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| 1 | COVID-19中肝脏检查异常:对美国一家主要医院网络的1827例患者的一项回顾性观察队列研究显示文摘【据Hepatology 2020年7月报道】题:COVID-19中肝脏检查异常:对美国一家主要医院网络的1827例患者的一项回顾性观察队列研究(作者Hundt MA等)由SARS-CoV-2病毒引起的COVID-19大流行与肺炎、急性呼吸窘迫综合征(ARDS)和多器官衰竭的发病率及病死率相关。据报道,肝损伤为COVID-19的一种非肺部表现,但肝脏检查异常及其与临床结果相关性的描述尚不完整。 | 万敏婕 高普均 HUNDT MA DENG Y CIARLEGLIO MM | 2020 | 临床肝胆病杂志2020，36，10： | 27 |
| 2 | Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma显示文摘AIM: To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma (HCC)eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria.METHODS: Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were: (1) histological assessment of tumor grade by means of percutaneous biopsies; (2) determination of AFP mRNA status in the blood; (3) patient's eligibility for radical therapies.RESULTS: At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery (resection or liver transplantation) was performed in 29 patients,while 21 had percutaneous ablation procedures. After a median follow-up of 28 mo, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables (AFP mRNA, HCC grade and gross vascular invasion) resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile (AFP mRNA negative and well-differentiated tumor without gross vascular invasion) as independent survival variables.CONCLUSION: The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies. | Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico | 2005 | World Journal of Gastroenterology2005，11，44： | 12 |
| 3 | Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia显示文摘AIM: To investigate the relationship between upper esophageal sphincter abnormalities achalasia treatment METHODS: We performed a retrospective study of 41 consecutive patients referred for high resolution esophageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence or absence of Upper esophageal sphincter(UES) abnormality, and clinical and manometric profiles were compared.Correlation between UES abnormality and sub-type(i.e.,hypertensive, hypotensive or impaired relaxation) and a number of variables, including qualitative treatment response, achalasia sub-type, co-morbid medical illness,psychiatric illness, surgical history, dominant presentingsymptom, treatment type, age and gender were also evaluated.RESULTS: Among all 41 patients, 24(58.54%) had a UES abnormality present. There were no significant differences between the groups in terms of age, gender or any other clinical or demographic profiles. Among those with UES abnormalities, the majority were either hypertensive(41.67%) or had impaired relaxation(37.5%) as compared to hypotensive(20.83%), although this did not reach statistical significance(P = 0.42). There was no specific association between treatment response and treatment type received; however, there was a significant association between UES abnormalities and treatment response. In patients with achalasia and concomitant UES abnormalities, 87.5% had poor treatment response, while only 12.5% had favorable response. In contrast, in patients with achalasia and no UES abnormalities, the majority(78.57%) had good treatment response, as compared to 21.43% with poor treatment response(P = 0.0001). After controlling for achalasia sub-type, those with UES abnormality had 26 times greater odds of poor treatment response than those with no UES abnormality(P = 0.009). Similarly, after controlling for treatment type, those with UES abnormality had 13.9 times greater odds of poor treatment response compared to those with no UES abnormality(P = 0.017).CONCLUSION: The presence of UES abnormalities in patients with achalasia significantly predicted poorer treatment response as compared to those with normal UES function. | Simon C Mathews Maria Ciarleglio Yamile Haito Chavez John O Clarke Ellen Stein Bani Chander Roland | 2014 | World Journal of Clinical Cases2014，2，9： | 5 |
