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| 1 | Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer:The role of inflammation显示文摘Chemotherapy-induced diarrhea(CID)is a common and often severe side effect experienced by colorectal cancer(CRC)patients during their treatment.As chemotherapy regimens evolve to include more efficacious agents,CID is increasingly becoming a major cause of dose limiting toxicity and merits further investigation.Inflammation is a key factor behind gastrointestinal(GI)toxicity of chemotherapy.Different chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in the small intestine and colonic mucosa.Here we review the current understanding of the mechanisms behind GI toxicity and the mucositis associated with systemic treatment of CRC.Insights into the inflammatory response activated during this process gained from various models of GI toxicity are discussed.The inflammatory processes contributing to the GI toxicity of chemotherapeutic agents are increasingly being recognised as having an important role in the development of anti-tumor immunity,thus conferring added benefit against tumor recurrence and improving patient survival.We review the basic mechanisms involved in the promotion of immunogenic cell death and its relevance in the treatment of colorectal cancer.Finally,the impact of CID on patient outcomes and therapeutic strategies to prevent or minimise the effect of GI toxicity and mucositis are discussed. | Chun Seng Lee Elizabeth J Ryan Glen A Doherty | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 2 | 植物提取液对脐橙致腐青霉菌的抑菌研究显示文摘从霉变赣南脐橙表皮分离出致病青霉菌,选择药食同源植物以70%乙醇为浸提剂,进行超声波提取研究,对比了不同浓度提取物的抑菌特性。实验结果表明7种材料的提取物,对青霉菌的菌丝生长没有显著的抑制作用,而对孢子萌发生长有抑制效果。超声波提取物效果最好的是丁香、厚朴和肉桂,其次为丹参,而甘草、苦参和大青等无抑制效果。实验初步确定了能抑制孢子萌发的提取物最小有效抑菌浓度,并在脐橙贮藏中进行应用,肉桂、丁香和厚朴提取液处理的脐橙贮藏120 d,失重率、腐烂率以及总糖、总酸和Vc的消耗均低于对照,表现出较好的防腐保鲜作用。 | 杨文侠 邓利珍 周亮 钟八莲 赖特明 Chun J | 2013 | 食品科技2013，38，12： | 8 |
| 3 | ATP-regulation of antioxidant properties and phenolics in litchi fruit during browning and pathogen infection process显示文摘 | YI Chun JIANG Yueming SHI J | 2010 | Food Chemistry2010，118，1： | 1 |
| 4 | Investigation of the curing variables of asphalt-rubber binder 显示文摘 | Billiter T C Chun J S Davison R R | 1997 | Pet Sci Technol1997，15，： | 1 |
| 5 | Microstructure and thermoelectric proper- ties of n-type 95%Bi2Te3 5%Bi2Se3 alloy produced by rapid solid- ification and hot extrusion显示文摘 | HONG S J CHUN B S | 2003 | Matefials Research Bulletin2003，38，： | 1 |
| 6 | Selective removal of HzS from coke oven gas显示文摘 | Park D W Chun S W Jang J Y | 1998 | Catalysis Today1998，44，14： | 1 |
| 7 | 查看详情显示文摘 | Chun J W Anthony R G | | 0，，： | 1 |
| 8 | The temperature effects on hydraulic conductivity of compacted bentonite显示文摘 | CHOW J LEE J O CHUN K S | 1999 | Applied Clay Science1999，14，1： | 1 |
| 9 | Use of a chiA probe for detection of chitinase genes in bacteria from the Chesapeake Bay 显示文摘 | RAMAIAH N HILL R T CHUN J | 2000 | Ferns Microbiol Ecol2000，34，1： | 1 |
| 10 | Radiological manage- ment of hemoptysis: a comprehensive review of diag- nostic imaging and bronchial arterial embolization显示文摘 | Chun J Y Morgan R Belli A M | 2010 | Cardiovasc Intervent Radiol2010，33，： | 1 |
| 11 | Pricing strategies in B2C electroniccommerce: Analytical and empirical approaches 显示文摘 | CHUN S H KIM J C | 2005 | DecisionSupport Systems2005，40，2： | 1 |
| 12 | BRCA1 and BRCA2 : different rolesin a common pathway of genome protection 显示文摘 | Roy R Chun J Powell SN | 2012 | Nat Rev Cancer2012，，1： | 1 |
| 13 | Strain improvement of Phaffia rhodozyma by protoplast fusion显示文摘 | Chin J E Bai S | 1992 | FEMS Microbiol Lett1992，93，： | 1 |
| 14 | Extrusion-spin coating:an efficient and deterministic photoresist coating method in microlithography显示文摘 | HAN Sang-jun DERKSEN J CHUN Jung-hoon | 2004 | IEEE Transactions on Semiconductor Manufacturing2004，17，1： | 1 |
| 15 | Comparison of Thermal/Mechanical Properties and Shape Memory Effect of Polyurethane Bloek-copolymers with Planar or Bent Shape of Hard Segment显示文摘 | Yang J H Chun B C Chung Y C | 2003 | Polymer2003，44，11： | 1 |
| 16 | Evaluation of design parameters of osseointegrated dental implants using finite element analysis 显示文摘 | Chun H J Cheong S Y Han J H | 2002 | J Oral Rehabil2002，29，6： | 1 |
| 17 | Lysophosphatidic acid receptors 显示文摘 | Contos JJ Ishii L Chun J | 2000 | Mol Pharmacol2000，58，6： | 1 |
| 18 | No significant correlation exists between core promoter mutations,viral replication,and liver damage in chronic hepatitis B infection显示文摘 | Chun YK Kim JY Woo H J | 2000 | Hepatology2000，32，5： | 1 |
| 19 | An Efficient Rerouting Scheme for MPLS-base Recovery and Its Performance Evaluation显示文摘 | Ahn G Jang J Chun W | 2001 | Telecommunication Systems2001，19，34： | 1 |
| 20 | Selective oxidation of H2S in the presence of ammonia and water using Co304/Si02 catalyst显示文摘 | Chun S W Jang J Y Park D W | 1997 | Korean Journal of Chemical Engineering1997，14，3： | 1 |
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