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| 1 | Nearfield acoustic holography based on the equivalent source method显示文摘On the basis of the nearfield acoustic holography (NAH) based on the distributed source boundary point method (DSBPM), a novel NAH based on the equivalent source method (ESM) is proposed. The theoretical model of the proposed method is established at first. And then, the error sensitivity and the reconstruction problems of a multi-source acoustic field and a semi-free acoustic field are analyzed, and the corresponding treatment methods are proposed. Subsequently, an experiment on a speaker is investigated to validate the feasibility and correctness of the method. In the method, no discretization is needed on the boundary of the vibrating body. The acoustic field is predicted directly by a set of weighted equivalent sources located inside the vibrating body. Therefore, the variable interpolation, the treatments of singular integrals and non-uniqueness of solutions in the characteristic wave number are avoided. Additionally, the method is adapted to arbitrary-shaped source, so it is really a meshless method. Furthermore, there are such merits as the simple principle, the high calculation efficiency and precision. It is valuabe for the NAH to be applied in the practical engineering field. | BI Chuanxing CHEN Xinzhao CHEN Jian ZHOU Rong | 2005 | Science China(Technological Sciences)2005，48，3： | 11 |
| 2 | Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma显示文摘Glioblastoma(GBM)is an incurable and highly heterogeneous brain tumor,originating from human neural stem/progenitor cells(hNSCs/hNPCs)years ahead of diagnosis.Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels,the de novo gliomagenic path from hNSCs is largely unknown due to technical difficulties in early-stage sampling and preclinical modeling.Here,we established two highly penetrant hNSC-derived malignant glioma models,which resemble the histopathology and transcriptional heterogeneity of human GBM.Integrating time-series analyses of whole-exome sequencing,bulk and single-cell RNA-seq,we reconstructed gliomagenic trajectories,and identified a persistent NSC-like population at all stages of tumorigenesis.Through trajectory analyses and lineage tracing,we showed that tumor progression is primarily driven by multi-step transcriptional reprogramming and fate-switches in the NSC-like cells,which sequentially generate malignant heterogeneity and induce tumor phenotype transitions.We further uncovered stage-specific oncogenic cascades,and among the candidate genes we functionally validated C1QL1 as a new glioma-promoting factor.Importantly,the neurogenic-to-gliogenic switch in NSC-like cells marks an early stage characterized by a burst of oncogenic alterations,during which transient AP-1 inhibition is sufficient to inhibit gliomagenesis.Together,our results reveal previously undercharacterized molecular dynamics and fate choices driving de novo gliomagenesis from hNSCs,and provide a blueprint for potential early-stage treatment/diagnosis for GBM. | Xiaofei Wang Ran Zhou Yanzhen Xiong Lingling Zhou Xiang Yan Manli Wang Fan Li Chuanxing Xie Yiming Zhang Zongyao Huang Chaoqiong Ding Kaidou Shi Weida Li Yu Liu Zhongwei Cao Zhen-Ning Zhang Shengtao Zhou Chong Chen Yan Zhang Lu Chen Yuan Wang | 2021 | Cell Research2021，31，6： | 8 |
| 3 | Reconstruction and prediction of multi-source acoustic field with the distributed source boundary point method based nearfield acoustic holography显示文摘In a multi-source acoustic field, the actual measured pressure is a scalar sum of pressures from all the sources. The pressure belonging to every source cannot be separated out with the existing techniques. Consequently, routine formulas cannot be used to reconstruct the acoustic source and predict the acoustic field directly. In this paper, a novel theoretical model of reconstruction and prediction of multi-source acoustic field in the distributed source boundary point method (DSBPM) based nearfield acoustic holography (NAH) is established. Three different methods, namely combination method with single surface measurement, combination method with multi-surface measurement and elimination method with multi-surface measurement, are proposed to realize the holographic reconstruction of sources. With these methods, the problem of reconstruction and prediction of acoustic field existing multiple coherent sources synchronously is solved effectively. Using the particular solutions constructed by the DSBPM to establish the vibro-acoustic transfer matrix, the calculation time, calculation precision and calculation stability are improved. These methods are valuable in localizing acoustic source and predicting acoustic field in engineering field. | BI Chuanxing CHEN Jian CHEN Xinzhao | 2004 | Science China(Technological Sciences)2004，47，2： | 7 |