| 4 | Prospective validation of the Barcelona Clinic Liver Cancer staging system显示文摘 | Umberto Cillo Alessandro Vitale Francesco Grigoletto Fabio Farinati Alberto Brolese Giacomo Zanus Daniele Neri Patrizia Boccagni Nela Srsen Francesco D’Amico Francesco Antonio Ciarleglio Alessio Bridda Davide Francesco D’Amico | 2006 | Journal of Hepatology2006，，4： | 2 |
| 5 | Exhaled carbon monoxide in sarcoidosis显示文摘 | Ciarleglio G Refini RM Pieroni MG | 2008 | Sarcoidosis Vasc Diffuse Lung Dis2008，25，1： | 1 |
| 6 | Genetic counseling throughout the life cycle显示文摘 | Ciarleglio LJ Bennett RL Williamson J | 2003 | J Clin Invest2003，112，9： | 1 |
| 7 | Comprehensive analysis of variables affecting delayed gastric emptying following pancreaticoduodenectomy 显示文摘 | Kunstman JW Fonseca AL Ciarleglio MM | 2012 | J Gastrointest Surg2012，16，7： | 1 |
| 8 | American Thyroid Association design and feasibility of a prospective randomized controlled trial of prophylactic central lymph node dissection for papillary thyroid carcinoma显示文摘 | Carling T Carty SE Ciarleglio MM | 2012 | Thyroid2012，22，3： | 1 |
| 9 | Genetic differences in human circadian clock genes among worldwide populations显示文摘 | Ciarleglio CM Ryckman K Servick SV | 2008 | J Biol Rhythms2008，23，4： | 1 |
| 10 | Risk factors associated with anal sphincter tear difference among midwife, private obstetrician, and resident deliveries Springer显示文摘 | Maria- Ciarleglio EH Hobbs G | 2008 | International Urogynecology Jour- nal2008，19，8： | 1 |
| 11 | American Thyroid Association design and feasibility of a prospective randomized controlled trial of prophylactic central lymph node dissection for papillary thyroid carcinoma显示文摘 | Carling T Carty SE Ciarleglio MM | 2012 | Thyroid2012，22，3： | 1 |
| 12 | Genetic differences in human circadian clock genes among worldwide populations显示文摘 | Ciarleglio CM Ryckman K Servick SV | 2008 | J Biol Rhythms2008，23，4： | 1 |
| 13 | Liver transplantation for the management of hepatoblastoma 显示文摘 | Cillo U Ciarleglio FA Bassanello M | 2003 | Transplantation Proceedings2003，35，8： | 1 |
| 14 | American Thyroid Association design and feasibility of a prospective randomized controlled trial of prophylactic central lymph node dissection for papillary thyroid carcinoma显示文摘 | Carling T Carry SE Ciarleglio MM | 2012 | Thyroid2012，22，3： | 1 |
| 15 | Genetic counseling throughout the life cycle显示文摘 | Ciarleglio LJ Bennett RL Williamson J | 2003 | J Clin Invest2003，112，： | 1 |
| 16 | Decompensated cirrhotics have slower intestinal transit times as compared with compensated cirrhotics and healthy controls显示文摘 | Chander Roland B Garcia-Tsao G Ciarleglio MM | 2013 | J Clin Gastroenterol2013，47，10： | 1 |
| 17 | Genetic differ- ences in human circadian clock genes among worldwide popula- tions 显示文摘 | Ciarleglio CM Ryckman KK Servick SV | 2008 | J Biol Rhythms2008，23，4： | 1 |
| 18 | Postoperative complications after gynec-ologic surgery 显示文摘 | Erekson EA Yip SO Ciarleglio MM etal | 2011 | Obstet Gynecol2011，118，4： | 1 |
| 19 | American Thyroid Asso- ciation design and feasibility of a prospective randomized controlled trial of prophylactic central lymph node dissection for papillary thy- roid carcinoma 显示文摘 | Cading T Carry SE Ciarleglio MM | 2012 | Thyroid2012，22，3： | 1 |
| 20 | American Thyroid Association design and feasibility of a prospective randomized controlled trial of prophylactic central lymph node dissection for papillary thyroid carcinoma显示文摘 | Carling T Carty SE Ciarleglio MM | 2012 | Thyroid2012，22，3： | 1 |
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