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| 1 | 克罗恩病:CT小肠成像、MR小肠成像和小肠灌肠造影的比较显示文摘目的前瞻性比较CT和MR小肠成像及小肠灌肠造影3种检查方法发现克罗恩病病人活动性小肠炎症和肠外并发症的准确性。方法机构伦理审查委员会批准本研究计划,并所有参与者知情同意。对连续31例克罗恩病或疑有克罗恩病的病人行CT和MR小肠成像、小肠灌肠造影和回肠结肠镜检查。2位独立的阅片者回顾CT和MR小肠成像及小肠灌肠造影影像以确定活动性末端回肠炎和肠道外并发症的存在。以回结肠镜检查结果作为参考标准,利用受试者工作特性曲线方法来评估CT和MR小肠成像及小肠灌肠造影确定活动性末端回肠炎的准确度。 | S.S. Lee A.Y. Kim S.K. Yang J. W. Chung S.Y. Kim S.H. Park 孙东辉(译) 万业达(校) | 2009 | 国际医学放射学杂志2009，32，4： | 57 |
| 2 | Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line显示文摘瞄准:与它行动的分子的机制调查在小檗硷和 apoptotic 小径的禁止的生长(细胞毒素的活动) 之间的关系。方法:在试管内细胞毒素的技术被房间周期分析和 sub-G1 的决心在人的胃的癌 SNU-5 房间为 apoptosis 补充。可行房间,房间周期,和 sub-G1 组(apoptosis ) 的百分比被流动 cytometric 方法检验并且决定。为房间周期拘捕和 apoptosis 的联系蛋白质被西方的弄污检验。结果:为 SNU-5 房间线, IC50 被发现是小檗硷的 48 micromol/L。在与 25-200 micromol/L 小檗硷对待的 SNU-5 房间, G2/M 房间周期拘捕被观察它与 p53, Wee1 和 CDk1 蛋白质和减少的 cyclin 的表示的显著增长被联系 B。在 G0/G1 阶段的房间和 G2/M 阶段的增加的集中依赖者减少被检测。另外,当在房间周期测量的 sub-G0 房间人口被监视 apoptotic 小径在 25-200 micromol/L 证明对待 berberine 的房间, apoptosis 检测了。 Apoptosis 被 sub-G0 房间人口识别,并且在 Bcl-2 的规定下面,Ca2+在 Bax 的规定上面释放,减少 mitochondrial 膜电位然后导致了 mitochondrial 细胞色素 C 的版本进细胞质并且引起了 caspase-3 的激活,并且最后导致了 apoptosis 的出现。结论:小檗硷导致 p53 表示并且为 apoptosis 的正式就职导致 mitochondrial 膜电位,细胞色素 C 版本和 caspase-3 的激活的减少。 | Jing-Pin Lin Jai-Sing Yang Jau-Hong Lee Wen-Tsong Hsieh Jing-Gung Chung | 2006 | World Journal of Gastroenterology2006，12，1： | 34 |
| 3 | 茶黄素双没食子酸酯的抗癌活性及其作用机理研究显示文摘以SephadexLH-20柱色谱分离得到茶黄素双没食子酸酯(TFDG)成分,以H1299和HCT-116细胞分析了该成分的抗癌活性及其作用机理。结果表明,TFDG具有良好的抑制H1299细胞生长的活性,IC50为25μmol/L;有调节细胞周期的活性,可增加HCT-116细胞G1期细胞的比例;有促进HCT-116细胞凋亡的作用,浓度为50μmol/L时效果显著,48h凋亡率达到40%以上;Western杂交技术分析结果表明,它可降低HCT-116细胞中促癌蛋白质因子Bcl-xL的表达量,可增加抑癌蛋白质因子Bax的表达量。 | 江和源 Hang Xiao 袁新跃 王川丕 Chung S Yang | 2007 | 茶叶科学2007，27，1： | 25 |
| 4 | Expression and regulation of IL-22 in the IL-17.producing CD4+T lymphocytes显示文摘IL-22 是在工作对感染支持纸巾的天生的免疫的 IL-10 家庭的新奇 cytokine。尽管 CD4+ 助手 T 淋巴细胞(TH ) 作为 IL-22 的来源被发现,这 cytokine 的规定糟糕被理解。这里,我们证明 IL-22 被也做 IL-17 的 TH 房间的一个新奇子集在 mRNA 和蛋白质层次表示。IL-22 和 IL-17 被发现被即时 PCR 以及 ELISA 分析被 TGFbeta 和 IL-6 并列地在 TH 区别期间调整。然而, IL-22 不调整 TH 区别;外长的 IL-22 或一个 IL-22 对手没在 TH 区别上有效果。这些数据表明 IL-17-producing T 房间表示的新奇 cytokine,并且建议在组织发炎和自体免疫的疾病表明小径的 IL-22 和 IL-17 的相互作用和协同作用。 | Yeonseok Chung Xuexian Yang Seon Hee Chang Li Ma Qiang Tian Chen Dong | 2006 | Cell Research2006，16，11： | 20 |
| 5 | Effect of Deformation Temperature on Microstructure and Mechanical Properties of AZ31 Mg Alloy Processed by Differential-Speed Rolling显示文摘A differential-speed rolling(DSR) was applied to AZ31 magnesium alloy sample at different rolling temperatures of 473,523,573,and 623 K with 1-pass and 2-pass operations.The microstructural evolution and mechanical properties of the deformed samples were investigated.The rolling temperature was found to be an important parameter affecting the microstructural development.After DSR at 473 K,the microstructure was more homogeneous than that obtained after deformation by equal-speed rolling(ESR).The fully recrystallized microstructures were generated after DSR at 573 and 623 K.As to mechanical properties,the