| 4 | RECONSTRUCTION STABILITY OF NEARFIELD ACOUSTIC HOLOGRAPHY显示文摘The distributed source boundary point method (DSBPM) is used as the spatial transform algorithm for realizing nearfield acoustic holography (NAH), the sensitivity of the reconstructed solution to the measurement errors is analyzed, and the regularization method is proposed to stabilize the reconstruction process, control the influence of the measurement errors and get a better approximate solution. An oscillating sphere is investigated as a numerical example, the influence of the measurement errors on the reconstruction solution is demonstrated, and the feasibility and validity of the regularization method are validated. | Bi Chuanxing Chen Xinzhao Zhou Rong Chen Jian | 2005 | Chinese Journal of Mechanical Engineering2005，18，4： | 7 |
| 5 | Microbiota in health and diseases显示文摘The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery.Depending on the localized regions,microbiota can be classified into gut,oral,respiratory,and skin microbiota.The microbial communities are in symbiosis with the host,contributing to homeostasis and regulating immune function.However,microbiota dysbiosis can lead to dysregulation of bodily functions and diseases including cardiovascular diseases(CVDs),cancers,respiratory diseases. | Kaijian Hou Zhuo-Xun Wu Xuan-Yu Chen Jing-Quan Wang Dongya Zhang Chuanxing Xiao Dan Zhu Jagadish B.Koya Liuya Wei Jilin Li Zhe-Sheng Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 6 |
| 6 | Effects of pantothenic acid on growth performance,slaughter performance, lipid metabolism, and antioxidant function of Wulong geese aged one to four weeks显示文摘This experiment was conducted to study the effects of pantothenic acid on the growth performance,slaughter performance, lipid metabolism, and antioxidant function of one-to four-week-old Wulong geese and determine the appropriate supplemental level of pantothenic acid. A total of 360 one-day-old Wulong geese were randomly divided into 6 groups with 6 replicates per group and 10 geese(5 males and 5 females) per replicate. The geese in group Ⅰ(control group) were fed a basal diet, and the geese in groups Ⅱ to Ⅵ(experimental groups) were given the basal diet supplemented with 8, 15, 30, 60, and120 mg/kg pantothenic acid, respectively. The experiment lasted for 4 weeks. Based on the results of unrelated comparative analysis, the body weight was the highest when the dietary pantothenic acid level was 27.57 mg/kg. When the dietary pantothenic acid level was 26.17 mg/kg, the average daily gain peaked. When the dietary pantothenic acid level was 15.50 mg/kg, the feed:gain ratio was the lowest.The percentage of abdominal fat in groups Ⅲ and Ⅳ was significantly lower than that in group Ⅰ(P < 0.05). The content of total cholesterol in serum in groups III to Ⅴ was significantly lower than that in group Ⅰ(P < 0.05). The triglyceride content in groups Ⅲ and Ⅳ was significantly lower than that in group Ⅰ(P < 0.01). The high-density lipoprotein—cholesterol content in group Ⅳ was significantly higher than that in group Ⅰ(P < 0.05). The total antioxidant capacity of serum and liver in group Ⅳ was significantly higher than that in group Ⅰ(P < 0.05). The malondialdehyde content in the liver in groups Ⅲ and Ⅳ was significantly lower than that in group Ⅰ(P < 0.05), Glutathione peroxidase activity in the serum in group Ⅳ was significantly higher than that in group Ⅰ(P < 0.05). Glutathione peroxidase activity in the liver in groups Ⅳ and Ⅴ was significantly higher than that in group Ⅰ(P < 0.01). The addition of pantothenic acid in the diet of one-to four-week-old Wulong geese significantly affected the growth performance,slaughter performance, lipid metabolism, and antioxidant function of the geese. In terms of economic benefits, the optimal supplemental level of pantothenic acid in one-to four-week-old geese was15.50 mg/kg. | Baowei Wang Xiao Zhang Bin Yue Wenhua Ge Mingai Zhang Chuanxing Ma Min Kong | 2016 | Animal Nutrition2016，，4： | 5 |
