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| 1 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 13 |
| 2 | Processing effects on the magnetic and mechanical properties of FeCoNiAl_(0.2)Si_(0.2) high entropy alloy显示文摘High entropy alloys with the composition of FeCoNiAl0.2Si0.2 were prepared by arc melting and induction melting, denoted by A1 and A2, respectively. The samples prepared by these two techniques have a face-centered cubic (FCC) phase structure and a typical dendrite morphology. The tensile yield strength and maximum strength of A2 samples are about 280 and 632 MPa, respectively. Moreover, the elongation can reach 41.7%. These two alloys prepared by the different methods possess the similar magnetic properties. The saturation magnetization and coercivity can reach 1.151 T and 1400 A/m for Al samples and 1.015 T and 1431 A/m for A2 samples, respectively. Phases in A2 samples do not change, which are heat treated at different temperatures, then quenched in water. Only the sample, which is heat treated at 600C for 3h and then furnace cooled, has a new phase precipitated. Besides, the coercivity decreases obviously at this temperature. Cold rolling and the subsequent heat treatment cannot improve the magnetic properties effectively. However, cold rolling plays an important role in improving the strength. | Ting-ting Zuo Song-bo Ren Peter K. Liaw Yong Zhang | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，6： | 12 |
| 3 | Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame显示文摘导致的 pluripotent 的产生从体的细胞的茎(iPS ) 细胞被定义 reprogramming 抄写因素(TF ) 的同时的病毒的 transduction 成功地完成了。然而,这个过程为基因交货要求多重病毒的向量。作为结果,产生了 iPS 房间港口在他们的染色体的众多的病毒的集成地点。这能增加基因 mutagenesis 和 genomic 不稳定性的概率,并且介绍重要障碍给研究和 iPS 房间的临床的申请研究。在这篇论文,我们在场定义因素是的一个简单 lentivirus reprogramming 在系统经由自我劈开的 2A 序列熔化了在里面框架进一个单个开的读物框架(ORF ) 。一个 GFP 标记下游地被放 transgene 启用 transgene 表示追踪。我们证明这个 polycistronic 表示系统高效地产生 iPS 房间。产生 iPS 房间有正常 karyotypes 并且类似于鼠标在形态学和基因表示的胚胎的干细胞。而且,他们能在 vitro 并且在 vivo 试金在两个区分进三胚胎的细菌层的房间类型。显著地,大多数这些 iPS 房间仅仅怀有病毒的向量的一个单个拷贝。这个系统提供一个珍贵工具因为 iPS 房间的产生,和我们的数据建议在每个房间的 transduced reprogramming TF 的表示的平衡为 reprogramming 进程是必要的。更重要地,当由非集成的基因交货系统交付了时,这重新设计的单个 ORF 将没有基因修正便于人的 iPS 房间的有效产生。 | Lijian Shao Wei Feng Yan Sun Hao Bai Jun Liu Caroline Currie Jaejung Kim Rafael Gama Zack Wang Zhijian Qian Lucy Liaw Wen-Shu Wu | 2009 | Cell Research2009，19，3： | 12 |
| 4 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update显示文摘 | Yun-Fan Liaw Nancy Leung Jia-Horng Kao Teerha Piratvisuth Edward Gane Kwang-Hyub Han Richard Guan George K. K. Lau Stephen Locarnini | 2008 | Hepatology International2008，，3： | 10 |
| 5 | 锂离子电池加速老化温度应力的滥用边界显示文摘为了探寻加速老化合适的温度应力区间,设计了温度变化为30~80℃的循环老化实验,通过电池外特性分析与解体分析等手段对锂离子电池老化机理进行了探讨。结果表明:老化速率随着温度的升高先降低、再升高。基于老化速率,将温度工况分为常温(30~56℃)、中高温(56~68℃)、高温(68~80℃)3个区域。在常温区域,老化速率随着温度升高而降低,锂离子电池存在析锂现象;在高温区域,电池电极出现活性物质脱落现象,导致锂离子电池容量的衰减;而在中高温区域,通过活化能计算判断电池老化机理为固体电解质界面膜(SEI)的生长。该研究成果可以指导加速老化实验的设计,也为寿命预测模型的开发提供参考。 | 吴正国 张剑波 李哲 LIAW Bor Yann | 2018 | 汽车安全与节能学报2018，9，1： | 10 |
| 6 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update显示文摘 | Yun-Fan Liaw Nancy Leung Jia-Horng Kao Teerha Piratvisuth Edward Gane Kwang-Hyub Han Richard Guan George K. K. Lau Stephen Locarnini | 2008 | Hepatology International2008，，3： | 7 |