yield strength(YS) and ultimate tensile strength(UTS) decreased monotonously with increasing rolling temperature.In contrast,the elongation of the DSR-deformed samples was improved as the rolling temperature increased.The strain hardening exponent(n) calculated by Hollomon equation increased with increasing the rolling temperature,which would explain an increase in the uniform elongation. | Mosab Kaseem Bong Kwon Chung Hae Woong Yang Kotiba Hamad Young Gun Ko | 2015 | Journal of Materials Science & Technology2015，31，5： | 19 |
| 6 | The association of benign prostatic hyperplasia with lower urinary tract stones in adult men: A retrospective multicenter study显示文摘Objective:To examine the relationship between benign prostatic hyperplasia(BPH)and the presence of lower urinary tract stones.Methods:We retrospectively reviewed the records of men with lower urinary tract stones who presented to three clinical centers in Korea over a 4-year period.We divided the patients into two groups based on the location of urinary stones:Group 1(bladder calculi)and Group 2(urethral calculi).We compared the characteristics of both groups and performed univariate and multivariate analyses with a logistic regression model to investigate the relationship between BPH and lower urinary tract stones.Results:Of 221 patients,194(87.8%)had bladder calculi and 27(12.2%)had urethral calculi.The mean age of Group 1 was higher than that of Group 2(68.9612.11 years vs.55.7414.20 years,p<0.001).The mean prostate volume of Group 1 was higher than that of Group 2(44.4727.14 mL vs.24.706.41 mL,respectively,p<0.001).Multivariate logistic regression showed that age(OR Z 1.075,95%CI:1.023e1.129)and prostate volume(OR Z 1.069,95%CI:1.017e1.123)were independently associated with increased risk for bladder calculi.Upper urinary tract stones and/or hydronephrosis conferred a 3-fold risk for urethral calculi(OR Z 3.468,95%CI:1.093e10.999).Conclusion:Age and prostate volume are independent risk factors for bladder calculi.In addition,men with upper urinary tract disease are at greater risk for urethral calculi,which may migrate from the upper urinary tract rather than from the bladder. | Jae Hung Jung Jinsung Park Won Tae Kim Hong Wook Kim Hyung Joon Kim Sungwoo Hong Hee Jo Yang Hong Chung | 2018 | Asian Journal of Urology2018，5，2： | 17 |
| 7 | Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey显示文摘AIM: To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire.RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis.CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. | Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon | 2009 | World Journal of Gastroenterology2009，15，1： | 15 |
