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| 1 | Expression and regulation of IL-22 in the IL-17.producing CD4+T lymphocytes显示文摘IL-22 是在工作对感染支持纸巾的天生的免疫的 IL-10 家庭的新奇 cytokine。尽管 CD4+ 助手 T 淋巴细胞(TH ) 作为 IL-22 的来源被发现,这 cytokine 的规定糟糕被理解。这里,我们证明 IL-22 被也做 IL-17 的 TH 房间的一个新奇子集在 mRNA 和蛋白质层次表示。IL-22 和 IL-17 被发现被即时 PCR 以及 ELISA 分析被 TGFbeta 和 IL-6 并列地在 TH 区别期间调整。然而, IL-22 不调整 TH 区别;外长的 IL-22 或一个 IL-22 对手没在 TH 区别上有效果。这些数据表明 IL-17-producing T 房间表示的新奇 cytokine,并且建议在组织发炎和自体免疫的疾病表明小径的 IL-22 和 IL-17 的相互作用和协同作用。 | Yeonseok Chung Xuexian Yang Seon Hee Chang Li Ma Qiang Tian Chen Dong | 2006 | Cell Research2006，16，11： | 20 |
| 2 | Ion Channels in Mesenchymal Stem Cells from Rat Bone Marrow显示文摘 | Li GR Deng XL Sun H Chung SS Tse HF Lau CP | 2006 | 中国生物学文摘2006，20，5： | 18 |
| 3 | Sorption and Dissipation of Tetracyclines in Soils and Compost显示文摘Two agricultural soils were collected from Dahu and Pinchen counties and swine manure compost (SMC) from Ping- tung County in Taiwan,China to investigate the sorption and dissipation of three tetracyclines (TCs),i.e.,oxytetracycline (OTC),tetracycline (TC) and chlortetracycline (CTC),in compost,soils and soil/compost mixtures with different organic carbon (OC) contents.There were seven treatments in total.TCs were most strongly adsorbed to SMC in all treatments due to the high OC content.When SMC was present in the soils,the sorption of TCs was significantly enhanced,which might be attributed to the increased OC content and CEC.The adsorption of TCs showed non-linear adsorption isotherms and fitted well to the Freundlich model.After 49 d of incubation at 25 ? C in soils and soil/compost mixtures in the dark,TCs elapsed in all substrates,with the time required for 50% degradation (DT 50 ) between 20 and 41 d,and the time for 90% degradation (DT 90 ) between 68 and 137 d.Soil amended with compost enhanced the stability of TCs and reduced their mobility.The dissipation of TCs in a soil environment was slow,indicating that these compounds might be persistent in soil. | LI Ling-Ling HUANG Li-Dong CHUNG Ren-Shih FOK Ka-Hang ZHANG Yong-Song | 2010 | Pedosphere2010，20，6： | 14 |
| 4 | ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma显示文摘Sorafenib is the first-line treatment of advanced hepatocellular carcinoma(HCC).However,there is a lack of validated biomarkers to predict sorafenib sensitivity.In this study we investigated the role of ACSL4,a positive-activating enzyme of ferroptosis,in sorafenib-induced cell death and HCC patient outcome.We showed that ACSL4 protein expression was negatively associated with IC50 values of sorafenib in a panel of HCC cell lines(R=−0.952,P<0.001).Knockdown of ACSL4 expression by specific siRNA/sgRNA significantly attenuated sorafenib-induced lipid peroxidation and ferroptosis in Huh7 cells,and also rescued sorafenib-induced inhibition of xenograft tumor growth in vivo.We selected 29 HCC patients with surgery as primary treatment and sorafenib as postoperative adjunct therapy from a hospital-based cohort.A high proportion(66.7%)of HCC patients who had complete or partial responses to sorafenib treatment(according to the revised RECIST guideline)had higher ACSL4 expression in the pretreated HCC tissues,compared with those who had stable or progressed tumor growth(23.5%,P=0.029).Since ACSL4 expression was independent of sorafenib treatment,it could serve as a useful predictive biomarker.Taken together,this study demonstrates that ACSL4 is essential for sorafenib-induced ferroptosis and useful for predicting sorafenib sensitivity in HCC.This study may have important translational impacts in precise treatment of HCC. | Ji Feng Pei-zhi Lu Guang-zhi Zhu Shing Chung Hooi Yong Wu Xiao-wei Huang Hui-qi Dai Pan-hong Chen Zhong-jie Li Wen-jing Su Chuang-ye Han Xin-ping Ye Tao Peng Jing Zhou Guo-dong Lu | 2021 | Acta Pharmacologica Sinica2021，42，1： | 11 |
