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| 1 | Titanium nitride hollow nanospheres with strong lithium polysulfide chemisorption as sulfur hosts for advanced lithium-sulfur batteries显示文摘因为他们的高理论的特定的能力和精力密度,锂硫电池正在答应电气化学的精力存储设备。一位理想的硫主人应该拥有高电导率并且拥抱物理监禁或强壮的化学吸着戏剧性地压制 polysulfide 溶解。此处,有 ~ 的一条平均直径的一致的听空 nanospheres 160 nm 为高效的锂硫电池作为高度有效的锂 polysulfide 水库被报导了。联合锂 polysulfides 套住的高传导性和化学药品, 70 wt.% 硫内容在的获得的 S/TiN 阴极合成在 0.5C 和 1.0C 交付了优秀长寿骑车表演超过 300 个周期。更重要地, 710.4 mAh | Chuanchuan Li Jingjing Shi Lin Zhu Yingyue Zhao Jun Lu Liqiang Xu | 2018 | Nano Research2018，11，8： | 9 |
| 2 | Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant显示文摘A moderate inflammatory response at the early stages of fracture healing is necessary for callus formation.Over-active and continuous inflammation,however,impairs fracture healing and leads to excessive tissue damage.Adequate fracture healing could be promoted through suppression of local over-active immune cells in the fracture site.In the present study,we achieved an enriched concentration of PD-L1 from exosomes(Exos)of a genetically engineered Human Umbilical Vein Endothelial Cell(HUVECs),and demonstrated that exosomes overexpressing PD-L1 specifically bind to PD-1 on the T cell surface,suppressing the activation of T cells.Furthermore,exosomal PD-L1 induced Mesenchymal Stem Cells(MSCs)towards osteogenic differentiation when pre-cultured with T cells.Moreover,embedding of Exos into an injectable hydrogel allowed Exos delivery to the surrounding microenvironment in a time-released manner.Additionally,exosomal PD-L1,embedded in a hydrogel,markedly promoted callus formation and fracture healing in a murine model at the early over-active inflammation phase.Importantly,our results suggested that activation of T cells in the peripheral lymphatic tissues was inhibited after local administration of PD-L1-enriched Exos to the fracture sites,while T cells in distant immune organs such as the spleen were not affected.In summary,this study provides the first example of using PD-L1-enriched Exos for bone fracture repair,and highlights the potential of Hydrogel@Exos systems for bone fracture therapy through immune inhibitory effects. | Ze Lin Yuan Xiong Weilin Meng Yiqiang Hu Lili Chen Lang Chen Hang Xue Adriana CPanayi Wu Zhou Yun Sun Faqi Cao Guodong Liu Liangcong Hu Chenchen Yan Xudong Xie Chuanchuan Lin Kaiyong Cai Qian Feng Bobin Mi Guohui Liu | 2022 | Bioactive Materials2022，7，7： | 4 |
| 3 | Enzymatically-degradable hydrogel coatings on titanium for bacterial infection inhibition and enhanced soft tissue compatibility via a self-adaptive strategy显示文摘Ideal percutaneous titanium implants request both antibacterial ability and soft tissue compatibility.ZnO structure constructed on titanium has been widely proved to be helpful to combat pathogen contamination,but the biosafety of ZnO is always questioned.How to maintain the remarkable antibacterial ability of ZnO and efficiently reduce the corresponding toxicity is still challenging.Herein,a hybrid hydrogel coating was constructed on the fabricated ZnO structure of titanium,and the coating was proved to be enzymatically-degradable when bacteria exist.Then the antibacterial activity of ZnO was presented.When under the normal condition(no bacteria),the hydrogel coating was stable and tightly adhered to titanium.The toxicity of ZnO was reduced,and the viability of fibroblasts was largely improved.More importantly,the hydrogel coating provided a good buffer zone for cell ingrowth and soft tissue integration.The curbed Zn ion release was also proved to be useful to regulate fibroblast responses such as the expression of CTGF and COL-I.These results were also validated by in vivo studies.Therefore,this study proposed a valid self-adaptive strategy for ZnO improvement.Under different conditions,the sample could present different functions,and both the antibacterial ability and soft tissue compatibility were finely preserved. | Jin Leng Ye He Zhang Yuan Bailong Tao Ke Li Chuanchuan Lin Kun Xu Maowen Chen Liangliang Dai Xuemin Li Tony Jun Huang Kaiyong Cai | 2021 | Bioactive Materials2021，6，12： | 2 |
| 4 | Antibacterial surface design of biomedical titanium materials for orthopedic applications显示文摘Titanium(Ti)and titanium alloys have become widely used as biomedical materials in orthopedics because of their good machinability,corrosion resistance,low elastic modulus and excellent biocompatibility.However,when Ti-based implants are used for bone repair and replacement,they are easy to cause bacteria adhesion and aggregation,which leads to postoperative infection.In addition,Ti and its alloys,as bio-inert materials,cannot induce desirable tissue responses such as osseointegration after implantation,which will eventually lead to implant loosening.Postoperative bacterial infection and lack of osseointegration directly lead to the failure of implantation surgery and are not conductive to the long-term service of titanium-based implants.Recently,researchers have made many attempts to focus