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| 1 | Endoscopic ultrasound guided radiofrequency ablation,for pancreatic cystic neoplasms and neuroendocrine tumors显示文摘AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound(EUS)-radiofrequency ablation(RFA) in pancreatic neoplasms using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation(RF) which was applied with an innovative monopolar RF probe(1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration(FNA) needle once FNA was performed in patients with a tumor in the head of the pancreas. The HabibTM EUSRFA is a 1 Fr wire(0.33 mm, 0.013') with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and pancreas.RESULTS: Eight patients [median age of 65(range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a pancreatic cysticneoplasm(four a mucinous cyst, one had intraductal papillary mucinous neoplasm and one a microcystic adenoma) and two had a neuroendocrine tumors(NET) in the head of pancreas. The mean size of the cystic neoplasm and NET were 36.5 mm(SD ± 17.9 mm) and 27.5 mm(SD ± 17.7 mm) respectively. The EUSRFA was successfully completed in all cases. Among the 6 patients with a cystic neoplasm, post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm(SD ± 21.7 mm) vs mean post RF 20 mm(SD ± 17.1 mm)] in size. In regards to the NET patients, there was a change in vascularity and central necrosis after EUS-RFA. No major complications were observed within 48 h of the procedure. Two patients had mild abdominal pain that resolved within 3 d. CONCLUSION: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size. | Madhava Pai Nagy Habib Hakan Senturk Sundeep Lakhtakia Nageshwar Reddy Vito R Cicinnati Iyad Kaba Susanne Beckebaum Panagiotis Drymousis Michel Kahaleh William Brugge | 2015 | World Journal of Gastrointestinal Surgery2015，7，4： | 23 |
| 2 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 3 | Radioembolization with yttrium‐90 glass microspheres in hepatocellular carcinoma: European experience on safety and long‐term survival显示文摘 | Philip Hilgard Monia Hamami Amr El Fouly André Scherag Stefan Müller Judith Ertle Till Heusner Vito R. Cicinnati Andreas Paul Andreas Bockisch Guido Gerken Gerald Antoch | 2010 | Hepatology2010，，： | 3 |
| 4 | Right Living Donor Liver Transplantation: An Option for Adult Patients: Single Institution Experience With 74 Patients显示文摘 | Massimo Malagó Giuliano Testa Andrea Frilling Silvio Nadalin Camino Valentin-Gamazo Andreas Paul Hauke Lang Ulrich Treichel Vito Cicinnati Guido Gerken Christoph Erich Broelsch | 2003 | Annals of Surgery2003，，6： | 2 |
| 5 | Use of paclitaxel-eluting balloons for endotherapy of anastomotic strictures following liver transplantation显示文摘 | I. Kabar V. Cicinnati S. Beckebaum S. Cordesmeyer Y. Avsar H. Reinecke H. Schmidt | 2012 | Endoscopy2012，，12： | 2 |
| 6 | DNA-based immunotherapy: potential for treatment of chronic viral hepatitis显示文摘 | Beckebaum S Cicinnati VR Gerken G | 2002 | Rev Med Virol2002，12，5： | 2 |
| 7 | MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity显示文摘 | Leibo Xu Susanne Beckebaum Speranta Iacob Gang Wu Gernot M. Kaiser Arnold Radtke Chao Liu Iyad Kabar Hartmut H. Schmidt Xiaoyong Zhang Mengji Lu Vito R. Cicinnati | 2013 | Journal of Hepatology2013，，： | 2 |
| 8 | Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivo-generated DC1 in chronic hepatitis B infection 显示文摘 | Beckebaum S Cicinnati VR Dworracki G | 2002 | Clin Immunol2002，104，2： | 1 |
| 9 | Hepatitis B virus induced defect of monocyte derived dendritic cells leads to impaired T helper type 1 response in vftro:mechanisms for viral immune escape 显示文摘 | Beckebaum S Cicinnati VR Zhang X | 2003 | Immunol2003，109，4： | 1 |
| 10 | Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro:mechanisms for viral immune escape显示文摘 | Beckebaum S Cicinnati VR Zhang X | 2003 | Immunology2003，109，4： | 1 |
| 11 | Clinical trial: switch to combined mycophenolate mofetil and minimal dose calcineurin inhibitor in stable liver transplant patients assessment of re- nal and allograft function, cardiovascular risk factors and im mune monitoring 显示文摘 | Cicinnati VR Yu Z Klein CG | 2007 | Aliment Pharmacol Ther2007，26，： | 1 |
| 12 | Role of microR- NA-199a-5p and discoidin domain receptor 1 in human hepa- tocellular carcinoma invasion显示文摘 | SHEN Q CICINNATI VR ZHANG X et at | 2011 | Molecular Cancer2011，9，2： | 1 |
| 13 | Hepatitis B vims-inducec defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro:mechanisms for viral immune escape显示文摘 | Cicinnati VR Zhang X | 2003 | Immunology2003，109，4： | 1 |
| 14 | Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion显示文摘 | Shen Q Cicinnati VR Zhang X | 2010 | Mol Cancer2010，9，： | 1 |
| 15 | Role of microRNA-199a-Sp and discoidin domain receptor 1 in human hepatocellular carcinoma ilxvasion显示文摘 | Shen Q Cicinnati VR Zhang X | 2010 | Mol Cancer2010，9，： | 1 |
| 16 | Validation of putative reference genes for gene expression studies in human hepatocellular carcinoma using Real-time quantitative RT-PCR显示文摘 | Cicinnati V R Shen Q L Sotiropoulos G C | | 0，，： | 1 |
| 17 | Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivogenerated DC1 in chronic hepatitis B infection显示文摘 | Beckebaum S Cicinnati VR Dworacki G | | 0，，： | 1 |
| 18 | Hepatitis B vi- rus-induced defect of monocyte-defived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escape显示文摘 | Beckebaum S Cicinnati VR Zhang X | 2003 | Immunology2003，109，4： | 1 |
| 19 | Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escape显示文摘 | Beckebaum S Cicinnati V R Zhang X et ai | 2003 | Immunology2003，109，： | 1 |
| 20 | Increased frequencies of CD8+ T lymphocytes recognizing wild-type p53-derived epitopes in peripheral blood correlate with presence of epitope loss tumor variants in patients with hepatocellular carcinoma 显示文摘 | Cicinnati V R Zhang X Yu Z | 2006 | lnt J Cancer2006，119，12： | 1 |
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