| 8 | Effects of Saccharomyces cerevisiae fermentation products on performance and rumen fermentation and microbiota in dairy cows fed a diet containing low quality forage显示文摘Background: A possible option to meet the increased demand of forage for dairy industry is to use the agricultural byproducts, such as corn stover. However, nutritional value of crop residues is low and we have been seeking technologies to improve the value. A feeding trial was performed to evaluate the effects of four levels of Saccharomyces cerevisiae fermentation product(SCFP; Original XP; Diamond V) on lactation performance and rumen fermentation in mid-lactation Holstein dairy cows fed a diet containing low-quality forage. Eighty dairy cows were randomly assigned into one of four treatments: basal diet supplemented with 0, 60, 120, or 180 g/d of SCFP per head mixed with 180, 120, 60, or 0 g of corn meal, respectively. The experiment lasted for 10 wks, with the first 2 weeks for adaptation.Results: Dry matter intake was found to be similar(P > 0.05) among the treatments. There was an increasing trend in milk production(linear, P ≤ 0.10) with the increasing level of SCFP supplementation, with no effects on contents of milk components(P > 0.05). Supplementation of SCFP linearly increased(P < 0.05) the N conversion, without affecting rumen pH and ammonia-N(P > 0.05). Increasing level of SCFP linearly increased(P < 0.05) concentrations of ruminal total volatile fatty acids, acetate, propionate, and butyrate, with no difference in molar proportion of individual acids(P > 0.05). The population of fungi and certain cel ulolytic bacteria(Ruminococcus albus, R. flavefaciens and Fibrobacter succinogenes)increased linearly(P < 0.05) but those of lactate-utilizing(Selenomonas ruminantium and Megasphaera elsdeni) and lactate-producing bacteria(Streptococcus bovis) decreased linearly(P ≤ 0.01) with increasing level of SCFP. The urinary purine derivatives increased linearly(P < 0.05) in response to SCFP supplementation, indicating that SCFP supplementation may benefit for microbial protein synthesis in the rumen.Conclusions: The SCFP supplementation was effective in maintaining milk persistency of mid-lactation cows receiving diets containing low-quality forage. The beneficial effect of SCFP could be attributed to improved rumen function; 1)microbial population shift toward greater rumen fermentation efficiency indicated by higher rumen fungi and cel ulolytic bacteria and lower lactate producing bacteria, and 2) rumen microbial fermentation toward greater supply of energy and protein indicated by greater ruminal VFA concentration and increased N conversion. Effects of SCFP were dose-depended and greater effects being observed with higher levels of supplementation and the effect was more noticeable during the high THI environment. | Wen Zhu Zihai Wei Ningning Xu Fan Yang Ilkyu Yoon Yihua Chung Jianxin Liu Jiakun Wang | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 13 |