on the surface modification of multifunctional Ti-based implants to endow them with both antibacterial activity and simultaneous osteoinductive property.In this review,we primarily highlighted the recent progresses in the surface design of Ti implants with both antimicrobial and osteoinductive properties for orthopedic applications.First,the challenges for treating implant-associated infections were briefly introduced such as the emergence of antibiotic resistance,the formation of biofilms,and the construction of cell-selective surfaces.Some of the essential fundamentals were concisely introduced to address these emerging challenges.Next,we intended to elaborate the potential strategies of multifunctional surface design to endow good osseointegration for antibacterial Ti implants and highlighted the recent advances of the implants.We hope that this review will provide theoretical basis and technical support for the development of new Ti implant with antibacterial and osteogenic functions. | Zhang Yuan Ye He Chuanchuan Lin Peng Liu Kaiyong Cai | 2021 | Journal of Materials Science & Technology2021，，19： | 2 |
| 5 | Comparison of tech- niques for extraction of isoflavones from the root of Radix Puerariae: ultrasonic and pressurized solvent extractions 显示文摘 | Leea Meihwaa Lin Chuanchuan | 2007 | Food Chemistry2007，105，1： | 1 |
| 6 | Comparison of techniques for extraction of isoflavones from the root of Radix Pereira: Ultrasonic and pressurized solvent extractions显示文摘 | LEE Meihua LIN Chuanchuan | 2007 | Food Chem2007，105，1： | 1 |
| 7 | Comprasion of techniques of isoflavones from the root of Radix Puerariae:Ultrasonic and pressurized solvent extractions显示文摘 | Lee Meihwa Lin Chuanchuan | 2007 | Food Chemistry2007，105，： | 1 |
| 8 | Underdetermined mixing matrix estimation by comprehensive application of cluster validity indexes显示文摘To solve the problem of mixing matrix estimation for underdetermined blind source separation(UBSS)when the number of sources is unknown,this paper proposed a novel mixing matrix estimation method based on average information entropy and cluster validity index(CVI).Firstly,the initial cluster center is selected by using fuzzy C-means(FCM)algorithm and the corresponding membership matrix is obtained,and then the number of clusters is obtained by using the joint decision of CVI and average information entropy index of membership matrix,then multiple cluster number estimation results can be obtained by using multiple CVIs.Then,according to the results of the number of multiple clusters estimation,the number of radiation sources is determined according to the principle of the subordination of the minority to the majority.The cluster center vectors obtained from the clustering operation of the estimated number of radiation sources are fused,that is the mixing matrix is estimated based on the degree of similarity of the cluster center vectors.When the source signal is not sufficiently sparse,the time-frequency single source detection processing can be combined with the proposed method to estimate the mixing matrix.The effectiveness of the proposed method is validated by experiments. | Wang Chuanchuan Jiang Lin Zeng Yonghu Wang Liandong | 2020 | The Journal of China Universities of Posts and Telecommunications2020，27，6： | 0 |
| 9 | Moderated crevice corrosion susceptibility of Ti6Al4V implant material due to albumin-corrosion interaction显示文摘Localized corrosion of metallic biomaterials is a concerning problem for implant applications.In the present work,the interaction between localized corrosion of Ti6Al4V implant material and adsorption of bovine serum albumin(BSA)was investigated by electrochemical tests,surface morphological and compositional analysis.The artificial crevice was set up on the Ti6Al4V surface to simulate the crevice corrosion of metallic implants.The results show that the BSA adsorption is regulated by the heterogeneous metallic ion release resulted from the crevice corrosion.The negatively charged BSA prefers to aggregate at the interior of artificial crevice due to electrostatic interaction with the concentrated metallic cations in the crevice.In return,the non-uniform BSA adsorption can decrease the crevice corrosion susceptibility of the Ti6Al4V implant material,even though the presence of BSA accelerates the dissolution of passive films.For the Ti6Al4V alloys with artificial crevice,stable localized corrosion occurs after 96 h of immersion in the PBS free of BSA while no stable localized corrosion can be determined in the presence of 4%BSA.It is deduced that the presence of BSA can reduce the surface potential discrepancy between the crevice interior and the crevice exterior.The disclosed mechanism of albumin-corrosion interaction is vital to the localized corrosion control of metallic implants in clinical use. | Jing Wu Meng Li Chuanchuan Lin Pengfei Gao Rui Zhang Xuan Li Jixi Zhang Kaiyong Cai | 2022 | Journal of Materials Science & Technology2022，，14： | 0 |
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