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| 1 | Functions and mechanisms of the CBL-CIPK signaling system in plant response to abiotic stress显示文摘To cope with environmental stimuli, plants have evolved precise regulatory mechanisms to perceive, transduce and respond to abiotic stresses that can negatively affect growth and development. The CBL-CIPK signaling system is a newly emerging plant-specific and Ca2+-dependent network mediating abiotic stress tolerance. CBLs may sense a Ca2+ signature triggered by abiotic stresses, and have specific interactions with novel CIPK-type kinases after binding Ca2+. The CBL/CIPK complexes may post-translationally phosphory-late downstream target proteins to regulate abiotic stress tolerance in a cell or tissue-specific manner. In some cases transcription factors are induced to activate stress-responsive genes that control adaptation reactions. The CBL-CIPK signaling system exhibits specificity, diversity and complexity. Meanwhile, cross talk also exists in the CBL-CIPK signaling. To date, significant progress has been made in the role of the CBL-CIPK signaling system in responding to salt, low K+ and to high pH, which will provide a fast and efficient method of molecular design breeding combined with the CBL/CIPK engineering of crop plants, for enhanced tolerance to abiotic stresses. However, more CBL/CIPK components remain to be identified, particularly from specific plants that grow in conditions with abiotic stress, and the specificity of their abiotic stress signaling will need to be dissected. | Ruifen Li Junwen Zhang Jianhua Wei Hongzhi Wang Yanzhen Wang Rongcai Ma | 2009 | Progress in Natural Science:Materials International2009，19，6： | 15 |
| 2 | CIC-3 chloride channels are essential for cell proliferation and cell cycle progression in nasopharyngeal carcinoma cells显示文摘ClC-3,为激活卷的氯化物编码候选人蛋白质的基因(Cl ?) 隧道,可以涉及肿瘤开发。此处,我们用 antisense 报导研究调查 ClC-3 在鼻咽的癌 CNE-2Z 房间由影响房间增长的机制的击倒的策略。与 immunoblots 和 MTT 试金,我们证明 ClC-3 的表示是房间周期依赖者并且以一种类似的集中依赖者方式,为 ClC-3 特定的 antisense oligonucleotide 禁止了 ClC-3 蛋白质表示和房间增长。ClC-3 的表示水平与房间增长相关。而且在暴露于 ClC-3 antisense oligonucleotide 的房间,克隆的效率被禁止,并且房间在 S 阶段被逮捕。ClC-3 antisense oligonucleotide 禁止了激活卷的 Cl 吗?当前(ICl,体积) 并且以一种集中依赖者方式的规章的体积减少(RVD ) 。另外, ICl,体积或 RVD 断然在对待的房间与房间增长被相关。在结论, ClC-3 通过包含 ICl,体积和 RVD 的调整的机制涉及房间增长和房间周期前进。CIC-3 可以在人的癌症代表一个治疗学的目标。 | Bin Xu Jianwen Mao Liwei Wang Linyan Zhu Hongzhi Li Weizhang Wang Xiaobao Jin Jiayong Zhu Lixin Chen | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 12 |
| 3 | Framework for Artificial Intelligence Analysis in Large-scale Power Grids Based on Digital Simulation显示文摘The planning,design,operation,control and scientific research of power systems all require a variety of simulation analysis.Thus power grid simulation analysis is a fundamental supporting technology of large-scale power grids.In power grid simulation analysis,in addition to simulation calculations,there are many links for analysis and decision-making,relying on specialists.The introduction of advanced artificial intelligence technology provides a new method to improve the efficiency and accuracy of power grid simulation analysis.Nevertheless,the research of the related artificial intelligence technologies face a great deal of new challenges due to the complexity of the largescale power grid simulation data,including massive volumes,high dimensionality,strong coupling and complex correlations.Also a great deal of knowledge and experience need to be integrated in the process of analysis.In order to deal with these challenges,based on the existing works,this paper focuses on the core scientific problem of artificial intelligence analysis and decision making related to the massive simulation results of large-scale power grids,and proposes an artificial intelligence analysis method framework for large-scale power grids based on digital simulation,which includes the power grid simulation analysis knowledge model with application method,the power grid simulation knowledge mining method and the artificial intelligence models with transfer learning ability of diversified grids as well as analyzing and calculation adjusting for largescale power grid simulation results,etc.This work is expected to open up a new technical approach for large-scale power grid simulation analysis and provide strong technical support for the safe and stable operation of large-scale power grids. | Yong Tang Yanhao Huang Hongzhi Wang Can Wang Qiang Guo Wei Yao | 2018 | CSEE Journal of Power and Energy Systems2018，4，4： | 12 |
