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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Comparison of survival outcomes between transthoracic and transabdominal surgical approaches in patients with Siewert-Ⅱ/Ⅲesophagogastric junction adenocarcinoma:a single-institution retrospective cohort study显示文摘Objective: To compare the survival outcomes of transabdominal(TA) and transthoracic(TT) surgical approaches in patients with Siewert-Ⅱ/Ⅲ esophagogastric junction adenocarcinoma.Methods: This retrospective study was conducted in patients with Siewert-Ⅱ/Ⅲ esophagogastric junction adenocarcinoma who underwent either TT or TA operations in the West China Hospital between January 2006 and December 2009.Results: A total of 308 patients(109 in the TT and 199 in the TA groups) were included in this study with a follow-up rate of 87.3%. The median(P25, P75) number of harvested perigastric lymph nodes was 8(5, 10) in the TT group and 23(16, 34) in the TA group(P<0.001), and the number of positive perigastric lymph nodes was 2(0, 5) in the TT group and 3(1, 8) in the TA group(P<0.004). The 5-year overall survival(OS) rate was 36% in the TT group and 51% in the TA group(P=0.005). Subgroup analysis by Siewert classification showed that 5-year OS rates for patients with Siewert Ⅱ tumors were 38% and 48% in TT and TA groups, respectively(P=0.134), whereas the 5-year OS rate for patients with Siewert Ⅲ tumors was significantly lower in the TT group than that in the TA group(33% vs. 53%; P=0.010). Multivariate analysis indicated that N2 and N3 stages, R1/R2 resection and a TT surgical approach were prognostic factors for poor OS.Conclusions: Improved perigastric lymph node dissection may be the main reason for better survival outcomes observed with a TA gastrectomy approach than with TT gastrectomy for Siewert Ⅲ tumor patients. | Weihan Zhang Xinzu Chen Kai Liu Kun Yang Xiaolong Chen Ying Zhao Yongfan Zhao Jiaping Chen Longqi Chen Jiankun Hu | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 3 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 4 | Genotyping of IL-8-251 T > A yields prognostic information in patients with gastric carcinoma显示文摘 | Xiuyu Cai Weihan Hu Bei Zhang Ni Dai Ruihua Xu Huijuan Qiu Deshen Wang Zhiming Li Wenqi Jiang | 2013 | Biomarkers2013，，7： | 1 |
| 5 | A virtual sculpting system based on triple Dexel models with haptics显示文摘 | Peng Xiaobo Zhang Weihan | 2009 | Computer-Aided Design and Applications2009，6，5： | 1 |
| 6 | A primary study of nitrous oxide emission in agriculture region of Northern China显示文摘Significance of nitrous oxide in atmospheric chemistry is reviewed briefly. Background concentration of N2O at Wudaoliang in Qinghai Province of Western China has been measured by collecting gas samples and analysing them with electron capture-gas chromatography. The atmospheric concentration fluctuates in the range of 303-315 ppb with the mean value of 308 ppb. The emission rate of N2O in agriculture region of Northern China has been studied primarily. Fertilization, rain and temperature of soil appear conductible to N2O emission. The interactions between greenhouse effect and N2O emission have been discussed. The catalytic action of N2O in stratospheric ozone depletion processes and the effect of high N2O concentration on ozone depletion in stratosphere have been considered and discussed. | Su Weihan, Song Wenzhi, Zhang Hua, Cao Meiqiu, Lu Hongrong and Zhou QuanResearch Center for Eco-Environmental Sciences,Academia Sinica,Beijing 100083,China | 1990 | Journal of Environmental Sciences1990，2，4： | 1 |
| 7 | Research strategy for constructing a green infrastructure network based on spatial prioritization显示文摘The destruction of the ecological system caused by urban expansion has led to the environmental deterioration,cities have become increasingly vulnerable.In this study,six districts and counties along the Yellow River in Zhengzhou were selected as the study area.First,green infrastructure elements were extracted by morphological spatial pattern analysis.Then,outside the urban areas,we used connectivity analysis to evaluate the importance of core areas,adopted minimum cumulative resistance model to extract potential corridors,and identified the important corridors by using the gravity model.Finally,in the urban areas,we set up an evaluation system to assess the demands for ecosystem services.The results showed that:(1)Seven landscape types of green infrastructure be identified in study area.(2)There are 17 vital cores,136 potential corridors,and 24 vital corridors outside the urban areas.(3)The blocks with high demand for ecosystem services are mostly concentrated in the old blocks with dense populations and poor infrastructure,and there are 5 blocks with comprehensive high-demand.Based on identified importance for green infrastructure land space,and high-demand level for ecosystem services areas in this study,a green infrastructure net plan was proposed based on spatial conservation prioritisation. | Dongmeng Wang Chang Liu Yue Guo Puxia Tang Jie Jiao Weihan Kong Ling Zhang Yiping Liu Dezheng Kong | 2022 | Ecosystem Health and Sustainability2022，8，1： | 0 |