| 7 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius Lesmana Jose | 2012 | Hepatology International2012，，3： | 6 |
| 8 | Hepatocyte growth factor gene therapy prevents radiation-induced liver damage显示文摘AIM: To transfer human HGF gene into the liver of rats by direct electroporation as a means to prevent radiationinduced liver damage.METHODS: Rat whole liver irradiation model was accomplished by intra-operative approach. HGF plasmid was injected into liver and transferred by electroporation using a pulse generator. Control rats (n = 8) received electrogene therapy (EGT) vehicle plasmid and another 8rats received HGF-EGT 100 μg 48 h before WLIR.Expression of HGF in liver was examined by RT-PCR and ELISA methods. Apoptosis was determined by TUNEL assay. Histopathology was evaluated 10 wk after whole liver irradiation.RESULTS: Marked decrease of apoptotic cells and downregulation of transforming growth factor-beta 1 (TGF-β1)mRNA were observed in the HGF-EGT group 2 d after liver irradiation compared to control animals. Less evidence of radiation-induced liver damage was observed morphologically in liver specimen 10 wk after liver irradiation and longer median survival time was observed from HGF-EGT group (14 wk) compared to control rats (5 wk). (P = 0.031).CONCLUSION: For the first time it has been demonstrated that HGF-EGT would prevent liver from radiation-induced liver damage by preventing apoptosis and down-regulation of TGF-β1. | Chau-Hua Chi I-Li Liu Wei-Yu Lo Bor-Song Liaw Yu-Shan Wang Kwan-Hwa Chi | 2005 | World Journal of Gastroenterology2005，11，10： | 6 |
| 9 | Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B显示文摘 | Yao-Shih Hsu Rong-Nan Chien Chau-Ting Yeh I-Shyan Sheen Hung-Yi Chiou Chia-Ming Chu Yun-Fan Liaw | 2002 | Hepatology2002，，6： | 6 |
| 10 | Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity显示文摘AIM: To evaluate whether the effect of Gln dipeptideenriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical patients.METHODS: Forty-eight patients with major abdominal surgery were allocated to two groups to receive isonitrogenous (0.228 g nitrogen/kg per d) and isocaloric(30 kcal/kg per d) TPN for 6 d. Control group (Conv)using conventional TPN solution received 1.5 g amino adds/kg per day, whereas the test group received 0.972 g amino acids/kg per day and 0.417 g L-alanyl-L-glutamine(Ala-Gln)/kg per day. Blood samples were collected on d 1 and d 6 postoperatively for plasma interleukin (IL)-2,IL-6, IL-8, and interferon (IFN)-γ analysis.RESULTS: Plasma IL-2 and IFN-γ were not detectable.IL-6 concentrations were significantly lower on the 6th postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE Ⅱ≤6, whereas no difference was noted in patients with APACHE Ⅱ>6. There was no difference in IL-8 levels between the two groups.No difference in cumulative nitrogen balance was observed on d 2-5 after the operation between the two groups(Ala-Gln -3.2±1.6 g vs Conv -6.5±2.7 g). A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group.CONCLUSION: TPN supplemented with Gln dipeptide had no effect on plasma IL-8 levels after surgery. However,Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered. | Ming-Tsan Lin Sung-Pao Kung Sung-Ling Yeh Koung-Yi Liaw Ming-Yang Wang Ming-Liang Kuo Po-Houng Lee Wei-Jao Chen | 2005 | World Journal of Gastroenterology2005，11，39： | 5 |
