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| 1 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 2 | Estimation of visceral fat is useful for the diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease显示文摘BACKGROUND Obesity is a risk factor for non-alcoholic fatty liver disease(NAFLD),although obese patients with NAFLD do not always develop significant fibrosis.The distribution of body fat could predict the risk of NAFLD progression.AIM To investigate the role of bioelectrical impedance-estimated visceral fat(VF)in assessing NAFLD severity.METHODS In this cross-sectional study,patients with biopsy-proven NAFLD were prospectively included.All patients underwent anthropometric evaluation,blood tests and bioelectrical impedance analysis.RESULTS Between 2017 and 2020,119 patients were included[66.4%male,56 years(SD 10.7),62.2%obese,61.3%with metabolic syndrome].Sixty of them(50.4%)showed significant fibrosis(≥F2)in liver biopsy.Age,VF and metabolic syndrome were associated with significant fibrosis(61 years vs 52 years,16.4 vs 13.1,73.3%vs 49.2%,respectively;P<0.001 for all).In the multivariate analysis,VF and age were independently associated with significant fibrosis(VF,OR:1.11,95%CI:1.02-1.22,P=0.02;age,OR:1.08,95%CI:1.03-1.12,P<0.01).A model including these variables showed and area under the receiver operating characteristic curve(AUROC)of 0.75,which was not inferior to transient elastography or NAFLD fibrosis score AUROCs.We developed a nomogram including age and VF for assessing significant fibrosis in routine practice.CONCLUSION VF is a surrogate marker of liver fibrosis in patients with NAFLD.Bioelectrical impedance analysis is an inexpensive and simple method that can be combined with age to guide patient referral when other resources may be unavailable. | Marta Hernández-Conde Elba Llop Carlos Fernández Carrillo Beatriz Tormo Javier Abad Luis Rodriguez Christie Perelló Marta López Gomez JoséLuis Martínez-Porras Natalia Fernández Puga Maria Trapero-Marugan Enrique Fraga Carlos Ferre Aracil JoséLuis Calleja Panero | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 3 | Selection of new Kynarbased electrolytes for lithium-ion batteries显示文摘 | Christie A M Christie L Vincent C A | 1998 | J Power Sources1998，74，1： | 1 |
| 4 | Decentralization of the firm:theory and evidence显示文摘 | CHRISTIE A A JOYE M P WATTS R L | 2003 | Journal of Corporate Finance2003，9，1： | 1 |
| 5 | lnflamm&Won &nd long term morality in &cute congestive heart fsilure显示文摘 | Christi&n M Kitten LK Andrezs C et &l | 2006 | Am He&rt J2006，15，4： | 1 |
| 6 | The natural progression of peanut allergy: resolution and the possibility of recurrence显示文摘 | David M F Conover M K Christie L | 2003 | J Allergy Clin Immunol2003，112，1： | 1 |
| 7 | Gender differences in perceptions of web-based shopping显示文摘 | CRAIG V S CHRISTIE L C | | 0，，08： | 1 |
| 8 | Phthalate ester-induced gubernacular lesions are associated with reduced ins 13 gene expression in the fetal rat testis显示文摘 | Vickie S W Christy L Johnathan F | 2004 | Toxicology Letters2004，46，： | 1 |
| 9 | Debittering of skim milk hydrolysates by absorption for incorporation into acidic beverage显示文摘 | HELBIG N B HO L CHRISTY G E | 1980 | Journal of Food Science1980，45，： | 1 |
| 10 | Effect of individual Ⅰ-amino acids on gastric acid secretion and serum gastrin and pancreatic polypeptide release in humans显示文摘 | Taylor I L Byrne W J Christie D L | 1982 | Gastroenterology1982，83，12： | 1 |
| 11 | The immune dysregulation,polyendocrinopathy,enteropathy,X-linked syndrome(IPEX) is caused by mutations of FoxP3显示文摘 | Bennett C L Christie J Ramsdell F | 2001 | Nat Genet2001，27，1： | 1 |
| 12 | Effects of EDTA and low molecular weight organic acids on soil solution properties of a heavy metal polluted soil显示文摘 | Wu L H Luo Y M Christie P | 2003 | Chemosphere2003，50，： | 1 |
| 13 | Changes in the soil environment from excessive application of fertilizers and manures to two contrasting intensive cropping systems on the north China plain显示文摘 | JU X T KOU C L CHRISTIE P | 2007 | Environ Pollut2007，145，2： | 1 |
| 14 | Persistent DDT metabolite, p,p'-DDE is a potent androgen receptor antagonist显示文摘 | William R K Christy R S Susan C L | 1995 | Nature1995，375，6532： | 1 |
| 15 | Autoantibodies to GAD arid IA-2 in Saudi Arabian diabetic patients 显示文摘 | Damanhouri L H Dromey J A Christie M R | 2005 | Diabetic Medicine2005，22，4： | 1 |
| 16 | Kinetics of 14C-photosynthate translocation in morning groly vines显示文摘 | CHRISTY A L FISHER D B | | 0，，： | 1 |
| 17 | The Effects of Finn Size and Indus try on Corporate Giving显示文摘 | Amato L H Amato Christie H | 2007 | Journal of Business Ethics2007，，72： | 1 |
| 18 | Changes in Soil Solution Zn and pH and Uptake of Zn by Arbuscular Mycorrhizal Red Clover in Zn^2+ Contaminated Soil显示文摘 | LI X L CHRISTIE P | 2001 | Chemosphere2001，42，2： | 1 |
| 19 | Source pool kinetics of 14C-photosynthate translocation in morning groly and soybean显示文摘 | FISHER D B HOUSLEY T L CHRISTY A L | | 0，，： | 1 |
| 20 | Changes in the soil environment from excessive application of fertilizers and manures to two contrast- ing intensive cropping systems on the north China plain显示文摘 | Ju X T Kou C L Christie P | 2007 | Environ- mental Pollution2007，145，： | 1 |
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