| 9 | Intravoxel incoherent motion diffusion-weighted imaging for monitoring chemotherapeutic efficacy in gastric cancer显示文摘AIM: To assess intravoxel incoherent motion diffusionweighted imaging(IVIM-DWI) for monitoring early efficacy of chemotherapy in a human gastric cancer mouse model.METHODS: IVIM-DWI was performed with 12 b-values(0-800 s/mm2) in 25 human gastric cancer-bearing nude mice at baseline(day 0), and then they were randomly divided into control and 1-, 3-, 5- and 7-d treatment groups(n = 5 per group). The control group underwent longitudinal MRI scans at days 1, 3, 5 and 7, and the treatment groups underwent subsequent MRI scans after a specified 5-fluorouracil/calciumfolinate treatment. Together with tumor volumes(TV), the apparent diffusion coefficient(ADC) and IVIM parameters [true water molecular diffusion coefficient(D), perfusion fraction(f) and pseudo-related diffusion coefficient(D*)] were measured. The differences in those parameters from baseline to each measurement(ΔTV%, ΔADC%, ΔD%, Δf% and ΔD*%) were calculated. After image acquisition, tumor necrosis, microvessel density(MVD) and cellular apoptosis were evaluated by hematoxylin-eosin(HE), CD31 and terminal-deoxynucleotidyl transferase mediated nick end labeling(TUNEL) staining respectively, to confirm the imaging findings. Mann-Whitney test and Spearman's correlation coefficient analysis were performed.RESULTS: The observed relative volume increase(ΔTV%) in the treatment group were significantly smaller than those in the control group at day 5(ΔTV_(treatment)% = 19.63% ± 3.01% and ΔTVcontrol% = 83.60% ± 14.87%, P = 0.008) and day 7(ΔTV_(treatment)% = 29.07% ± 10.01% and ΔTV_(control)% = 177.06% ± 63.00%, P = 0.008). The difference in ΔTV% between the treatment and the control groups was not significant at days 1 and 3 after a short duration of treatment. Increases in ADC in the treatment group(ΔADC%_(treatment), median, 30.10% ± 18.32%, 36.11% ± 21.82%, 45.22% ± 24.36%) were significantly higher compared with the control group(ΔADC%_(control), median, 4.98% ± 3.39%, 6.26% ± 3.08%, 9.24% ± 6.33%) at days 3, 5 and 7(P = 0.008, P = 0.016, P = 0.008, respectively). Increases in D in the treatment group(ΔD%_(treatment), median 17.12% ± 8.20%, 24.16% ± 16.87%, 38.54% ± 19.36%) were higher than those in the control group(ΔD%_(control), median-0.13% ± 4.23%, 5.89% ± 4.56%, 5.54% ± 4.44%) at days 1, 3, and 5(P = 0.032, P = 0.008, P = 0.016, respectively). Relative changes in f were significantly lower in the treatment group compared with the control group at days 1, 3, 5 and 7 follow-up(median,-34.13% ± 16.61% vs 1.68% ± 3.40%, P = 0.016;-50.64% ± 6.82% vs 3.01% ± 6.50%, P = 0.008;-49.93% ± 6.05% vs 0.97% ± 4.38%, P = 0.008, and-46.22% ± 7.75% vs 8.14% ± 6.75%, P = 0.008, respectively). D* in the treatment group decreased significantly compared to those in the control group at all time points(median,-32.10% ± 12.22% vs 1.85% ± 5.54%, P = 0.008;-44.14% ± 14.83% vs 2.29% ± 10.38%, P = 0.008;-59.06% ± 19.10% vs 3.86% ± 5.10%, P = 0.008 and-47.20% ± 20.48% vs 7.13% ± 9.88%, P = 0.016, respectively). Furthermore, histopathologic findings showed positive correlations with ADC and D and tumor necrosis(r_s = 0.720, P < 0.001; r_s = 0.522, P = 0.007, respectively). The cellular apoptosis of the tumor also showed positive correlations with ADC and D(r_s = 0.626, P = 0.001; r_s = 0.542, P = 0.005, respectively). Perfusionrelated parameters(f and D*) were positively correlated to MVD(r_s = 