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| 1 | Tunable liquid crystal grating based holographic 3D display system with wide viewing angle and large size显示文摘As one of the most ideal display approaches,holographic 3-dimensional(3D)display has always been a research hotspot since the holographic images reproduced in such system are very similar to what humans see the actual environment.However,current holographic 3D displays suffer from critical bottlenecks of narrow viewing angle and small size.Here,we propose a tunable liquid crystal grating-based holographic 3D display system with wide viewing angle and large size.Our tunable liquid crystal grating,providing an adjustable period and the secondary diffraction of the reconstructed image,enables to simultaneously implement two different hologram generation methods in achieving wide viewing angle and enlarged size,respectively.By using the secondary diffraction mechanism of the tunable liquid crystal grating,the proposed system breaks through the limitations of narrow viewing angle and small size of holographic 3D display.The proposed system shows a viewing angle of 57.4°,which is nearly 7 times of the conventional case with a single spatial light modulator,and the size of the reconstructed image is enlarged by about 4.2.The proposed system will have wide applications in medical diagnosis,advertising,education and entertainment and other fields. | Yi-Long Li Nan-Nan Li Di Wang Fan Chu Sin-Doo Lee Yi-Wei Zheng Qiong-Hua Wang | 2022 | Light(Science & Applications)2022，11，7： | 15 |
| 2 | Sol-gel synthesis and characterization of hydroxyapatite nanorods显示文摘In the present study hydroxyapatite (HA) nano-hexagonal rods with 70-90 nm diameter and 400-500 nm length are synthesized using a simple sol-gel route with calcium nitrate and potassium dihydrogenphos-phate as calcium and phosphorus precursors respectively. Deionized water was used as a diluting media for HA sol preparation and ammonia was used to adjust the pH=9. After aging, the HA gel was dried at 60 ℃ and calcined at different temperatures ranging from 300 to 700 ℃. The dried and calcined powders were characterized for phase composition using X-ray diffractrometry, elemental dispersive X-ray and Fourier transform infrared spectroscopy. Rietveld analysis showed the calcined HA powders of high purity with a hexagonal unit cell structure. Calcination yielded HA nanopowders of increased particle size and crystallinity with increase in temperature. The particle size and morphology was studied using transmission electron microscopy. The aspect ratio (length to diameter ratio) of HA nanorods was measured to be between 6 and 7. | Sanosh Kunjalukkal Padmanabhan Avinash Balakrishnan Min-Cheol Chu Yong Jin Lee Taik Nam Kim Seong-Jai Cho | 2009 | Particuology2009，7，6： | 14 |
| 3 | 罗格列酮单用或者与阿伐他汀联合使用对于2型糖尿病患者心血管疾病的非传统标志物的作用显示文摘 | Chu CS Lee KT Lee MY 菅鑫妍 | 2006 | 中国处方药2006，，6： | 13 |
| 4 | Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells显示文摘Ursolic acid(UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer(BC) and colorectal cancer(CRC)that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways.There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the –OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives.Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed. | Eric Wei Chiang Chan Chu Yong Soon Joash Ban Lee Tan Siu Kuin Wong Yew Woh Hui | 2019 | Journal of Integrative Medicine2019，17，3： | 11 |
