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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 4 | 食管和贲门癌前病变癌基因c-erbB_2、c-myc和cyclin D_1的表达研究显示文摘为了解食管和贲门癌变的分子生物学发生基础,采用免疫组化技术测定人食管和贲门正常上皮和癌前病变组织的癌基因蛋白c-erbB2,c-myc和cyclinD1的表达状况。研究对象来自食管癌高发区河南辉县。结果:在食管,未观察到c-erbB2的阳性表达(0/54);而c-myc和cyclinD1的阳性表达率分别为25%(6/24)和82%(94/115)。贲门上皮c-erbB2和c-myc的阳性表达率分别为73%(16/26)和78%(31/40),均明显高于食管组织的表达。贲门组织cyclinD1的阳性表达率为78%(31/40),但是,随着贲门上皮病变加重,cyclinD1的阳性表达率呈现下降趋势。提示同一地区食管和贲门癌前病变发生存在不同的分子学改变;食管和贲门癌变的不同阶段可能由多种癌基因参与作用;c-erbB2可能是贲门癌变的重要分子学变化。 | 王立东 周琦 李永欣 邢莹 刘保池 裘宋良 Susan Goldstein Stephenie T Shi Jun Y.Hong Chung S.Yang | 1995 | 河南医科大学学报1995，30，2： | 7 |
| 5 | Oxygen Atom Exchange Mechanism in Reaction of OH Radical with AsO显示文摘Oxygen atom exchange reaction mechanism in the reaction of OH radicals with AsO was investigated by means of the density functional theory (DFT) with 6 311++G( 3df,3pd ) and 6 311++G( d,p ) basis sets. The calculated results suggest that the reaction between OH and AsO should make the oxygen atoms exchange rapidly because the barrier to isomerization is significantly less than the HO-AsO bond dissociation energy. | CHI Yu-juan 1, YU Hai tao 1,2** , FU Hong gang 1,2 HUANG Xu ri 2, LI Ze sheng 2 and SUN Chia chung 21. College of Chemistry and Chemical Engineering, Heilongjiang University, Harbin 150080, P. R. China 2. State Key Laboratory of T | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 6 | 根治性切缘状态在接受完整结肠系膜切除术治疗的结肠癌患者中的预后价值显示文摘目的:与直肠癌的环周切缘(CRM)相比,根治性切缘(Ra?dial Margin)可能是结肠癌的潜在预后影响因素。目前尚无关于在完整结肠系膜切除术(CME)理念下探索根治性切缘对预后影响的研究。本研究旨在探索在CME治疗结肠癌前提下,根治性切缘状态对肿瘤结局的影响。方法:基于Severance医院的前瞻性结直肠癌登记系统数据,回顾性分析从2010年10月至2013年3月接受根治性切除的Ⅰ~Ⅲ期结肠癌患者资料。共834例接受CME的连续性结肠腺癌患者纳入本研究。根据根治性切缘距离将患者分为3组:A组,根治性切缘≥2 mm;B组,1 mm≤根治性切缘<2 mm;C组,根治性切缘<1 mm。比较各组的总生存期和无病生存期。 | 王枭杰 LEE J M CHUNG T KIM K M | 2020 | 结直肠肛门外科2020，26，2： | 3 |
| 7 | Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage显示文摘Anabolic steroid abuse is common among athletes and is associated with a number of medical complications. We describe a case of a 27-year-old male bodybuilder with multiple hepatic adenomas induced by anabolic steroids. He initially presented with tumor hemorrhage and was treated with left lateral hepatic segmentectomy. Regression of the remaining tumors was observed with cessation of steroid use. However, 3 years and a half after his initial hepatic segmentectomy, he presented with recurrent tumor enlargement and intraperitoneal hemorrhage in the setting of steroid abuse relapse. Given his limited hepatic reserve, he was conservatively managed with embolization of the right accessory hepatic artery. This is the first reported case of hepatic adenoma re- growth with recidivistic steroid abuse, complicated by life-threatening hemorrhage. While athletes and bodybuilders are often aware of the legal and social ramifications of steroid abuse, they should continue to be counseled about its serious medical risks. | Nicole M Martin Barham K Abu Dayyeh Raymond T Chung | 2008 | World Journal of Gastroenterology2008，14，28： | 3 |
