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| 1 | Arabidopsis Protein Phosphatase 2C ABI1 Interacts with Type I ACC Synthases and Is Involved in the Regulation of Ozone-Induced Ethylene Biosynthesis显示文摘它的生合成严格地是的在各种各样的生物过程并且因此的一个关键角色由 multiplemechanisms 调整了的乙烯戏。Posttranslational 规定,在控制乙烯生合成枢轴,经由特定的因素的复杂相互影响影响 1-aminocyclopropane1-carboxylate synthase (交流) 蛋白质稳定性。这里,我们证明 Arabidopsis thaliana 蛋白质磷酸酶打 2C, ABI1, abscisic 酸发信号的一个否定管理者,在氧化压力条件下面涉及 ethylenebiosynthesis 的规定。我们发现 ABI1 与 ACS6 和 dephosphorylates 交往它的 C-terminalfragment,压力应答的激活 mitogen 的蛋白质 kinase 的一个目标, MPK6。另外, ABI1 控制 MPK6 也 activitydirectly 并且由这个工具影响 ACS6 phosphorylation 水平。一致地与这,在 ABI1 猛烈紧张(abi1td ) 显著地更高的导致臭氧的乙烯 productionwas 比在野类型的植物。重要地,在 abi1td 异种的导致压力的乙烯生产的增加由一个更高的 ascorbate 氧化还原作用状态被补偿并且提高了抗氧化剂活动。总的来说, thisstudy 的结果提供 ABI1 由影响 ACS6 的活动限制乙烯合成的证据。ABI1 贡献 tostress 显型支撑它在在 abscisic 酸(骆驼毛的织物) 和表明 pathways.Key 词的乙烯之间的相互影响的角色: | Agnieszka Ludwikow Agata Ciesla Anna Kasprowicz-Malusk Filip Mitula Malgorzata Tajdel lukasz Gaigarnski Piotr A. Ziolkowski Piotr Kubiak Arleta Malecka Aneta Piechalak Marta Szabat Alicja Gorska Maciej Dabrowskia Izabela Ibragimow Jan Sadowski | 2014 | Molecular Plant2014，7，6： | 6 |
| 2 | Ordered mesoporous materials显示文摘 | Ulrike Ciesla Ferdi Schüth | 1998 | Microporous and Mesoporous Materials1998，，2： | 2 |
| 3 | Intrahepatic expression of genes related to metabotropic receptors in chronic hepatitis显示文摘AIM:To screen for genes related to metabotropic receptors that might be involved in the development of chronic hepatitis.METHODS:Assessment of 20 genes associated with metabotropic receptors was performed in liver specimens obtained by punch biopsy from 12 patients with autoimmune and chronic hepatitis type B and C.For this purpose,a microarray with low integrity grade and with oligonucleotide DNA probes complementary to target transcripts was used.Evaluation of gene expression was performed in relation to transcript level,correlation between samples and grouping of clinical parameters used in chronic hepatitis assessment.Clinical markers of chronic hepatitis included alanine and aspartate aminotransferase,-glutamyltranspeptidase,alkaline phosphatase and cholinesterase activity,levels of iron ions,total cholesterol,triglycerides,albumin,glucose,hemoglobin,platelets,histological analysis of inflammatory and necrotic status,fibrosis according to METAVIR score,steatosis,as well as anthropometric body mass index,waist/hip index,percentage of adipose tissue and liver size in ultrasound examination.Gender,age,concomitant diseases and drugs were also taken into account.Validation of oligonucleotide microarray gene expression results was done with the use of quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS:The highest(0.002 < P < 0.046) expression among genes encoding main components of metabotropic receptor pathways,such as the α subunit of G-coupled protein,phosphoinositol-dependent protein kinase or arrestin was comparable to that of angiotensinogen synthesized in the liver.Carcinogenesis suppressor genes,such as chemokine ligand 4,transcription factor early growth response protein 1 and lysophosphatidic acid receptor,were characterized by the lowest expression(0.002 < P < 0.046),while the factor potentially triggering hepatic cancer,transcription factor JUN-B,had a 20-fold higher expression.The correlation between expression of genes of protein kinases PDPK1,phosphoinositide 3-kinase and protein kinase