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	题名	作者	年代	出处	被引量
1	Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer.	Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur	2008	World Journal of Gastroenterology2008，14，7：	3
2	Characterization of the effect of hemicellulose on the deposition of calcium soaps of tall oil using fac- torial design analysis 显示文摘	Clas S D Koller E Alien L H	1993	Journal of Pulp and Paper Science1993，19，5：	1
3	Crystallinties of copolymers of ethylene and 1-alkene显示文摘	Clas S D Heyding R D McFadding D C	1988	J Polym Sci Polym Phys Ed1988，26，：	1
4	A multi-scale approach to improve reservoir charac- terization and forecasting: the Albacora Field (deep water offshore Brazil) study显示文摘	Luciane B C Alberto cla S B Cristiano L S	2001	Petroleum Geosci- ence2001，7，5：	1
5	Impact of Deferred Treatment of Blunt Diaphragmatic Rupture:A 15 -Year Experience in Six Trauma Centers in Quebec 显示文摘	Bergeron E Clas D Ratte S	2002	J Trauma2002，52，4：	1
6	Crystallinties of copolymers of ethylene and 1-alkene显示文摘	Clas S D Heyding R D McFadding D C		Journal of Polymer Science Part B:Polymer Physics0，，：	1
7	Impact of deferred treament of blunt diaphragmatic rupture:a 15-year experience in six trauma centers in Quebec显示文摘	Bergeron E Clas D Ratts S	2002	Trauma2002，52，：	1
8	Evaluation of disintegration tes- ting of different fast dissolving tab -lets using the texture analyzer显示文摘	Arini E Kocova S Clas S	2002	Pharmaceutical Development and Technology2002，7，3：	1
9	Impact of deferred treament of blunt diaphragmatic rupture:a 15-year experience in six trauma centers in Quebec显示文摘	BERGERON E CLAS D RATTS S	2002	Trauma2002，52，4：	1
10	Impact of deferred treatment of blunt diaphragmatic rapture: A 15-year experience in six trauma Centers in Quebec 显示文摘	Bergeron E Clas D Ratte S	2002	J Trauma2002，52，4：	1
11	Characterization of the effect of hemicellulose on the deposition of calcium soaps of tall oil using factorial design analysis显示文摘	Clas S D Koller E Allen L H		Journal of Pulp and Paper Science 9930，19，5：	1
12	Impact of deferred treat ment of blunt diaphragmatic rupture: a 15-year experience in six trauma centers in Quebec显示文摘	Bergeron E Clas D Ratte S	2002	J Trauma2002，52，4：	1
13	Lmpaet of deferred treatment of blunt diaphragmatic rupture: a 15 - year experience in six trauma centers in Quebec显示文摘	Bergeron E Clas D Ratte S	2002	The J Trauma2002，52，4：	1
14	Neurokinins produce selective venoconstriction via NK - 3 receptors in the rat mesenteric vascular bed显示文摘	D'Orleans- Juste P Claing A Telemaque S	1991	Eur J Pharmacol1991，204，3：	1
15	lmpact of deferred treatment of blunt diaphragmatic rupture: a 15 -year ex- perience in six trauma centers in Quebec 显示文摘	Bergeron E Clas D Ratte S	2002	Trauma2002，52，4：	1
16	Impact of deferred treat- ment of blunt diaphragmatic rupture: a 15-year experience in six trauma centers in Quebec显示文摘	Bergeron E Clas D Ratts S	2002	Trauma2002，52，4：	1
17	Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis显示文摘	Caprio M Fève B Cla(e)s A		0，，09：	1
18	Endocytosis of G protein-coupled receptors:roles of G protein-coupled receptor kinases and betaarrestin proteins显示文摘	CLAING A LAPORTE S A CARON M G	2002	Prog Neurobiol2002，66，：	1
19	ARF1 regulates adhesion of MDA - MB -231 invasive breast cancer cells through formation of focal adhe- sions 显示文摘	Schlienger S Ramirez RA Claing A	2015	Cell Signal2015，27，3：	1
20	Accessibility of infotmation of the web 显示文摘	Lawrence S Giles CLA	1999	Nature1999，，400：	1

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