|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhanced bio hydrogen production from sweet sorghum stalk with alkalization pretreatment by mixed anaerobic eultures显示文摘 | SHI Xingxing SONG Hongchuan WANG Chunren | 2010 | International Journal of Energy Research2010，34，8： | 1 |
| 2 | A Study of Wind Statistics Through Auto-Regressive and Moving-Average (ARMA) Modeling显示文摘Statistical properties of winds near the Taichung Harbour are investigated. The 26 years′incomplete data of wind speeds, measured on an hourly basis, are used as reference. The possibility of imputation using simulated results of the Auto-Regressive (AR), Moving-Average (MA), and/or Auto-Regressive and Moving-Average (ARMA) models is studied. Predictions of the 25-year extreme wind speeds based upon the augmented data are compared with the original series. Based upon the results, predictions of the 50- and 100-year extreme wind speeds are then made. | John Z.YIM(尹彰) ChunRen CHOU(周宗仁) | 2001 | China Ocean Engineering2001，16，1： | 1 |
| 3 | In vitro genotoxicity evaluation and metabolic study of residual glutaraldehyde in animal-derived biomaterials显示文摘Glutaraldehyde(GA)is an important additive that is mainly used in animal-derived biomaterials to improve their mechanical and antimicrobial capacities.However,GA chemical toxicity and the metabolic mechanism remain relatively unknown.Therefore,residual GA has always been a major health risk consideration for animal-derived medical devices.In this study,extracts of three biopatches were tested via the GA determination test and mouse lymphoma assay(MLA).The results showed that dissolved GA was a potential mutagen,which could induce significant cytotoxic and mutagenic effects in mouse lymphoma cells.These toxic reactions were relieved by the S9 metabolic activation(MA)system.Furthermore,we confirmed that GA concentration decreased and glutaric acid was generated during the catalytic process.We revealed GA could be oxidized via cytochrome P450 which was the main metabolic factor of S9.We found that even though GA was possibly responsible for positive reactions of animal-derived biomaterials’biocompatibility evaluation,it may not represent the real situation occurring in human bodies,owing to the presence of various detoxification mechanisms including the S9 system.Overall,in order to achieve a general balance between risk management and practical application,rational decisions based on comprehensive analyses must be considered. | Jianfeng Shi Huan Lian Yuanli Huang Danmei Zhao Han Wang Chunren Wang Jingli Li Linnan Ke | 2020 | Regenerative Biomaterials2020，7，6： | 1 |
| 4 | Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity显示文摘 | Lun Li Jie Sun Xiaoran Li Yan Zhang Zhaoxu Wang Chunren Wang Jianwu Dai Qiangbin Wang | 2011 | Biomaterials2011，，6： | 1 |
| 5 | THE HEMODYNAMIC EFFECTS OF THE DOUBLE CHAMBER INTRA-AORTIC BALLOON PUMPING显示文摘Our experimental results showed that the effect of the double chamber intra-aortic balloon pumping was better than that of single chamber intraaortic balloon pumping. It significantly improved the hemodynamic parameters andimproved the efficiency of the counterpulsation. The result is consistent with the design of the computer simulation. | Songfang Lu Yi Peng Yusheng Bao Chunren Wang Xiaojun Yu Hua Kong Zibin Yang(Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，2： | 0 |
| 6 | Effects on the renal artery blood flow during the intra-aortic balloonpumping was used显示文摘The effects of intra-aortic balloon pumping(IABP) on hemodynamic parameters inthe kidney were studied. The pulse produced by pumping activated the renal nervoussystem and reduced the renal vascular resistance. Therefore, the reduction of the renalvascular resistance is an important reason for the increase the renal blood flow duringintra-aortic balloon pumping. | Songfang Lu Yusheng Bao Yi Peng Chunren Wang Zibin Yang(Institute of Basic Medical Sciences, PUMC & CAMS, Beijing 100005, China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，3： | 0 |