| 4 | NbMoTiVSi_(x) refractory high entropy alloys strengthened by forming BCC phase and silicide eutectic structure显示文摘In order to improve mechanical properties of refractory high entropy alloys,silicide was introduced and NbMoTiVSi_(x)(x=0,0.1,0.2,0.3,and 0.4,molar ratio) refractory high entropy alloys are prepared by vacuum arc melting.Phase composition,micro structure evolution and mechanical properties were systematically studied.Results show that the silicide phase is formed in the alloys with addition of silicon,and the volume fraction of silicide increases from 0 to 8.3 % with increasing of silicon.Microstructure observation shows that the morphology of dendrite changes from columnar to near equiaxed,eutectic structure is formed at grain boundaries and composed of secondary BCC phase and silicide phase.The average length of the primary and second dendrites decreases with the increasing of silicon.Whereas,the ratio of eutectic structure increases from 0 to 19.8 % with the increment of silicon.The refinement of microstructure is caused by heterogeneous nucleation from the silicide.Compressive tests show that the yield and ultimate strength of the alloys increases from 1141.5 MPa to 2093.1 MPa and from 1700.1 MPa to 2374.7 MPa with increasing silicon content.The fracture strain decreases from 24.7 %-11.0 %.Fracture mechanism is changed from ductile fracture to ductile and brittle mixed fracture.The improvement of the strength is caused by grain bounda ry strengthening,which includes more boundaries around primary BCC phase and eutectic structure in grain boundary,both of them is resulted from the formation of silicide. | Qin Xu Dezhi Chen Chongyang Tan Xiaoqin Bi Qi Wang Hongzhi Cui Shuyan Zhang Ruirun Chen | 2021 | Journal of Materials Science & Technology2021，，1： | 9 |
| 5 | Revealing the hidden performance of metal phthalocyanines for CO2 reduction electrocatalysis by hybridization with carbon nanotubes显示文摘Metal phthalocyanines(MePcs)have been considered as promising catalysts for CO2 reduction electrocatalysis due to high turnover frequency and structural tunability.However,their performance is often limited by low current density and the performance of some systems is con troversial.Here,we report a carb on nano tube(CNT)hybridizati on approach to study the electrocatalytic performa nee of MePcs(Me=Co,Fe and Mn).MePc molecules are anchored on CNTs to form the hybrid materials without noticeable molecular aggregations.The MePc/CNT hybrids show higher activities and better stabilities than their molecular counterparts.FePc/CNT is slightly less active than CoPc/CNT,but it could deliver higher Faradaic efficiencies for CO production at low overpotentials.In contrast,the catalytic performance of MePc molecules directly loaded on substrate is hin dered by molecular aggregati on,especially for FePc and MnPc.Our results suggest that carbon nano tube hybridization is an efficient approach to construct advaneed MePc electrocatalysts and to understand their catalytic performance. | Zhan Jiang Yang Wang Xiao Zhang Hongzhi Zheng Xiaojun Wang Yongye Liang | 2019 | Nano Research2019，12，9： | 9 |