| 8 | Network Traffic Generation Based on Statistical Packet-Level Characteristics显示文摘Network traffic is very important for testing network equipment, network services, and security products. A new method of generating traffic based on statistical packet-level characteristics is proposed. In every time unit, the generator determines the sent packets number, the type and size of every sent packet according to the statistical characteristics of the original traffic. Then every packet, in which the protocol headers of transport layer, network layer and ethernet layer are encapsulated, is sent via the responding network interface card in the time unit. The results in the experiment show that the correlation coefficients between the bandwidth, the packet number, packet size distribution, the fragment number of the generated network traffic and those of the original traffic are all more than 0.96. The generated traffic and original traffic are very highly related and similar. | WANG Dongbin ZHUO Weihan ZHANG Junhui WU Kexin OUYANG Wen | 2015 | China Communications2015，12，S2： | 0 |
| 9 | Rational design of ZnCdS/TpPa-1-COF heterostructure photocatalyst by strengthening the interface connection in solar hydrogen production reactions显示文摘ZnCdS quantum dots(QDs)are highly coveted in photocatalysis research for their exceptional visible-light responses and high light-absorption coefficients.However,their practical application is hindered by their tendency to aggregate,due to having high surface energies.To address this issue,herein,a heterostructure is synthesized by growing ZnCdS QDs with a size of approximately 5 nm onto the surface of a two-dimensional(2D)covalent organic framework(COF),TpPa-1-COF.This approach suppresses the aggregation of the QDs and improves their stability.The ZnCdS/TpPa-1-COF composite exhibited a peak hydrogen evolution rate of 6244.16μmol·g^(-1)·h^(-1),which was 2.89 and 4.18 times greater than that of ZnCdS and TpPa-1-COF,respectively.The zero-dimensional/two-dimensional(0D/2D)heterojunction formed by ZnCdS and TpPa-1-COF generates a strong interfacial force,which is attributed to the intimate contact between the interfaces.Tight connections accelerate charge separation,improve the utilisation of reduced electrons,and reduce the extent of agglomeration of the ZnCdS QDs,thereby resulting in high hydrogen production activity of the composites.Meanwhile,the photocatalytic mechanism is studied using Kelvin probe force microscopy and theoretical calculations.This study offers a novel approach for creating sulfide photocatalysts and is crucial for investigating the potential practical applications of the related photocatalysts. | Di Yang Zhi-Gang Li Xinghao Zhang Zenghuan Ren Weihan Lu Haining Liu Xiaomeng Guo Jijie Zhang Xian-He Bu | 2024 | Nano Research2024，17，3： | 0 |
| 10 | Dual-single-atoms of Pt-Co boost sulfur redox kinetics for ultrafast Li-S batteries显示文摘Applications of lithium-sulfur(Li-S)batteries are still limited by the sluggish conversion kinetics from polysulfide to Li_(2)S.Although various single-atom catalysts are available for improving the conversion kinetics,the sulfur redox kinetics for Li-S batteries is still not ultrafast.Herein,in this work,a catalyst with dual-single-atom Pt-Co embedded in N-doped carbon nanotubes(Pt&Co@NCNT)was proposed by the atomic layer deposition method to suppress the shuttle effect and synergistically improve the interconversion kinetics from polysulfides to Li_(2)S.The X-ray absorption near edge curves indicated the reversible conversion of Li_(2)Sx on the S/Pt&Co@NCNT electrode.Meanwhile,density functional theory demonstrated that the Pt&Co@NCNT promoted the free energy of the phase transition of sulfur species and reduced the oxidative decomposition energy of Li_(2)S.As a result,the batteries assembled with S/Pt&Co@NCNT electrodes exhibited a high capacity retention of 80%at 100 cycles at a current density of 1.3 mA cm^(−2)(S loading:2.5 mg cm^(−2)).More importantly,an excellent rate performance was achieved with a high capacity of 822.1 mAh g^(−1) at a high current density of 12.7 mA cm^(−2).This work opens a new direction to boost the sulfur redox kinetics for ultrafast Li-S batteries. | Hanyan Wu Xuejie Gao Xinyang Chen Weihan Li Junjie Li Lei Zhang Yang Zhao Ming Jiang Runcang Sun Xueliang Sun | 2024 | Carbon Energy2024，6，3： | 0 |
| 11 | Micro/nanomotor: A promising drug delivery system for cancer therapy显示文摘Micro/nanomotors(MNMs)are small-scale devices that can effectively convert various forms of energy into mechanical motion.Their controllable motility and good permeability have attracted the interest of researchers as promising drug carriers in cancer therapy.Compared with traditional formulations,micro/nanomotor drug delivery systems can greatly improve therapeutic efficiency and reduce the side effects of antitumor drugs.This review mainly discusses the advantages of micro/nanomotor drug delivery systems and the applications of MNMs propelled by exogenous,endogenous,and biohybrid power in cancer therapy.Finally,the main challenges of the applications of micro/nanomotor drug delivery systems,as well as future development trends and opportunities are discussed. | Weihan Zhang Zipeng Zhang Shunli Fu Qingping Ma Yongjun Liu Na Zhang | 2023 | ChemPhysMater2023，2，2： | 0 |