| 7 | THE INFLUENCE OF MACROMOLECULES ON FIBRINOGEN COAGULANILITY显示文摘THEINFLUENCEOFMACROMOLECULESONFIBRINOGENCOAGULANILITYTHEINFLUENCEOFMACROMOLECULESONFIBRINOGENCOAGULANILITYWangChunren;YangZib... | Wang Chunren Yang Zibin Lu Songfang Xi Tingfei (Institute of Basic Medicine,PUMC,CAMS & Beijing 100005 China) (National institute for the Control of Pharmaceutical andBiological Products,Beijing 100050 China)Ma Weiyuan ( Department of Medical Physi | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 0 |
| 8 | THE INFLUENCES OF SMALL MOLECULES ON FIBRINOGEN COAGULABILITY显示文摘THEINFLUENCESOFSMALLMOLECULESONFIBRINOGENCOAGULABILITYTHEINFLUENCESOFSMALLMOLECULESONFIBRINOGENCOAGULABILITYWangChunren;YangZ... | Wang Chunren Yang Zibin Xi Tingfei(Institute of Basic Medicine,PUMC & CAMS. Beijin 100005,China)( National institute for the Control of Pharmaceutical andBiological Products, Beijing 100050,China)In our previous study we find that plasma dilution an | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 0 |
| 9 | THE CORRELATION STUDY BETWEEN THE PLASMA DILUTION EFFECTS AND FIBRINOGEN COAGULABILITY显示文摘 THECORRELATIONSTUDYBETWEENTHEPLASMADILUTIONEFFECTSANDFIBRINOGENCOAGULABILITYTHECORRELATIONSTUDYBETWEENTHEPLASMADILUTIONEFFECT... | Wang Chunren Yang Zibin Xi Tingfei(Institute of Basic Medicine,PUMC &. CAMS’ Beijing 100005,China)( National institute for the Control of Pharmaceutical andBiological Products, Bet im 100050,China)The microenviroment around fibrinogen molecules is v | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 0 |
| 10 | THE CORRELATION STUDY BETWEEN PLASMA VISCOSITY AND FIBRINOGEN COAGULABILITY显示文摘 THECORRELATIONSTUDYBETWEENPLASMAVISCOSITYANDFIBRINOGENCOAGULABILITYTHECORRELATIONSTUDYBETWEENPLASMAVISCOSITYANDFIBRINOGENCOAG... | Wang Chunren Yang Zibin Xi Tingfei(Institute of Basic Medicine,PUMC &. CAMS’ Beijing 100005,China)( National institute for the Control of Pharmaceutical andBiological Products, Bet im 100050,China)The microenviroment around fibrinogen molecules is v | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 0 |
| 11 | Quantification of rhBMP2 in bioactive bone materials显示文摘Bone morphogenetic protein(BMP),belongs to transforming growth factor-b(TGF-b)superfamily except BMP-1.Implanting BMP into muscular tissues induces ectopic bone formation at the site of implantation,which provides opportunity for the treatment of bone defects.Recombinant human BMP-2(rhBMP-2)has been used clinically,but the lack of standard methods for quantifying rhBMP-2 biological activity greatly hindered the progress of commercialization.In this article,we describe an in vitro rhBMP-2 quantification method,as well as the data analyzation pipeline through logistic regression in RStudio.Previous studies indicated that alkaline phosphatase(ALP)activity of C2C12 cells was significantly increased when exposed to rhBMP-2,and showed dose-dependent effects in a certain concentration range of rhBMP-2.Thus,we chose to quantify ALP activity as an indicator of rhBMP-2 bioactivity in vitro.A sigmoid relationship between the ALP activity and concentration of rhBMP-2 was discovered.However,there are tons of regression models for such a non-linear relationship.It has always been a major concern for researchers to choose a proper model that not only fit data accurately,but also have parameters representing practical meanings.Therefore,to fit our rhBMP-2 quantification data,we applied two logistic regression models,three-parameter log-logistic model and four-parameter log-logistic model.The four-parameter log-logistic model(adj-R2>0.98)fits better than three-parameter log-logistic model(adj-R2>0.75)for the sigmoid curves.Overall,our results indicate rhBMP-2 quantification in vitro can be accomplished by detecting ALP activity and fitting four-parameter log-logistic model.Furthermore,we also provide a highly adaptable R script for any additional logistic models. | Huan Lian Han Wang Qianqian Han Chunren Wang | 2020 | Regenerative Biomaterials2020，7，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员