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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Transition of Adolescents With Inflammatory Bowel Disease From Pediatric to Adult Care: A Survey of Adult Gastroenterologists显示文摘 | Elizabeth J Hait Renée M Barendse Janis H Arnold Clarissa Valim Bruce E Sands Joshua R Korzenik Laurie N Fishman | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，1： | 1 |
| 3 | Function of Candida albicans adhesin Hwpl in biofilm formation 显示文摘 | Clarissa J Jeniel E David R | 2006 | Cell2006，5，10： | 1 |
| 4 | Post-activation depression of Soleus stretch reflexes in healthy and spastic humans显示文摘 | MICHAEL J GREY KLAUS KLINGE CLARISSA CRONE | 2008 | Exp Brain Res2008，185，： | 1 |
| 5 | Atorvastatin withdrawal elicits oxidative/nitrosative damage in the rat cerebral cortex显示文摘 | Clarissa Vasconcelos de Oliveira Vinícius Rafael Funck Letícia Meier Pereira Jéssica Grigoletto Leonardo Magno Rambo Leandro Rodrigo Ribeiro Luiz Fernando Freire Royes Ana Flávia Furian Mauro Schneider Oliveira | 2013 | Pharmacological Research2013，，： | 1 |
| 6 | Obesity in people with diabetes in COVID-19 times: Important considerations and precautions to be taken显示文摘At the end of 2019,a new disease with pandemic potential appeared in China.It was a novel coronavirus called coronavirus disease 2019(COVID-19).Later,in the first quarter of 2020,the World Health Organization declared the outbreak of this disease a pandemic.Elderly people,people with comorbidities,and health care professionals are more vulnerable to COVID-19.Obesity has been growing exponentially worldwide,affecting several age groups.It is a morbidity that is associated with genetic,epigenetic,environment factors and/or interaction between them.Obesity is associated with the development of several diseases including diabetes mellitus,mainly type 2.Diabetes affects a significant portion of the global population.Obesity and diabetes are among the main risk factors for the development of severe symptoms of COVID-19,and individuals with these conditions constitute a risk group.Based on a literature review on obesity in people with diabetes in the framework of the COVID-19 pandemic,this study presents updated important considerations and care to be taken with this population. | Adriano Alberti Fabiana Schuelter-Trevisol Betine Pinto Moehlecke Iser Eliane Traebert Viviane Freiberger Leticia Ventura Gislaine Tezza Rezin Bruna Becker da Silva Fabiana Meneghetti Dallacosta Leoberto Grigollo Paula Dias Gracielle Fin Josiane Aparecida De Jesus Fabiane Pertille Carina Rossoni Ben Hur Soares Rudy JoséNodari Júnior Clarissa Martinelli Comim | 2021 | World Journal of Clinical Cases2021，9，20： | 0 |
| 7 | Liver biopsy for visceral leishmaniasis diagnosis in pregnancy: report of 2 cases显示文摘Visceral leishmaniasis(VL) or kala-azar is a zoonosis caused by intracellular protozoa of the Leishmania genus and is transmitted to humans by the bite of phlebotomine sandflies. It particularly affects cells in the phagocytic mononuclear system, accompanied by disturbances of cellular and humoral immunity. VL is potentially fatal and is characterized by fever, hepatosplenomegaly, diarrhea, epistaxis, jaundice, anemia, leucopenia, thrombocytopenia, hypoalbuminemia and hyperglobulinemia. Diagnostic suspicion is based on epidemiological, clinical and laboratory data and isconfirmed by detecting the parasite in infected tissue. Splenic aspiration is the most sensitive method, followed by bone marrow aspiration(BMA) by sternal puncture, liver biopsy and lymph node aspiration; but, due to safety concerns, BMA is the most recommended method. VL is included as a target disease by players in drug research and development. Severe liver dysfunction associated with VL is uncommon. We report two VL cases in pregnant women from Bauru, Sao Paulo state, Brazil, considered an endemic area. The first of them developed hepatic failure due to fulminant hepatitis. In both cases, BMA was unable to find the protozoan; thus, liver biopsy was the only means of making the diagnosis. | Talles Bazeia Lima Clarissa Ribeiro Villar Maria Aparecida Marchesan Rodrigues Júlio Pinheiro Baima Fábio da Silva Yamashiro Letícia Campos Franzoni Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro Lígia Yukie Sassaki | 2013 | World Journal of Clinical Infectious Diseases2013，3，2： | 0 |
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