonella as a model organism显示文摘 | Fey A Eichler S Flavier S | 2004 | App Environ Microbiol2004，70，6： | 1 |
| 12 | Use of recombinant human DNase for processing of athawed umbilical cord blood transplant in a patient with relapsed acute lymphoblastic leukemia显示文摘 | Beck C Bernard F | 2002 | Ann Hematol2002，81，： | 1 |
| 13 | Should 5-hydroxytryptamine-3 receptor antagonists be administered beyond 24 hours after chemotherapy to prevent delayed emesis Systematic reevaluation of clinical evidence and drug cost implications显示文摘 | Geling O Eichler HG | 2005 | J Clin Oncol2005，23，6： | 1 |
| 14 | Initial sequence of the chimpanzee genome and comparison with the human genome显示文摘 | Mikkelsen TS Hillier LW Eichler EE | 2005 | Nature2005，437，： | 1 |
| 15 | The biology of brain metastases- translation to new therapies显示文摘 | Eichler AF Chung E Kodack DP | 2011 | Nat Rev Clin Oncol2011，8，6： | 1 |
| 16 | Malignant liver tumors trea- ted with MR imaging-guided laser-induced thermotherapy: experi- ence with complications in 899 patients ( 2,520 lesions ) 显示文摘 | Vogl TJ Straub R Eichler K | 2002 | Radiology2002，225，2： | 1 |
| 17 | Limitations of next-generation genome sequence assembly显示文摘 | Alkan C Sajjadian S Eichler EE | 2011 | Nature Methods2011，8，1： | 1 |
| 18 | Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue显示文摘 | Kern S Eichler H Stoeve J | 2006 | Stem Cells2006，24，5： | 1 |
| 19 | The new ID-heparin/PF4 antibody test for rapid detection of heparin- induced antibodies in comparison with functional and antigenic assays显示文摘 | EICHLER P RASCHKE R LUBENOW N | 2002 | BrJ Haematol2002，116，4： | 1 |
| 20 | EGFR mutation status and survival after diagnosis of brain metastasis in non small cell lung can- cer显示文摘 | Eichler AF Kahle KT Wang DL | 2010 | Neuro Oncol2010，12，11： | 1 |
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