| 5 | Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na^+/K^+- ATPase显示文摘 | Ronald JY CHEN Tse-yu CHUNG Feng-yin LI Wei-hung YANG Tzyy-rong JINN Jason TC TZEN | 2010 | Acta Pharmacologica Sinica2010，31，6： | 10 |
| 6 | Effect of sugar positions in ginsenosides and their inhibitory potency on Na^+/K^+-ATPase activity显示文摘 | Ronald JY CHEN Tse-yu CHUNG Feng-yin LI Nan-hei LIN Jason TC TZEN | 2009 | Acta Pharmacologica Sinica2009，30，1： | 10 |
| 7 | High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells显示文摘 | Hua LI Amy LAM Ai-min XU Karen SL LAM Sookja KIM CHUNG | 2010 | Acta Pharmacologica Sinica2010，31，5： | 10 |
| 8 | L-Carnitine protects against tacrolimus-induced renal injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling显示文摘Reducing immunosuppressant-related complications using conventional drugs is an efficient therapeutic strategy.L-carnitine(LC)has been shown to protect against various types of renal injury.In this study,we investigated the renoprotective effects of LC in a rat model of chronic tacrolimus(TAC)nephropathy.SD rats were injected with TAC(1.5 mg·kg^(−1)·d^(−1),sc)for 4 weeks.Renoprotective effects of LC were assessed in terms of renal function,histopathology,oxidative stress,expression of inflammatory and fibrotic cytokines,programmed cell death(pyroptosis,apoptosis,and autophagy),mitochondrial function,and PI3K/AKT/PTEN signaling.Chronic TAC nephropathy was characterized by severe renal dysfunction and typical histological features of chronic nephropathy.At a molecular level,TAC markedly increased the expression of inflammatory and fibrotic cytokines in the kidney,induced oxidative stress,and led to mitochondrial dysfunction and programmed cell death through activation of PI3K/AKT and inhibition of PTEN.Coadministration of LC(200 mg·kg^(−1)·d^(−1),ip)caused a prominent improvement in renal function and ameliorated histological changes of kidneys in TAC-treated rats.Furthermore,LC exerted anti-inflammatory and antioxidant effects,prevented mitochondrial dysfunction,and modulated the expression of a series of apoptosis-and autophagy-controlling genes to promote cell survival.Human kidney proximal tubular epithelial cells(HK-2 cells)were treated with TAC(50μg/mL)in vitro,which induced production of intracellular reactive oxygen species and expression of an array of genes controlling programmed cell death(pyroptosis,apoptosis,and autophagy)through interfering with PI3K/AKT/PTEN signaling.The harmful responses of HK-2 cells to TAC were significantly attenuated by cotreatment with LC and the PI3K inhibitor LY294002(25μM).In conclusion,LC treatment protects against chronic TAC nephropathy through interfering the PI3K/AKT/PTEN signaling. | Hai-lan Zheng Hai-yue Zhang Chun-lian Zhu Hui-ying Li Sheng Cui Jian Jin Shang-guo Piao Yu-ji Jiang Mei-ying Xuan Ji-zhe Jin Ying-shun Jin Jung-pyo Lee Byung-ha Chung Bum-soon Choi Chul-woo Yang Can Li | 2021 | Acta Pharmacologica Sinica2021，42，1： | 7 |
