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| 1 | Portal hypertensive biliopathy: A single center experience and literature review显示文摘Portal hypertensive biliopathy (PHB) is characterized by anatomical and functional abnormalities of the intrahepatic, extrahepatic and pancreatic ducts, in patients with portal hypertension associated to extrahepatic portal vein obstruction and less frequently to cirrhosis. These morphological changes, consisting in dilatation and stenosis of the biliary tree, are due to extensive venous collaterals occurring in an attempt to decompress the portal venous blockage. It is usually asymptomatic until it progresses to more advanced stages with cholestasis, jaundice, biliary sludge, gallstones, cholangitis and finally biliary cirrhosis. Imaging mo-dalities of the biliary tree such as Doppler ultrasound, computed tomography, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography are essential to establish the diagnosis and the need of therapeutical interventions. Once the diagnosis is established, treatment with ursodesoxycholic acid seems to be beneficial. Decompression of the biliary tree to dilate, remove stones or implant biliary prosthesis by endoscopic or surgical procedures (hepato-yeyunostomy) usually resolves the cholestatic picture and prevents septic complications. The ideal treatment is the decompression of the portal system, with transjugular intrahepatic porto-systemic shunt or a surgical porto-systemic shunt. Unfortunately, few patients will be candidates for these procedures due to the extension of the thrombotic process. The purpose of this paper is to report the first 3 cases of PHB seen in a Colombian center and to review the literature. | Vanessa Suárez Andrés Puerta Luisa Fernanda Santos Juan Manuel Pérez Adriana Varón Rafael Claudino Botero | 2013 | World Journal of Hepatology2013，5，3： | 10 |
| 2 | Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease显示文摘This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. | Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana | 2023 | Neural Regeneration Research2023，18，12： | 2 |
| 3 | Periodontitis and arthritis interaction in mice involves a shared hypeF inflammatory genotype and functional immunological interferences显示文摘 | Trombone AP Claudino M Colavite P | 2010 | Genes Immun2010，11，6： | 1 |
| 4 | Adsorption equilibrium and breakthrough analysis for NO adsorption on activated carbons at low temperatures显示文摘 | Claudino A Soares J L Moreira R F P M | 2004 | Carbon2004，42，： | 1 |
| 5 | Non-in- flammatory destructive periodontal disease : a clinical, mi- crobiological, immunological and genetic investigation 显示文摘 | Repeke C E Cardoso C R Claudino M | 2012 | Journal of Application Oral Science2012，20，1： | 1 |
| 6 | Preventive and therapeutic euphol treatment attenuates experimental colitis in mice显示文摘 | Dutra R C Claudino R F Bento A F | 2011 | PLo S One2011，6，27： | 1 |
| 7 | Down- regu- lation of expression of osteoblast and osteocyte markers in pe- riodontal tissues associated with the spontaneous alveolar bone loss of interleukin- 10 knockout mice 显示文摘 | Claudino M Garlet TP Cardoso CR | 2010 | Eur J Oral Sci2010，118，1： | 1 |
| 8 | Evaluation of chemical mediators and cellular response during acute and chronic gut inflammatory response induced by dextran sodium sulfate in mice显示文摘 | Allisson Freire Bento Daniela Ferraz Pereira Leite Rodrigo Marcon Rafaela Franco Claudino Rafael Cypriano Dutra Maíra Cola Alessandra Cadete Martini Jo?o B. Calixto | 2012 | Biochemical Pharmacology2012，，11： | 1 |
| 9 | Evidences of the cooperative role of the chemokines CCL3,CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL + cell migration throughout experimental periodontitis in mice显示文摘 | Repeke CE Ferreira SB Jr Claudino M | 2010 | Bone2010，46，4： | 1 |
| 10 | New strategies to identify molecular markers predicting chemotherapy activity and toxicity in breast cancer显示文摘 | Di Leo A Claudino W Colangiuli D | 2007 | Ann Oncol2007，1812，： | 1 |
| 11 | Adsorption equilibrium and breakthrough analysis for NO adsorption on activated carbons at low temperatures显示文摘 | CLAUDINO A SOARES J L MOREIRA R F P M | 2004 | Carbon2004，42，： | 1 |
| 12 | Aerobic Exercise Decreases Chronic Allergic Lung Inflammation and Airway Remode- ling in Mice显示文摘 | RP Vieira RC Claudino ACS Duarte | 2007 | American Journal of Respiratory and Critical Care Medicine2007，176，9： | 1 |
| 13 | New strategies to identify molecu- lar markers predicting chemotherapy activity and toxicity in breast cancer显示文摘 | Leo AD Claudino W Colangiuli D | 2007 | Annals of Oncology2007，18，12： | 1 |
| 14 | Metabolomics: available resuits, current research projects in breast cancer future applications显示文摘 | Claudino WM Quattrone A Bigan- zoli L | 2007 | J Clin Oncol2007，25，： | 1 |
| 15 | Metabo- lomics in biomarker discovery:future uses for cancer pre- vention显示文摘 | Claudino W M Quattrone A Biganzoli L | 2007 | Clin2007，4，1： | 1 |
| 16 | Acinetobacter strains IH9 and OCI1, two rhizospheric phosphate solubilizing isolates able to promote plant growth, constitute a new genomovar ofAcinetobacter calcoaceticus显示文摘 | Alvaro P Elke L Susanne V Cathrin S Rau'lR Ignacio SR Pedro FM Eustoquio MM Claudino RB Encama V | 2009 | Systematic and Applied Microbiology2009，32，5： | 1 |
| 17 | Identification of a serum-detectable metabolomic fingerprint potentially correlated with the presence of micrometastatic disease in early breast cancer patients at varying risks of disease relapse by traditional prognostic methods显示文摘 | Oakman C Tenori L Claudino WM | 2011 | Ann Oncol2011，22，6： | 1 |
| 18 | Eating disorders 显示文摘 | Treasure J Claudino AM Zucker N | 2010 | Lancet2010，375，9714： | 1 |
| 19 | Alloxan-induced diabetes triggers the development of periodontal disease in rats显示文摘 | Claudino M Ceolin DS Alberti S | 2007 | PLoS ONE2007，2，12： | 1 |
| 20 | Intraplantar PGE2 causes nociceptive behaviour and mechanical allodynia: the role of prostanoid E receptors and protein kinases显示文摘 | Kassuya CA Ferreira J Claudino RF Calixto JB | 2007 | Br J Pharmacol2007，150，6： | 1 |
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