| 5 | Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study显示文摘BACKGROUND Constipation is a common functional gastrointestinal disorder and its etiology is multifactorial.Growing evidence suggests that intestinal dysbiosis is associated with the development of constipation.Prebiotics are subjected to bacterial fermentation in the gut to produce short-chain fatty acids(SCFAs),which can help relieve constipation symptoms.The prebiotic UG1601 consists of inulin,lactitol,and aloe vera gel,which are known laxatives,but randomized,controlled clinical trials that examine the effects of this supplement on gut microbiota composition are lacking.AIM To assess the efficacy of the prebiotic UG1601 in suppressing constipation-related adverse events in subjects with mild constipation.METHODS Adults with a stool frequency of less than thrice a week were randomized to receive either prebiotics or a placebo supplement for 4 wk.All participants provided their fecal and blood samples at baseline and at the end of intervention.Gastrointestinal symptoms and stool frequency were evaluated.The concentrations of serum endotoxemia markers and fecal SCFAs were determined.The relative abundance of SCFA-producing bacteria and the gut microbial community in the responders and non-responders in the prebiotics supplementation group were evaluated.RESULTS There were no significant differences in gastrointestinal symptoms between groups,although the prebiotic group showed greater symptom improvement.However,after prebiotic usage,serum cluster of differentiation(CD)14 and lipopolysaccharide(LPS)concentrations were significantly decreased(CD14,P=0.012;LPS,P<0.001).The change in LPS concentration was significantly larger in the prebiotic group than in the placebo group(P<0.001).Fecal SCFAs concentrations did not differ between groups,while the relative abundance of Roseburia hominis,a major butyrate producer,was significantly increased in the prebiotic group(P=0.045).The abundances of the phylum Firmicutes and the family Lachnospiraceae(phylum Firmicutes,class Clostridia)(P=0.009)were decreased in the responders within the prebiotic group.In addition,the proportions of the phylum Firmicutes,the class Clostridia,and the order Clostridiales were inversely correlated with several fecal SCFAs(P<0.05).CONCLUSION Alterations in gut microbiota composition,including a decrease in the phylum Firmicutes and an increase in butyrate-producing bacteria,following prebiotic UG1601 supplementation might help alleviate symptom scores and endotoxemia. | Jae Ryang Chu Saem-Yi Kang Sung-Eun Kim Sol-Ji Lee Young-Chul Lee Mi-Kyung Sung | 2019 | World Journal of Gastroenterology2019，25，40： | 10 |
