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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | The effect of body contact series resistance on SOI CMOS amplifier stages显示文摘 | CHRISTOPHER F E WILLIAM R W BERNARD M T | 1997 | IEEE Trans Electron Devices1997，44，12： | 1 |
| 3 | Perceptual-Cognitive Expertise in Sport: A Meta-Analysis 显示文摘 | DEREK T Y WILLIAMS M A CHRISTOPHER M | 2007 | Journal of Sport & Exercise Psychology2007，，29： | 1 |
| 4 | Direct and indirect photolysis of sulfamethoxazole and trimethoprim in wastewater treatment plant effluent显示文摘 | Christopher C R David T T William A A | 2011 | Water research2011，45，3： | 1 |
| 5 | Surface kinetics model for SiLK chemical mechanical polishing显示文摘 | Christopher L B Dipto G T William N G | 2002 | J Electrochem Soc2002，149，： | 1 |
| 6 | Sacral tuberculosis: a case report and review of the literature显示文摘 | John C Wellons Ali R Zomorodi Alan T Villaviciencio Christopher W Woods William T Lawson James D Eastwood | 2004 | Surgical Neurology2004，，2： | 1 |
| 7 | Generation of 3-pyridyl biaryl sys- tems via palladium-catalyzed Suzuki cross-couplings of aryl halides with 3-pyridylboroxin 显示文摘 | Christopher L Ciogl William T Spencer Justin J Pdchards | 2004 | J Org Chem2004，69，6： | 1 |
| 8 | SPQD14090400000528显示文摘 | Gerhard Glenn S Chu Xin Wood G Craig Gerhard Genevieve M Benotti Peter Petrick Anthony T Gabrielsen Jon Strodel William E Still Christopher D Argyropoulos George | 2013 | Human Heredity (-)2013，，2： | 1 |
| 9 | Polymer-derived silicon carbide fibers with low oxygen content and improved thermomechanical stability 显示文摘 | Christopher D B Sacks M D | 1994 | Composites Sci Technol1994，51，2： | 1 |
| 10 | Surface-enhanced Raman spectroscopy as an in situ real-time probe of catalytic mechanisms at high gas pressures 显示文摘 | Christopher Williams T | 1996 | Journal of Catalysis1996，163，： | 1 |
| 11 | Soft robotics:Biological inspiration,state of the art,and future research显示文摘 | DEEPAK T CHRISTOPHER D R WILLIAM M K | 2008 | Applied Bionics and Biomechanics2008，5，3： | 1 |
| 12 | SPQD14090400000528显示文摘 | Gerhard Glenn S Chu Xin Wood G Craig Gerhard Genevieve M Benotti Peter Petrick Anthony T Gabrielsen Jon Strodel William E Still Christopher D Argyropoulos George | 2013 | Human Heredity . 2013 (2-4)2013，，2： | 1 |
| 13 | Catalyst development for uhra-deep hydrodesulfurization ( HDS ) of dibenzothiophenes ( I ) : Effects of Ni promotion in molybdenum-based catalysts 显示文摘 | Gao Qiang Thomas N K Ofosu Ma Shuguo Vasileios G Komvokis Christopher T Williams Koichi Segawa | 2011 | Catalysis Today2011，164，： | 1 |
| 14 | Soft robotics: biological inspiration, state of the art, and future research 显示文摘 | Deepak T Christopher D R William M K | 2008 | Applied Bionics and Bit)mechanics2008，5，3： | 1 |
| 15 | Adhesion of head and neck squamous cell carcinoma to endothelial cells显示文摘 | Wenzel Christopher T Scher Richard L Richtsmeier William J | 1995 | Archives of Otolaryngology-Head & Neck Surgery1995，121，11： | 1 |
| 16 | Robot-aided neurorehabilitation:a novel robot for ankle rehabiliration显示文摘 | Krebs Hermano Igo Williams Dustin J Bever Christopher T | 2009 | obofics Tmmacfions on2009，25，3： | 1 |
| 17 | Softrobotics:biologicalin spiration,state of the art,and future research显示文摘 | Deepak T Christopher DR William MK | 2008 | Applied Bionics and Biomechanics2008，5，3： | 1 |
| 18 | Beyond Urban Legends: An Emerging Framework of Urban Ecology, as Illustrated by the Baltimore Ecosystem Study显示文摘 | Pickett Steward T A Cadenasso Mary L Grove J Morgan Groffman Peter M Band Lawrence E Boone Christopher G Burch William R Grimmond C Susan B Hom John Jenkins Jennifer C Law Neely L Nilon Charles H Pouyat Richard V Szlavecz Katalin Warren Pai | 2008 | Bioscience2008，，2： | 1 |
| 19 | Negative -pressure wound therapy ap- plied to high - risk surgical incisions显示文摘 | William T Christopher F | 2010 | J Foot Ankle Surg2010，49，3： | 1 |
| 20 | Hypoxia-mediated down-regulation of bid and bax in tumors occurs via hypoxia-inducible factor 1-dependent and independent mechanisms and contributes to drug resistance 显示文摘 | Erler J T Christopher J Cawthorne Kaye J Williams | 2004 | Molecular and Cellular Biology2004，24，7： | 1 |
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