| 6 | Advanced Functional Fiber and Smart Textile显示文摘The research and applications of fiber materials are directly related to the daily life of social populace and the development of relevant revolutionary manufacturing industry.However,the conventional fibers and fiber products can no longer meet the requirements of automation and intellectualization in modern society,as well as people’s consumption needs in pursuit of smart,avant-grade,fashion and distinctiveness.The advanced fiber-shaped electronics with most desired designability and integration features have been explored and developed intensively during the last few years.The advanced fiber-based products such as wearable electronics and smart clothing can be employed as the second skin to enhance information exchange between humans and the external environment.In this review,the significant progress on flexible fiber-shaped multifunctional devices,including fiber-based energy harvesting devices,energy storage devices,chromatic devices,and actuators are discussed.Particularly,the fabrication procedures and application characteristics of multifunctional fiber devices such as fiber-shaped solar cells,lithium-ion batteries,actuators and electrochromic fibers are introduced in detail.Finally,we provide our perspectives on the challenges and future development of functional fiber-shaped devices. | Qiuwei Shi Jianqi Sun Chengyi Hou Yaogang Li Qinghong Zhang Hongzhi Wang | 2019 | Advanced Fiber Materials2019，1，1： | 7 |
| 7 | Mining the key regulatory genes of chicken inosine 5'-monophosphate metabolism based on time series microarray data显示文摘IMP(inosine 5'-monophosphate) is a compound that enhances the flavor of poultry meat.IMP has become a new breeding trait to improve poultry meat quality.We tried to identify several potential regulatory genes,and construct their predicted regulatory relationships.Time series gene expression profiles of thigh muscle tissues of Rugao chicken,a famous indigenous breed in China,were performed for analysis of genes that are co-expressed or correlated with the concentration of IMP.We found 15 crucial co-expression genes,which are Hspa2,Pten,Gabpa,Bpi,Mkl1,Srf,Cd34,Hspa4,Etv6,Bmpr2,Gde1,Igfbp5,Cd28,Pecam1 and Gja1,that may directly or indirectly regulate IMP metabolism.Eventually,we computed the correlation coefficient between 19 IMP Genes and 15 CGs(15co-expression genes),and we identified and constructed a predicted regulation network.In conclusion,variation of IMP concentration was primarily connected with the muscle development process.During this process,15 CGs were identified that may have significant influence on IMP metabolism.In particular,Bmpr2,Pten and co-expression genes correlated with Entpd8 might play important roles in regulating IMP de novo synthesis,decomposition and salvage synthesis. | Teng Ma Lu Xu Hongzhi Wang Jing Chen Lu Liu Guobin Chang Guohong Chen | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 6 |
| 8 | Correlation between Traditional Chinese Medicine symptom patterns and serum concentration of zinc,iron,copper and magnesium in patients with hepatitis B and associated liver cirrhosis显示文摘OBJECTIVE:To investigate the correlation between the patterns of Traditional Chinese Medicine(TCM)syndromes and the serum concentration of zinc,iron,copper and magnesium of patients with chronic hepatitis B(CHB) and hepatitis B virus(HBV)-induced liver cirrhosis.METHODS:A total of 86 patients were included in the study between March 1,2009 and January 1,2010.All were diagnosed with CHB or HBV-induced liver cirrhosis according to the diagnosis standard of the Chinese Medical Association.Fasting serum concentrations of zinc,iron,copper and magnesium were measured.Patients were classified into different patterns of TCM symptoms according to TCM theory and clinical experience.RESULTS:In the HBV-induced liver cirrhosis group,the mean zinc concentration in patients with the TCM pattern of stagnation of fluid-Dampness was lower than that in patients with obstruction of collaterals by Blood stasis(P < 0.034).In the CHB group,the mean magnesium concentration in patients with toxic Heat flourishing was significantly lower than that in those with Damp-Heat in the Liver and Gallbladder,and those with Liver depression and Spleen deficiency(P < 0.021).The concentrations of iron and copper showed little difference among the different TCM symptom patterns.CONCLUSION:The serum zinc and magnesium concentrations correlated with certain TCM patterns of symptoms in patients with HBV-induced liver cirrhosis and CHB.It may be helpful to interpret the pathogenic change in the TCM symptom patterns in liver cirrhosis and CHB,and also to conduct clinical treatment of the diseases based on identified TCM patterns. | Teng Lichun Zhang Jiongshan Dai Min Wang Fenglin Yang Hongzhi | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 6 |