| 6 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 7 | Arsenic trioxide alleviates airway hyperresponsiveness and eosinophilia in a murine model of asthma显示文摘Asthma is one of the most common chronic airway inflammatory diseases.The clinical hallmarks of asthma include elevated serum levels of immunoglobulin E(IgE),eosinophilic inflammation and airway hyper-responsiveness(AHR).Arsenic trioxide(As2O3)is considered a carcinogen;however,it has also been used to treat diseases,such as syphilis,in traditional Chinese and Western medicine.Today,As2O3 is used as one of the standard therapies for acute promyelocytic leukemia(APL).Previous studies have indicated that As2O3 can induce apoptosis in eosinophils.However,the effect of As2O3 on asthma has not been investigated.We used ovalbumin(OVA)-immunized mice as a model for asthma and treated mice with As2O3 at doses of 2.5 and 5 mg/kg.The mice were then monitored for OVA-specific IgE production,airway inflammatory cell infiltration and AHR.We found that administration of As2O3 in OVA-immunized mice abrogated airway eosinophil recruitment by downregulating eotaxin expression but did not alter serum IgE or IL-5 levels in bronchoalveolar lavage fluid(BALF).Furthermore,the development of AHR and cellular infiltration into the airway were reduced by treating mice with As2O3.In vitro data suggested that low concentrations of As2O3 could induce only a small degree of apoptosis in primary pulmonary cells but could significantly inhibit the secretion of eotaxin by these cells.These results indicate that the administration of As2O3 to OVA-immunized mice can suppress lung allergic inflammatory responses.As2O3 might therefore have therapeutic potential in treating allergic airway inflammatory diseases. | Kuan-Hua Chu Chen-Chen Lee Shao-Chi Hsin Bao-Chang Cai Jin-Hong Wang Bor-Luen Chiang | 2010 | Cellular & Molecular Immunology2010，7，5： | 7 |
| 8 | Petrology and geochemistry at the Lower zone-Middle zone transition of the Panzhihua intrusion,SW China:Implications for differentiation and oxide ore genesis显示文摘显示出各向同性、分层、有细密纹理的质地的斑粝岩的一个序列在 260 妈 Panzhihua 侵入的南部的尖端在 Nalaqing 矿被暴露, SW 中国。岩石的域关系,结构,质地和矿物学显示顺序代表在更低的地区和侵入的中间的地区之间的转变。更低的地区特征的各向同性的斑粝岩通过 5 m 厚的 microgabbro 表向上过去到中间的地区的分层的斑粝岩,在以内并且近到哪个 small-scaled,一致 Fe-Ti 氧化物矿石地平线被识别。在在样品的一个子集的 HFSE 和 REE 之间的强壮的分别被归功于到 HFSE 优先地在 REE 上被合并到,在在 Nb/La 之间的平行关系思考了的积云 titanomagnetite Hf/Sm 和 Ti/Ti * 。两个都,各向同性、分层的斑粝岩显示堆积质地并且有类似的矿物质作文(clinopyroxene = 的 Mg# 7679 并且 An5961 ) ,同位素的作文[(87Sr/86Sr ) i = 0.70440.7045 并且 Nd (t)=+2.4 到 +3.9 ] 并且套住的液体内容从 Zr 推断了丰富(1734 ppm ) 。然而,在元素的丰富(V, Cr 和 PGE ) 和在斑粝岩的二种类型之间的比率(Ti/V, La/Yb, Ba/Y 和 Cu/Pd ) 有实质的变化,不能被解释由的特征在一个封闭系统从普通岩浆堆积形成。microgabbros 通常在主要元素作文类似于 high-Ti Emeishan 暗岩,但是他们的低踪迹元素丰富显示一些剩余液体输了尽管有快速的成核,是不可避免的并且冷却。与可得到的数据和观察结合了,我们建议在原处包含结晶化的一个模型,由岩浆列在后面再装并且在 Nalaqing 解释 texturally 特殊的斑粝岩的形成的靠近系统的分别和 Panzhihua 侵入的更低的部分的进化。 | Kwan-Nang Pang Mei-Fu Zhou Liang Qi Sun-Lin Chung Chiu-Hong Chu Hao-Yang Lee | 2013 | Geoscience Frontiers2013，4，5： | 6 |
| 9 | Fabrication of sintering-free flexible copper nanowire/ polymer composite transparent electrodes with enhanced chemical and mechanical stability显示文摘长铜 nanowires (CuNWs ) 的热分解合成被控制合成参数完成。详细研究被执行在产品的最后的形状上决定铜氯化物的臼齿的比率的效果到镍 acetylacetonate,温度,和激动人心的率。透明电极(TE ) 被湿处理与醋酸(AA ) 制作,没有使用一个 sintering 过程。低氧化稳定性和高表面粗糙是 CuNW TE 的主要劣势,它限制他们的应用。以便克服这些问题,我们准备了 CuNW/polymer 由 CuNWs 的部分嵌入进的合成 TE poly (甲基 methacrylate )(PMMA ) 在上 poly (乙烯 terephthalate )( 宠物) 底层。CuNW/PMMA 合成 TE 展出优秀 optoelectronic 性能(91.3% 在 100.7 /sq ) ,低表面粗糙(在高度的 4.6 nm ) ,和好机械、化学的稳定性同样与 CuNW TE 相比。根据这些性质,我们相信基于 CuNW 的合成 TE 能为大量新 optoelectronic 设备用作便宜材料。 | Cho Rong Chu Changsoo Lee Jahyun Koo Hyuck Mo Lee | 2016 | Nano Research2016，9，7： | 6 |
