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| 1 | Prevalence of functional dyspepsia and its subgroups in patients with eating disorders显示文摘AIM:To study the prevalence of functional dyspepsia(FD)(Rome Ⅲ criteria) across eating disorders(ED),obese patients,constitutional thinner and healthy volunteers.METHODS:Twenty patients affected by anorexia nervosa,6 affected by bulimia nervosa,10 affected by ED not otherwise specified according to diagnostic and statistical manual of mental disorders,4th edition,nine constitutional thinner subjects and,thirtytwo obese patients were recruited from an outpatients clinic devoted to eating behavior disorders.Twentytwo healthy volunteers matched for age and gender were enrolled as healthy controls.All participants underwent a careful clinical examination.Demographic and anthropometric characteristics were obtained from a structured questionnaires.The presence of FD and,its subgroups,epigastric pain syndrome and postprandial distress syndrome(PDS) were diagnosed according to Rome Ⅲ criteria.The intensity-frequency score of broader dyspeptic symptoms such as early satiety,epigastric fullness,epigastric pain,epigastric burning,epigastric pressure,belching,nausea and vomiting were studied by a standardized questionnaire(0-6).Analysis of variance and post-hoc Sheffè tests were used for comparisons.RESULTS:90% of patients affected by anorexia nervosa,83.3% of patients affected by bulimia nervosa,90% of patients affected by ED not otherwise specified,55.6% of constitutionally thin subjects and 18.2% healthy volunteers met the Postprandial Distress Syndrome Criteria(χ 2,P < 0.001).Only one bulimic patient met the epigastric pain syndrome diagnosis.Postprandial fullness intensity-frequency score was significantly higher in anorexia nervosa,bulimia nervosa and ED not otherwise specified groups compared to the score calculated in the constitutional thinner group(4.15 ± 2.08 vs 1.44 ± 2.35,P = 0.003;5.00 ± 2.45vs 1.44 ± 2.35,P = 0.003;4.10 ± 2.23vs 1.44 ± 2.35,P = 0.002,respectively),the obese group(4.15 ± 2.08vs 0.00 ± 0.00,P < 0.001;5.00 ± 2.45vs 0.00 ± 0.00,P < 0.001;4.10 ± 2.23 vs 0.00 ± 0.00,P < 0.001,respectively) and healthy volunteers(4.15 ± 2.08 vs 0.36 ± 0.79,P < 0.001;5.00 ± 2.45 vs 0.36 ± 0.79,P < 0.001;4.10 ± 2.23 vs 0.36 ± 0.79,P < 0.001,respectively).Early satiety intensity-frequency score was prominent in anorectic patients compared to bulimic patients(3.85 ± 2.23 vs 1.17 ± 1.83,P = 0.015),obese patients(3.85 ± 2.23 vs 0.00 ± 0.00,P < 0.001) and healthy volunteers(3.85 ± 2.23 vs 0.05 ± 0.21,P < 0.001).Nausea and epigastric pressure were increased in bulimic and ED not otherwise specified patients.Specifically,nausea intensity-frequencyscore was significantly higher in bulimia nervosa and ED not otherwise specified patients compared to anorectic patients(3.17 ± 2.56 vs 0.89 ± 1.66,P = 0.04;2.70 ± 2.91 vs 0.89 ± 1.66,P = 0.05,respectively),constitutional thinner subjects(3.17 ± 2.56 vs 0.00 ± 0.00,P = 0.004;2.70 ± 2.91 vs 0.00 ± 0.00,P = 0.005,respectively),obese patients(3.17 ± 2.56 vs 0.00 ± 0.00,P < 0.001;3.17 ± 2.56 vs 0.00 ± 0.00,P < 0.001 respectively) and,healthy volunteers(3.17 ± 2.56 vs 0.17 ± 0.71,P = 0.002;3.17 ± 2.56 vs 0.17 ± 0.71,P = 0.001,respectively).Epigastric pressure intensityfrequency score was significantly higher in bulimic and ED not otherwise specified patients compared to constitutional thin subjects(4.67 ± 2.42 vs 1.22 ± 1.72,P = 0.03;4.20 ± 2.21 vs 1.22 ± 1.72,P = 0.03,respectively),obese patients(4.67 ± 2.42 vs 0.75 ± 1.32,P = 0.001;4.20 ± 2.21vs 0.75 ± 1.32,P < 0.001,respectively) and,healthy volunteers(4.67 ± 2.42 vs 0.67 ± 1.46,P = 0.001;4.20 ± 2.21vs 0.67 ± 1.46,P = 0.001,respectively).Vomiting was referred in 100% of bulimia nervosa patients,in 20% of ED not otherwise specified patients,in 15% of anorexia nervosa patients,in 22% of constitutional thinner subjects,and,in 5.6% healthy volunteers(χ 2,P < 0.001).CONCLUSION:PDS is common in eating disorders.Is it mandatory in outpatient gastroenterological clinics to investigate eating disorders in patients with PDS? | Antonella Santonicola Monica Siniscalchi Pietro Capone Serena Gallotta Carolina Ciacci Paola Iovino | 2012 | World Journal of Gastroenterology2012，18，32： | 5 |