| 12 | A quantum mode theory of the micromaser显示文摘Failure of the steady solution of the master equation was analysed. It was found that the state of sustained oscillation exists only when the ratio of photon decay rate γ to injection rate r is satisfied. Based on this understanding, a quantum mode micromaser theory was developed. The threshold ν th and photon distribution for π and 2π mode were calculated. The instability of quantum mode was analyzed as well. | Renhong Liu Weihan Tan Wencang Xu Jufang Zhang | 1998 | Chinese Science Bulletin1998，43，5： | 0 |
| 13 | Effect of the air pollution on atmospheric visibility in Beijing-Tianjin area显示文摘Simultaneous measurements of air pollutant concentrations and atmospheric visibility were made in Beijing and Tianjin areas in 1983-1985. The relationship between air pollution and visibility was studied. It was found that atmospheric particulates have the most high contribution to visibility decreasing. The percentages of contributions of sulfates and soot are 52-58% and 22-29% respectively. According to the results, we suggest that the emission of SO2 and particulates must be controlled in order to improve the atmospheric visibility. | Su Weihan, Zhang Qiupeng, Song Wenzhi, Luo Chao and Yuan Jiwen1 Research Center for Eco-Environmental Sciences,Academia Sinica,P.O.Box 934,beijing 100083,China2 Tianjin Environmental Monitoring Center,Tianjin,China. | 1990 | Journal of Environmental Sciences1990，2，1： | 0 |
| 14 | DDQ as an effective p-type dopant for the hole-transport material X1 and its application in stable solid-state dye-sensitized solar cells显示文摘X1(Me O-TPD) is an inexpensive and easily synthesized π-conjugated molecule that has been used as a hole-transport material(HTM) in solid-state dye-sensitized solar cells(ssDSSCs), achieving relatively high efficiency. In this paper, we characterize the physicochemical properties of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone(DDQ) and show that it is a promising p-dopant in a spin-coating solution with X1 as the HTM. The doped ssDSSCs showed an increase in short-circuit current density from 5.38 mA cm^(-2) to7.39 mA cm^(-2), and their overall power conversion efficiency increased from 2.9% to 4.3%. Also, ssDSSCs with DDQ-doped X1 were more stable than the undoped samples, demonstrating that DDQ can act as a p-type dopant in X1 as an HTM for highly efficient, stable ssDSSCs. | Yanyun Zhang Xichuan Yang Weihan Wang Xiuna Wang Licheng Sun | 2018 | Journal of Energy Chemistry2018，27，2： | 0 |
| 15 | Real atom economy and its application for evaluation the green degree of a process显示文摘Green chemistry has attracted more attention in the past century.Among the 12 principles of green chemistry,only atom economy and E factor can be expressed quantitatively to depict the impact of a chemical process to environment.Atom economy was thought better than the traditional yield for evaluating the atom efficiency of raw materials.But it is not enough to reflect the conversion degree of raw material.In this paper,we proposed the concept of real atom economy(RAE)as a metric.RAE could combine the above two factors together to better express the green degree of a process.We further suggested an equation to correlate E factor with RAE.The concept of RAE is proved to be helpful for estimating an environmentally benign process. | Weihan WANG Jing LÜ Li ZHANG Zhenhua LI | 2011 | Frontiers of Chemical Science and Engineering2011，5，3： | 0 |
| 16 | SA-Model:Multi-Feature Fusion Poetic Sentiment Analysis Based on a Hybrid Word Vector Model显示文摘Sentiment analysis in Chinese classical poetry has become a prominent topic in historical and cultural tracing,ancient literature research,etc.However,the existing research on sentiment analysis is relatively small.It does not effectively solve the problems such as the weak feature extraction ability of poetry text,which leads to the low performance of the model on sentiment analysis for Chinese classical poetry.In this research,we offer the SA-Model,a poetic sentiment analysis model.SA-Model firstly extracts text vector information and fuses it through Bidirectional encoder representation from transformers-Whole word masking-extension(BERT-wwmext)and Enhanced representation through knowledge integration(ERNIE)to enrich text vector information;Secondly,it incorporates numerous encoders to remove text features at multiple levels,thereby increasing text feature information,improving text semantics accuracy,and enhancing the model’s learning and generalization capabilities;finally,multi-feature fusion poetry sentiment analysis model is constructed.The feasibility and accuracy of the model are validated through the ancient poetry sentiment corpus.Compared with other baseline models,the experimental findings indicate that SA-Model may increase the accuracy of text semantics and hence improve the capability of poetry sentiment analysis. | Lingli Zhang Yadong Wu Qikai Chu Pan Li Guijuan Wang Weihan Zhang Yu Qiu Yi Li | 2023 | Computer Modeling in Engineering & Sciences2023，，10： | 0 |
| 17 | Atomic Hydrogen in Strong Converging Laser Field of Circular Polarization显示文摘We first proved that the modified potential of atomic hydrogen in the converging laser field of circular polarizatipn is an exact uniform field in the range of r≤R0(αI^(1/2)ω^(-2)) but Coulomb potential in the range of r>R0.Then the energy levels shallow and split,the wavefunction undergoes distortion. | ZHANG Wenqing TAN Weihan | 1992 | Chinese Physics Letters1992，9，5： | 0 |
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