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| 1 | Bone marrow microenvironment: The guardian of leukemia stem cells显示文摘Bone marrow microenvironment (BMM) is the main sanctuary of leukemic stem cells (LSCs) and protects these cells against conventional therapies. However, it may open up an opportunity to target LSCs by breaking the close connection between LSCs and the BMM. The elimination of LSCs is of high importance, since they follow cancer stem cell theory as a part of this population. Based on cancer stem cell theory, a cell with stem cell-like features stands at the apex of the hierarchy and produces a heterogeneous population and governs the disease. Secretion of cytokines, chemokines, and extracellular vesicles, whether through autocrine or paracrine mechanisms by activation of downstream signaling pathways in LSCs, favors their persistence and makes the BMM less hospitable for normal stem cells. While all details about the interactions of the BMM and LSCs remain to be elucidated, some clinical trials have been designed to limit these reciprocal interactions to cure leukemia more effectively. In this review, we focus on chronic myeloid leukemia and acute myeloid leukemia LSCs and their milieu in the bone marrow, how to segregate them from the normal compartment, and finally the possible ways to eliminate these cells. | Mohammad Houshmand Teresa Mortera Blanco Paola Circosta Narjes Yazdi Alireza Kazemi Giuseppe Saglio Mahin Nikougoftar Zarif | 2019 | World Journal of Stem Cells2019，11，8： | 2 |
| 2 | Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B- cell chronic lymphocytic leukemia显示文摘 | GRANZIERO L GHIA P CIRCOSTA P | 2001 | Blood2001，97，9： | 1 |
| 3 | Biological and analytical characterization of two extracts from Valeriana officinalis 显示文摘 | Circosta C De Pasquale R Samperi S | 2007 | J Ethnopharmacol2007，112，2： | 1 |
| 4 | Agrobacterium-mediated transformation of the ectomycorrhizal symbiont Laccaria bicolor S238N显示文摘 | Kemppainen M Circosta A Tagu D | 2005 | Mycorrhiza2005，，16： | 1 |
| 5 | New model for controls on gold-silver mineralization on Misima Island显示文摘 | Appleby K Circosta G Fanning M | 1996 | Mining Engi- neering1996，48，： | 1 |
| 6 | Ab-indu- ted ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity 显示文摘 | PETRELLI A CIRCOSTA P GRANZIERO L | 2006 | Proc Natl Acad Sci2006，103，13： | 1 |
| 7 | T cell receptor (TCR) gene transfer with lentiviral vectors allows efficient redirection of tumor specificity in naive and memory T cells without prior stimulation of endogenous TCR 显示文摘 | Circosta P Granziero L Follenzi A | 2009 | Hum Gene Ther2009，20，12： | 1 |
| 8 | Cardiovascular effects of the aqueous extract of Gynostemma pemaphyllum Makino 显示文摘 | CIRCOSTA C DE PASQUALE R OCCHIUTO F | 2005 | Phytomedicine2005，12，9： | 1 |
| 9 | Cardiovascular effects of the aqueous extract of Gynostemma pentaphyllum Maki- no显示文摘 | Circosta C de Pasquale R Occhiuto F | 2005 | Phytomedicine2005，12，9： | 1 |
| 10 | Estrogenic activity of standardized extract of Angelica sinensis 显示文摘 | Circosta C Pasquale R D Palumbo D R | 2006 | Phytother Res2006，20，8： | 1 |
| 11 | Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B- cell chronic lymphocytic leukemia 显示文摘 | Granziero L Ghia P Circosta P | 2001 | Blood2001，97，9： | 1 |
| 12 | Cardiovascular effects of the aqueous extract of Gynostemma pentaphyllum Makino 显示文摘 | Circosta C Pasquale R D Occhiuto F | 2005 | Phytomedicine2005，12，9： | 1 |
| 13 | survivinis expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia 显示文摘 | Granziero L Ghia P Circosta P | 2001 | Blood2001，97，9： | 1 |
| 14 | Sunrvivin is expressed on CD4Ostimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia显示文摘 | Granziero L Ghia P Circosta P | 2001 | Blood2001，97，： | 1 |
| 15 | Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity显示文摘 | Petrelli A Circosta P Granziero L | 2006 | Proc Natl Acad Sci USA2006，103，13： | 1 |
| 16 | CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes显示文摘 | Granziero L Circosta P Scielzo C | 2003 | Blood2003，101，5： | 1 |
| 17 | CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes显示文摘 | Granziero L Circosta P Scielzo C | 2003 | Blood2003，101，5： | 1 |
| 18 | Estrogenic activity of standardized extract of Angelica sinensis显示文摘 | Circosta C Pasquale RD Palumbo DR | 2006 | Phytother Res(S0034- 7515)2006，20，8： | 1 |
| 19 | Cardiovascular effects of the aqueous extract of Gynostemma pentaphyllum Makino 显示文摘 | Circosta C De Pasquale R Occhiuto F | 2005 | Phytomedicine2005，12，9： | 1 |
| 20 | Bronchodilatory effects of the aqueous extract of Gynostemma pentaphyllum and gypenosides Ⅲ and Ⅷ in a naesthetized guinea-pigs显示文摘 | Circosta C De Pasquale R Palumbo DR | 2005 | J Pharm Pharmacol2005，57，8： | 1 |
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