| 7 | Recovery of the free field in noisy environment by using the spherical wave superposition method显示文摘To remove the scattering effect of the disturbing sound on the target source when implementing nearfield acoustic holography in a non-free field,a free field recovery technique based on the spherical wave superposition method is proposed.In the method,the sound field separation technique based on the spherical wave superposition method is first used to separate the incoming and outgoing fields,and a further step for separating the radiated and scattered fields is performed by utilizing the surface admittance of the target source as the boundary conc1ition.The technique makes it possible to correctly identify noise sources in a non-free sound feld.The basic principle of the technique is described firstly,a method for choosing the optimal number of spherical wave expansion terms is given,and two numerical simulations are used to demonstrate the validity of this technique.It is shown that,for the lower frequency,the scattering effect can be neglected,and the radiated field of the target source can be obtained by the sound field separation technique,however,as the increasing of the frequcncy,the scattering effcct cannot be neglected,and the frec field recovery technique has to be used to obtain the radiated field of the target source. | BI Chuanxing HU Dingyu XU Liang ZHANG Yongbin | 2014 | Chinese Journal of Acoustics2014，33，1： | 5 |
| 8 | Landweber iterative regularization for nearfield acoustic holography显示文摘On the basis of the distributed source boundary point method (DSBPM)-based nearfield acoustic holography (NAH), Landweber iterative regularization method is proposed to stabilize the NAH reconstruction process, control the influence of measurement errors on the reconstructed results and ensure the validity of the reconstructed results. And a new method, the auxiliary surface method, is pro- posed to determine the optimal iterative number for optimizing the regularization effect. Here, the optimal number is determined by minimizing the relative error between the calculated pressure on the auxiliary surface corresponding to each iterative number and the measured pressure. An experiment on a speaker is investigated to demonstrate the high sensitivity of the reconstructed results to measurement errors and to validate the chosen method of the optimal iterative number and the Landweber iterative regularization method for controlling the influence of measurement errors on the reconstructed results. | BI Chuanxing CHEN Xinzhao ZHOU Rong CHEN Jian | 2006 | Chinese Science Bulletin2006，51，11： | 3 |
| 9 | Patch nearfield acoustic holography based on the equivalent source method显示文摘On the basis of nearfield acoustic holography (NAH) based on the equivalent source method (ESM), patch NAH based on the ESM is proposed. The method overcomes the shortcoming in the conventional NAH that the hologram surface should be larger than the source surface. It need not to discretize the whole source and its measurement need not to cover the whole source. The measurement may be performed over the region of interest, and the reconstruction can be done in the region directly. The method is flexible in applications, stable in computation, and very easy to implement. It has good potential applications in engineering. The nu- merical simulations show the invalidity of the conventional NAH based on the ESM and prove the validities of the proposed method for reconstructing a partial source and the regularization for reducing the error effect of the pressure measured on the hologram surface. | BI ChuanXing CHEN XinZhao XU Liang CHEN Jian | 2008 | Science China(Technological Sciences)2008，51，1： | 3 |
| 10 | A feature ensemble technology to identify molecular mechanisms for distinction between multiple subtypes of lymphoma显示文摘由于复杂性和生物显型的基因异质,柔韧的计算途径是合乎需要的与多重分类器,数据结构的不安,和生物解释完成高归纳性能。这研究的目的是扩大我们的发达整体决定途径区分多重异构的显型并且阐明缠绕子类型的内在的分子的桥。我们的工作识别支撑的重要分子的机制(疾病相关的基因和功能) 为在多重显型之间的区别的复杂分子的机制。特征基因和我们的方法识别的层次基因核心在多重显型的分类完成了高精确性。结果证明建议分析策略在生物子类型的分类并且在在临床的显型之间的分子的连接的解释可行、强大。有基因本体论的生物解释为一些淋巴瘤子类型揭示了一致基因小径。 | Yueying Yang Haiyun Wang Xia Li Xue Xiao Su Fei Chuanxing Li Hongzhi Wang Shaoqi Rao Yadong Wang | 2008 | Progress in Natural Science:Materials International2008，18，12： | 2 |
| 11 | Patch nearfield acoustic holography combined with sound field separation technique applied to a non-free field显示文摘The conventional nearfield acoustic holography(NAH) is usually based on the assumption of free-field conditions, and it also requires that the measurement aperture should be larger than the actual source. This paper is to focus on the problem that neither of the above-mentioned requirements can be met, and to examine the feasibility of reconstructing the sound field radiated by partial source, based on double-layer pressure measurements made in a non-free field by using patch NAH combined with sound field separation technique. And also, the sensitivity of the reconstructed result to the measurement error is analyzed in detail. Two experiments involving two speakers in an exterior space and one speaker inside a car cabin are presented. The experimental results demonstrate that the patch NAH based on single-layer pressure measurement cannot obtain a satisfied result due to the influences of disturbing sources and reflections, while the patch NAH based on double-layer pressure measurements can successfully remove these influences and reconstruct the patch sound field effectively. | BI ChuanXing ING WenQian ZHANG YongBin XU Liang | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，2： | 2 |
