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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 3 | Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives显示文摘Hepatocellular carcinoma(HCC),the predominant form of adult liver malignancies,is a global health concern.Its dismal prognosis has prompted recent significant advances in the understanding of its etiology and pathogenesis.The deregulation of epigenetic mechanisms,which maintain heritable gene expression changes and chromatin organization,is implicated in the development of multiple cancers,including HCC.This review summarizes the current knowledge of epigenetic mechanisms in the pathogenesis of HCC,with an emphasis on HCC mediated by chronic hepatitis B virus infection.This review also discusses the encouraging outcomes and lessons learnt from epigenetic therapies for hematological and other solid cancers,and highlights the future potential of similar therapies in the treatment of HCC. | Li Ma Mei-Sze Chua Ourania Andrisani Samuel So | 2014 | World Journal of Gastroenterology2014，20，2： | 12 |
| 4 | Long-term survival after Cisplatin-based induction chemotherapy and radiotherapy for nasopharyngealcarcinoma: A pooled data analysis of two phase Ⅲ trials显示文摘 | Chua DT Ma J Sham JS | 2005 | J Clin Oncol2005，23，6： | 1 |
| 5 | Formation of in vivo tissue engineered human hyaline cartilage in the shape of a trachea with internal support 显示文摘 | Ruszymah BH Chua K Latif MA | 2005 | Int J Pediatr Otorhinolaryngol2005，69，11： | 1 |
| 6 | Long-term survival after cisplat in-based induction chemotherapy and radiotherapy for nasopha ryngeal carcinoma: a pooled data analysis of two phase m trials显示文摘 | Chua DT Ma J Sham JS | 2005 | J Clin Oncol2005，23，6： | 1 |
| 7 | Pulse oximeter as a home assessment tool:Knowledge and user experience among the community in Malaysia during the COVID-19 pandemic显示文摘Objective:To determine the degree of knowledge in the usage of pulse oximeter as a home assessment tool among the community in Malaysia.Methods:A cross-sectional survey was conducted in November 2021.The questionnaire assessed the knowledge in using pulse oximeters,user experience and opinions in using pulse oximeter as a home assessment tool during the pandemic.Results:A total of 504 respondents were included in the study,and the mean score in knowledge related to application of pulse oximetry was 73.00%,while the mean score in knowledge related to factors affecting pulse oximetry readings was only 38.51%.A total of 90.5% of the respondents recognised normal pulse rate and 88.5% knew the blood oxygen saturation levels of a healthy adult,while 69.4% recognised the definition of silent hypoxia.In addition,the majority of the respondents agreed that factors such as poor blood circulation(71.2%),excessive movements(69.8%),and hand position(60.7%)affected oximetry readings.However,61.7%,81.7%,77.2% and 76.8% of the respondents could not identify nail polish,skin colour,skin thickness and tattoos as factors that may affect oximetry readings respectively.Conclusions:The respondents showed a satisfactory level of knowledge related to application of pulse oximetry,but a poor level of knowledge related to factors affecting pulse oximetry readings among the community in Malaysia.Continuous efforts in educating the community on the correct use of pulse oximeters are crucial for appropriate home assessment and avoiding unnecessary stress. | Siew-Keah Lee Jin Wei Ma Khai Ying Chan Yi Song Cheong Wan Ting Hong Regine Chew Yi Ong Wei Cheng Tay Ang-Lim Chua | 2022 | Asian Pacific Journal of Tropical Medicine2022，15，5： | 1 |
| 8 | Long - term survival after cisplatin - based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma:a pooled data analysis of tow phase III trials显示文摘 | Chua DT Ma J Sham JS | 2005 | J Clin Oncol2005，23，6： | 1 |
| 9 | Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma:a pooled data analysis of two phase Ⅲ trials显示文摘 | Chua DT Ma J Sham JS | 2005 | J Clin Oncol2005，23，6： | 1 |
| 10 | Human epidermal keratinocyte cell response on integrin-speeifie artificial extraeellular matrix proteins显示文摘 | Tjin MS Chua AW Ma DR | 2014 | Maeramol Biosei2014，14，8： | 1 |
| 11 | Long term survival after cispla tin-based induction chemotherapy and radiotherapy for nasopha- ryngeal carcinomata pooled deta analysis of two phase Ⅲ trials 显示文摘 | Chua DT Ma J Sham JS | 2005 | J Clin Oncol2005，23，6： | 1 |
| 12 | Long-term survival after cis platin based induction chemotherapy and radiotherapy for naso pharyngeal carcinoma: a pooled data analysis of two phase Ⅲ tri als显示文摘 | Chua D T Ma J Sham J S | 2005 | J ClinOncol2005，23，6： | 1 |
| 13 | Derivation of cochlea hair cell for in vitro expansion and characterization 显示文摘 | lbnubaidah MA Chua KH Mazila A | 2008 | Med J Malaysia2008，63，： | 1 |
| 14 | Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma:subgroup analysis of two phase Ⅲ trials显示文摘 | CHUA D T MA J SHAM J S | 2006 | Int J Radiat Oncol Biol Phys2006，65，5： | 1 |
| 15 | Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopha- ryngeal carcinama: a pooled data analysis of two phase Ⅲ trials显示文摘 | Chua DT Ma J Sham JS | 2005 | J Clin Oncol2005，23，6： | 1 |
| 16 | Long-time survival after cisplatin-based induction chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma:a pooled data analysis of two phase Ⅲ trials显示文摘 | Chua AT Ma J Sham JS | | 0，，： | 1 |
| 17 | Genetic characterization of the partial mitochondrial cytochrome oxidase e subunit I (cox1) gene of the zoonotic parasitic nematode, Ancylostoma ceylanicum from humans, dogs and cats 显示文摘 | Ngui R Mahdy MA Chua KH | 2013 | Acta Trop2013，128，1： | 1 |
| 18 | Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: subgroup ananlysis of two phase m trials 显示文摘 | Chua DTY Ma J Sham JST | 2006 | Int J Radi- at Oncol Biol Phys2006，65，5： | 1 |
| 19 | Optimal production of polyhydroxyalkanoates in activated sludge biomass显示文摘 | Ma C K Chua H Yu PHF | 2000 | Applied Biochemistry and Biotechehnology2000，84，6： | 1 |
| 20 | Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma:subgroup ananlysis of two phaseⅢtrials显示文摘 | Chua DTT Ma J Sham JST | 2006 | Int J Radiat Oncol Biol Phys2006，65，5： | 1 |
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