| 9 | Pulping performance of transgenic poplar with depressed Caffeoyl-CoA O-methyltransferase显示文摘This paper evaluated pulping performance of 3-year-old field-grown transgenic poplar (Populus tremula × Populus alba). The transgenic poplar with anti-sense CCoAOMT had an about 13% decreased lignin content, in which a slight increment was found in S/G ratio. Chemical analysis showed that the transgenic poplar had significantly less benezene-ethanol extractive than that of control wood, but no significant differences were found in contents of ash, cold water extractive, hot water extractive, 1% NaOH extractive, holocellulose, pentosans and cellulose. Fiber assay demonstrated that down-regulation of CCoAOMT expression improved the fiber quality in transgenic poplar. Kraft pulping showed that lower lignin in transgenic poplar led to remarkable improved pulp quality and increased pulp yield. | WEI JianHua WANG YanZhen WANG HongZhi LI RuiFen LIN Nan MA RongCai QU LeQing SONG YanRu | 2008 | Chinese Science Bulletin2008，53，22： | 5 |
| 10 | Production of aryl oxygen-containing compounds by catalytic pyrolysis of bagasse lignin over LaTi0.2Fe0.8O3 prepared by different methods显示文摘To realize the resource and high-value utilization,a new approach,named bagasse lignin(BL) used to produce aryl oxygen-containing compounds by catalytic pyrolysis over perovskite,was proposed,LaTi0.2Fe0.8O3(LTF) samples prepared by the sol-gel method(SG) and the solid-state reaction method(SS)were characterized.The catalytic action on BL pyrolysis was performed by the test of TG-DTG and the evaluation of the fixed bed micro-reactor,the components and contents of the products were determined.The results show that LTF samples have cubic perovskite phase,LTF prepared by SG(LTF-SG) is porous with larger specific surface area than LTF prepared by SS(LTF-SS).During the pyrolysis of BL,the addition of LTF lowers the pyrolysis temperature and the activation energy,the contents of CO2 and CO in gaseous products reduce by 4.6%-8.0% and 30.7%-34.3%,respectively,the total content of aryl oxygencontaining compounds(including phenolics,guaiacols,syringols and phenylates) in liquid products increases from 62 wt% to more than 72 wt%,and LTF-SG shows better catalytic performance.LTF samples have nice phase and catalytic stabilities for BL pyrolysis after five successive redox cycles. | Haiying Wang Hongjing Han Enhao Sun Yanan Zhang Jinxin Li Yanguang Chen Hua Song Hongzhi Zhao Yue Kang | 2020 | Journal of Rare Earths2020，38，1： | 5 |
| 11 | Research on cohesive sediment erosion by flow: An overview显示文摘Erosion of cohesive sediment by flow is a very complicated phenomenon occurring worldwide. Understanding and modeling of the erosion process are important for many issues such as the breaching of embankments, riverbank stability, siltation of harbors and navigation channels, service life of reservoirs, distribution of (heavy metal) pollutants and water quality problems. In the last few decades, numerous studies have been done on the erosion of cohesive sediment by flow. Nevertheless, the factors affecting the erosion resistance of cohesive sediment are still not fully understood and the knowledge of the physics of cohesive sediment erosion is in- adequate, as a result the mathematical modeling of this erosion is far from satis- factory. In this paper an overview of the studies on the erosion resistance, erosion threshold and the erosion rate of cohesive sediment by flow is presented. The outcomes achieved so far from the studies and the existing problems have been analyzed and summarized, based on which recommendations are proposed for future research. | YongHui Zhu JinYou Lu HongZhi Liao JiaSheng Wang BeiLin Fan ShiMing Yao | 2008 | Science China(Technological Sciences)2008，51，11： | 5 |