| 10 | Simultaneous Paragonimus infection involving the breast and lung:A case report显示文摘BACKGROUND Paragonimiasis is a food-borne parasitic infection caused by lung flukes of the genus Paragonimus. Although the most common site of infection is the pleuropulmonary area, the parasite can also reach other parts of the body on its journey from the intestines to the lungs, ending up in locations such as the brain,abdomen, skin, and subcutaneous tissues. Ectopic paragonimiasis is difficult to diagnose due to the rarity of this disease.CASE SUMMARY Here, we report a rare case of simultaneous breast and pulmonary paragonimiasis in a woman presenting painless breast mass and lung nodule with a history of eating raw trout. To confirm the diagnosis, serologic testing and tissue confirmation of the breast mass were performed. The patient was treated with surgical resection of the mass and praziquantel medication.CONCLUSION Ectopic paragonimiasis is difficult to diagnose due to the rarity of this disease.Thus, thorough history-taking and clinical suspicion of parasitic infection are important. | Moon Young Oh Ajung Chu Jeong Hwan Park Jong Yoon Lee Eun Youn Roh Young Jun Chai Ki-Tae Hwang | 2019 | World Journal of Clinical Cases2019，7，24： | 5 |
| 11 | Design of multi-functional dual hole patterned carbon nanotube composites with superhydrophobicity and durability显示文摘关于 nanocomposites 的最当前的研究集中了于他们的体积属性,即,电,微波,热、机械的性质。在实际应用,如果内在的性质将被坚持说,象对环境污染的坚韧性那样的表面性质是批评设计考虑。这研究的目的是把 nanocomposites 的体积性质与 superhydrophobic 表面性质由印技术与提高的体积性质创造一个单个多功能的系统提供了相结合。我们报导高度传导性的 superhydrophobic nanotube 的发展合成,它直接通过印技术与一个持久的双洞模式被附加。双洞模式避免导致对物理损坏柔韧的表面的高苗条比率结构的使用。它的稳定的 superhydrophobic 性质理论上并且试验性地被描绘。由合并高方面比率碳 nanotubes (CNT ) ,双有图案的 composites 能有效地也为在低电压的形成和他们的快电的加热反应消除仍然是霜的他们的 superhydrophobic 表面压制冰的反糖衣和除去的应用被使用。另外,防护有效性(SE ) 的优异电磁的干扰(EMI ) 被达到,与曾经在文学报导的最高的价值之一。 | Sung-Hoon Park Eun-Hyoung Cho Jinseung Sohn Paul Theilmann Kunmo Chu Sunghee Lee Yoonchul Sohn Dongouk Kim Byunghoon Kim | 2013 | Nano Research2013，6，6： | 4 |
| 12 | Radiotherapy Plus Transarterial Chemoembolization for Hepatocellular Carcinoma Invading the Portal Vein: Long-Term Patient Outcomes显示文摘 | Sang Min Yoon Young-Suk Lim Hyung Jin Won Jong Hoon Kim Kang Mo Kim Han Chu Lee Young-Hwa Chung Yung Sang Lee Sung Gyu Lee Jin-hong Park Dong Jin Suh | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，5： | 3 |
| 13 | Transcriptional activation of endoplasmic reticulum chaperone GRP78 by HCMV IE1-72 protein显示文摘调整葡萄糖的蛋白质 78 (GRP78 ) , endoplasmic 蜂窝胃的一个关键管理者(嗯) 应力,便于癌症细胞生长和病毒的复制。在病毒的感染期间导致 grp78 基因激活的机制大部分是未知的。在这研究,我们证明立即早 1 (IE1-72 ) 人的 cytomegalovirus (HCMV ) 的蛋白质为调停 HCMV 的 GRP78 激活是必要的。取决于 ATP 有约束力的地点,锌手指领域和 IE1-72 的通常认为的白氨酸拉链主题的 IE1-72 upregulated grp78 基因表示,以及 grp78 倡导者上的 ER 压力反应元素(苏格兰之盖尔语) 。净化的 IE1-72 蛋白质在 vitro 在苏格兰之盖尔语以内跳了到 CCAAT 盒子,而在 grp78 倡导者刺激缺乏的 IE1-72 的删除异种没能那么做。而且,对在感染的房间的 grp78 倡导者有约束力的 IE1-72 伴随了 TATA 盒子绑定的招募联系蛋白质的因素 1 (TAF1 ) , histone acetyltransferase,和 acetylated histone H4 的增加的水平,活跃状态的染色质的指示物。这些结果提供 HCMV IE1-72 通过直接倡导者绑定和本地染色质结构的调整激活 grp78 基因表示的证据,显示为病毒的生长感应的细胞的女伴的活跃病毒的机制。 | Derick Shi-Chen Ou Sung-Bau Lee Chi-Shuen Chu Liang-Hao Chang Bon-chu Chung Li-Jung Juan | 2011 | Cell Research2011，21，4： | 3 |
| 14 | Delayed diagnosis of 22q11.2 deletion syndrome in an adult Chinese lady显示文摘 | SHEA Yat-fung LEE Chi-ho Harinder Gill CHOW Wing-sun LAM Yui-ming LUK Ho-ming LAM Stephen Tak-sum CHU Leung-wing | 2012 | Chinese Medical Journal2012，，16： | 3 |