A(Spearman's coefficient range:0.762-0.769) confirmed a functional link between these enzymes.Gender(P = 0.0046) and inflammation severity,measured by alanine aminotransferase activity(P = 0.035),were characterized by diverse metabotropic receptor gene expression patterns.The Pearson's coefficient ranging from-0.35 to 0.99 from the results of qRT-PCR and microarray indicated that qRT-PCR had certain limitations as a validation tool for oligonucleotide microarray studies.CONCLUSION:A microarray-based analysis of hepatocyte metabotropic G-protein-related gene expression can reveal the molecular basis of chronic hepatitis. | Andrzej Ciesla Maciej Kusmider Agata Faron-Górecka Marta Dziedzicka-Wasylewska Monika Bocisga-Jasik Danuta Owczarek Irena Cieko-Michalska Dorota Cibor Tomasz Mach | 2012 | World Journal of Gastroenterology2012，18，31： | 2 |
| 4 | Meta-analysis of the relationship between HIV infection and risk for depressive disorders显示文摘 | Ciesla JA Roberts JE | 2001 | Am J psychiatry2001，158，： | 1 |
| 5 | MicroRNAs as biomarkers of disease onset显示文摘 | Ciesla M Skrzypek K Kozakowska M | | 0，，07： | 1 |
| 6 | Generalized synthesis of periodic surfactant/inorganic composite materials 显示文摘 | Huo Q S Margolese D I Ciesla U | 1994 | Nature1994，368，6469： | 1 |
| 7 | Mesenteric lymph is responsible for post-hemorrhagic shock systemic neutrophil priming显示文摘 | Gonzalez R J Moore E E Ciesla D J | 2001 | J Trauma2001，51，6： | 1 |
| 8 | 显示文摘 | Margolese D I Ciesla U etal | 1994 | Nature1994，368，： | 1 |
| 9 | Organization of organic molecules with inorganic molecular species into nanocomposite biphase arrays显示文摘 | Huo Q Margolese D I Ciesla U | 1994 | Chem Mater1994，6，： | 1 |
| 10 | Meta-analysis of the relationship between HIV Infection and risk for depressive disorders 显示文摘 | CIESLA J A ROBERTS J E | 2001 | Am J Psychiatry2001，158，5： | 1 |
| 11 | Generalized synthesis of periodic surfactant/inorganic composite materials显示文摘 | Ciesla U Margolese D | 1994 | Nature1994，368，6469： | 1 |
| 12 | Hypertonic saline inhibits neutrophil priming via attenuation of p38 MAPK signaling显示文摘 | Ciesla DJ Moore EE Gonzalel RJ | 2000 | Shock2000，14，3： | 1 |
| 13 | The start-to-end chemometrie image processing of 2D thin-layer videoscans显示文摘 | Komsta L Ciesla L Bogucka-Koeka A | 2011 | J Chromatogr A2011，1218，19： | 1 |
| 14 | Geochemical assessment of heavy metals pollution of urban soils显示文摘 | Grzebisz W Ciesla L Komisarek J | 2002 | Polish Journal of Environmental Studies2002，11，： | 1 |
| 15 | Channel of relative crystallinity of potato starch under gamma irradiation显示文摘 | Krystyna Ciesla Ewa Gwardys Tadeusz Zoltowski | 1991 | Starch1991，43，7： | 1 |
| 16 | Stage-specific modulation of cortical neuronal development by Mmu-miR-134显示文摘 | Gaughwin P Ciesla M Yang H | 2011 | Cereb Cortex2011，21，8： | 1 |
| 17 | The adrenal response after severe trauma显示文摘 | Offner PJ Moore EE Ciesla D | | 0，，06： | 1 |
| 18 | Influence of gamma radiation on potato starch gelatinization studied by differential scanning calorimetry显示文摘 | Ciesla K Eliasson A C | 2002 | Rad Phys Chem2002，64，2： | 1 |
| 19 | Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling显示文摘 | Ciesla DJ Moore EE Gonzalez RJ | 2000 | Shock2000，14，： | 1 |
| 20 | Hypertonic saline attenuation of neutrophil cytotoxic function is reversed upon return to normotonicity显示文摘 | Ciesla DJ Zallen G Biffl WL | 1999 | Surg Forum1999，50，2： | 1 |
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