0.618, P = 0.001; r_s = 0.538, P = 0.006, respectively), and negatively correlated to cellular apoptosis of the tumor(r_s =-0.550, P = 0.004; r_s =-0.692, P < 0.001, respectively).CONCLUSION: IVIM-DWI is potentially useful for predicting the early efficacy of chemotherapy in a human gastric cancer mouse model. | Xiao-Li Song Heoung Keun Kang Gwang Woo Jeong Kyu Youn Ahn Yong Yeon Jeong Yang Joon Kang Hye Jung Cho Chung Man Moon | 2016 | World Journal of Gastroenterology2016，22，24： | 12 |
| 10 | Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up显示文摘AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities.METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed.RESULTS: Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori(H pylori) regimen only. The duration to reach complete remission was 12 months (85 percentile, 2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases.CONCLUSION: Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloninfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication. | Sang Kil Lee Yong Chan Lee Jae Bock Chung Chae Yoon Chon Young Myoung Moon Jin Kyung Kang In-Suh Park Chang Ok Suh Woo Ik Yang | 2004 | World Journal of Gastroenterology2004，10，2： | 12 |
| 11 | Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats显示文摘人的良性的 prostatic 增生可能从雌激素 / 雄激素(E/T ) 产生,这被知道不平衡。我们学习了阉割的老鼠前列腺的反应到传播 E/T 的不同比率。阉割的男 Wistar 老鼠随机在不同比率与 E/T 被注射 4 个星期。染色的 prostatic 索引, hematoxylin 和曙红给不同 prostatic 增生回答看的 E/T (1:100 ) 组的前列腺,和光滑的肌肉肌动朊(SMA ) 的量的 immunohistochemical 分析。在这个组,为 Vimentin 积极的房间,非肌肉肌浆球蛋白重链(NMMHC ) 和原子抗原(PCNA ) 在基质和上皮增加了的增殖的房间。而且, mRNA 光滑的肌肉肌浆球蛋白铺平重链(SMMHC ) 和增加的 NMMHC。在 1:100 的比率的 E/T 能因此导致 stromal 在阉割的老鼠的前列腺的增生的反应。观察的主要变化是光滑的肌肉房间的增加,而一些上皮的变化也在老鼠前列腺被看见。 | Ying Zhou Xiang-Qian Xiao Lin-Feng Chen Rui Yang Jian-Dang Shi Xiao-Ling Du Helmut Klocker Irwin Park Chung Lee Ju Zhang | 2009 | Asian Journal of Andrology2009，11，4： | 10 |
| 12 | Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na^+/K^+- ATPase显示文摘 | Ronald JY CHEN Tse-yu CHUNG Feng-yin LI Wei-hung YANG Tzyy-rong JINN Jason TC TZEN | 2010 | Acta Pharmacologica Sinica2010，31，6： | 10 |
| 13 | RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement显示文摘The bone remodeling process in response to orthodontic forces requires the activity of osteoclasts to allow teeth to move in the direction of the force applied. Receptor activator of nuclear factor-κB ligand(RANKL) is essential for this process although its cellular source in response to orthodontic forces has not been determined. Orthodontic tooth movement is considered to be an aseptic inflammatory process that is stimulated by leukocytes including T and B lymphocytes which are presumed to stimulate bone resorption. We determined whether periodontal ligament and bone lining cells were an essential source of RANKL by tamoxifen induced deletion of RANKL in which Cre recombinase was driven by a 3.2 kb reporter element of the Col1α1 gene in experimental mice(Col1α1.CreER^(TM+).RANKL^(f/f)) and compared results with littermate controls(Col1α1.CreER^(TM-).RANKL^(f/f)). By