| 15 | Refeeding syndrome in Southeastern Taiwan:Our experience with 11 cases显示文摘AIM:To present our experience with refeeding syndrome in southeastern Taiwan.METHODS:We conducted a retrospective study during a 2-year period at the Mackay Memorial Hospital,Taitung Branch.We enrolled patients with very little or no nutrition intake for more than 10 d,a high risk group of refeeding syndrome,including those suffering from alcohol abuse,cancerous cachexia,chronic malnutrition,and prolonged starvation.RESULTS:A total of 11 patients(7 males,4 females)with nasogastric feeding were included as having refeeding syndrome.Most of them had the symptoms of diarrhea,lethargy,and leg edema.The initial nutritional supplement was found to be relatively high in calories(1355.1±296.2 kcal/d),high in protein(47.3±10.4 gm/d),low in vitamin B1(2.0±0.5 mg/d),low in potassium(1260.4±297.7 mg/d),and low in phosphorus(660.1±151.8 mg/d).Furthermore,hypophosphatemia(2.4±0.9 mg/dL)was noted during follow-up.Based on the suggestions of a dietician and a gastroenterologist,the clinical disorders of diarrhea,malaise and leg edema were significantly improved.The level of phosphate was also increased(3.3±0.6mg/dL).CONCLUSION:Refeeding syndrome is an overlooked and risky disorder that has some potentially fatal complications.Nasogastric feeding in nursing homes is an important risk factor for patients and deserves greater attention based on the initial results of this study. | Li-Ju Chen Huan-Lin Chen Ming-Jong Bair Chia-Hsien Wu I-Tsung Lin Yuan-Kai Lee Cheng-Hsin Chu | 2014 | World Journal of Gastroenterology2014，20，30： | 3 |
| 16 | Emergency surgery for obstructing colorectal cancers: a comparison between right-sided and left-sided lesions 1 1 No competing interests declared.显示文摘 | Yee Man Lee Wai Lun Law Kin Wah Chu Ronnie T.P. Poon | 2001 | Journal of the American College of Surgeons2001，，6： | 3 |
| 17 | Estimation of peak relative velocity and peak absolute acceleration of linear SDOF systems显示文摘在结构的地震分析和设计,真速度 andabsolute 加速被他们的相应伪值通常接近。简单的这 approachis 和为有小抑制的结构好的工作(说,不到 15%) 。当抑制 ofa 结构为反应减小的目的被提高时,它可以导致大分析 anddesign 错误。基于随机的颤动和地震 responsespectra 分析的确定的机制的理论,一个方法被开发(1 ) 从 5% 标准伪加速光谱直接铺平与 anydamping 比率预言相对速度系列;并且(2 ) 达到顶点到 estimatethe 绝对加速。两个的精确性被使用二个选择整体 ofground 运动记录验证。 | Jianwei Song Yi-Lun Chu Zach Liang George C. Lee | 2007 | Earthquake Engineering and Engineering Vibration2007，6，1： | 3 |
| 18 | Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma显示文摘 | Shi-Ming Lin Ming-Lung Yu Chuan-Mo Lee Rong-Nan Chien I-Shyan Sheen Chia-Ming Chu Yun-Fan Liaw | 2006 | Journal of Hepatology2006，，1： | 3 |
| 19 | Mortality, Liver Transplantation, and Hepatocellular Carcinoma Among Patients with Chronic Hepatitis B Treated with Entecavir vs Lamivudine显示文摘 | Young-Suk Lim Seungbong Han Nae-Yun Heo Ju Hyun Shim Han Chu Lee Dong Jin Suh | 2014 | Gastroenterology2014，，： | 3 |
| 20 | Effect of surface mechanical attrition treatment of titanium using alumina balls: surface roughness, contact angle and apatite forming ability显示文摘 | M. JAMESH T. S. N. SANKARA NARAYANAN Paul K. CHU II Song PARK Min Ho LEE | 2013 | Frontiers of Materials Science2013，7，3： | 3 |
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