|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function显示文摘Rho-associated kinases(ROCKs)are serinethreonine protein kinases that act downstream of small Rho GTPases to regulate the dynamics of the actin cytoskeleton.Two ROCK isoforms(ROCK1 and ROCK2)are expressed in the mammalian central nervous system.Although ROCK activity has been implicated in synapse formation,whether the distinct ROCK isoforms have different roles in synapse formation and function in vivo is not clear.Here,we used a genetic approach to address this long-standing question.Both Rock1^+/- and Rock2^+/- mice had impaired glutamatergic transmission,reduced spine density,and fewer excitatory synapses in hippocampal CA1 pyramidal neurons.In addition,both Rockl^+/- and Rock2^+/- mice showed deficits in long-term potentiation at hippocampal CA1 synapses and were impaired in spatial learning and memory based on the water maze and contextual fear conditioning tests.However,the spine morphology of CA1 pyramidal neurons was altered only in Rock2^+/- but not Rock1^+/- mice.In this study we compared the roles of ROCK1 and ROCK2 in synapse formation and function in vivo for the first time.Our results provide a better understanding of the functions of distinct ROCK isoforms in synapse formation and function. | Jinglan Yan Youcan Pan Xiaoyan Zheng Chuanan Zhu Yu Zhang Guoqi Shi Lin Yao Yongjun Chen Nenggui Xu | 2019 | Neuroscience Bulletin2019，35，4： | 7 |
| 2 | Effect of chronic corticosterone-induced depression on circadian rhythms and age-related phenotypes in mice显示文摘Disrupted circadian rhythms are a recognized effect of depression,and our previous article demonstrated an association between depression and premature aging,but the underlying mechanisms are not well understood.In the present study,we used a mouse model of chronic corticosterone (CORT)-treated depression to elucidate a mechanism by which depression may be associated with the circadian clock and mediate age-related phenotypes.Mice received a daily injection of 20 mg/kg CORT for 21 consecutive days,and the depression-like behaviors of mice were identified by the sucrose intake test,tail suspension test and open field test.Our findings indicated that CORT injection may be correlatedwith the circadian clock by impairing circadian rhythms or shifting the phase values of clock genes.We also showed that CORT-treated mice exhibited a significant gradual reduction in body weight gain with increased oxidative stress, including reduced activity of antioxidant-related enzymes,reduced glutathione:glutathione disulfide ratio and cytochrome (Cyt)-C level,and elevated reactive oxygen species content.Moreover, chronic CORT injection affected inflammatory responses,the production of mitochondrial ATP and telomere shortening,which may be associated with the Sirtuin 3 (SIRT3)signaling pathway. Additionally,chronic CORT injection disrupted the circadian rhythms of some indexes of aging phenotypes and altered the phase values of these indexes.Our findings suggest that psychologically stressful conditions such as depression are linked to changes in circadian rhythms and agerelated phenotypes. | Lingyan iVla Qichen Shen Song Yang Xiaoxian Xie Qingfeng Xiao Chuanan Yu Lisha Cao Zhengwei Fu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 4 |
| 3 | Effect of burn injury on apoptosis and expression of apoptosis-related genes/proteins in skeletal muscles of rats显示文摘 | Hongjie Duan Jiake Chai Zhiyong Sheng Yongming Yao Huinan Yin Liming Liang Chuanan Shen Jing Lin | 2009 | Apoptosis2009，，1： | 2 |
| 4 | Loop quantum gravity and black hole entropy quantization显示文摘Using the spin networks and the asymptotic quasinormal mode frequencies of black holes given by loop quantum gravity,the minimum horizon area gap is obtained.Then the quantum area spectrum of black holes is derived and the black hole entropy is a realized quantization.The results show that the black hole entropy given by loop quantum gravity is in full accord with the Bekenstein-Hawking entropy with a suitable Immirzi. | LI ChuanAn JIANG JiJian SU JiuQing | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，8： | 2 |
| 5 | The dynamical model and quantization of the Schwarzschild black hole显示文摘The mass of the Schwarzschild black hole, an observable quantity, is defined as a dynamical variable, while the corresponding conjugate is considered as a general- ized momentum. Then a two-dimensional phase space is composed of the two variables. In the two-dimensional phase space, a harmonic oscillator model of the Schwarzschild black hole is obtained by a canonical transformation. By this model, the mass spectrum of the Schwarzschild black hole is firstly obtained. Further the horizon area operator, quantum area spectrum and entropy are obtained in the Fock representation. Lastly, the wave function of the horizon area is derived also. | LI ChuanAn SU JiuQing JIANG JiJian MENG QingMiao | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，12： | 2 |
| 6 | An Anti-Eavesdrop Transmission Scheduling Scheme Based on Maximizing Secrecy Outage Probability in Ad Hoc Networks显示文摘In this paper,we consider a wireless ad hoc network consisting of multiple source nodes transmitting to their respective destinations,where an eavesdropper attempts to intercept their transmissions.We propose an optimal transmission scheduling scheme to defend against the eavesdropper,where a source node having the highest secrecy rate is scheduled to access the wireless medium for transmitting to its destination in an opportunistic manner.To be specific,the secrecy rate between a pair of the source and destination in the presence of an eavesdropper varies temporally due to the wireless fading effect.The proposed optimal transmission scheduling scheme opportunistically selects a source node with the highest secrecy rate to transmit its data for the sake of maximizing the security of the ad hoc network against eavesdropping attacks.For comparison purposes,we also consider the conventional round-robin scheduling as a benchmark,where multiple source nodes take turns in accessing their shared wireless medium for transmitting to their respective destinations.We derive closed-form secrecy outage probability expressions of both the round-robin scheduling and the proposed optimal scheduling schemes over Rayleigh fading environments.Numerical results show that the proposed transmission scheduling scheme outperforms the conventional round-robin method in terms of its secrecy outage probability.Additionally,upon increasing the number of source-destination pairs,the secrecy outage probability of the round-robin scheme keeps unchanged,whereas the secrecy outage performance of the proposed transmission scheduling significantly improves,showing the security benefits of exploiting transmission scheduling for protecting wireless ad hoc networks against eavesdropping. | WANG Yajun LIAO Tongqing WANG Chuanan | 2016 | China Communications2016，13，1： | 1 |
| 7 | Set partitions with restrictions 显示文摘 | Chu Wenchang Wei Chuanan | 2008 | Discrete Mathematics2008，308，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员