| 12 | Addition Al and/or Ti Induced Modifi cations of Microstructures, Mechanical Properties, and Corrosion Properties in CoCrFeNi High-Entropy Alloy Coatings显示文摘The purpose of this work is to study the influences of Al and/or Ti addition on the microstructures, mechanical properties and corrosion properties of CoCrFeNi-(Al, Ti) high entropy alloy(HEA) coatings. Three coatings, AlCoCrFeNi(Ⅰ), CoCrFeNiTi_(0.5)(Ⅱ) and AlCoCrFeNiTi_(0.5)(Ⅲ), were fabricated by laser cladding successfully. The AlCoCrFeNi(Ⅰ) coating exhibited a simple body-centered cubic(BCC) solid-solution structure, whereas the CoCrFeNiTi_(0.5)(Ⅱ) alloy exhibited a face-centered cubic(FCC) solid-solution and a small amount of Laves phase. The BCC phases in AlCoCrFeNiTi _(0.5)(Ⅲ) coating were characterized as Fe–Cr rich disordered BCC phases(A2) and Al-Ni–Ti-rich ordered BCC phases(L2_1) separately. The AlCoCrFeNiTi_(0.5)(Ⅲ) coating with dual-phase BCC structure showed the optimal performance of both mechanical and corrosion properties, which was superior to BCC-based AlCoCrFeNi(Ⅰ) and FCC-based CoCrFeNiTi_(0.5)(Ⅱ) coatings. Nanoindentation tests and quantitative investigations on the strengthening mechanisms of AlCoCrFeNiTi_(0.5)(Ⅲ) coating were conducted, suggesting that the precipitation strengthening is the dominant strengthening mechanism. In short, the addition of moderate amount of Al and Ti in CoCrFeNi HEA shows potential for the development of a high strength and corrosion-resistant coating. | Guoliang Ma Yong Zhao Hongzhi Cui Xiaojie Song Mingliang Wang Kwangmin Lee Xiaohua Gao Qiang Song Canming Wang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，8： | 4 |
| 13 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 14 | Trajectory Big Data Processing Based on Frequent Activity显示文摘With the rapid development and wide use of Global Positioning System in technology tools, such as smart phones and touch pads, many people share their personal experience through their trajectories while visiting places of interest. Therefore, trajectory query processing has emerged in recent years to help users find their best trajectories. However, with the huge amount of trajectory points and text descriptions, such as the activities practiced by users at these points, organizing these data in the index becomes tedious. Therefore, the parallel method becomes indispensable. In this paper, we have investigated the problem of distributed trajectory query processing based on the distance and frequent activities. The query is specified by start and final points in the trajectory, the distance threshold, and a set of frequent activities involved in the point of interest of the trajectory.As a result, the query returns the shortest trajectory including the most frequent activities with high support and high confidence. To simplify the query processing, we have implemented the Distributed Mining Trajectory R-Tree index(DMTR-Tree). For this method, we initially managed the large trajectory dataset in distributed R-Tree indexes.Then, for each index, we applied the frequent itemset Apriori algorithm for each point to select the frequent activity set. For the faster computation of the above algorithms, we utilized the cluster computing framework of Apache Spark with MapReduce as the programing model. The experimental results show that the DMTR-Tree index and the query-processing algorithm are efficient and can achieve the scalability. | Amina Belhassena Hongzhi Wang | 2019 | Tsinghua Science and Technology2019，24，3： | 4 |