| 9 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 10 | Bifidobacterium infantis attenuates colitis by regulating T cell subset responses显示文摘AIM:to investigate the effect of Bifidobacterium infantis(B.infantis)on the T cell subsets and in attenuating the severity of experimental colitis in mice.METHODS:Normal BALB/c mice were fed different doses of B.infantis for 3 wk,and T cell subsets and related cytokine profiles in mesenteric lymph nodes(MLNs)were detected by flow cytometry and realtime RT-PCR.Colitis was induced by administration of trinitrobenzene sulfonic acid(TNBS)in mice.Before colitis induction,mice were fed high dose B.infantisfor 3 wk.Cytokine profiles in MLNs and histological changes of colonic tissue were examined 6 d after colitis induction.RESULTS:No significant change in cytokine profiles was observed in normal mice fed low dose B.infantis.However,Th1-related cytokines(IL-2,IFN-γ,IL-12p40),Th17-related transcription factor and cytokines(RORγt,IL-21,IL-23),regulatory T cell(Treg)-related transcription factor and cytokines(Foxp3,IL-10)were increased in normal mice fed high dose B.infantis.Furthermore,flow cytometry assay showed B.infantis increased the numbers of CD4+Foxp3+Tregs and Th17cells in MLNs.Colitis was successfully induced by TNBS in mice,characterized by colonic inflammation and aberrant Th1 and Th17 responses.Feeding high dose B.infantis for 3 wk before colitis induction decreased the inflammatory cell infiltration and goblet cell depletion and restored the intestinal epithelium.In addition,B.infantis feeding reduced Th1-related cytokines(T-bet,IL-2 and IFN-γ)and Th17-related cytokines(IL-12p40,RORγt,IL-17A,IL-21 and IL-23),and increased Tregrelated molecules(Foxp3,IL-10 and TGF-β)in colitis mice.CONCLUSION:B.infantis effectively attenuates TNBSinduced colitis by decreasing Th1 and Th17 responses and increasing Foxp3+Treg response in the colonic mucosa. | Li Zuo Kai-Tao Yuan Li Yu Qing-Hong Meng Peter Chee-Keung Chung Ding-Hua Yang | 2014 | World Journal of Gastroenterology2014，20，48： | 5 |
| 11 | A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction显示文摘 | Yin, L. Chung, C. M. Huo, R. Liu, H. Zhou, C. Xu, W. Zhu, H. Zhang, J. Shi, Q. Wong, H. Y.C. Chen, J. Lu, Y. Bi, Y. Zhao, C. Du, Y. Ma, M. Cai, Y. Chen, W. Y. Fok, K. L. Tsang, L. L. Li, K. Ni, Y. Chung, Y. W. Zhou, Z. Sha, J. Chan, H. C. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 5 |
| 12 | Tree of life for the genera of Chinese vascular plants显示文摘我们重建了使用的中国脉管的植物(Tracheophyta ) 的一棵种系发生的树叶绿体基因 atpB, matK, ndhF,和 rbcL 和 mitochondrial matR 定序。我们生产了包括 6098 种类并且包括 13 个 695 DNA 序列, 1803 最新被产生的一个矩阵。我们的分类采样跨越了代表中国脉管的植物的 323 个家庭的 3114 个类,盖住从中国知道的超过 93% 所有类。全面大发展史支持大多数关系在之中并且在最近的分子的种系发生的研究为 lycophytes,蕨纲植物(monilophytes ) ,裸子植物,和被子植物认出的家庭以内。为被子植物,在被子植物发展史组 IV 的大多数家庭作为 monophyletic 被养活,除了 paraphyletic Dipterocarpaceae 和 Santalaceae。一些大类的几个大家庭并且 monophyly 的 infrafamilial 关系被我们的稠密的分类采样很好支持。我们的结果证明 Eberhardtia 的二种是到 Sapotaceae 的所有另外的 taxa 形成的 clade 的姐妹,除了 Sarcosperma。我们经由 SoTree (http://www.darwintree.cn/flora/index.shtml ) 做了我们为子树的创造公开地可得到的中国脉管的植物的发展史,为生态学家的一个自动化发展史集会工具。 | Zhi-Duan Chen Tuo Yang Li Lin Li-Min Lu Hong-Lei Li Miao Sun Bing Liu Min Chen Yan-Ting Niu Jian-Fei Ye Zhi-Yong Cao Hong-Mei Liu Xiao-Ming Wang Wei Wang Jing-Bo Zhang Zhen Meng Wei Cao Jian-Hui Li Sheng-Dan Wu Hui-Ling Zhao Zhong-Jian Liu Zhi-Yuan Du Qing-Feng Wang Jing Guo Xin-Xin Tan Jun-Xia Su Lin-Jing Zhang Lei-Lei Yang Yi-Ying Liao Ming-He Li Guo-Qiang Zhang Shih-Wen Chung Jian Zhang Kun-Li Xiang Rui-qi Li Douglas E. Soltis Pamela S. Soltis Shi-Liang Zhou Jin-Hua Ran Xiao-quan Wang Xiao-Hua Jin You-Sheng Chen Tian-Gang Gao Jian-Hua Li Shou-Zhou Zhang An-Ming Lu China Phylogeny Consortium | 2016 | Journal of Systematics and Evolution2016，54，4： | 5 |