| 2 | Assessment of proximal gastric accommodation in patients with functional dyspepsia显示文摘Impaired gastric accommodation is one of the most important etiologic factors in the pathophysiology of functional dyspepsia.Ultrasound is a potential alternative method to study changes in gastric volume as a reflection of gastric accommodation.Ultrasound is suitable for patients because it is a non-invasive,easily repeated and non-radioactive procedure,and a previous study has demonstrated the feasibility of 3-dimensional ultrasound in examining functional dyspepsia.The brief article by Fan et al demonstrated that both the proximal gastric area and volume,measured by 2-and 3-dimensional ultrasound respectively,were significantly smaller in patients with functional dyspepsia than in healthy controls.These results are very interesting,but we raise the relevant point that it should have been mandatory to study both changes in gastric volume and their relationship with upper gastrointestinal symptoms in functional dyspepsia.In fact,the relationship between cardinal symptoms and several pathophysiologic mechanisms in functional dyspepsia remains a matter of debate.Moreover,further evaluation of distal gastric volume that has been previously implicated in the origin of functional dyspeptic symptoms is advisable.Therefore,impaired gastric accommodation does not serve as a clear marker of the cardinal symptoms experienced by patients with functional dyspepsia in daily life. | Paola Iovino Antonella Santonicola Carolina Ciacci | 2013 | World Journal of Gastroenterology2013，19，47： | 4 |
| 3 | Celiac disease: Alternatives to a gluten free diet显示文摘Celiac disease is a chronic inflammatory disorder of the small intestine caused by the ingestion of gluten or related rye and barley proteins. At present, the only available treatment is a strict gluten-exclusion diet. However, recent understanding of the molecular basis for this disorder has improved and enabled the identif ication of targets for new therapies. This article aims to critically summarize these recent studies. | Fabiana Zingone Pietro Capone Carolina Ciacci | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，1： | 3 |
| 4 | Differing Temporal Patterns of Onset in Subgroups of Patients With Intracerebral Hemorrhage显示文摘 | Stefano Passero Fabio Reale Giuseppe Ciacci Ettore Zei | 2000 | Stroke: Journal of the American Heart Association2000，，： | 2 |
| 5 | Human leukocyte antigen DQ2/8 prevalence in non-celiac patients with gastrointestinal diseases显示文摘AIM: To investigate the prevalence of human leukocyte antigen (HLA) DQ2/8 alleles in Southern Italians with liver and gastrointestinal (GI) diseases outside of celiac disease. METHODS: HLA DQ2/8 status was assessed in 443 patients from three ambulatory gastroenterology clinics in Southern Italy (University of Federico Ⅱ, Naples, Loreto Crispi Hospital, Ruggi D'Aragona Hospital, Salerno). Patients were grouped based on disease status [pre-post transplant liver disease, esophageal/gastric organic and functional diseases, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)] and DQ2/8 alleles, which correspond to a celiac disease genetic risk gradient. Subject allele frequencies were compared to healthy Italian controls. RESULTS: One hundred and ninety-six out of four hundred and forty-three (44.2%) subjects, median age 56 years and 42.6% female, were DQ2/8 positive. When stratifying by disease we found that 86/188 (45.7%) patients with liver disease were HLA DQ2/8 positive, 39/73 (53.4%) with functional upper GI diseases and 19/41 (46.3%) with organic upper GI diseases were positive. Furthermore, 38/105 (36.2%) patients with IBS and 14/36 (38.9%) with IBD were HLA DQ2/8 positive (P = 0.21). Compared to healthy controls those with functional upper GI diseases disorders had a 1.8 times higher odds of DQ2/8 positivity. Those with liver disease had 1.3 times the odds, albeit not statistically significant, ofDQ2/8 positivity. Both those with IBS and IBD had a lower odds of DQ2/8 positivity compared to healthy controls. CONCLUSION: The proportion of individuals HLA DQ2/8 positive is higher in those with liver/upper functional GI disease and lower in IBS/IBD as compared to general population estimates. | Daniel DiGiacomo Antonella Santonicola Fabiana Zingone Edoardo Troncone Maria Cristina Caria Patrizia Borgheresi Gianpaolo Parrilli Carolina Ciacci | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 6 | High risk of temporomandibular disorder in irritable bowel syndrome: Is there a correlation with greater illness severity?