| 15 | Photocatalytic H2 Evolution on TiO2 Assembled with Ti3C2 MXene and Metallic 1T-WS2 as Co-catalysts显示文摘The biggest challenging issue in photocatalysis is efficient separation of the photoinduced carriers and the aggregation of photoexcited electrons on photocatalyst’s surface.In this paper,we report that double metallic co-catalysts Ti3C2 MXene and metallic octahedral(1T)phase tungsten disulfide(WS2)act pathways transferring photoexcited electrons in assisting the photocatalytic H2 evolution.TiO2 nanosheets were in situ grown on highly conductive Ti3C2 MXenes and 1T-WS2 nanoparticles were then uniformly distributed on TiO2@Ti3C2 composite.Thus,a distinctive 1T-WS2@TiO2@Ti3C2 composite with double metallic co-catalysts was achieved,and the content of 1T phase reaches 73%.The photocatalytic H2 evolution performance of 1T-WS2@TiO2@Ti3C2 composite with an optimized 15 wt%WS2 ratio is nearly 50 times higher than that of TiO2 nanosheets because of conductive Ti3C2 MXene and 1T-WS2 resulting in the increase of electron transfer efficiency.Besides,the 1T-WS2 on the surface of TiO2@Ti3C2 composite enhances the Brunauer–Emmett–Teller surface area and boosts the density of active site. | Yujie Li Lei Ding Shujun Yin Zhangqian Liang Yanjun Xue Xinzhen Wang Hongzhi Cui Jian Tian | 2020 | Nano-Micro Letters2020，12，1： | 4 |
| 16 | Evaluating Common Land Model Energy Fluxes Using FLUXNET Data显示文摘Given the crucial role of land surface processes in global and regional climates, there is a pressing need to test and verify the performance of land surface models via comparisons to observations. In this study, the eddy covariance measurements from 20 FLUXNET sites spanning more than 100 site-years were utilized to evaluate the performance of the Common Land Model(Co LM) over different vegetation types in various climate zones. A decomposition method was employed to separate both the observed and simulated energy fluxes, i.e., the sensible heat flux, latent heat flux, net radiation, and ground heat flux, at three timescales ranging from stepwise(30 min) to monthly. A comparison between the simulations and observations indicated that Co LM produced satisfactory simulations of all four energy fluxes, although the different indexes did not exhibit consistent results among the different fluxes. A strong agreement between the simulations and observations was found for the seasonal cycles at the 20 sites, whereas Co LM underestimated the latent heat flux at the sites with distinct dry and wet seasons, which might be associated with its weakness in simulating soil water during the dry season. Co LM cannot explicitly simulate the midday depression of leaf gas exchange, which may explain why Co LM also has a maximum diurnal bias at noon in the summer. Of the eight selected vegetation types analyzed, Co LM performs best for evergreen broadleaf forests and worst for croplands and wetlands. | Xiangxiang ZHANG Yongjiu DAI Hongzhi CUI Robert E.DICKINSON Siguang ZHU Nan WEI Binyan YAN Hua YUAN Wei SHANGGUAN Lili WANG Wenting FU | 2017 | Advances in Atmospheric Sciences2017，34，9： | 4 |
| 17 | Versatile synthesis of yolk/shell hybrid nanocrystals via ion-exchange reactions for novel metal/semiconductor and semiconductor/semiconductor conformations显示文摘Yolk/shell (Y-S) hybrid nanoarchitectures, owing to the interior voids createdfor individualized catalyst applications, have emerged as new candidates foreffectively isolating catalytic species. However, the well-defined hollow interiorswith flexible core and shell compositions--such as noble-metal cores, metal-oxidecores, and widespread semiconductor shells--and a flexible anisotropic shapeare far from the requirements. In particular, the introduction of catalytic noblemetals or metal-oxide nanocrystals (NCs) with isotropic or anisotropic shapesinto various hollow semiconductor structures with well-defined morphologieshas been rarely reported but is urgently needed. Herein, we propose a strategyinvolving the careful sulfuration of as-prepared cavity-free core/shell NCs ormetal-oxide NCs followed by phosphine-initialized cation-exchange reactionsfor preparing metal@semiconductor and metal oxide@semiconductor (II-VI) Y-SNCs. The geometry, size, and conformations of the core and shell are fully andindependently considered. New and unprecendented metal@semiconductorand metal oxide@semiconductor (II-VI) Y-S NCs are prepared via widespreadDhosDhine-initialized cation-exchange reactions. | Muwei Ji Xinyuan Li Hongzhi Wang Liu Huang Meng Xu Jia Liu Jiajia Liu Jin Wang Jiatao Zhang | 2017 | Nano Research2017，10，9： | 4 |
