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| 1 | Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation显示文摘Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral Published online: January 27, 2019 recurrence after LT.Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral recurrence after LT. | Maria J Citores Jose L Lucena Sara de la Fuente Valentin Cuervas-Mons | 2019 | World Journal of Hepatology2019，11，1： | 12 |
| 2 | Decrease of regulatory T cells in patients with systemic lupus erythematosos 显示文摘 | Mellor - Pita S Citores MJ Castejon R | 2006 | Ann Rheum Dis2006，65，4： | 1 |
| 3 | Decrease of regulatory T cells in patients with systemic lupus erythematosus 显示文摘 | Mellor-Pita S Citores M J Castejon R | 2006 | Ann Rheum Dis2006，65，4： | 1 |
| 4 | Increased risk of severe hepatitis C virus recurrence after liver transplantation in patients with a T allele of IL28B rs12979860显示文摘 | Cisneros E Ba(n)os I Citores MJ | | 0，，： | 1 |
| 5 | HSP-70 as a nonspecific early marker in cisplatin ototoxicity显示文摘 | Ramírez-Camacho R Citores MJ Trinidad A et a1 | 2007 | Acta Otolaryngol2007，127，： | 1 |
| 6 | HSP70 as a nonspecific early marker in eisplatin ototoxicity显示文摘 | Ramirez-Camacho R Citores MJ Trinidad A | 2007 | Acta Otolaryngol2007，127，6： | 1 |
| 7 | Decrease of regu- latory T cells in patients with systemic lupus erythematosus显示文摘 | Mellor-Pita S Citores M J Castejon R et aI | 2006 | Ann Rheum Dis2006，65，4： | 1 |
| 8 | Decrease of regulatory Tcells in patients with systemic lupus erythematosus显示文摘 | Mellor-Pita S Citores MJ Castejon R | 2006 | Ann RheumDis2006，65，4： | 1 |
| 9 | Toll-like receptor 3 L412F polymorphism may protect against acute graft rejection in adult patients undergoing liver transplantation for hepatitis C-related cirrhosis显示文摘 | Citores MJ Banos I Noblejas A | 2011 | Transplant Proc2011，43，6： | 1 |
| 10 | Decrease of regulatory T cells in patients with systemic lupus crvthematosus 显示文摘 | Mellor- Pita S Citores M J Castejon R | 2006 | Ann Rheum Dis2006，65，4： | 1 |
| 11 | Contribution of monoeytes to overproduction of interleukin-6 in a ease of cardiac myxoma显示文摘 | Garcia-Zubiri C Citores M J Yebra-Bango M | 2009 | Am J Med Sei2009，338，4： | 1 |
| 12 | Decrease of regulatory T cells in patients with systemic lupus erythematosus显示文摘 | Mellor-Pita S Citores MJ Castejon R | 2006 | Ann Rheum Dis2006，65，4： | 1 |
| 13 | Angiolymphoid hyperplasia with eosinophilia of the tongue:report of a case and review of the literature显示文摘 | Razquin S Mayayo E Citores MA | 1991 | Hum Pathol1991，22，8： | 1 |
| 14 | Monocytes and T lymphocytes conmbute to a predominance of interleukin 6 and interleukin 10 in systemic lupus erythematosus显示文摘 | Mellor-Pita S Citores M J Castejon R | 2009 | Cytometry B Clin Cytom2009，76，4： | 1 |
| 15 | Monocytes and T lymphocytes contribute to a predominance of interleukin 6 and interleukin 10 in systemic lupus erythematosus显示文摘 | Mellor-Pita S Citores MJ Castejon R | 2009 | Cytometry B Clin Cytom2009，76，4： | 1 |
| 16 | Lymphocytic variant of the hypereosinophilic syndrome显示文摘 | Roldan MA Citores SMJ Perales FI | | 0，，06： | 1 |
| 17 | Toll-like receptor 3 L412F polymorphism may protect against acute graft rejection in adult patients undergoing liver transplantation for hepatitis C-related cirrhosis显示文摘 | Citores M Banos I Noblejas A | 2011 | Transplant Proc2011，43，6： | 1 |
| 18 | Toll-like receptor 3 L412F polymorphism may protect against acute graft rejection in adult patients undergoing liver transplantation for hepatitis C- related cirrhosis 显示文摘 | Citores MJ Bafios I Noblejas A | 2011 | Transplant Proc2011，43，6： | 1 |
| 19 | Decrease of regulatory T cells in patients with systemic lupus erythematosus显示文摘 | Mellor-Pita S Citores MJ Castejon R | 2006 | Ann Rheum Dis2006，65，4： | 1 |
| 20 | Prognostic value of neutrophils and NK cells in bronchoalveolar lavage of sarcoidosis 显示文摘 | Tutor-Ureta P Citores MJ Castejon R | 2006 | Cytometry B Clin Cytom2006，70，6： | 1 |
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