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| 1 | Study on the Relationship between P-glycoprotein and CD44 Expression in Gastric Carcinoma显示文摘客观:在 P-glycoprotein (P-gp ) 和象他们在胃的癌的临床的意义一样的粘附分子 CD44 之间的关系的调查。方法:Toexamine 在有由流动 cytometryand 的胃的癌的 98 种情况中的 P-gp 和 CD44 的表示水平与 clinicopathological 因素评估他们的关系。结果:在 98 胃的癌之中, 40 个盒子(40.8%) 是 P-gp negative (积极房间 <
25%) ;P-gp 积极房间的 14 盒子(14.2%)were25%-40% 表示;17 个盒子(17.3%) 是 P-gp 积极房间的 41%-60% 表示;27 个盒子(27.5%) 是高表示(积极房间 >
60%) 在有胃的癌的所有病人的 P-gp。当肿瘤尺寸是超过 6 厘米时, CD44 积极的 P-gp 显示出有效差量(P <
0.05 ) 在有 P-gp 的 35 种情况中积极,与它相比在 24 情况 withP-gp negative。当肿瘤在低中等的区分的胃的癌时, CD44 的表示显示出有效差量(P <
0.05 ) 在有 P-gp 的 44 种情况中积极,作为与它相比在有 P-gp 的 30 种情况中否定。当病人在临床的Ⅲ - Ⅳ舞台时, CD44 的表示显示出有效差量(P <
0.05 ) 在有 P-gp 的 42 种情况中积极,作为与它相比在有 P-gp 的 30 种情况中否定。什么时候有淋巴节点转移的病人, theirCD44 表示显示出有效差量(P <
0.05 ) 在有 P-gp 的 46 种情况中积极,与它相比在有 P-gp 的 32 种情况中否定。肿瘤 P-gp 什么时候表示了积极,他们的 CD44expression 将是增加。结论:当 CD44 和 P-gp 两个都有积极高表示时,它将显著地与胃的癌前进和转移被联系因此两个是在胃的癌的积极表情,它可能建议差、相反的预后结果。 | YU Chuanding XU Shenhua LING Yutian ZHU Chihong ZHOU Xinming LIU Xianglin | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 3 |
| 2 | Study on the relationship between P-glycoprotein(P-gp) and C-erbB-2 expression in gastric carcinoma显示文摘Objective: To understand the relationship between C-erbB-2 and multidrug resistance (MDR) as well as its clini- cal significance. Methods: P-gp level was detected by flow cytometry and simultaneously to examine the C-erbB-2 expression level by immunohistochemistry assay in the operating samples. Their relationship was analyzed from 59 cases with gastric carcinoma. Results: The P-gp positive expression was 38/59 (64.4%) cases with gastric carcinoma. The C-erbB-2 positive expression was 21/59 (35.6%) cases with gastric carcinoma. From the analysis of the P-gp and C-erbB-2 relationship, which was involving, range in the gastric carcinoma, that involving two or three sites were more than the site one, in the cases with C-erbB-2 negative. Compared this two groups, there was a significant difference (P = 0.026). When the C-erbB-2 was positive, the P-gp expression had a significant difference (P = 0.04) in comparing the III–IV stage (lymph node metastasis) with I–II stage (without lymph node metastasis). The tumor’s size, differentiation degree, ages and sex were not related to the C-erbB- 2 and P-gp expression. Conclusion: High level of P-gp expression was related to the C-erbB-2 positive expression in clinical III–IV stage patient with gastric carcinoma (lymph node metastasis). It suggested that the double positive patient might be a poor prognosis. However, when the C-erbB-2 was negative expression, the clinical staging (with lymph node metastasis) was not related to the P-gp expression in gastric carcinoma patients. | Chuanding Yu Shenhua Xu Xinghao Ni Yutian Ling Gu Zhang Chihong Zhu Xianglin Liu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 1 |
| 3 | Gene Expression Profile Differences in Gastric Cancer and Normal Gastric Mucosa by Oligonucleotide Microarrays显示文摘OBJECTIVE To study the difference of gene expression in gastric cancer (T) and normal tissue of gastric mucosa (C), and to screen for associated novel genes in gastric cancers by oligonucleotide microarrays. METHODS U133A (Affymetrix, Santa Clara, CA) gene chip was used to detect the gene expression profile difference in T and C. Bioinformatics was used to analyze the detected results. RESULTS When gastric cancers were compared with normal gastric mucosa, a total of 270 genes were found with a difference of more than 9 times in expression levels. Of the 270 genes, 157 were up-regulated (Signal Log Ratio [SLR] ≥3), and 113 were down-regulated (SLR ≤-3). Using a classification of function, the highest number of gene expression differences related to enzymes and their regulatory genes (67, 24.8%), followed by signal-transduction genes (43,15.9%). The third were nucleic acid binding genes (17, 6.3%), fourth were transporter genes (15, 5.5%) and fifth were protein binding genes (12, 4.4%). In addition there were 50 genes of unknown function, accounting for 18.5%. The five above mentioned groups made up 56.9% of the total gene number. CONCLUSION The 5 gene groups (enzymes and their regulatory proteins, signal transduction proteins, nucleic acid binding proteins, transporter and protein binding) were abnormally expressed and are important genes for further study in gastric cancers. | Chuanding Yu Shenhua Xu HangZhou Mou Zhiming Jiang Chihong Zhu Xianglin Liu | 2006 | Chinese Journal of Clinical Oncology2006，3，1： | 1 |
