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| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis显示文摘The Helicobacter pylori(H. pylori) infection is a determinant factor in gastric cancer(GC) development. However, the infection outcomes are variable and depend on both host and bacterial characteristics. Some host cytokines such as interleukin(IL)-1β, IL-1 Ra, IL-8, IL-10 and tumor necrosis factor-α play important roles in the host immune system response to the pathogen, in the development of gastric mucosal lesions and in cell malignant transformation. Therefore, these host factors are crucial in neoplastic processes. Certain polymorphisms in genes that encode these cytokines have been associated with an increased risk of GC. On the other hand, various virulence factors found in distinct H. pylori bacterial strains, including cytotoxinassociated antigen A, vacuolating cytotoxin, duodenal ulcer promoting gene A protein, outer inflammatory protein and blood group antigen binding adhesin, have been associated with the pathogenesis of different gastric diseases. The virulent factors mentioned above allow the successful infection by the bacterium and play crucial roles in gastric mucosa lesions, including malignant transformation. Moreover, the role of host polymorphisms and bacterial virulence factors in gastric carcinogenesis seems to vary among different countries and populations. The identification of host and bacterium factors that are associated with an increased risk of GC development may be useful in determining the prognosis of infection in patients, what could help in clinical decision-making and in providing of an optimized clinical approach. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Fabrício Freire de Melo | 2018 | World Journal of Clinical Oncology2018，9，5： | 9 |
| 3 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 4 | Nephrotoxicity in cancer treatment:An overview显示文摘Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer treatment.The kidney is an important elimination pathway for many antineoplastic drugs and their metabolites,which occurs by glomerular filtration and tubular secretion.Chemotherapeutic agents,both conventional cytotoxic agents and molecularly targeted agents,can affect any segment of the nephron including its microvasculature,leading to many clinical manifestations such as proteinuria,hypertension,electrolyte disturbances,glomerulopathy,acute and chronic interstitial nephritis,acute kidney injury and at times chronic kidney disease.The clinician should be alert to recognize several factors that may maximize renal dysfunction and contribute to the increased incidence of nephrotoxicity associated with these drugs,such as intravascular volume depletion,the associated use of nonchemotherapeutic nephrotoxic drugs(analgesics,antibiotics,proton pump inhibitors,and bonetargeted therapies),radiographic ionic contrast media or radiation therapy,urinary tract obstruction,and intrinsic renal disease.Identification of patients at higher risk for nephrotoxicity may allow the prevention or at least reduction in the development and severity of this adverse effect.Therefore,the aim of this brief review is to provide currently available evidences on oncologic drug-related nephrotoxicity. | Maria Luísa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio FranÇa da Silva Anelise Costa dos Santos Botelho Fabrício Freire de Melo | 2020 | World Journal of Clinical Oncology2020，11，4： | 4 |
| 5 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 6 | 应变速率和晶体包裹体对大块非晶和部分结晶的Zr_(52.5)Cu_(17.9)Ni_(14.6)Al_(10)Ti_5合金力学性能的影响(英文)显示文摘研究Zr_(52.5)Cu_(17.9)Ni_(14.6)Al_(10)Ti_5合金的力学性能,着重研究应变速率和晶体包裹体对合金变形和断裂机制的影响。X射线衍射分析表明,低氧含量时形成完全非晶态的合金组织,而当氧含量较高时,形成部分晶化组织;但是观察到完全不同的压缩变形行为。单轴压缩试验表明,全非晶合金具有弹性变形、屈服、明显塑性变形和锯齿流变行为。当应变速率从1×10^(-4) s^(-1)增加到1×10^(-2) s^(-1)时,屈服强度没有变化,然而,压缩断裂强度和塑性应力均降低。扫描电镜(SEM)和能谱(EDS)分析表明,即使在低氧含量的合金中,依然存在金属间化合物相CuZr_2,从而降低了合金的断裂强度和韧性。结果还证实在高氧含量的样品中存在枝晶状的Zr_(51)Cu_(28)Al_(21)相,会进一步降低其断裂强度。在断口表面可观察到韧性试样和脆性试样之间的差异。塑性应变越大,变形过程中形成的剪切带的密度越高,表现为应力-应变曲线上的锯齿流变行为。 | Tomasz KOZIE? Krzysztof PAJOR Grzegorz CIOS Piotr BA?A | 2019 | Transactions of Nonferrous Metals Society of China2019，29，5： | 3 |
| 7 | Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report显示文摘This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral hospital.The images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid sinus.An analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle tissue.The immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR MS.The treatment protocol included initial chemotherapy followed by radiotherapy and finally surgery.The total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment. | Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella Lima Arrais Ribeiro Alexandre Rolim da Paz Paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a | 2017 | World Journal of Clinical Cases2017，5，12： | 3 |
| 8 | Resection of a rapid-growing 40-cm giant liver hemangioma显示文摘Hemangiomas are the most frequent benign tumors of the liver. Most hemangiomas are asymptomatic and therefore largely diagnosed only in routine screening tests. Usually they are small and require no specific treatment. In some situations they can reach great dimensions, causing some discomfort to the patient. Resection of liver hemangioma is indicated in cases of great dimension tumors causing symptoms such as pain, nausea or bloating caused by compression of adjacent organs. We report a case of a rare giant hemangioma with rapid growth in short time:a 50 year old female reported to our institution with a 40 cm giant liver hemangioma and then underwent a left hepatectomy. | Andreas JM Koszka Fabio G Ferreira Caio GG de Aquino Maurício A Ribeiro André S Gallo Elisa MC Aranzana Luiz A Szutan | 2010 | World Journal of Hepatology2010，2，7： | 3 |