显示文摘AIM To investigate the prevalence and the risk of temporomandibular disorders(TMDs)in patients with irritable bowel syndrome(IBS)(including each subtype:constipation,diarrhoea,and mixed)compared to the general population.METHODS Between January 2014 and December 2015 we enrolled consecutively adult patients diagnosed with IBS at the outpatient clinic of the University of Salerno and healthy controls(HC)without IBS.At enrollment,we analyzed all patients for the presence of TMDs according to the Research Diagnostic Criteria for TMD.RESULTS We enrolled 91 IBS patients(23 IBS-D,30 IBS-C and38 IBS-M)and 57 HC in the study.We found a higher risk of having TMD(OR=3.41,95%CI:1.66-7.01)compared to the HC.The risk of having TMD was independent of IBS-subtype.Multiple regression analysis showed that facial pain was positively related to abdominal pain and higher level of depression.CONCLUSION IBS patients had a more than three times greater risk of TMD compared to HC.The risk of having TMDwas similar in different IBS subtypes.IBS patients that also fulfilled criteria for TMD seem to share along with chronic facial and abdominal pain a significant co-occurrence with psychiatric disorders and female preponderance.Key words:Temporomandibular disorders;Irritable bowel syndrome;Chronic pain;Facial pain;Abdominal pain;Irritable bowel syndrome severity score symptoms;Irritable bowel syndrome predominant diarrhea;Irritable bowel syndrome predominant constipation;Irritable bowel syndrome mixed?The Author(s)2017.Published by Baishideng Publishing Group Inc.All rights reserved. | Serena Gallotta Vincenzo Bruno Santo Catapano Nicola Mobilio Carolina Ciacci Paola Iovino | 2017 | World Journal of Gastroenterology2017，23，1： | 2 |
| 7 | Effect of Helicobacter pylori on gasteic epithelial cell migration and prolix feration invitro: role of VacA and CagA显示文摘 | Ricci V Ciacci C Zarrilli R | 1996 | Infect Immun1996，64，： | 1 |
| 8 | Transforming growth factor β regulation of migration in wounded rat intestinal epithelial monolayers显示文摘 | Ciacci C Lind SE Podolsky DK | 1993 | Gastroenterology1993，105，： | 1 |
| 9 | The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage显示文摘 | PASSERO S CIACCI G ULIVELLI M | 2003 | Neurology2003，61，： | 1 |
| 10 | Pleiotropic effects of hex-avalent chromium(CrVI)in Mytilus galloprovincialis digestivegland显示文摘 | Barmo C Ciacci C Fabbri R | 2011 | Chemosphere2011，83，8： | 1 |
| 11 | Helicobacter pylori impairs iron absorption in infected individuals显示文摘 | Ciacci C Sabbatini E Cavallaro R | 2004 | Dig Liver Dis2004，36，7： | 1 |
| 12 | Numerical simulation of the electromagnetic field and the heat and mass transfer processes during microwave-induced pyrolysis of a wood block显示文摘 | CIACCI T GALGANO A BLASI C D | 2010 | Chemical Engineering Science2010，65，14： | 1 |
| 13 | Mortality in patients with coeliac disease and their relatives: a cohort study显示文摘 | Giovanni Corrao Gino Roberto Corazza Vincenzo Bagnardi Giovanna Brusco Carolina Ciacci Mario Cottone Carla Sategna Guidetti Paolo Usai Pietro Cesari Maria Antonietta Pelli Silvano Loperfido Umberto Volta Antonino Calabró Maria Certo | 2001 | The Lancet . 2001 (9279)2001，，9279： | 1 |
| 14 | Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study显示文摘 | C Sategna-Guidetti U Volta C Ciacci P Usai A Carlino L De Franceschi A Camera A Pelli C Brossa | 2001 | The American Journal of Gastroenterology2001，，3： | 1 |
| 15 | Unused clinical features andearly brain MRI lesions in a family with cererbal autosomal dominant ar teriopathy显示文摘 | Malandrini A Carrera P Ciacci G | 1997 | Neurology1997，48，5： | 1 |
| 16 | Functional interleukin-2 receptors on intestinal epithelial cells显示文摘 | CIACCI C MAHIDA Y R DIGNASS A | 1993 | J Clin Invest1993，92，1： | 1 |
| 17 | The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage显示文摘 | Passero S Ciacci G Ulivelli M | 2003 | Neurology2003，61，： | 1 |
| 18 | The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage 显示文摘 | Passero S Ciacci G Ulivelli M | 2003 | Neurology2003，61，： | 1 |
| 19 | Transforming growth factor β regulation of migration in wounded rat intestinal epithelial monolayers显示文摘 | CIACCI C LIND S E PODOLSKY D K | 1993 | Gastroenterology1993，105，1： | 1 |
| 20 | Functional differential immune responses of Mytilus galloprovincialis to bacterial challenge显示文摘 | Ciacci C Citterio B Betti M | 2009 | Comparative Biochemistry and Physiology2009，153，4： | 1 |
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