| 13 | RiMOM-IM: A Novel Iterative Framework for Instance Matching显示文摘匹配的例子,瞄准发现在知识库之间的例子的通讯,在语义网是为分享的本体论的数据和集成的一个基本问题。尽管可观的例子匹配途径已经被建议了,怎么保证当处理大规模知识库时,高精确性和效率仍然是大挑战。这份报纸建议一个反复的框架, RiMOM-IM (匹配的 RiMOM 例子) 。在这个框架后面的关键想法是充分利用特殊、可得到的匹配的信息改进效率并且控制错误繁殖。我们参予了本体论排列评估行动(OAEI ) 的 2013 和 2014 比赛,并且我们的系统被评价第一。而且,以前的 OAEI 数据集的实验也证明我们的系统执行最好。 | Chao Shao Lin-Mei Hu Juan-Zi Li Zhi-Chun Wang Tonglee Chung Jun-Bo Xia | 2016 | Journal of Computer Science & Technology2016，31，1： | 4 |
| 14 | The strategic framework of tuberculosis control and prevention in the elderly:a scoping review towards End TB targets显示文摘With the rapid pace of population ageing,tuberculosis(TB)in the elderly increasingly becomes a public health challenge.Despite the increasing burden and high risks for TB in the elderly,targeted strategy has not been well understood and evaluated.We undertook a scoping review to identify current TB strategies,research and policy gaps in the elderly and summarized the results within a strategic framework towards End TB targets.Databases of Embase,MEDLINE,Global health and EBM reviews were searched for original studies,review articles,and policy papers published in English between January 1990 and December 2015.Articles examining TB strategy,program,guideline or intervention in the elderly from public health perspective were included.Nineteen articles met the inclusion criteria.Most of them were qualitative studies,issued in high-and middle-income countries and after 2000.To break the chain of TB transmission and reactivation in the elderly,infection control,interventions of avoiding delay in diagnosis and containment are essential for preventing transmission,especially in elderly institutions and aged immigrants;screening of latent TB infection and preventive therapy had effective impacts on reducing the risk of reactivation and should be used less reluctantly in older people;optimizing early case-finding with a high index of suspicion,systematic screening for prioritized high-risk groups,initial empirical and adequate follow-up treatment with close monitoring and evaluation,as well as enhanced programmatic management are fundamental pillars for active TB elimination.Evaluation of TB epidemiology,risk factors,impacts and cost-effectiveness of interventions,adopting accurate and rapid diagnostic tools,shorter and less toxic preventive therapy,are critical issues for developing strategy in the elderly towards End TB targets.TB control strategies in the elderly were comprehensively mapped in a causal link pathway.The framework and principals identified in this study will help to evaluate and improve current program,develop targeted strategy,as well as raise more discussions on the research priority settings and policy transitions.Given the scarceness of policy and evaluated interventions,as well as the unawareness of shifting TB epidemiology and strategy especially in developing countries,the increasing need of a ready TB program for the elderly warrants further research. | Jun Li Pui-Hong Chung Cyrus L.K.Leung Nobuyuki Nishikiori Emily Y.Y.Chan Eng-Kiong Yeoh | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 15 | Magnesium lithospermate B extracted from Salvia miltiorrhiza elevats intracellular Ca2+ level in SHSY5Y cells显示文摘 | Yi-ching CHEN Tzyy-rong JINN Tse-yu CHUNG Feng-yin LI Ruey-jane FAN Jason TC TZEN | 2010 | Acta Pharmacologica Sinica2010，31，8： | 4 |