examination of Col1α1.CreER^(TM+).ROSA26 reporter mice we showed tissue specificity of tamoxifen induced Cre recombinase predominantly in the periodontal ligament and bone lining cells. Surprisingly we found that most of the orthodontic tooth movement and formation of osteoclasts was blocked in the experimental mice, which also had a reduced periodontal ligament space. Thus, we demonstrate for the first time that RANKL produced by periodontal ligament and bone lining cells provide the major driving force for tooth movement and osteoclastogenesis in response to orthodontic forces. | Chia-Ying Yang Hyeran Helen Jeon Ahmed Alshabab Yu Jin Lee Chun-Hsi Chung Dana T. Graves | 2018 | International Journal of Oral Science2018，10，1： | 10 |
| 14 | A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma显示文摘AIM: To explore the expression pattern of E2F5 in primary hepatocellular carcinomas (HCCs) and elucidate the roles of E2F5 in hepatocarcinogenesis. METHODS: E2F5 expression was analyzed in 120 primary HCCs and 29 normal liver tissues by immunohistochemistry analysis. E2F5-small interfering RNA was transfected into HepG2, an E2F5-overexpressed HCC cell line. After E2F5 knockdown, cell growth capacity and migrating potential were examined. RESULTS: E2F5 was significantly overexpressed in primary HCCs compared with normal liver tissues (P = 0.008). The E2F5-silenced cells showed significantly reduced proliferation (P = 0.004). On the colony formation and soft agar assays, the number of colonies was significantly reduced in E2F5-silenced cells (P = 0.004 and P = 0.009, respectively). E2F5 knockdown resulted in the accumulation of G0/G1 phase cells and a reduction of S phase cells. The number of migrating/invading cells was also reduced after E2F5 knockdown (P = 0.021). CONCLUSION: To our knowledge, this is the first evidence that E2F5 is commonly overexpressed in primary HCC and that E2F5 knockdown significantly repressed the growth of HCC cells. | Yuzhu Jiang Seon-Hee Yim Hai-Dong Xu Seung-Hyun Jung So Young Yang Hae-Jin Hu Chan-Kwon Jung Yeun-Jun Chung | 2011 | World Journal of Gastroenterology2011，17，4： | 10 |
| 15 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet2012，，9813： | 10 |
| 16 | Methylprednisolone Inhibits the Expression of Glial Fibrillary Acidic Protein and Chondroitin Sulfate Proteoglycans in Reactivated Astrocytes显示文摘创伤后的神经胶质增生导致硫酸软骨素蛋白聚糖(CSPG)的显著表达,从而抑制轴突生长和再生。甲基强地松龙(MP),一种合成的糖皮质激素,在急性脊髓损伤(SCI)的治疗中有神经保护作用和抗炎效应。但是,MP对于CSPG在活性胶质细胞中的表达的作用尚不清楚。本文用a-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯(AM-PA)诱导星形胶质细胞再活化,用环噻嗪模拟SCI的兴奋性中毒刺激。AMPA治疗后,星形胶质细胞再活化的标志物-胶质纤维酸性蛋白(GFAP)、CSPG神经聚糖和磷酸盐的表达都显著上调。AMPA治疗星形胶质细胞的条件培养液强烈抑制大鼠背根神经节中神经元的轴突生长,但这种作用能被MP的预处理所逆转。此外,MP下调成年SCI大鼠中GFAP和CSPG的表达,对抗RU486的糖皮质激素受体(GR)和GR si RNA能逆转MP对GFAP和神经聚糖表达的抑制作用。这些结果提示,MP能在兴奋性中毒损伤后通过GR介导的星形胶质细胞再活化下调和GSPG表达抑制来改善神经修复,促进轴突生长。 | WEI-LIN LIU YI-HSUAN LEE SHIH-YING TSAI CHUNG YI HSU YU-YO SUN LIANG-YO YANG SHING-HAN TSAI AND WEI-CHUNG VIVIAN YANG | 2008 | 神经损伤与功能重建2008，3，5： | 9 |
