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| 1 | Expression and regulation of IL-22 in the IL-17.producing CD4+T lymphocytes显示文摘IL-22 是在工作对感染支持纸巾的天生的免疫的 IL-10 家庭的新奇 cytokine。尽管 CD4+ 助手 T 淋巴细胞(TH ) 作为 IL-22 的来源被发现,这 cytokine 的规定糟糕被理解。这里,我们证明 IL-22 被也做 IL-17 的 TH 房间的一个新奇子集在 mRNA 和蛋白质层次表示。IL-22 和 IL-17 被发现被即时 PCR 以及 ELISA 分析被 TGFbeta 和 IL-6 并列地在 TH 区别期间调整。然而, IL-22 不调整 TH 区别;外长的 IL-22 或一个 IL-22 对手没在 TH 区别上有效果。这些数据表明 IL-17-producing T 房间表示的新奇 cytokine,并且建议在组织发炎和自体免疫的疾病表明小径的 IL-22 和 IL-17 的相互作用和协同作用。 | Yeonseok Chung Xuexian Yang Seon Hee Chang Li Ma Qiang Tian Chen Dong | 2006 | Cell Research2006，16，11： | 20 |
| 2 | Understanding the development and function of T follicular helper cells显示文摘A fundamental function of T helper(Th)cells is to regulate B-cell proliferation and immunoglobulin class switching,especially in the germinal centers.Th1 and Th2 lineages of CD41 T cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a(IgG2a)and IgG1/IgE,respectively.Recently,it has become clear that a subset CD41 T cells,named T follicular helper(Tfh)cells,is critical to B-cell response induction.In this review,we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation,the relationship of Tfh cells to other CD41 T-cell lineages,and the role of Tfh cells in health and disease. | Roza I Nurieva Yeonseok Chung | 2010 | Cellular & Molecular Immunology2010，7，3： | 18 |
| 3 | A critical regulation of Th2 cell responses by RORa in allergic asthma显示文摘Allergic asthma is a chronic inflammatory disease of the lung and the airway,which is characterized by aberrant type 2 immune responses to otherwise unharmful aeroallergens.While the central role of Th2 cells and type 2 cytokines in the pathogenesis of allergic asthma is well documented,the regulation and plasticity of Th2 cells remain incompletely understood.By using an animal model of allergic asthma in IL-4-reporter mice,we found that Th2 cells in the lung expressed higher levels of Rora than those in the lymph nodes,and that treatment with an RORa agonist SRI 078 resulted in diminished Th2 cell responses in vivo.To determine the T cell-intrinsic role of RORa in allergic asthma in vivo,we established T cell-specific RORa-deficient^(f/f)fyf(Cd4creRora^(f/f))mice.Upon intranasal allergen challenges,Cd4creRora^(f/f)mice exhibited a significantly increased Th2 cells in the lungs and the airway and showed an enhanced eosinophilic inflammation compared to littermate control mice.Studies with Foxp3^(YFP-cre)Rora^(f/f)mice and CD^(8+)T cell depletion showed that the increased Th2 cell responses in the Cd4creRora^(f/f)mice were independent of Treg cells and CD^(8+)T cells.Our findings demonstrate a critical regulatory role of RORa in Th2 cells,which suggest that RORa agonists could be effective for the treatment of allergic diseases. | Jeong-Eun Lee Garam Cho Minkyoung Cho Daehong Kim Mi-Ock Lee Yeonseok Chung | 2021 | Science China(Life Sciences)2021，64，8： | 5 |
| 4 | T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ显示文摘 | Xuexian O. Yang Bhanu P. Pappu Roza Nurieva Askar Akimzhanov Hong Soon Kang Yeonseok Chung Li Ma Bhavin Shah Athanasia D. Panopoulos Kimberly S. Schluns Stephanie S. Watowich Qiang Tian Anton M. Jetten Chen Dong | 2008 | Immunity2008，，1： | 3 |
| 5 | Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation显示文摘 | Reynolds JM Martinez GJ Yeonseok C | 2012 | Proe Natl Acad Sci USA2012，109，13： | 1 |
| 6 | T helper 17 cells promote cytotoxic T cell activation in tumor immunity 显示文摘 | Natalia Martin-Orozco Pawel Muranski Yeonseok Chung | 2009 | Immunity2009，31，5： | 1 |
| 7 | Thl7 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Thl cells显示文摘 | Natalia MO Yeonseok C Seon Hee C | 2009 | Enr J Immunol2009，216，39： | 1 |
| 8 | 肠上皮的营养感知通过Hes1的翻译调控协调粘膜抗菌防御显示文摘文章简介近年来许多研究发现,经典免疫细胞如T细胞和巨噬细胞能够整合多种营养介导的分子信号来调控细胞代谢,进而影响免疫功能。肠道上皮细胞作为肠道免疫防御系统的第一道防线,在抵抗肠道病原菌感染过程中发挥了重要作用。在生物体内,胃肠道最先感知营养波动,其中位于肠腔侧的单层肠道上皮细胞尤为关键。 | Shaonan Liang Xue-Kun Guo Jiayao Ou Rongyao Huang Qing Xue Bin Zhang Yeonseok Chung Wei Wu Chen Dong Xuerui Yang 胡小玉 | 2020 | 科学新闻2020，，2： | 0 |
| 9 | Removal of non-point pollutants from bridge runoff by a hydrocyclone using natural water head显示文摘 | Jianghua YU Yeonseok KIM Youngchul KIM | 2013 | Frontiers of Environmental Science & Engineering2013，7，6： | 0 |
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