| 9 | Ecosystem services and legal protection of private property.Problem or solution?显示文摘Ecosystem services(ES)delivery in quantity and quality are essential to improve human wellbeing.Nevertheless,often a considerable part of ES provisioning depends on the use of private land(e.g.,flood retention,carbon sequestration,water purification).In this context,the operationalization and implementation of ES concept may collide with legal property rights.Therefore,it is essential to find constructive mechanisms to engage and encour-age private owners to implement sustainable land uses to reduce the onsite and offsite impacts of their activities.This paper aims to identify if ES delivery can be constrained by legal private land and how it can be tackled.It is undeniable that land-use changes(e.g.,urbanization,agriculture intensification,and land abandonment)affect the territory’s capacity to deliver ES in quality and quantity.These changes,especially land abandonment,are in-creasing the tradeoffs among ES(e.g.,between carbon sequestration and water yield).Land-use planning should consider these aspects.Therefore,incorporating ES into spatial plans is crucial for stakeholders to understand the impacts of land-use change in the loss of ES value.This information can be transmitted through maps that communicate the message in a simplified way.Private owners can easily perceive the ES relevance that their land can provide if an understandable message is delivered.Although this can be a good solution,conflicts can appear even with the implementation of schemes such as Payment for ES(PES).PES is not always effective and can im-pose losses to farmers,disregard their cultural traditions,or not prevent poverty alleviation.In this context,it is crucial to consider local specificities to safeguard PES’s success,create a“win-win”and transform a problem into a solution.Private owners’active participation in implementing sustainable practices or a determined land-use in their properties is vital to achieving global targets such as sustainable development goals. | Katažyna Mikša Marius Kalinauskas Miguel Inácio Eduardo Gomes Paulo Pereira | 2020 | Geography and Sustainability2020，1，3： | 2 |
| 10 | Helicobacter pylori infection:How does age influence the inflammatory pattern?显示文摘The inflammatory pattern during Helicobacter pylori(H.pylori)infection is changeable and complex.During childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor FOXP3.On the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among H.pylori-positive adults.In the last few years,the participation of the Th17 response in the gastric inflammation against H.pylori infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the infection.Moreover,this cytokine profile might play a pivotal role in the effectiveness of anti-H.pylori vaccines.It is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with H.pylori,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism. | Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo | 2022 | World Journal of Gastroenterology2022，28，4： | 2 |
| 11 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 12 | CAIM discretization algorithm 显示文摘 | Kurgan L A Cios K J | 2004 | IEEE Transactions on Knowledge and Data Engineering2004，16，2： | 1 |
| 13 | Enhanced flux through the methylerythritol 4-phosphate pathway in Arobidopsis plants overexpressing , deoxyxylulose 5- phosphate reductoisomerase显示文摘 | CARRETERO-PAULET L CAIRO A BOTELLA-PAV:A P BE- SUMBES O CAMPOS N BORONAT A RODRfGUEZ-CONCEP- CIO M | 2006 | Plant Mol Biol2006，62，45： | 1 |
| 14 | A multidimensional approach to information security risk management using FMEA and fuzzy theory显示文摘 | Maisa Mendon?a Silva Ana Paula Henriques de Gusm?o Thiago Poleto Lúcio Camara e Silva Ana Paula Cabral Seixas Costa | 2014 | International Journal of Information Management2014，，： | 1 |
| 15 | A knowledge discovery approach to diagnosing myocardial perfusion 显示文摘 | Cios KJ Teresinska A Konieczna S | 2000 | IEEE Engineering in Medicine Biology2000，4，19： | 1 |
| 16 | Is ranibizumab effective in stopping the loss of vi- sion for choroidal neovascularisation in pathologic myopia - A long-term follow-up study 显示文摘 | Vadal M Pece A Cipolla S Monte|eone C Fasolino G Casuc- cio A | 2011 | Br J Ophthalmol2011，95，5： | 1 |
| 17 | Validation of a solid-phase microextraction method for the determination of organophosphorus pesticides in fruits and fruit juice显示文摘 | Simplício A L Boas V L | 1999 | Journal of Chromatography A1999，833，1： | 1 |
| 18 | Prevalence and Pathogenesis of Duodenal Ulcer in Chronic Alcoholic Pancreatitis显示文摘 | Julio Maria Fonseca Chebli Aécio Flávio Meirelles de Souza Pedro Duarte Gaburri Kátia Valeria Bastos Tarsila Campanha Rocha Ribeiro Roberto José Carvalho Filho Liliana Andrade Chebli Lincoln Eduardo V.V. Castro Ferreira | 2002 | Journal of Clinical Gastroenterology2002，，1： | 1 |
| 19 | A Method for Extracting the Fundamental Frequency Positive Sequence Voltage Vector Based on Simple Mathematical Transformations显示文摘 | Helber E P de Souza Fabrício Bradaschia Francisco A S Neves Marcelo C Cavalcanti Gustavo M S Azevedo Josué P de Arruda | | 0，，05： | 1 |
| 20 | Polycrystalline diamond coatings on steel substrates显示文摘 | NETO V F SHOKUHFAR T OLIVEIRA M S A GR CIO J ALI N | 2008 | Int J Nanomanufacturing2008，2，12： | 1 |
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