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| 1 | Long acting octreotide in the treatment of advanced hepatocellular cancer and overexpression of somatostatin receptors: Randomized placebo-controlled trial显示文摘AIM: To estimate if and to what extent long acting octreotide (LAR) improves survival and quality of life in patients with advanced hepatocellular carcinoma (HCC). METHODS: A total of 127 cirrhotics, stages A-B, due to chronic viral infections and with advanced HCC, were enrolled in the study. Scintigraphy with 111Indium labeled octreotide was performed in all cases. The patients with increased accumulation of radionuclear compound were randomized to receive either oral placebo only or octreotide/octreotide LAR only as follows: octreotide 0.5mg s.c. every 8 h for 6 wk, at the end of wk 4-8 octreotide LAR 20 mg i.m. and at the end of wk 12 and every 4 wk octreotide LAR 30mg i.m.. Follow-up was worked out monthly as well as the estimation of quality of life (QLQ-C30 questionnaire). Patients with negative somatostatin receptors (SSTR) detection were followed up in the same manner. RESULTS: Scintigraphy demonstrated SSTR in 61 patients. Thirty were randomized to receive only placebo and 31 only octreotide. A significantly higher survival time was observed for the octreotide group (49 ± 6 wk) as compared to the control group (28 ± 1 wk) and to the SSTR negative group (28 ± 2 wk), LR = 20.39, df = 2, P < 0.01. The octreotide group presented 68.5% lower hazard ratio [95% CI (47.4%-81.2%)]. During the f irst year, a 22%, 39% and 43% decrease in the QLQ-C30 score was observed in each group respectively.CONCLUSION: The proposed therapeutic approach has shown to improve the survival and quality of life in SSTR positive patients with advanced HCC. | D Dimitroulopoulos D Xinopoulos K Tsamakidis A Zisimopoulos E Andriotis D Panagiotakos A Fotopoulou C Chrysohoou A Bazinis D Daskalopoulou E Paraskevas | 2007 | World Journal of Gastroenterology2007，13，23： | 18 |
| 2 | The association between secondhand smoke and the risk of developing scute coronary syndromes, among non-smokers, under the presence of several cardiovascular risk factors : The CARDIO2000 case-control study 显示文摘 | Panagiotakos DB Chrysohoou C Pitsavos C | 2002 | BMC Public Health2002，2，1： | 1 |
| 3 | Associationbetween prehypertension status and inflammatory markers relat-ed to atherosclerotic disease:The ATTICA study 显示文摘 | Chrysohoou C Pitsavos C Panagiotakos DB | 2004 | Am J Hyp-tertens2004，17，7： | 1 |
| 4 | Inflammation,coagulation and depressive symtomatoloy in cardiovasuder disease-free people,the ATTICA study显示文摘 | Panagiotakos DB pitsavos C Chrysohoou C | 2004 | Eur Heart J2004，25，6： | 1 |
| 5 | Effect of exposure to secondhand smoke on markers of inflammation:the ATHCA study显示文摘 | Panagiotakos DB Pitsavos C Chrysohoou C | 2004 | Am J Med2004，116，3： | 1 |
| 6 | Association between prehypertension status and inflammatory markers related to atherosclerotic disease:the ATTICA study显示文摘 | Chrysohoou C Pitsavos C Panagiotakos DB | 2004 | Am J Hyptertens2004，17，7： | 1 |
| 7 | Gender difference on the risk evaluation of acute coronary syndrome (ACS): the CARDIO 2000 Study显示文摘 | CHRYSOHOOU C PANAGIOTAKOS D B | 2003 | Prey Cardio2003，6，： | 1 |
| 8 | Senlm uric acid levels corre- late with left atrial function and systolic right ventricular thnction in patients with newly diagnosed heart failure: the hellenic heart failure study 显示文摘 | Chrysohoou C Pitsavos C Barhetseas J | 2008 | Con- gest tfeart Fail2008，14，5： | 1 |
| 9 | Inflammation,coagulation,and depressive symptomatology in cardiovascular disease-free people;the ATTICA study显示文摘 | Panagiotakos DB Pitsavos C Chrysohoou C | 2004 | Eur Heart J2004，25，6： | 1 |
| 10 | Association between exposure to environmental tobacco smoke and the development of acute coronary syndrome: the CARDIO2000 casecontrol study 显示文摘 | Pitsavos C Panagiotakos DB Chrysohoou C | 2002 | Tob Contrl2002，11，： | 1 |
| 11 | Exercise capacity and heart rate recovery as predictors of coronary heart disease events, in patients with heterozygous Familial Hypercholesterolemia显示文摘 | Pitsavos CH Chrysohoou C Panagiotakos DB | 2004 | Atherosclerosis2004，173，2： | 1 |
| 12 | Association between prehypertension status and inflammatory markers related to atherosclerotic disease:The ATTICA study显示文摘 | Pitsavos C Panagiotakos DB | 2004 | Am J Hypter-tens2004，17，： | 1 |
| 13 | Exercise capacity and heart rate recovery as predictors of coronary heart disease events,in patients with hetemzygous familial hypercholesterolemia显示文摘 | Pitsaves CH Chrysohoou C Panagiotakos DB | | 0，，02： | 1 |
| 14 | Impact of lifestyle habits on the prevalence of the metabolic syndrome among Greek adults from the ATTICA study显示文摘 | Panagiotakos DB Pitsavos C Chrysohoou C | 2004 | Am Heart J2004，147，1： | 1 |
| 15 | The J-Shaped affect of coffee consumption on the risk of developing acute coronary syndromes : The CARDIO2000 case-control study显示文摘 | Panaqiotokos DB Pitsavos C Chrysohoou C | 2003 | J Nutr2003，133，10： | 1 |
| 16 | Beta-blockade mitigates exercise blood pressure in hypertensive male patients 显示文摘 | Kokkinos P Chrysohoou C Panagiotakos D | 2006 | J Am Coll Cardiol2006，47，4： | 1 |
| 17 | The association between secondhand smoke and the risk of developing acute coronary syndromes, among nonsmokers, under the presence of several cardiovascular risk factors: The CARDIO2000 case - control study显示文摘 | Chrysohoou C Pitsavos C | 2002 | BMC Public Health2002，2，1： | 1 |
| 18 | Climatological variations in daily hospital admissions for acute coronary syndromes显示文摘 | Panagiotakos DB Chrysohoou C Pitsavos C | 2004 | International Journal of Cardiology2004，94，： | 1 |
| 19 | Effect of exposure to secondhand smoke on markers of inflammation:the ATTICA study显示文摘 | PANAGIOTAKOS D B PITSAVOS C CHRYSOHOOU C | 2004 | Am J Med2004，116，3： | 1 |
| 20 | Association between prehypertension status and inflammatory markers related to atherosclerotic disease:the ATTICA study显示文摘 | Chrysohoou C Pitsavos C Panagiotakos DB | 2004 | Am J Hypertens2004，17，7： | 1 |
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