| 8 | Hospital readmissions in decompensated cirrhotics: Factors pointing toward a prevention strategy显示文摘AIM To reduce readmissions and improve patient outcomes in cirrhotic patients through better understanding of readmission predictors.METHODS We performed a single-center retrospective study of patients admitted with decompensated cirrhosis from January 1, 2011 to December 31, 2013(n = 222). Primary outcomes were time to first readmission and 30-d readmission rate due to complications of cirrhosis. Clinical and demographic data were collected to help describe predictors of readmission, along with care coordination measures such as post-discharge status and outpatient follow-up. Univariate and multivariateanalyses were performed to describe variables associated with readmission.RESULTS One hundred thirty-two patients(59.4%) were readmitted at least once during the study period. Median time to first and second readmissions were 54 and 93 d, respectively. Thirty and 90-d readmission rates were 20.7 and 30.1 percent, respectively. Predictors of 30-d readmission included education level, hepatic encephalopathy at index, ALT more than upper normal limit and Medicare coverage. There were no statistically significant differences in readmission rates when stratified by discharge disposition, outpatient follow-up provider or time to first outpatient visit.CONCLUSION Readmissions are challenging aspect of care for cirrhotic patients and risk continues beyond 30 d. More initiatives are needed to develop enhanced, longitudinal post-discharge systems. | Siamak M Seraj Emily J Campbell Sarah K Argyropoulos Kara Wegermann Raymond T Chung James M Richter | 2017 | World Journal of Gastroenterology2017，23，37： | 3 |
| 9 | Angiotensin receptors 显示文摘 | Unger T Chung O Csikos T | 1996 | J Hypertens1996，14，5： | 2 |
| 10 | Normal maturing distal tibia and fibula: changes with age at MR imaging显示文摘 | Chung T Jaramillo D | 1995 | Radiology1995，194，1： | 2 |
| 11 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 12 | Gas separation performance of poly ( 4-vinylpyridine )/ polyetherimide composite hollow fibers 显示文摘 | SHIEH J J CHUNG T S WANG Rong | 2001 | Journal of Membrane Science2001，，182： | 1 |
| 13 | Excited - state properties of dioxorhenium(V) generation and reactivity of dioxorhenium(Ⅵ) 显示文摘 | Che C M Chung W C Lai T F | 1989 | Inorg Chem1989，28，： | 1 |
| 14 | Analysis of sum-product decoding of low-density parity-check codes using a Gaussian approximation 显示文摘 | CHUNG S Y RICHARDSON T J URBANKE R L | 2001 | IEEE Transaction on Information Theory2001，47，2： | 1 |
| 15 | Degrees of freedom in adaptive modulation: a unified view显示文摘 | Chung S T and Goldsmith A J | 2001 | IEEE Transactions on Communication2001，49，9： | 1 |
| 16 | Angiotensin receptors显示文摘 | Chung O Csikos T | 1996 | J Hypertens1996，14，5： | 1 |
| 17 | Anionic ring-o- pening Alternating eopolymerization of bicyclic and spirocyclic Bis-laetone with epoxides via a tandem double ring-opening isomerization Of the bislactones 显示文摘 | Takata T Tadokoro A Chung K | 1995 | Macromolecules1995，28，： | 1 |
| 18 | Transvaginal sonography and theconservative management of spontaneous abortion 显示文摘 | Haines C J Chung T Leung DY | 1994 | Gyneeol Obstet Invest1994，37，1： | 1 |
| 19 | Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development显示文摘 | Chung IH Yamaza T Zhao H | 2009 | Stem Cells2009，27，4： | 1 |
| 20 | Direct numerical simulation of a three-dimensional temporal mixing layer with particle dispersion显示文摘 | Ling W Chung J N Troutt T R | 1998 | J Fluid Mech1998，358，： | 1 |
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