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| 1 | Prevalence and Pathogenesis of Duodenal Ulcer in Chronic Alcoholic Pancreatitis显示文摘 | Julio Maria Fonseca Chebli Aécio Flávio Meirelles de Souza Pedro Duarte Gaburri Kátia Valeria Bastos Tarsila Campanha Rocha Ribeiro Roberto José Carvalho Filho Liliana Andrade Chebli Lincoln Eduardo V.V. Castro Ferreira | 2002 | Journal of Clinical Gastroenterology2002，，1： | 1 |
| 2 | Prevalence and Pathogenesis of Duodenal Ulcer in Chronic Alcoholic Pancreatitis显示文摘 | Julio Maria Fonseca Chebli Aécio Flávio Meirelles de Souza Pedro Duarte Gaburri Kátia Valeria Bastos Tarsila Campanha Rocha Ribeiro Roberto José Carvalho Filho Liliana Andrade Chebli Lincoln Eduardo V.V. Castro Ferreira | 2002 | Journal of Clinical Gastroenterology2002，，1： | 1 |
| 3 | Ventilator-associated events: From surveillance to optimizing management显示文摘Mechanical ventilation(MV)is a life-support therapy that may predispose to morbid and lethal complications,with ventilator-associated pneumonia(VAP)being the most prevalent.In 2013,the Center for Disease Control(CDC)defined criteria for ventilator-associated events(VAE).Ten years later,a growing number of studies assessing or validating its clinical applicability and the potential benefits of its inclusion have been published.Surveillance with VAE criteria is retrospective and the focus is often on a subset of patients with higher thanlower severity.To date,it is estimated that around 30%of ventilated patients in the intensive care unit(ICU)develop VAE.While surveillance enhances the detection of infectious and non-infectious MV-related complicationsthat are severe enough to impact the patient’s outcomes,there are still many gaps in its classification and management.In this review,we provide an update by discussing VAE etiologies,epidemiology,and classification.Preventive strategies on optimizing ventilation,sedative and neuromuscular blockade therapy,and restrictivefluid management are warranted.An ideal VAE bundle is likely to minimize the period of intubation.We believethat it is time to progress from just surveillance to clinical care.Therefore,with this review,we have aimed toprovide a roadmap for future research on the subject. | Sergio Ramirez-Estrada Yolanda Peña-Lopez Tarsila Vieceli Jordi Rello | 2023 | Journal of Intensive Medicine2023，3，3： | 0 |
| 4 | Prevention of ventilator-associated pneumonia through care bundles:A systematic review and meta-analysis显示文摘Background Ventilator-associated pneumonia(VAP)represents a common hospital-acquired infection among mechanically ventilated patients.We summarized evidence concerning ventilator care bundles to prevent VAP.Methods A systematic review and meta-analysis were performed.Randomized controlled trials and controlled observational studies of adults undergoing mechanical ventilation(MV)for at least 48 h were considered for inclusion.Outcomes of interest were the number of VAP episodes,duration of MV,hospital and intensive care unit(ICU)length of stay,and mortality.A systematic search was conducted in the MEDLINE,the Cochrane Library,and the Web of Science between 1985 and 2022.Results are reported as odds ratio(OR)or mean difference(MD)with 95%confidence intervals(CI).The PROSPERO registration number is CRD42022341780.Results Thirty-six studies including 116,873 MV participants met the inclusion criteria.A total of 84,031 participants underwent care bundles for VAP prevention.The most reported component of the ventilator bundle was head-of-bed elevation(n=83,146),followed by oral care(n=80,787).A reduction in the number of VAP episodes was observed among those receiving ventilator care bundles,compared with the non-care bundle group(OR=0.42,95%CI:0.33,0.54).Additionally,the implementation of care bundles decreased the duration of MV(MD=−0.59,95%CI:−1.03,−0.15)and hospital length of stay(MD=−1.24,95%CI:−2.30,−0.18)in studies where educational activities were part of the bundle.Data regarding mortality were inconclusive.Conclusions The implementation of ventilator care bundles reduced the number of VAP episodes and the duration of MV in adult ICUs.Their application in combination with educational activities seemed to improve clinical outcomes. | Raquel Martinez-Reviejo Sofia Tejada Miia Jansson Alfonsina Ruiz-Spinelli Sergio Ramirez-Estrada Duygu Ege Tarsila Vieceli Bert Maertens Stijn Blot Jordi Rello | 2023 | Journal of Intensive Medicine2023，3，4： | 0 |
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