| 4 | Screening of the carcinogenesis associated gene in gastric mucosa by gene chip显示文摘Objective: To study the difference of gene expression and screen the carcinogenesis associated gene in gastric mucosa by oligonucleotide microarray. Methods: Using the U133A gene chip to detect the gene expression profile difference between pericancerous mucosa (mucosa inside nearly 2 cm by cancer) and normal section of gastric mucosa. Bioinformatics was used to analyze the detected result on their localization and function in chromosome. Results: (1) A total of 150 genes with a difference of more than 3 times in expression levels by comparing the pericancerous mucosa with normal gastric mucosa, of 130 genes were up-regulated (SLR>1.5), and 20 were down- regulated (SLR< –1.5). From the gene expression difference was to do the function classification, among those 22 enzyme and 6 enzyme regular genes were most one (18.7%). The next were 17 nucleic acid binding associated genes (11.3%). The third were 15 signal transduction associated genes (10%). Fourth, were 13 protein binding associated genes (8.7%). Besides the 40 genes were unknown their function, above mentioned 4 groups were 48.7% of the gene total number; (2) The pericancerous mucosa (P) and gastric cancer (T) were simultaneously compared with normal gastric mucosa, which had 71 genes with the same expression difference, of 61 genes were up-regulated (pericancerous SLR>1.5), and other 10 genes were down-regulated (pericancerous SLR< –1.5). From their localization on the chromosome, there was simultaneously 71 genes appearance both in the pericancerous mucosa and in gastric cancer. The most one was 11 abnormal genes on the No. 19 chromosome. The next was No. 1, 2, 16 and 17 chromosomes which had 6 genes, respectively. It was not finding an abnormal gene on the No. 5, 14, 22 and Y chromosome. Conclusion: It suggested those genes may be related to the promotion in early gastric carcinogenesis and their progress. Four main groups (enzyme and enzyme regular, nucleic acid binding, signal transduction, protein binding) that associated gene’s abnormality be played an importance role in studying the carcinogenesis of gastric cancer. The No. 19 and No. 1, 2, 16, 17 chromosomes are important sites of the oncogene transformation. | Shenhua Xu Chuanding Yu Hangzhou Mou Zhiming Jiang Chihong Zhu Xianglin Liu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，1： | 1 |
| 5 | A novel carbon cycle process assisted by Ni/La_(2)O_(3) catalyst for enhanced thermochemical CO_(2) splitting显示文摘Thermochemical two-step CO_(2) splitting is a potential approach that fixes the sustainable resource into transportable liquid fuels.However,the harsh CO_(2) splitting conditions,the limited oxygen release kinetics and capacity of metal oxides block further promoted the CO yield and solar-to-fuel energy efficiency.Here,we propose a different carbon cycle assisted by Ni/La_(2)O_(3) via coupling methane decomposition with thermochemical CO_(2) splitting,replacing conventional metal oxides cycle.Superior performance was demonstrated with methane conversion reached around 94%with almost pure H_(2) generation.Encouragingly,CO_(2) conversion of 98%and CO yield of 6.9 mmol g^(-1) derived from CO_(2) were achieved,with peak CO evolution rate(402 mL min^(-1) g^(-1))of orders of magnitude higher than that in metal oxide process and outstanding thermodynamic solar-to-fuel energy efficiency(55.5%vs.18.5%).This was relevant to the synergistic activation of La_(2)O_(3) and Ni for CO_(2) in carbon cycle,thus improving CO_(2) splitting reaction with carbon species. | Yu Kang Yujia Han Cong Wei Kuo Liu Ming Tian Chuande Huang Chaojie Wang Jian Lin Baolin Hou Xiaoli Pan Yang Su Lin Li Riguang Zhang Yong Hao Xiaodong Wang | 2021 | Journal of Energy Chemistry2021，30，10： | 0 |
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