| 11 | Hepatitis B virus infection显示文摘 | Yun-Fan Liaw Chia-Ming Chu | 2009 | The Lancet2009，，9663： | 5 |
| 12 | PTEN,a putative protein tyrosine phosphatase gene mutated in human brain,breast,and prostate cancer显示文摘 | Li J Yen C Liaw D | | 0，，： | 4 |
| 13 | Long‐term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B显示文摘 | Ting‐Tsung Chang Yun‐Fan Liaw Shun‐Sheng Wu Eugene Schiff Kwang‐Hyub Han Ching‐Lung Lai Rifaat Safadi Samuel S. Lee Waldemar Halota Zachary Goodman Yun‐Chan Chi Hui Zhang Robert Hindes Uchenna Iloeje Suzanne Beebe Bruce Kreter | 2010 | Hepatology2010，，： | 4 |
| 14 | Preternatural Hexagonal High-Entropy Alloys: A Review显示文摘Recently,various topics on high-entropy alloys have been reported and great amounts of excellent properties have been investigated,including high strength,great corrosion resistance,great thermal stability,good fatigue and fracture properties,etc.Among all these research activities,high-entropy alloys tend to form face-centered-cubic(FCC)or body-centeredcubic(BCC)solid solutions due to their high-entropy stabilization effect,while the hexagonal structures are rarely reported.Up to now,the reported hexagonal high-entropy alloys are mainly composed of rare-earth elements and transitional elements.Their phase transformation and magnetic properties have also aroused wide concern.This study summarizes the above results and provides the forecast to the future. | Rui-Xuan Li Jun-Wei Qiao Peter K. Liaw Yong Zhang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，8： | 4 |
| 15 | Hepatitis B virus infection显示文摘 | Yun-Fan Liaw Chia-Ming Chu | 2009 | 2009 (9663)2009，，9663： | 4 |
| 16 | A trend based investment decision approach using clustering and heuristic algorithm显示文摘This paper proposes a stock price trend clustering and trend investment decision model by using a genetic algorithm to search for optimal solutions and the best investment strategies for different stock price trends.The new price trend clustering model identifies three types of stock price movements:uptrends,sideways trends,and downtrends.Unfortunately,trends discovered through stock price movements or technical indicator graphs are typically subjective and unquantifiable.This paper takes daily stock prices and trading volume data from the China Shanghai Stock Exchange Composite Index(SSECI)from January 2,1997 to August31,2012,to examine the performance of the proposed trend clustering model.The proposed model is also compared to other popular stock market investment strategies to verify its validity.Research result shows that the proposed trend clustering model correctly identifies three different trends in the stock market.Furthermore,the trend investment strategy model developed by using genetic algorithm methodology performs better than other investment strategies,namely,Granville’s rule,the KD indicator strategy,the buys and holds strategy,and GMA rules,in both bull and bear market periods.Research results prove the proposed new model to be a stable and valid investment strategy. | WU ChungMin CHOU ShengChun LIAW HorngTwu | 2014 | Science China(Information Sciences)2014，57，9： | 4 |