| 18 | Identification of predictive MRI and functional biomarkers in a pediatric piglet traumatic brain injury model显示文摘Traumatic brain injury(TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a strong influence on the extent of functional impairments;however, identification of specific magnetic resonance imaging(MRI) biomarkers that are most reflective of injury severity and functional prognosis remain elusive. Therefore, the objective of this study was to utilize advanced statistical approaches to identify clinically relevant MRI biomarkers and predict functional outcomes using MRI metrics in a translational large animal piglet TBI model. TBI was induced via controlled cortical impact and multiparametric MRI was performed at 24 hours and 12 weeks post-TBI using T1-weighted, T2-weighted, T2-weighted fluid attenuated inversion recovery, diffusion-weighted imaging, and diffusion tensor imaging. Changes in spatiotemporal gait parameters were also assessed using an automated gait mat at 24 hours and 12 weeks post-TBI. Principal component analysis was performed to determine the MRI metrics and spatiotemporal gait parameters that explain the largest sources of variation within the datasets. We found that linear combinations of lesion size and midline shift acquired using T2-weighted imaging explained most of the variability of the data at both 24 hours and 12 weeks post-TBI. In addition, linear combinations of velocity, cadence, and stride length were found to explain most of the gait data variability at 24 hours and 12 weeks post-TBI. Linear regression analysis was performed to determine if MRI metrics are predictive of changes in gait. We found that both lesion size and midline shift are significantly correlated with decreases in stride and step length. These results from this study provide an important first step at identifying relevant MRI and functional biomarkers that are predictive of functional outcomes in a clinically relevant piglet TBI model. This study was approved by the University of Georgia Institutional Animal Care and Use Committee(AUP: A2015 11-001) on December 22, 2015. | Hongzhi Wang Emily W.Baker Abhyuday Mandal Ramana M.Pidaparti Franklin D.West Holly A.Kinder | 2021 | Neural Regeneration Research2021，16，2： | 4 |
| 19 | Production of aryl oxygen-containing compounds from catalytic pyrolysis of bagasse lignin over LaTixFe1xO3显示文摘A new approach,named production of aryl oxygen-containing compounds from the catalytic pyrolysis of bagasse lignin(BL) over perovskite oxide,was proposed,A series of LaTixFe1-xO3(LTF-x) samples were prepared by the solid state reaction method.The crystal phase and morphology of LTF-x were characterized by XRD and SEM respectively.Catalytic pyrolysis performance of LTF-x was performed by TG-DTG and the distribution patterns of gaseous,liquid and solid products from BL was investigated using a fixed-bed micro-reactor.The optimal reaction conditions were determined:the pyrolysis temperature was 600℃,the mass ratio of mBL:mLTF-0.2 was 3:1,the veloeity of earrier gas was 100 ml·min-1.The gaseous produets were mainly eomposed of CO2,CO,CH4 and CnHm(n=2-4,m=2 n+2 or m=2 n),The main aryl oxygen-containing compounds in liquid products were phenolics,guaiacols,syringols and phenylates,the rest were benzenes,furans,esters and carboxylic acid.The total contents of aryl oxygencontaining compounds were from 62% up to more than 72% under the action of the perovskite.Moreover,the LTF-0.2 sample had nice regenerability. | Haiying Wang Hongjing Han Enhao Sun Yanan Zhang Jinxin Li Yanguang Chen Hua Song Hongzhi Zhao | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 4 |
| 20 | Effect of micro-bubbles on coagulation flotation process of dyeing wastewater显示文摘 | Shu Liu Qunhui Wang Hongzhi Ma Peikun Huang Jun Li Takashige Kikuchi | 2010 | Separation and Purification Technology2010，，3： | 3 |
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