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| 1 | Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance and enhances T-cell exhaustion in a mouse model显示文摘肝炎 B 病毒(HBV ) 复活和复发在经历免疫力的抑制治疗的病人是普通的。肿瘤坏死因素(TNF ) 阻塞治疗为许多自体免疫的煽动性的疾病的治疗是有效的。然而, TNF-α 的角色;在对 HBV 的天生、适应的有免疫力的回答的阻塞治疗仍然不是清楚的。A 在 TNF-α 下面详细说明了 HBV 感染的分析;阻塞治疗为 HBV 复活和复发为预防和治疗是必要的。在这研究, HBV 清理和 T 房间回答在 anti-TNF 阻塞治疗下面在一个 HBV-transfected 老鼠模型被分析。我们的结果在 TNF-α 下面表明了那;阻塞治疗, HBV 病毒的清理在一个剂量依赖者和时间依赖者的举止与坚持的提高的 HBV 病毒的负担被损害。在 anti-TNF-α 下面的 HBV 清理的缺陷;阻塞治疗在 HBV 感染以后发生在早时间点。另外, TNF-α封锁维持了更高的浆液 HBV 病毒的负担并且增加了 intrahepatic 的数字用尽的规划房间死亡(PD )-1highCD127low T 房间。而且, TNF-α封锁废除像使用费的受体 9 (TLR9 ) HBV 的导致 ligand 的容易病毒的清理。一起拿, TNF-α封锁损害 HBV 清理并且提高病毒的负担,和这些效果在 HBV 感染以后取决于早管理。我们这里的结果表明那早 TNF-α封锁减少病毒的清理并且固执地在一个老鼠模型维持提高的 HBV 病毒的负担,建议 HBV 可以在有 TNF-α 的治疗期间重新激活;堵住代理人。 | Hsu Chyuan Hwei-Fang Tsai Horng-Tay Tzeng Chi-Chang Sung Chien-Sheng Wu Pei-Jer Chen Ping-Ning Hsu | 2015 | Cellular & Molecular Immunology2015，12，3： | 9 |
| 2 | An apoptosis-independent role of TRAIL in suppressing joint inflammation and inhibiting T-cell activation in inflammatory arthritis显示文摘Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has been implicated in the regulation ofinflammation in rheumatoid arthritis (RA), primarily due to its ability to promote apoptosis in synoviocytes andinfiltrating lymphocytes. The aim of this study was to investigate the immunomodulatory mechanism and role ofTRAIL in inflammatory arthritis. We created an animal model of inflammatory arthritis and demonstrated that TRAILsignificantly inhibited joint inflammation and reduced the severity of arthritis. The suppression of joint inflammationwas not due to the TRAIL-mediated induction of apoptosis in T cells, macrophages or synovial fibroblasts. Incontrast, TRAIL directly inhibited T-cell proliferation and suppressed the production of cytokines, which indicatedthat TRAIL exerted its anti-inflammatory effects by direct inhibition of T-cell activation. Moreover, TRAIL receptor(TRAIL-R)-knockout mice developed more severe disease, and the protective effects of TRAIL were abolished in theexperimental arthritis model in TRAIL-R knockout mice. From these results, we conclude that TRAIL suppressesjoint inflammation via an apoptosis-independent pathway and directly inhibits T-cell activation. Our results providea novel apoptosis-independent, immune regulatory role for TRAIL in suppressing inflammatory arthritis and shedlight on the development of effective new therapies for autoimmune inflammatory diseases. | I-Tsu Chyuan Hwei-Fang Tsai Hsiu-Jung Liao Chien-Sheng Wu Ping-Ning Hsu | 2018 | Cellular & Molecular Immunology2018，15，9： | 4 |
| 3 | Asialo GM1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus显示文摘Persistent hepatitis B virus(HBV)infection results in chronic liver diseases that may progress to chronic hepatitis,liver cirrhosis,and subsequent hepatocellular carcinoma.Previous studies demonstrated that adaptive immunity,in particular CD8 T cells,is critical in HBV elimination.Recent studies have revealed a distinct tissue-localized T cell lineage,tissue-resident memory(TRM)cells,that is crucial for protective immunity in peripheral tissues.In this study,we showed that treatment with an anti-asialo GM1(ASGM1)antibody(Ab),which depletes NK cells,led to impairment of HBV clearance in a mouse animal model.Unexpectedly,the ability to clear HBV was not significantly impaired in NFIL3 KO mice,which are deficient in NK cells,implying that other non-NK ASGM1-positive immune cells mediate HBV clearance.We isolated intrahepatic ASGM1-positive cells from NFIL3 KO mice and analyzed the immune phenotype of these cells.Our results demonstrated a distinct population of CD44+LFA-1hi CD8 T cells that were the major intrahepatic ASGM1-positive immune cells in NFIL3 KO mice.Importantly,transcriptome