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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Crocetin protects against oxidative damage in rat primary hopatocyte 显示文摘 | Tseng TH Chu CY Huang JM | 1995 | Cancer lett1995，97，4： | 2 |
| 3 | Interleukin-6 induced basic fibroblast growth factor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and PI3-kinase/Akt path ways显示文摘 | Jee SH Chu CY Chiu H | 2004 | J Invest Dermatol2004，123，6： | 1 |
| 4 | Crocetin protects against oxidative damage in rat primary, hepatocyte 显示文摘 | Tseng TH Chu CY Huang JM | 1995 | Cancer Lett1995，97，4： | 1 |
| 5 | Efficacy of allergen-arrayed chips for detecting allergen specific immunoglobulin E in aller- gic patient显示文摘 | Chu SL Chen K J Tsai CY | 2004 | Mid Taiwan J Med2004，9，2： | 1 |
| 6 | Induction of apoptosis by Hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma phosphorylation and Bcl-2 expression 显示文摘 | Kao TW Chu CY | 2000 | Biochemical Pharmacology2000，60，3： | 1 |
| 7 | Interleukin-6 induced basic fibroblast growth aetor-dependent angiogenesis in basal cell carcinoma eell line via JAK/STAT3 and PI3-ki-nase/Akt pathways 显示文摘 | Jee SH Chu CY Chiu HC el al | 2004 | J Invest Dermatol2004，123，6： | 1 |
| 8 | Bronchorrhea following stroke显示文摘 | Sung CY lee TH Chu NS | 2012 | Eur Neurol2012，67，1： | 1 |
| 9 | Radiological prognosticators of hepatocellular carcinoma treated by hepatectomy显示文摘BACKGROUND: Hepatectomy is the main curative treatment for hepatocellular carcinoma (HCC), but postoperative long- term survival is poor. Preoperative radiological features of HCC displayed by computed tomography or magnetic resonance imaging could serve as additional prognostic factors. This study aimed to identify preoperative radiological features of HCC that may be of prognostic significance in hepatectomy. METHODS: Ninety-two patients who underwent hepatectomy for HCC were included in this study. Preoperative radiological features including tumor number, size, location (peripheral, middle, central), portal vein invasion, hepatic vein invasion, and presence of pseudo-capsule were analyzed in relation to survival. RESULTS: With a median follow-up period of 41.7 months, the 1-, 3- and 5-year overall survival rates were 85%, 65% and 58%, respectively. Univariate analysis showed that portal vein invasion and absence of pseudo-capsule were significant prognostic factors for overall survival, while all the examined radiological features were prognostic factors for disease-free survival. Multivariate analysis for overall survival found no significant factor. On multivariate analysis for disease-free survival, patients who had tumors with portal vein invasion had poorer survival with a hazard ratio of 2.26 (95% CI, 1.05-4.91; P=0.038) and patients with single nodular HCC or pseudo-capsulated HCC had better survival with a hazard ratio of 0.50 (95% CI, 0.27-0.94; P=0.032) and 0.38 (95% CI, 0.14-0.99; P=0.048), respectively. CONCLUSIONS: Demonstrable pseudo-capsule of HCC and solitary HCC on imaging and absence of portal vein invasionare features associated with better disease-free survival after hepatectomy. These features may guide treatment planning for HCC. | Kevin KW Chu See Ching Chan Sheung Tat Fan Kenneth SH Chok Tan To Cheung William W Sharr Albert CY Chan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，6： | 1 |
| 10 | Interleukin-6 induced basic fibroblast growth actor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and Pl3-ki- nase/Akt pathways 显示文摘 | Jee SH Chu CY Chiu HC | 2004 | J Invest Dermatol2004，123，6： | 1 |
| 11 | The effect of cognitive behavioral group therapy for depression: a meta-analysis 2000 -2010 显示文摘 | Feng CY Chu H Chen CH | 2012 | Worldviews Evid Based Nurs2012，9，1： | 1 |
| 12 | Right ventricular dysfunction secondary to acute massive pulmonary embolism detected by helical computed tomography pulmonary angiography 显示文摘 | Lim KE Chan CY Chu PH | 2005 | J Clin Imaging2005，29，1： | 1 |
| 13 | Epileptic seizures in intracerebral haemorrthage 显示文摘 | Sung CY Chu NS | 1999 | J Neurol Neurosur8 Psychiatry1999，52，11： | 1 |
| 14 | Status epilepticus in the elderly:etiology,seizure type and outcome显示文摘 | Chu NS | 1989 | Acta Neurol Scand1989，80，： | 1 |
| 15 | The use of 1 pimecrolimus cream for the treatment of steroid-induxed rosacea显示文摘 | Chu CY | 2005 | Br J Deamatol2005，152，2： | 1 |
| 16 | Epileptic seizures in intraeerebral hae morrhage显示文摘 | Sung CY Chu NS | 1999 | J Neurol Neurosurg Psychiatry1999，52，11： | 1 |
| 17 | Monoclonality and surface lesionspecific micr osatellite alterations in premalignant and malignant neoplasia of uterine cercvix:a localfield effect of genomic instability and clonal evolution显示文摘 | Chu TY Shen CY Lee HS | 1999 | Genes Chromosomes Cancer1999，24，： | 1 |
| 18 | Comparison of antiplateletand antithrombotic therapy for secondary prevention of ischemic stroke in patients with peripheral artery disease: population-based follow-up study in Taiwan显示文摘 | Lee WH Chu CY Hsu PC | 2013 | Circ J2013，77，4： | 1 |
| 19 | Expressions of Abetal-40, Abetal-42, tau202, tau396 and tau404 after intracerebroventricular injection of streptozotocin in rats 显示文摘 | Chu WZ Qian CY | 2005 | Di Yi Jun Yi Da Xue Xue Bao2005，25，2： | 1 |
| 20 | Preparation, characterization and immunogenicity of conjugates composed of the O-specific polytsaccharide of Shigel la dysenteriae typel (Shiga' s bacillus) bound to tetanus toxiod显示文摘 | Chu CY Liu BK Watson D | 1991 | Infect Immun1991，59，12： | 1 |
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