| 17 | Design of near-α Ti alloys via a cluster formula approach and their high-temperature oxidation resistance显示文摘The multi-component composition characteristics of high-temperature near-α Ti alloys were investigated in the present work by means of a cluster formula approach. The uniform cluster formula [CN12 cluster](glue atom)3 for the hexagonal close-packed α solid solution was first obtained based on the Friedel oscillation theory, with a total atom number in the formula of Z = 16. Then it was analyzed that the Z values in the cluster composition formulas of typical near-α Ti alloys are within the range of Z = 16.0016.30, being perfectly consistent with the ideal Z = 16. Based on it, a series of new alloys with Z = 16 and with Nb/Ta substitution for Mo in Ti1100 alloy were designed, suction-cast into φ 6 mm rods, and then heat-treated with solid solution and aging. It was found that the alloy with co-addition of Mo, Ta and Nb has a high strength and good ductility at both room and high temperatures. More importantly, the additions of Nb and Ta can contribute to the formation of continuous and compact Al2O3 scales, resulting in an obvious improvement of oxidation resistances at both 923 K and 1073 K. The effects of Mo, Ta and Nb on the oxidation behaviors of the designed alloys at 1073 K were further discussed. | Beibei Jiang Donghui Wen Qing Wang Jinda Che Chuang Dong Peter K. Liaw Fen Xu Lixian Sun | 2019 | Journal of Materials Science & Technology2019，35，6： | 4 |
| 18 | Advanced polyimide materials: Syntheses, physical properties and applications显示文摘 | Der-Jang Liaw Kung-Li Wang Ying-Chi Huang Kueir-Rarn Lee Juin-Yih Lai Chang-Sik Ha | 2012 | Progress in Polymer Science2012，，7： | 3 |
| 19 | Hepatitis B virus infection显示文摘 | Yun-Fan Liaw Chia-Ming Chu | 2009 | The Lancet . 2009 (9663)2009，，： | 3 |
| 20 | 世界家庭医生组织(WONCA)研究论文摘要汇编——居住在“冷点社区”与健康欠佳、享有卫生服务质量欠佳间的关系显示文摘目的患者居住的社区情况与其所享有的卫生服务质量之间的关系尚未完全明确。本研究旨在调查居住在'冷点社区'(经普查证实的低收入、低文化程度以及不享有多种福利的社区)与享有的卫生服务质量间的关系。方法在12个全科诊所中选取152 962例患者进行调查。将患者所住社区(根据普查所得结果)按照全科诊所服务范围进行编码,并根据低收入(收入低于联邦贫困线水平的2倍被认定为低收入)人群比例、低于高中文化人群比例以及社会剥夺指数水平的四分位数进行分类,具有最低收入、低学历人群比例或最高社会剥夺指数的社区被认定为'冷点社区'。采用双变量回归和Logistic回归分析患者所住'冷点社区'情况与患者慢性病患病情况(肥胖、未得到有效控制的糖尿病)、享有的卫生服务情况[肺炎疫苗接种、癌症(结肠癌、宫颈癌、前列腺癌)筛查以及应用阿司匹林防治心血管疾病情况]间的关系。结果各'冷点社区'患者的分布比例不同,最高比例是最低比例的10倍(29.1%比2.6%)。除了应用阿司匹林之外,享受其他卫生服务情况以及慢性病患病情况均受到了'冷点社区'状况的影响。居住在低学历'冷点社区'的患者患有未得到有效控制的糖尿病的比例高于居住在非'冷点社区'的患者(15%比13%,P<0.05)。回归分析表明,与居住在非'冷点社区'的患者相比,居住在贫困'冷点社区'、低学历'冷点社区'、社会剥夺指数高'冷点社区'的患者享有的宫颈癌筛查服务比例稍高,但享有的结肠癌筛查服务比例较低[OR(95%CI)分别为0.88(0.83,0.93)、0.87(0.82,0.92)、0.89(0.83,0.95)]。结论居住在冷点社区的患者拥有较高的慢性病患病率,且其享有的部分筛查服务质量较差。全科医生可应用领域数据来分配资源,主动积极筛查出此类社区中的慢性病患者以及应该享有却未能享受到筛查服务的患者。 | LIAW W KRIST A H TONG S T 本刊编辑部 | 2018 | 中国全科医学2018，21，19： | 3 |
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