| 12 | Separation theory of the incident and scattered sound fields in spherical coordinate显示文摘By the spherical wave spectrum transform,the sound pressures on the two spherical surfaces surrounding the scattering objects with arbitrarily-shaped sur-faces are decomposed into spherical wave components that propagate in a known manner,the relationships between the spherical wave components of the same order on the two spherical surfaces are established by the wave field extrapolation theorem,and the formula of the separation theory in the spherical coordinate is established in the wave-number domain. After separating the scattered pressure,the total scattered field can be obtained by holographic reconstruction and predic-tion. In order to overcome the instability of acoustic inverse problem,a new wave-number domain filter technique is proposed. It is proved that,as long as the two holographic spherical surfaces are taken to be close enough,the singularity of the separation formula can be avoided. The results of numerical simulation dem-onstrate the feasibility and validity of the separation theory. | LI WeiBing LIAN MeiZhuan BI ChuanXing CHEN Jian CHEN XinZhao | 2007 | Science China(Technological Sciences)2007，50，3： | 2 |
| 13 | Recovery of injured corticospinal tracts after late recanalisation of basilar artery occlusion显示文摘In this study,we performed emergency stent angioplasty in a patient with basilar artery occlusion(BAO)at 21 hours after onset.Serial diffusion tensor tract imaging revealed that the ischaemic corticospinal tracts(CSTs),which passed through pontine infarct,rapidly recovered to normal level even after delayed reperfusion.This case provided in vivo evidences that ischaemic white matter was still salvageable even after prolonged ischaemia.It also provided a new method(diffusion tensor tract imaging)and a novel therapeutic target(white matter)in the evaluation and treatment of acute BAO. | Xiaodi Li Yuzhou Wang Zhanhang Wang Peiming Wang Chuanxing Shao Jinlong Ye | 2018 | Stroke & Vascular Neurology2018，3，4： | 2 |
| 14 | Resolution enhancement of nearfield acoustic holography by interpolation using band-limited signal restoration method显示文摘A new method based on interpolation using band-limited signal restoration method was proposed for enhancing the resolution of the nearfield acoustic holography. According to the band-limited property of the pressure on the hologram surface, a band-limited signal restoration method named Papoulis-Gerchberg algorithm was used to realize the interpolation of acoustic pressure. Therefore acoustic pressure data on the hologram surface were increased, the sampling interval was reduced, the information on evanescent waves which was lost because of the large sampling interval was partially recovered, and the resolution of nearfield acoustic holography image was improved. The experimental result shows that the method can enhance the resolution of the nearfield acoustic holography image efficiently. | XU Liang BI ChuanXing CHEN XinZhao CHEN Jian | 2008 | Chinese Science Bulletin2008，53，20： | 2 |
| 15 | Dispersion polym-erization of acrylamide with 2-acrylamide-2-methyl-1-propanesulfonate in aqueous solution of sodium sulfate显示文摘 | Xu Jun Wu Yumin Wang Chuanxing | 2009 | Journal ofPolymer Research2009，16，5： | 1 |
| 16 | Preparation and properties of amphoteric polyacrylamide by seeded dispersion polymerization in ammonium sulfate solution显示文摘 | Wang Chuanxing Wang Xiaoxiang Miao Chunbao | 2011 | Polymer Engineering and Science2011，51，9： | 1 |
| 17 | Aqueous dispersion polymerization of amphoteric polyacrylamide显示文摘 | Wu Yumin Wang Chuanxing Xu Jun | 2010 | Journal of Applied Polymer Science2010，115，2： | 1 |
| 18 | Reconstruction of the free-field radiation from a vibrating structure based on measurements in a noisy environment显示文摘 | Bi Chuanxing Hu Dingyu Zhang Yongbin | 2013 | Journal of the Acoustical SocietyofAmerica2013，134，4： | 1 |
| 19 | Intercalation of CuCl2 into expanded graphite显示文摘 | ChuanX Chen D Zhou X | 1997 | Carbon1997，35，2： | 1 |
| 20 | Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production显示文摘 | CHUANXING WU YONGXIANG XIA PING WANG | 2011 | International Immunopharmacology2011，，11： | 1 |
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