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110篇 您的检索式:作者名="Chuan J"
    题名 作者 年代 出处 被引量
1YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He 2017Cell Research2017,27,3:156
2Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He 2017Cell Research2017,27,9:96
3Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong 2017Cell Research2017,27,10:61
4Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors显示文摘Benjamin J Moeller Yiting Cao Chuan Y Li Mark W Dewhirst 2004Cancer Cell2004,,5:2
5NeuralNetwork-Based Self-Tuning PI Controller for Precise Motion Control of PMAC Motors显示文摘Wang Gou -Jen Fong Chuan -Tzueng Chang Kang J 2001IEEE Transactions on Industrial Electronics2001,,48:1
6Enhanced rifampicin delivery to alveolar macrophages by solid lipid nanoparticles显示文摘Chuan J Li Y Yang L 2013J Nanopart Res2013,15,5:1
7Improved method for efficient production of biodiesel from palm oil显示文摘RAHMAN TALUKDER M M MIN BEATRICE K L PUAY SONG O PUAH S CHUAN WU J JAE WON C CHOW Y 2008Energy Fuels2008,22,1:1
8Our wormy world genomics, proteomics and transcriptomics in East and southeast Asia 显示文摘Chuan J Feng Z Brindley PJ 2010Adv Parasitol2010,73,:1
9Isolation and characterisation of a novel angiotensin t-converting enzyme (ACE) inhibitory peptide from the algae protein waste显示文摘I Chuan Sheih Tony J Fang Tung-Kung Wu 2009Food Chemistry2009,115,:1
10Development of a method for analyzing energy,environmental and economic efficiency for an integrated steel plant显示文摘Larsson M Chuan W Dahl J 2006Applied Thermal Engineering2006,26,:1
11Effect of processing parame- ters on the properties of transglutaminase-treated soy protein iso-late films 显示文摘Yan J Chuan H T Qi B W 2007Innovative Food Science and Emerging Technolo gies2007,,8:1
12Overview of I)RS un- cooled VOx infrared detector development 显示文摘Chuan Li C J Han G Skidmore 2011Optical Engineering2011,50,6:1
13Estimating nutrient uptake requirements for wheat in China 显示文摘Chuan L M He P Jin J Y 2013Field Crops Research2013,146,:1
14Solubility of heavy metals in a contaminated soil: effects ofredox potential and pH 显示文摘Chuan M C Shu G Y Liu J C 1996Water Air and Soil Pollution1996,90,54:1
15Enhanced rifampicin delivery to alveo- lax macrophages by solid lipid nanoparticles 显示文摘Chuan J Li Y Yang L 2013J Nanopaxt Res2013,15,:1
16Vision-based neuro-fuzzy control of weld penetration in gas tungsten arc welding of thin sheets 显示文摘Wu Chuan Song Gao J Q 2006Int J Mod- elling Identification and Control2006,1,2:1
17A CFD study on the effect of cone dimensions on sampling aero-cyclones performance and hydrodynamics显示文摘CHUAN T GIMBUN J CHOONG T S 2006Powder Technology2006,162,2:1
18Overview of DRS uncooled VOx infrared detector development 显示文摘Chuan Li C J Han George Skidmore 2011Optical Engineering2011,50,06:1
19Needle stick and sharps in juries among health care works in Taiwan显示文摘Guo YL Shiao J Chuan G 1999Epidemiol Infect1999,122,2:1
20A facile direct anti- selective catalytic asymmetric Mannich reaction of alde- hydes with preformed N- Boc and N- Cbz imines 显示文摘CHUAN Y CHEN G GAO J 2011Chem Commun2011,47,:1
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