| 17 | Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy:A prospective randomized,multicenter study显示文摘AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. RESULTS:A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall,bleeding complications occurred in 7.6% (37/486) of the patients,including 4.9% (12/244) in the epinephrine group,and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients,respectively,including 4.5% (11/244),0.4% (1/244) in the epinephrine group,and 8.7% (21/242),1.7% (4/242) in the saline group. No significant differences in the rates of overall,early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Won-Ho Kim Hyun-Soo Kim Dong-IL Park Hyo-Jong Kim Jeong-Sik Byeon Suk-Kyun Yang Byeong Ik Jang Sung-Ae Jung Yoon-Tae Jeen Jai-Hyun Choi Hwang Choi Dong-Soo Han Jae Suk Song | 2007 | World Journal of Gastroenterology2007，13，21： | 9 |
| 18 | 茶对人体健康的作用显示文摘茶是最流行的饮料,全世界每年生产和消费300万t茶叶。历史上茶叶曾被当作治病的药物,当今人们主要对其可以预防各种疾病的功效感兴趣。茶叶有效成分可能存在的保健作用以前已做过调查和研究,并有专门论述。本文就日前已知的有关茶及其保健作用的科研情况作一综述。 | Chung S. Yang Joshua Lambert 江和源 Mousumi Bose 桑圣民 翁蔚(译) | 2006 | 中国茶叶2006，28，5： | 9 |
| 19 | Active ingredients in Chinese medicines promoting blood circulation as Na+/K+-ATPase inhibitors显示文摘心脏的 glycosides 的积极 inotropic 效果在人的心肌层在膜界限 Na+/K+-ATPase 上躺在他们的可逆抑制。包含类似于心脏的 glycosides 的核心结构的像类固醇的混合物在通常使用支持血循环的许多中国药被发现。他们中的一些被表明是 Na+/K+-ATPase 禁止者并且这样为他们经由象心脏的 glycosides 的一样的分子的机制的治疗学的效果通常认为地负责。在另一方面, danshen 的镁 lithospermate B 也被建议由有效地禁止 Na+/K+-ATPase 施加它的心脏的治疗学的效果。理论建模建议氢契约的数字和在在 Na+/K+-ATPase 的有约束力的衣袋附近的各种各样的药和残余的有效成分之间的恐水病的相互作用的力量为这些活跃成分的禁止的力量是关键的。人参皂甙,在人参和 sanqi 的活跃成分,当糖一半仅仅被纳入他们的像类固醇的结构的 C-3 位置时,实质地禁止 Na+/K+-ATPase,等价于在心脏的 glycosides 的糖位置。然而,当糖一半被连接到 C-6 或类固醇原子核的 C-20 位置时,他们的禁止的力量被废除;大概,这些糖附件为人参皂甙的入口导致位的阻碍者进 Na+/K+-ATPase 的有约束力的衣袋。心脏的 glycosides,几像类固醇的混合物,和对 ischemic 击的镁 lithospermate B 的 Neuroprotective 效果是因此在一个外皮的大脑观察到基于片的试金模型,和累积数据支持那在大脑的 Na+/K+-ATPase 的有效禁止者能是为 ischemic 的治疗的潜在的药中风。 | Ronald JY CHEN Tzyy-rong JINN Yi-ching CHEN Tse-yu CHUNG Wei-hung YANG Jason TC TZEN | 2011 | Acta Pharmacologica Sinica2011，32，2： | 8 |
| 20 | Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy显示文摘Dendritic cell(DC)-based vaccines continue to be considered an attractive tool for cancer immunotherapy.DCs require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1(Th1)or Th2 responses.DCs play a role in natural killer(NK)cell activation,and NK cells are also able to activate and induce the maturation of DCs.We investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions occur.DCs that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce IL-12p70.NK cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte responses.Our data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses,which suggests that these cells may be useful for cancer immunotherapy. | Thanh-Nhan Nguyen-Pham Deok-Hwan Yang Truc-Anh Thi Nguyen Mi-Seon Lim Cheol Yi Hong Mi-Hyun Kim Hyun Ju Lee Youn-Kyung Lee Duck Cho Soo-Young Bae Jae-Sook Ahn Yeo-Kyeoung Kim Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee | 2012 | Cellular & Molecular Immunology2012，9，1： | 8 |
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