analysis revealed that these ASGM1-positive CD8 T cells had distinct gene profiles and shared a similar core gene signature with TRM cells.In addition to both transcriptional and phenotypic liver residency characteristics,ASGM1-positive CD8 T cells were able to home to and be retained in the liver after adoptive transfer.Taken together,our study results indicate that these ASGM1-positive liver-resident CD8 T cells are the major effector immune cells mediating anti-HBV immunity. | Chi-Chang Sung Jau-Hau Horng Shih-Hong Siao I-Tsu Chyuan Hwei-Fang Tsai Pei-Jer Chen Ping-Ning Hsu | 2021 | Cellular & Molecular Immunology2021，18，7： | 3 |
| 4 | A strategic website evaluation of online travel agencies显示文摘 | Wen-Chih Chiou Chin-Chao Lin Chyuan Perng | 2010 | Tourism Management2010，，6： | 2 |
| 5 | A critical review on the recent progress of synthesizing techniques and fabrication of TiO 2 -based nanotubes photocatalysts显示文摘 | Yean Ling Pang Steven Lim Hwai Chyuan Ong Wen Tong Chong | 2014 | Applied Catalysis A, General2014，，： | 1 |
| 6 | Dynamic analysis of solid propellant grains subjected to ignition pressurization loading显示文摘 | Chyuan S W | 2003 | Journal of Sound and Vibration2003，268，3： | 1 |
| 7 | Nonlinear thermoviscoelastic analysis of solid propellant grains subjected to temperature loading 显示文摘 | Chyuan S-W | 2002 | Finite Elements in Analysis and Design2002，，38： | 1 |
| 8 | Studies of poisson's ratio variation for solid propellant grains under ignition pressure loading 显示文摘 | Chyuan S W | 2003 | Pressure Vessels and Piping2003，80，： | 1 |
| 9 | A strategic framework for website evaluation based on a review of the literature from 1995 - 2006 显示文摘 | CHIOU WEN - CHIH LIN CHIN - CHAO PERNG CHYUAN | 2010 | Information & Management2010，47，56： | 1 |
| 10 | Nonlinear thermoviscoelastic analysis of solid propellant grains subjected to temperature loading显示文摘 | Shiang-Woei Chyuan | 2002 | Finite Elements in Analysis and Design2002，38，： | 1 |
| 11 | A study of loading history effect for thermoviscoelastic solid propellant grains显示文摘 | Shiang-Woei Chyuan | 2000 | Computers and Structures2000，77，： | 1 |
| 12 | Mining Customer Knowledge for Product Line and Brand Extension in Retailing 显示文摘 | Shu -Hsien Liao Chyuan - Meei Chen Chung - Hsin Wu | 2008 | Expert Systems with Applications2008，34，3： | 1 |
| 13 | External technol- ogy sourcing and innovation performance in LMT sectors: An analysis based on the Taiwanese technological innovation survey 显示文摘 | KUEN - HUNG TSAI JIANN - CHYUAN WANG | 2008 | Re- search Policy2008，，3： | 1 |
| 14 | Cytotoxicity of arsenic trioxide to transitional carcinoma cells显示文摘 | Pu Tzyh chyuan Hour Jun Chen | 2002 | UROLOGY2002，60，2： | 1 |
| 15 | Cyclic Behavior of Low Yield Point Steel Shear Walls显示文摘 | Chen Shengjin Chyuan Jhang | 2006 | Thin Walled Structures2006，44，： | 1 |
| 16 | Studies of Poisson' s ratio variation for solid propellant grains under ignitionpressure loading 显示文摘 | Chyuan Shiang-Woei | 2003 | The International Journal of Pressure Vessels and Piping2003，80，12： | 1 |
| 17 | A study of loading history effect for thermoviscoelastic solid propellant grains显示文摘 | Shiang-Woei Chyuan | 2000 | Jounal of Computers and Structures2000，77，： | 1 |
| 18 | Regulation of CCAAT/en-hancerbinging protein - β isoform synthesis by alternative translational initiation at mulitiple AUG start sites显示文摘 | Wei Xiong Citing- Chyuan Hsieh | 2001 | Nucleic Acids Reseanrch2001，29，14： | 1 |
| 19 | A Study of Loading History Effect for Thermoviscoelastic Solid Propellant Grains 显示文摘 | Chyuan S W | 2000 | Journal of Computers and Structures2000，77，： | 1 |
| 20 | A study of loading history effect for thermoviscoelastic solid propellant grains显示文摘 | Shiang-Woei Chyuan | 2000 | Computers and Structures2000，，6： | 1 |
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