| 16 | Monosialoganglioside 1 may alleviate neurotoxicity induced by propofol combined with remifentanil in neural stem cells显示文摘Monosialoganglioside 1(GM1) is the main ganglioside subtype and has neuroprotective properties in the central nervous system. In this study, we aimed to determine whether GM1 alleviates neurotoxicity induced by moderate and high concentrations of propofol combined with remifentanil in the immature central nervous system. Hippocampal neural stem cells were isolated from newborn Sprague-Dawley rats and treated with remifentanil(5, 10, 20 ng/m L) and propofol(1.0, 2.5, 5.0 μg/m L), and/or GM1(12.5, 25, 50 μg/m L). GM1 reversed combined propofol and remifentanil-induced decreases in the percentage of 5-bromodeoxyuridine(+) cells and also reversed the increase in apoptotic cell percentage during neural stem cell proliferation and differentiation. However, GM1 with combined propofol and remifentanil did not affect β-tubulin(+) or glial fibrillary acidic protein(+) cell percentage during neural stem cell differentiation. In conclusion, we show that GM1 alleviates the damaging effects of propofol combined with remifentanil at moderate and high exposure concentrations in neural stem cells in vitro, and exerts protective effects on the immature central nervous system. | Jiang Lu Xue-qin Yao Xin Luo Yu Wang Sookja Kim Chung He-xin Tang Chi Wai Cheung Xian-yu Wang Chen Meng Qing Li | 2017 | Neural Regeneration Research2017，12，6： | 4 |
| 17 | Laparoscopic approach of surgical treatment for primary hepatolithiasis: a cohort study显示文摘 | Eric C.H. Lai Tang Chung Ngai George P.C. Yang Michael K.W. Li | 2010 | The American Journal of Surgery2010，，5： | 4 |
| 18 | T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ显示文摘 | Xuexian O. Yang Bhanu P. Pappu Roza Nurieva Askar Akimzhanov Hong Soon Kang Yeonseok Chung Li Ma Bhavin Shah Athanasia D. Panopoulos Kimberly S. Schluns Stephanie S. Watowich Qiang Tian Anton M. Jetten Chen Dong | 2008 | Immunity2008，，1： | 3 |
| 19 | Oxygen Atom Exchange Mechanism in Reaction of OH Radical with AsO显示文摘Oxygen atom exchange reaction mechanism in the reaction of OH radicals with AsO was investigated by means of the density functional theory (DFT) with 6 311++G( 3df,3pd ) and 6 311++G( d,p ) basis sets. The calculated results suggest that the reaction between OH and AsO should make the oxygen atoms exchange rapidly because the barrier to isomerization is significantly less than the HO-AsO bond dissociation energy. | CHI Yu-juan 1, YU Hai tao 1,2** , FU Hong gang 1,2 HUANG Xu ri 2, LI Ze sheng 2 and SUN Chia chung 21. College of Chemistry and Chemical Engineering, Heilongjiang University, Harbin 150080, P. R. China 2. State Key Laboratory of T | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 20 | Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma显示文摘 | Chuen–Fei Chen Wen–Chung Lee Hwai–I. Yang Hung–Chuen Chang Chin–Lan Jen Uchenna H. Iloeje Jun Su Chuhsing K. Hsiao Li–Yu Wang San–Lin You Sheng–Nan Lu Chien–Jen Chen | 2011 | Gastroenterology2011，，4： | 3 |
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